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Hemoglobin, alpha 2

January 12, 2023

This article is about a gene. For the similarly named Hemoglobin tetramer, HbA2, see Hemoglobin A2.

Hemoglobin, alpha 2[5] also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin.[6][7]

HBA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHBA2, HBA-T2, HBH, Hemoglobin, alpha 2, hemoglobin subunit alpha 2, ECYT7
External IDsOMIM: 141850 MGI: 96015 HomoloGene: 469 GeneCards: HBA2
Orthologs
SpeciesHumanMouse
Entrez

3040

15122

Ensembl

ENSG00000188536

ENSMUSG00000069919

UniProt

P69905

Q91VB8

RefSeq (mRNA)

NM_000517

NM_008218

RefSeq (protein)

NP_000508
NP_000508.1
NP_000549.1

NP_001077424

Location (UCSC)Chr 16: 0.17 – 0.17 MbChr 11: 32.23 – 32.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb, including seven alpha like globin genes and pseudogenes: 5'- HBZ - HBZP1 - HBM - HBAP1 - HBA2 - HBA1 - HBQ1 -3'. The HBA2 (α2) and HBA1 (α1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions.

Protein

Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin.

Clinical significance

Alpha-thalassemias most commonly result from deletions of any of the four alpha alleles, although some alpha thalassemias have been reported that are due to mutations other than deletion. Deletion of 1 or 2 alleles is clinically silent. Deletion of 3 alleles causes HbH disease, resulting in anemia and hepatosplenomegaly. Deletion of all 4 alleles is lethal because it renders the body unable to make fetal hemoglobin (HbF), adult hemoglobin (HbA) or adult variant hemoglobin (HbA2), and results in hydrops fetalis.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188536 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069919 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "HBA2 gene: MedlinePlus Genetics".
  6. ^ Liebhaber SA, Goossens MJ, Kan YW (Dec 1980). "Cloning and complete nucleotide sequence of human 5'-alpha-globin gene". Proceedings of the National Academy of Sciences of the United States of America. 77 (12): 7054–8. Bibcode:1980PNAS...77.7054L. doi:10.1073/pnas.77.12.7054. PMC 350439. PMID 6452630.
  7. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (Apr 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  8. ^ "Entrez Gene: HBA2 hemoglobin, alpha 2".

