Grimm's Hydride Displacement Law is an early hypothesis, formulated in 1925, to describe bioisosterism, the ability of certain chemical groups to function as or mimic other chemical groups.[1][2]
“Atoms anywhere up to four places in the periodic system before an inert gas change their properties by uniting with one to four hydrogen atoms, in such a manner that the resulting combinations behave like pseudoatoms, which are similar to elements in the groups one to four places respectively, to their right.”[3]
According to Grimm, each vertical column (of Table below) would represent a group of isosteres.
Table 1: Grimm's Hydride Displacement Law
C
N
O
F
Ne
Na
CH
NH
OH
FH
-
CH2
NH2
OH2
FH2+
CH3
NH3
OH3+
CH4
NH4+
Referencesedit
^ Grimm, H. G. Structure and Size of the Non-metallic HydridesZ. Electrochem.1925, 31, 474–480.
^ Grimm, H. G. On the Systematic Arrangement of Chemical Compounds from the Perspective of Research on Atomic Composition; and on Some Challenges in Experimental Chemistry.Naturwissenschaften1929, 17, 557–564.
^ Patani, G. A.; LaVoie, E. J. Bioisosterism: A Rational Approach in Drug Design.Chem. Rev.1996, 96, 3147–3176. (doi:10.1021/cr950066q PMID 11848856)
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