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Wikipedia

HIST2H2AC

April 13, 2024

Histone H2A type 2-C is a protein that in humans is encoded by the HIST2H2AC gene.[5][6][7][8]

H2AC20
Identifiers
AliasesH2AC20, H2A, H2A-GL101, H2A/q, H2AFQ, histone cluster 2, H2ac, histone cluster 2 H2A family member c, H2A clustered histone 20, HIST2H2AC
External IDsOMIM: 602797 MGI: 2448316 HomoloGene: 128596 GeneCards: H2AC20
Orthologs
SpeciesHumanMouse
Entrez

8338

319176

Ensembl

ENSG00000184260

ENSMUSG00000068855

UniProt

Q16777

Q64523

RefSeq (mRNA)

NM_003517

NM_175662

RefSeq (protein)

NP_003508

NP_783593

Location (UCSC)Chr 1: 149.89 – 149.89 MbChr 3: 96.13 – 96.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184260 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068855 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Collart D, Romain PL, Huebner K, Pockwinse S, Pilapil S, Cannizzaro LA, Lian JB, Croce CM, Stein JL, Stein GS (Jan 1993). "A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing". J Cell Biochem. 50 (4): 374–85. doi:10.1002/jcb.240500406. PMID 1469070. S2CID 7732783.
  6. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. ^ a b "Entrez Gene: HIST2H2AC histone cluster 2, H2ac".

Further reading edit

  • El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
  • Kimura A, Horikoshi M (1999). "Tip60 acetylates six lysines of a specific class in core histones in vitro". Genes Cells. 3 (12): 789–800. doi:10.1046/j.1365-2443.1998.00229.x. PMID 10096020.
  • Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
  • Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
  • Chen A, Kleiman FE, Manley JL, et al. (2002). "Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase". J. Biol. Chem. 277 (24): 22085–92. doi:10.1074/jbc.M201252200. PMID 11927591.
  • Lahn BT, Tang ZL, Zhou J, et al. (2002). "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8707–12. Bibcode:2002PNAS...99.8707L. doi:10.1073/pnas.082248899. PMC 124363. PMID 12072557.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
  • Fujita K, Shimazaki N, Ohta Y, et al. (2004). "Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone". Genes Cells. 8 (6): 559–71. doi:10.1046/j.1365-2443.2003.00656.x. PMID 12786946. S2CID 25223336.
  • Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
  • Zhang Y, Griffin K, Mondal N, Parvin JD (2004). "Phosphorylation of histone H2A inhibits transcription on chromatin templates". J. Biol. Chem. 279 (21): 21866–72. doi:10.1074/jbc.M400099200. PMID 15010469.
  • Aihara H, Nakagawa T, Yasui K, et al. (2004). "Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo". Genes Dev. 18 (8): 877–88. doi:10.1101/gad.1184604. PMC 395847. PMID 15078818.
  • Wang H, Wang L, Erdjument-Bromage H, et al. (2004). "Role of histone H2A ubiquitination in Polycomb silencing". Nature. 431 (7010): 873–8. Bibcode:2004Natur.431..873W. doi:10.1038/nature02985. PMID 15386022. S2CID 4344378.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Braastad CD, Hovhannisyan H, van Wijnen AJ, et al. (2005). "Functional characterization of a human histone gene cluster duplication". Gene. 342 (1): 35–40. doi:10.1016/j.gene.2004.07.036. PMID 15527963.
  • Hagiwara T, Hidaka Y, Yamada M (2005). "Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes". Biochemistry. 44 (15): 5827–34. doi:10.1021/bi047505c. PMID 15823041.
  • Bonenfant D, Coulot M, Towbin H, et al. (2006). "Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry". Mol. Cell. Proteomics. 5 (3): 541–52. doi:10.1074/mcp.M500288-MCP200. PMID 16319397.
 