Further reading

  • Richter F, Meurers BH, Zhu C, Medvedeva VP, Chesselet MF (Aug 2009). "Neurons express hemoglobin alpha- and beta-chains in rat and human brains". The Journal of Comparative Neurology. 515 (5): 538–47. doi:10.1002/cne.22062. PMC 3123135. PMID 19479992.
  • Phylipsen M, Vogelaar IP, Schaap RA, Arkesteijn SG, Boxma GL, van Helden WC, Wildschut IC, de Bruin-Roest AC, Giordano PC, Harteveld CL (Aug 2010). "A new alpha(0)-thalassemia deletion found in a Dutch family (--(AW))". Blood Cells, Molecules & Diseases. 45 (2): 133–5. doi:10.1016/j.bcmd.2010.05.004. PMID 20682466.
  • Sessa R, Puzone S, Ammirabile M, Piscopo C, Pagano L, Colucci S, Izzo P, Grosso M (Feb 2010). "Identification and molecular characterization of the --CAMPANIA deletion, a novel alpha (0) -thalassemic defect, in two unrelated Italian families [corrected]". American Journal of Hematology. 85 (2): 143–4. doi:10.1002/ajh.21591. PMID 20054848. S2CID 26190193.
  • Yin XL, Zhang XH, Zhou TH, Zhang TL, Luo RG, Wang L, Zhou YL, Chen YS, Kong XJ, Liang B, He YY, Peng L, Lu LB, Fang SP, Wu ZK (2010). "Hemoglobin H disease in Guangxi province, Southern China: clinical review of 357 patients". Acta Haematologica. 124 (2): 86–91. doi:10.1159/000314058. PMID 20639625. S2CID 38841342.
  • Joly P, Lacan P, Bererd M, Garcia C, Zanella-Cleon I, Becchi M, Aubry M, Couprie N, Francina A (2009). "Description of two new alpha variants: Hb Canuts [alpha85(F6)Asp-->His (alpha1)] and Hb Ambroise Pare [alpha117(GH5)Phe-->Ile (alpha2)]; two new beta variants: Hb Beaujolais [beta84(EF8)Thr-->Asn] and Hb Monplaisir [beta147 (Tyr-Lys-Leu-Ala-Phe-Phe-Leu-Leu-Ser-Asn-Phe-Tyr-158-COOH)] and one new delta variant: Hb (A2)North Africa [delta59(E3)Lys-->Met]". Hemoglobin. 33 (3): 196–205. doi:10.1080/03630260903058685. PMID 19657833. S2CID 26959240.
  • Harteveld CL, Oosterhuis WP, Schoenmakers CH, Ananta H, Kos S, Bakker Verweij M, van Delft P, Arkesteijn SG, Phylipsen M, Giordano PC (Apr 2010). "alpha-thalassaemia masked by beta gene defects and a new polyadenylation site mutation on the alpha2-globin gene". European Journal of Haematology. 84 (4): 354–8. doi:10.1111/j.1600-0609.2009.01380.x. PMID 19912309. S2CID 20511683.
  • Kapralov A, Vlasova II, Feng W, Maeda A, Walson K, Tyurin VA, Huang Z, Aneja RK, Carcillo J, Bayir H, Kagan VE (Oct 2009). "Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages". The Journal of Biological Chemistry. 284 (44): 30395–407. doi:10.1074/jbc.M109.045567. PMC 2781594. PMID 19740759.
  • Roy P, Bhattacharya G, Banerjee D, Chandra S, Ghosh M, Choudhuri U, Das M, Dasgupta UB (2009). "Hb Sallanches [alpha104(G11)Cys-->Tyr, TGC>TAC] occurs frequently on the Indian subcontinent". Hemoglobin. 33 (6): 486–91. doi:10.3109/03630260903336164. PMID 19958194. S2CID 22370275.
  • Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Critical Reviews in Biochemistry and Molecular Biology. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
  • Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (Apr 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  • Ribeiro DM, Sonati MF (2008). "Regulation of human alpha-globin gene expression and alpha-thalassemia". Genetics and Molecular Research. 7 (4): 1045–53. doi:10.4238/vol7-4gmr472. PMID 19048483.
  • Waye JS, Eng B, Dutly F, Frischknecht H (2009). "alpha-Thalassemia caused by two novel splice mutations of the alpha2-globin gene: IVS-I-1 (G>A and G>T)". Hemoglobin. 33 (6): 519–22. doi:10.3109/03630260903333377. PMID 19958200. S2CID 41033036.
  • Coelho A, Picanço I, Seuanes F, Seixas MT, Faustino P (Aug 2010). "Novel large deletions in the human alpha-globin gene cluster: Clarifying the HS-40 long-range regulatory role in the native chromosome environment" (PDF). Blood Cells, Molecules & Diseases. 45 (2): 147–53. doi:10.1016/j.bcmd.2010.05.010. hdl:10400.18/117. PMID 20580289.
  • Sharma V, Kumar B, Kumar G, Saxena R (Oct 2009). "Alpha globin gene numbers: an important modifier of HbE/beta thalassemia". Hematology. 14 (5): 297–300. doi:10.1179/102453309X446126. PMID 19843387. S2CID 11461489.
  • Turbpaiboon C, Wilairat P (2010). "Alpha-hemoglobin stabilizing protein: molecular function and clinical correlation". Frontiers in Bioscience. 15 (1): 1–11. doi:10.2741/3601. PMID 20036801.
  • Voon HP, Vadolas J (Dec 2008). "Controlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia". Haematologica. 93 (12): 1868–76. doi:10.3324/haematol.13490. PMID 18768527.
  • Giordano PC, Cnossen MH, Joosten AM, Jansen CA, Hakvoort TE, Bakker-Verweij M, Arkesteijn SG, van Delft P, Waye JS, Bouva MJ, Harteveld CL (2010). "Codon 24 (TAT>TAG) and codon 32 (ATG>AGG) (Hb Rotterdam): two novel alpha2 gene mutations associated with mild alpha-thalassemia found in the same family after newborn screening". Hemoglobin. 34 (4): 354–65. doi:10.3109/03630269.2010.486341. PMID 20642333. S2CID 35413104.
  • Mahdavi MR, Kowsarian M, Karami H, Mohseni A, Vahidshahi K, Roshan P, Hojjati MT, Ebrahimzadeh MA (Oct 2010). "Prevalence of hemoglobin alpha-chain gene deletion in neonates in North of Iran". European Review for Medical and Pharmacological Sciences. 14 (10): 871–5. PMID 21222374.
  • Balakrishnan G, Zhao X, Podstawska E, Proniewicz LM, Kincaid JR, Spiro TG (Apr 2009). "Subunit-selective interrogation of CO recombination in carbonmonoxy hemoglobin by isotope-edited time-resolved resonance Raman spectroscopy". Biochemistry. 48 (14): 3120–6. doi:10.1021/bi802190f. PMC 2722936. PMID 19245215.
  • Zhu C, Yu W, Xie J, Chen L, Ding H, Shang X, Xu X (Oct 2010). "Hemoglobin H disease due to a de novo mutation at the α2-globin gene and an inherited common α-thalassemia deletion found in a Chinese boy". Blood Cells, Molecules & Diseases. 45 (3): 223–6. doi:10.1016/j.bcmd.2010.07.005. PMID 20691621.

