Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000277224 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000047246 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
^Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
Ohe Y, Hayashi H, Iwai K (1979). "Human spleen histone H2B. Isolation and amino acid sequence". J. Biochem. 85 (2): 615–24. doi:10.1093/oxfordjournals.jbchem.a132371. PMID 422550.
Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC110633. PMID 9566873.
Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132. S2CID 12807248.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC291826. PMID 14657027.
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hist1h2bf, histone, type, protein, that, humans, encoded, gene, h2bc7available, structurespdbortholog, search, pdbe, rcsblist, codes5kgfidentifiersaliasesh2bc7, h2bfg, histone, cluster, h2bf, histone, cluster, family, member, clustered, histone, h2bc10, h2bc8,. Histone H2B type 1 C E F G I is a protein that in humans is encoded by the HIST1H2BF gene 5 6 7 H2BC7Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes5KGFIdentifiersAliasesH2BC7 H2B g H2BFG histone cluster 1 H2bf histone cluster 1 H2B family member f H2B clustered histone 7 HIST1H2BF H2BC10 H2BC8 H2BC6 H2BC4External IDsOMIM 602804 MGI 2448380 HomoloGene 136358 GeneCards H2BC7Gene location Human Chr Chromosome 6 human 1 Band6p22 2Start26 199 516 bp 1 End26 199 988 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A3 1Start23 767 653 bp 2 End23 805 107 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbone marrow cellsoocytecorpus epididymisbronchial epithelial cellthymusmonocyteinternal globus pallidusamniotic fluidright ventriclecaput epididymisTop expressed inuteruswhite adipose tissuequadriceps femoris muscleskeletal muscle tissuelenspancreasislet of Langerhansesophagusproximal tubuleheartMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding protein binding protein heterodimerization activity identical protein bindingCellular componentchromosome nucleosome extracellular exosome nucleus nucleoplasm extracellular space cytosolBiological processnucleosome assembly innate immune response in mucosa defense response to bacterium protein ubiquitination antimicrobial humoral immune response mediated by antimicrobial peptideSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8343319179EnsemblENSG00000277224ENSMUSG00000047246UniProtP62807Q6ZWY9RefSeq mRNA NM 003522NM 001177653NM 001290530NM 178194RefSeq protein NP 003517NP 001368918NP 001171124NP 001277459NP 835501NP 835503NP 001277309NP 075911Location UCSC Chr 6 26 2 26 2 MbChr 13 23 77 23 81 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes Two molecules of each of the four core histones H2A H2B H3 and H4 form an octamer around which approximately 146 bp of DNA is wrapped in repeating units called nucleosomes The linker histone H1 interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures This gene is intronless and encodes a member of the histone H2B family Transcripts from this gene lack polyA tails but instead contain a palindromic termination element This gene is found in the large histone gene cluster on chromosome 6 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000277224 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000047246 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Albig W Kioschis P Poustka A Meergans K Doenecke D Apr 1997 Human histone gene organization nonregular arrangement within a large cluster Genomics 40 2 314 22 doi 10 1006 geno 1996 4592 PMID 9119399 Marzluff WF Gongidi P Woods KR Jin J Maltais LJ Oct 2002 The human and mouse replication dependent histone genes Genomics 80 5 487 98 doi 10 1016 S0888 7543 02 96850 3 PMID 12408966 a b Entrez Gene HIST1H2BF histone cluster 1 H2bf Further reading editOhe Y Hayashi H Iwai K 1979 Human spleen histone H2B Isolation and amino acid sequence J Biochem 85 2 615 24 doi 10 1093 oxfordjournals jbchem a132371 PMID 422550 Albig W Doenecke D 1998 The human histone gene cluster at the D6S105 locus Hum Genet 101 3 284 94 doi 10 1007 s004390050630 PMID 9439656 S2CID 38539096 El Kharroubi A Piras G Zensen R Martin MA 1998 Transcriptional activation of the integrated chromatin associated human immunodeficiency virus type 1 promoter Mol Cell Biol 18 5 2535 44 doi 10 1128 mcb 18 5 2535 PMC 110633 PMID 9566873 Albig W Trappe R Kardalinou E et al 1999 The human H2A and H2B histone gene complement Biol Chem 380 1 7 18 doi 10 1515 BC 1999 002 PMID 10064132 S2CID 12807248 Deng L de la Fuente C Fu P et al 2001 Acetylation of HIV 1 Tat by CBP P300 increases transcription of integrated HIV 1 genome and enhances binding to core histones Virology 277 2 278 95 doi 10 1006 viro 2000 0593 PMID 11080476 Deng L Wang D de la Fuente C et al 2001 Enhancement of the p300 HAT activity by HIV 1 Tat on chromatin DNA Virology 289 2 312 26 doi 10 1006 viro 2001 1129 PMID 11689053 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Lusic M Marcello A Cereseto A Giacca M 2004 Regulation of HIV 1 gene expression by histone acetylation and factor recruitment at the LTR promoter EMBO J 22 24 6550 61 doi 10 1093 emboj cdg631 PMC 291826 PMID 14657027 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HIST1H2BF amp oldid 1142706400, wikipedia, wiki, book, books, library,
