Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000233822 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000114279 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
^Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC110633. PMID 9566873.
Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132. S2CID 12807248.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Cheung WL, Ajiro K, Samejima K, et al. (2003). "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase". Cell. 113 (4): 507–17. doi:10.1016/S0092-8674(03)00355-6. PMID 12757711. S2CID 21854.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC291826. PMID 14657027.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation". Mol. Cell. 20 (4): 601–11. doi:10.1016/j.molcel.2005.09.025. PMID 16307923.
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This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
hist1h2bn, histone, type, protein, that, humans, encoded, gene, h2bc15identifiersaliasesh2bc15, h2bfd, histone, cluster, h2bn, histone, cluster, family, member, clustered, histone, external, idsomim, 602801, 2448404, homologene, 135961, genecards, h2bc15gene, . Histone H2B type 1 N is a protein that in humans is encoded by the HIST1H2BN gene 5 6 7 H2BC15IdentifiersAliasesH2BC15 H2B d H2BFD histone cluster 1 H2bn histone cluster 1 H2B family member n H2B clustered histone 15 HIST1H2BNExternal IDsOMIM 602801 MGI 2448404 HomoloGene 135961 GeneCards H2BC15Gene location Human Chr Chromosome 6 human 1 Band6p22 1Start27 838 545 bp 1 End27 855 709 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A3 1Start21 906 214 bp 2 End21 906 737 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inbone marrow cellsmonocyteAchilles tendonstromal cell of endometriumthymusstriated muscle tissueskeletal muscle tissuepopliteal arterybloodventricleTop expressed inspermatidspermatocyteuterusbone marrowmorulamesencephalonsecondary oocytethymusyolk sacblastocystMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding protein heterodimerization activityCellular componentchromosome nucleosome extracellular exosome nucleus nucleoplasm cytosolBiological processnucleosome assembly protein ubiquitinationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8341319186EnsemblENSG00000233822ENSMUSG00000114279UniProtQ99877P10854RefSeq mRNA NM 003520NM 178200RefSeq protein NP 003511NP 835507Location UCSC Chr 6 27 84 27 86 MbChr 13 21 91 21 91 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes Two molecules of each of the four core histones H2A H2B H3 and H4 form an octamer around which approximately 146 bp of DNA is wrapped in repeating units called nucleosomes The linker histone H1 interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures This gene is intronless and encodes a member of the histone H2B family Transcripts from this gene lack polyA tails but instead contain a palindromic termination element This gene is found in the small histone gene cluster on chromosome 6p22 p21 3 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000233822 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000114279 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Albig W Doenecke D Feb 1998 The human histone gene cluster at the D6S105 locus Hum Genet 101 3 284 94 doi 10 1007 s004390050630 PMID 9439656 S2CID 38539096 Marzluff WF Gongidi P Woods KR Jin J Maltais LJ Oct 2002 The human and mouse replication dependent histone genes Genomics 80 5 487 98 doi 10 1016 S0888 7543 02 96850 3 PMID 12408966 a b Entrez Gene HIST1H2BN histone cluster 1 H2bn Further reading editEl Kharroubi A Piras G Zensen R Martin MA 1998 Transcriptional activation of the integrated chromatin associated human immunodeficiency virus type 1 promoter Mol Cell Biol 18 5 2535 44 doi 10 1128 mcb 18 5 2535 PMC 110633 PMID 9566873 Albig W Trappe R Kardalinou E et al 1999 The human H2A and H2B histone gene complement Biol Chem 380 1 7 18 doi 10 1515 BC 1999 002 PMID 10064132 S2CID 12807248 Deng L de la Fuente C Fu P et al 2001 Acetylation of HIV 1 Tat by CBP P300 increases transcription of integrated HIV 1 genome and enhances binding to core histones Virology 277 2 278 95 doi 10 1006 viro 2000 0593 PMID 11080476 Deng L Wang D de la Fuente C et al 2001 Enhancement of the p300 HAT activity by HIV 1 Tat on chromatin DNA Virology 289 2 312 26 doi 10 1006 viro 2001 1129 PMID 11689053 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Cheung WL Ajiro K Samejima K et al 2003 Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase Cell 113 4 507 17 doi 10 1016 S0092 8674 03 00355 6 PMID 12757711 S2CID 21854 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 11 doi 10 1038 nature02055 PMID 14574404 Lusic M Marcello A Cereseto A Giacca M 2004 Regulation of HIV 1 gene expression by histone acetylation and factor recruitment at the LTR promoter EMBO J 22 24 6550 61 doi 10 1093 emboj cdg631 PMC 291826 PMID 14657027 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Golebiowski F Kasprzak KS 2007 Inhibition of core histones acetylation by carcinogenic nickel II Mol Cell Biochem 279 1 2 133 9 doi 10 1007 s11010 005 8285 1 PMID 16283522 S2CID 25071586 Zhu B Zheng Y Pham AD et al 2006 Monoubiquitination of human histone H2B the factors involved and their roles in HOX gene regulation Mol Cell 20 4 601 11 doi 10 1016 j molcel 2005 09 025 PMID 16307923 Beck HC Nielsen EC Matthiesen R et al 2006 Quantitative proteomic analysis of post translational modifications of human histones Mol Cell Proteomics 5 7 1314 25 doi 10 1074 mcp M600007 MCP200 PMID 16627869 Pavri R Zhu B Li G et al 2006 Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II Cell 125 4 703 17 doi 10 1016 j cell 2006 04 029 PMID 16713563 S2CID 2614680 Kim SC Sprung R Chen Y et al 2006 Substrate and functional diversity of lysine acetylation revealed by a proteomics survey Mol Cell 23 4 607 18 doi 10 1016 j molcel 2006 06 026 PMID 16916647 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HIST1H2BN amp oldid 1142706444, wikipedia, wiki, book, books, library,