External links

  • GeneReviews/NCBI/NIH/UW entry on Alpha-Thalassemia
  • OMIM entries on Alpha-Thalassemia

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


January 12, 2023
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This article is about a gene For the similarly named Hemoglobin tetramer HbA2 see Hemoglobin A2 Hemoglobin alpha 2 5 also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin 6 7 HBA2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FDH 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1SHR 1SI4 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y01 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 1Z8U 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HXN 3IA3 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3OVU 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S48 3S65 3S66 3SZK 3WCP 3WHM 4FC3 4HHB 4IJ2 4L7Y 4M4A 4M4B 4MQC 4MQG 4MQH 4MQI 4MQJ 4MQK 4N7N 4N7O 4N7P 4N8T 4NI0 4NI1 4ROL 4ROM 4WJG 4X0L 4XS0 6HBW 5E29 5E6E 5EE4 5HU6 5JDO 5KDQ 5E83 s1Y01 1Z8U 1BZ1IdentifiersAliasesHBA2 HBA T2 HBH Hemoglobin alpha 2 hemoglobin subunit alpha 2 ECYT7External IDsOMIM 141850 MGI 96015 HomoloGene 469 GeneCards HBA2Gene location Human Chr Chromosome 16 human 1 Band16p13 3Start172 876 bp 1 End173 710 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 A4 11 18 86 cMStart32 233 511 bp 2 End32 234 465 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytebloodbone marrowbone marrow cellsplacentaspleenganglionic eminenceupper lobe of left lungamygdalasubstantia nigraTop expressed inbone marrowspleenlungyolk sacneural tubemesencephalonheartcerebellar cortexzone of skinadrenal glandMore reference expression dataBioGPSn aGene ontologyMolecular functioniron ion binding oxygen binding peroxidase activity oxygen carrier activity metal ion binding protein binding heme binding haptoglobin binding organic acid bindingCellular componentcytosol endocytic vesicle lumen blood microparticle membrane extracellular region cytosolic small ribosomal subunit hemoglobin complex extracellular exosome haptoglobin hemoglobin complex extracellular spaceBiological processpositive regulation of cell death protein heterooligomerization oxygen transport receptor mediated endocytosis bicarbonate transport hydrogen peroxide catabolic process response to hydrogen peroxide cellular oxidant detoxification transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez304015122EnsemblENSG00000188536ENSMUSG00000069919UniProtP69905Q91VB8RefSeq mRNA NM 000517NM 008218RefSeq protein NP 000508NP 000508 1NP 000549 1NP 001077424Location UCSC Chr 16 0 17 0 17 MbChr 11 32 23 32 23 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Protein 3 Clinical significance 4 References 5 Further reading 6 External linksFunction EditThe human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb including seven alpha like globin genes and pseudogenes 5 HBZ HBZP1 HBM HBAP1 HBA2 HBA1 HBQ1 3 The HBA2 a2 and HBA1 a1 coding sequences are identical These genes differ slightly over the 5 untranslated regions and the introns but they differ significantly over the 3 untranslated regions Protein EditTwo alpha chains plus two beta chains constitute HbA which in normal adult life comprises about 97 of the total hemoglobin alpha chains combine with delta chains to constitute HbA 2 which with HbF fetal hemoglobin makes up the remaining 3 of adult hemoglobin Clinical significance EditAlpha thalassemias most commonly result from deletions of any of the four alpha alleles although