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

April 13, 2024
hist2h2ac, histone, type, protein, that, humans, encoded, gene, h2ac20identifiersaliasesh2ac20, gl101, h2afq, histone, cluster, h2ac, histone, cluster, family, member, clustered, histone, external, idsomim, 602797, 2448316, homologene, 128596, genecards, h2ac2. Histone H2A type 2 C is a protein that in humans is encoded by the HIST2H2AC gene 5 6 7 8 H2AC20IdentifiersAliasesH2AC20 H2A H2A GL101 H2A q H2AFQ histone cluster 2 H2ac histone cluster 2 H2A family member c H2A clustered histone 20 HIST2H2ACExternal IDsOMIM 602797 MGI 2448316 HomoloGene 128596 GeneCards H2AC20Gene location Human Chr Chromosome 1 human 1 Band1q21 2Start149 886 918 bp 1 End149 887 411 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 3 F2 1Start96 127 677 bp 2 End96 128 196 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendonbone marrow cellscorpus callosumsural nervebloodthymuscervixmonocyteright adrenal glandgastric mucosaTop expressed inuterusspermatocytemesencephalonyolk sacbone marrowmorulastomachlensneural tubetesticleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein heterodimerization activity DNA binding molecular functionCellular componentnucleosome nucleus chromosome extracellular exosomeBiological processchromatin organization biological processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8338319176EnsemblENSG00000184260ENSMUSG00000068855UniProtQ16777Q64523RefSeq mRNA NM 003517NM 175662RefSeq protein NP 003508NP 783593Location UCSC Chr 1 149 89 149 89 MbChr 3 96 13 96 13 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes Two molecules of each of the four core histones H2A H2B H3 and H4 form an octamer around which approximately 146 bp of DNA is wrapped in repeating units called nucleosomes The linker histone H1 interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures This gene is intronless and encodes a member of the histone H2A family 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000184260 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000068855 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Collart D Romain PL Huebner K Pockwinse S Pilapil S Cannizzaro LA Lian JB Croce CM Stein JL Stein GS Jan 1993 A human histone H2B 1 variant gene located on chromosome 1 utilizes alternative 3 end processing J Cell Biochem 50 4 374 85 doi 10 1002 jcb 240500406 PMID 1469070 S2CID 7732783 Albig W Doenecke D Feb 1998 The human histone gene cluster at the D6S105 locus Hum Genet 101 3 284 94 doi 10 1007 s004390050630 PMID 9439656 S2CID 38539096 Marzluff WF Gongidi P Woods KR Jin J Maltais LJ Oct 2002 The human and mouse replication dependent histone genes Genomics 80 5 487 98 doi 10 1016 S0888 7543 02 96850 3 PMID 12408966 a b Entrez Gene HIST2H2AC histone cluster 2 H2ac Further reading editEl Kharroubi A Piras G Zensen R Martin MA 1998 Transcriptional Activation of the Integrated Chromatin Associated Human Immunodeficiency Virus Type 1 Promoter Mol Cell Biol 18 5 2535 44 doi 10 1128 mcb 18 5 2535 PMC 110633 PMID 9566873 Kimura A Horikoshi M 1999 Tip60 acetylates six lysines of a specific class in core histones in vitro Genes Cells 3 12 789 800 doi 10 1046 j 1365 2443 1998 00229 x PMID 10096020 Deng L de la Fuente C Fu P et al 2001 Acetylation of HIV 1 Tat by CBP P300 increases transcription of integrated HIV 1 genome and enhances binding to core histones Virology 277 2 278 95 doi 10 1006 viro 2000 0593 PMID 11080476 Deng L Wang D de la Fuente C et al 2001 Enhancement of the p300 HAT activity by HIV 1 Tat on chromatin DNA Virology 289 2 312 26 doi 10 1006 viro 2001 1129 PMID 11689053 Chen A Kleiman FE Manley JL et al 2002 Autoubiquitination of the BRCA1 BARD1 RING ubiquitin ligase J Biol Chem 277 24 22085 92 doi 10 1074 jbc M201252200 PMID 11927591 Lahn BT Tang ZL Zhou J et al 2002 Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis Proc Natl Acad Sci U S A 99 13 8707 12 Bibcode 2002PNAS 99 8707L doi 10 1073 pnas 082248899 PMC 124363 PMID 12072557 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Yoon HG Chan DW Huang ZQ et al 2003 Purification and functional characterization of the human N CoR complex the roles of HDAC3 TBL1 and TBLR1 EMBO J 22 6 1336 46 doi 10 1093 emboj cdg120 PMC 151047 PMID 12628926 Fujita K Shimazaki N Ohta Y et al 2004 Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone Genes Cells 8 6 559 71 doi 10 1046 j 1365 2443 2003 00656 x PMID 12786946 S2CID 25223336 Lusic M Marcello A Cereseto A Giacca M 2004 Regulation of HIV 1 gene expression by histone acetylation and factor recruitment at the LTR promoter EMBO J 22 24 6550 61 doi 10 1093 emboj cdg631 PMC 291826 PMID 14657027 Zhang Y Griffin K Mondal N Parvin JD 2004 Phosphorylation of histone H2A inhibits transcription on chromatin templates J Biol Chem 279 21 21866 72 doi 10 1074 jbc M400099200 PMID 15010469 Aihara H Nakagawa T Yasui K et al 2004 Nucleosomal histone kinase 1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo Genes Dev 18 8 877 88 doi 10 1101 gad 1184604 PMC 395847 PMID 15078818 Wang H Wang L Erdjument Bromage H et al 2004 Role of histone H2A ubiquitination in Polycomb silencing Nature 431 7010 873 8 Bibcode 2004Natur 431 873W doi 10 1038 nature02985 PMID 15386022 S2CID 4344378 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Braastad CD Hovhannisyan H van Wijnen AJ et al 2005 Functional characterization of a human histone gene cluster duplication Gene 342 1 35 40 doi 10 1016 j gene 2004 07 036 PMID 15527963 Hagiwara T Hidaka Y Yamada M 2005 Deimination of histone H2A and H4 at arginine 3 in HL 60 granulocytes Biochemistry 44 15 5827 34 doi 10 1021 bi047505c PMID 15823041 Bonenfant D Coulot M Towbin H et al 2006 Characterization of histone H2A and H2B variants and their post translational modifications by mass spectrometry Mol Cell Proteomics 5 3 541 52 doi 10 1074 mcp M500288 MCP200 PMID 16319397 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HIST2H2AC amp oldid 1188152022, wikipedia, wiki, book, books, library,

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