some alpha thalassemias have been reported that are due to mutations other than deletion Deletion of 1 or 2 alleles is clinically silent Deletion of 3 alleles causes HbH disease resulting in anemia and hepatosplenomegaly Deletion of all 4 alleles is lethal because it renders the body unable to make fetal hemoglobin HbF adult hemoglobin HbA or adult variant hemoglobin HbA2 and results in hydrops fetalis 8 References Edit a b c GRCh38 Ensembl release 89 ENSG00000188536 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000069919 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine HBA2 gene MedlinePlus Genetics Liebhaber SA Goossens MJ Kan YW Dec 1980 Cloning and complete nucleotide sequence of human 5 alpha globin gene Proceedings of the National Academy of Sciences of the United States of America 77 12 7054 8 Bibcode 1980PNAS 77 7054L doi 10 1073 pnas 77 12 7054 PMC 350439 PMID 6452630 Higgs DR Vickers MA Wilkie AO Pretorius IM Jarman AP Weatherall DJ Apr 1989 A review of the molecular genetics of the human alpha globin gene cluster Blood 73 5 1081 104 doi 10 1182 blood V73 5 1081 1081 PMID 2649166 Entrez Gene HBA2 hemoglobin alpha 2 Further reading EditRichter F Meurers BH Zhu C Medvedeva VP Chesselet MF Aug 2009 Neurons express hemoglobin alpha and beta chains in rat and human brains The Journal of Comparative Neurology 515 5 538 47 doi 10 1002 cne 22062 PMC 3123135 PMID 19479992 Phylipsen M Vogelaar IP Schaap RA Arkesteijn SG Boxma GL van Helden WC Wildschut IC de Bruin Roest AC Giordano PC Harteveld CL Aug 2010 A new alpha 0 thalassemia deletion found in a Dutch family AW Blood Cells Molecules amp Diseases 45 2 133 5 doi 10 1016 j bcmd 2010 05 004 PMID 20682466 Sessa R Puzone S Ammirabile M Piscopo C Pagano L Colucci S Izzo P Grosso M Feb 2010 Identification and molecular characterization of the CAMPANIA deletion a novel alpha 0 thalassemic defect in two unrelated Italian families corrected American Journal of Hematology 85 2 143 4 doi 10 1002 ajh 21591 PMID 20054848 S2CID 26190193 Yin XL Zhang XH Zhou TH Zhang TL Luo RG Wang L Zhou YL Chen YS Kong XJ Liang B He YY Peng L Lu LB Fang SP Wu ZK 2010 Hemoglobin H disease in Guangxi province Southern China clinical review of 357 patients Acta Haematologica 124 2 86 91 doi 10 1159 000314058 PMID 20639625 S2CID 38841342 Joly P Lacan P Bererd M Garcia C Zanella Cleon I Becchi M Aubry M Couprie N Francina A 2009 Description of two new alpha variants Hb Canuts alpha85 F6 Asp gt His alpha1 and Hb Ambroise Pare alpha117 GH5 Phe gt Ile alpha2 two new beta variants Hb Beaujolais beta84 EF8 Thr gt Asn and Hb Monplaisir beta147 Tyr Lys Leu Ala Phe Phe Leu Leu Ser Asn Phe Tyr 158 COOH and one new delta variant Hb A2 North Africa delta59 E3 Lys gt Met Hemoglobin 33 3 196 205 doi 10 1080 03630260903058685 PMID 19657833 S2CID 26959240 Harteveld CL Oosterhuis WP Schoenmakers CH Ananta H Kos S Bakker Verweij M van Delft P Arkesteijn SG Phylipsen M Giordano PC Apr 2010 alpha thalassaemia masked by beta gene defects and a new polyadenylation site mutation on the alpha2 globin gene European Journal of Haematology 84 4 354 8 doi 10 1111 j 1600 0609 2009 01380 x PMID 19912309 S2CID 20511683 Kapralov A Vlasova II Feng W Maeda A Walson K Tyurin VA Huang Z Aneja RK Carcillo J Bayir H Kagan VE Oct 2009 Peroxidase activity of hemoglobin haptoglobin complexes covalent aggregation and oxidative stress in plasma and macrophages The Journal of Biological Chemistry 284 44 30395 407 doi 10 1074 jbc M109 045567 PMC 2781594 PMID 19740759 Roy P Bhattacharya G Banerjee D Chandra S Ghosh M Choudhuri U Das M Dasgupta UB 2009 Hb Sallanches alpha104 G11 Cys gt Tyr TGC gt TAC occurs frequently on the Indian subcontinent Hemoglobin 33 6 486 91 doi 10 3109 03630260903336164 PMID 19958194 S2CID 22370275 Giardina B Messana I Scatena R Castagnola M 1995 The multiple functions of hemoglobin Critical Reviews in Biochemistry and Molecular Biology 30 3 165 96 doi 10 3109 10409239509085142 PMID 7555018 Higgs DR Vickers MA Wilkie AO Pretorius IM Jarman AP Weatherall DJ Apr 1989 A review of the molecular genetics of the human alpha globin gene cluster Blood 73 5 1081 104 doi 10 1182 blood V73 5 1081 1081 PMID 2649166 Ribeiro DM Sonati MF 2008 Regulation of human alpha globin gene expression and alpha thalassemia Genetics and Molecular Research 7 4 1045 53 doi 10 4238 vol7 4gmr472 PMID 19048483 Waye JS Eng B Dutly F Frischknecht H 2009 alpha Thalassemia caused by two novel splice mutations of the alpha2 globin gene IVS I 1 G gt A and G gt T Hemoglobin 33 6 519 22 doi 10 3109 03630260903333377 PMID 19958200 S2CID 41033036 Coelho A Picanco I Seuanes F Seixas MT Faustino P Aug 2010 Novel large deletions in the human alpha globin gene cluster Clarifying the HS 40 long range regulatory role in the native chromosome environment PDF Blood Cells Molecules amp Diseases 45 2 147 53 doi 10 1016 j bcmd 2010 05 010 hdl 10400 18 117 PMID 20580289 Sharma V Kumar B Kumar G Saxena R Oct 2009 Alpha globin gene numbers an important modifier of HbE beta thalassemia Hematology 14 5 297 300 doi 10 1179 102453309X446126 PMID 19843387 S2CID 11461489 Turbpaiboon C Wilairat P 2010 Alpha hemoglobin stabilizing protein molecular function and clinical correlation Frontiers in Bioscience 15 1 1 11 doi 10 2741 3601 PMID 20036801 Voon HP Vadolas J Dec 2008 Controlling alpha globin a review of alpha globin expression and its impact on beta thalassemia Haematologica 93 12 1868 76 doi 10 3324 haematol 13490 PMID 18768527 Giordano PC Cnossen MH Joosten AM Jansen CA Hakvoort TE Bakker Verweij M Arkesteijn SG van Delft P Waye JS Bouva MJ Harteveld CL 2010 Codon 24 TAT gt TAG and codon 32 ATG gt AGG Hb Rotterdam two novel alpha2 gene mutations associated with mild alpha thalassemia found in the same family after newborn screening Hemoglobin 34 4 354 65 doi 10 3109 03630269 2010 486341 PMID 20642333 S2CID 35413104 Mahdavi MR Kowsarian M Karami H Mohseni A Vahidshahi K Roshan P Hojjati MT Ebrahimzadeh MA Oct 2010 Prevalence of hemoglobin alpha chain gene deletion in neonates in North of Iran European Review for Medical and Pharmacological Sciences 14 10 871 5 PMID 21222374 Balakrishnan G Zhao X Podstawska E Proniewicz LM Kincaid JR Spiro TG Apr 2009 Subunit selective interrogation of CO recombination in carbonmonoxy hemoglobin by isotope edited time resolved resonance Raman spectroscopy Biochemistry 48 14 3120 6 doi 10 1021 bi802190f PMC 2722936 PMID 19245215 Zhu C Yu W Xie J Chen L Ding H Shang X Xu X Oct 2010 Hemoglobin H disease due to a de novo mutation at the a2 globin gene and an inherited common a thalassemia deletion found in a Chinese boy Blood Cells Molecules amp Diseases 45 3 223 6 doi 10 1016 j bcmd 2010 07 005 PMID 20691621 External links EditGeneReviews NCBI NIH UW entry on Alpha Thalassemia OMIM entries on Alpha ThalassemiaThis article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Hemoglobin alpha 2 amp oldid 1118740028, wikipedia, wiki, book, books, library,

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