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Goitrogen

April 10, 2024

Goitrogens are substances that disrupt the production of thyroid hormones. This triggers the pituitary to release thyroid-stimulating hormone (TSH), which then promotes the growth of thyroid tissue, eventually leading to goiter.[1]

Goitrogenic drugs and chemicals edit

Chemicals that have been shown to have goitrogenic effects include:

Goitrogenic foods edit

Foods which have been demonstrated to have goitrogenic effects include soy, cassava (when crushed and not detoxified by soaking,[7]) vegetables in the genus Brassica (such as broccoli and cabbage),[9][page needed] and other cruciferous vegetables.[10] In places where iodine deficiency exists in tandem with millet being a major component of the diet, millet consumption can contribute to thyroid enlargement which is the start of endemic goiter.[11]

See also edit

References edit

  1. ^ Bender, David A. (2009). "Goitrogens". A dictionary of food and nutrition (3rd ed.). Oxford: Oxford University Press. ISBN 9780199234875.
  2. ^ Blackwell T, Werdin R, Eisenmenger M, FitzSimmons M (March 1989). "Goitrogenic effects in offspring of swine fed sulfadimethoxine and ormetoprim in late gestation". Journal of the American Veterinary Medical Association. 194 (4): 519–523.
  3. ^ Rosenfeld H, Ornoy A, Shechtman S, Diav-Citrin O (2009). "Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: a controlled cohort study". Br J Clin Pharmacol. 68 (4): 609–17. doi:10.1111/j.1365-2125.2009.03495.x. PMC 2780286. PMID 19843064.
  4. ^ Soldin OP, Braverman LE, Lamm SH (2001). "Perchlorate Clinical Pharmacology and Human Health: A Review". Ther Drug Monit. 23 (4): 316–31. doi:10.1097/00007691-200108000-00002. PMC 3640367. PMID 11477312.
  5. ^ Andreucci M, Solomon R, Tasanarong A (2014). "Side Effects of Radiographic Contrast Media: Pathogenesis, Risk Factors, and Prevention". Biomed Res Int. 2014: 741018. doi:10.1155/2014/741018. PMC 4034507. PMID 24895606.
  6. ^ Verhoeven DT, Verhagen H, Goldbohm RA, van den Brandt PA, van Poppel G (February 1997). "A review of mechanisms underlying anticarcinogenicity by brassica vegetables". Chem. Biol. Interact. 103 (2): 79–129. doi:10.1016/S0009-2797(96)03745-3. PMID 9055870.
  7. ^ a b Vanderpas J (2006). "Nutritional epidemiology and thyroid hormone metabolism". Annu. Rev. Nutr. 26: 293–322. doi:10.1146/annurev.nutr.26.010506.103810. PMID 16704348.
  8. ^ Erdogan MF (2003). "Thiocyanate overload and thyroid disease". BioFactors (Review). 19 (3–4): 107–11. doi:10.1002/biof.5520190302. PMID 14757960.
  9. ^ Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). Robbins Basic Pathology (8th ed.). Philadelphia: Saunders. ISBN 978-1-4160-2973-1.
  10. ^ Gaitan, Eduardo (July 1990). "Goitrogens in Food and Water". Annual Review of Nutrition. 10 (1): 21–37. doi:10.1146/annurev.nu.10.070190.000321. PMID 1696490.
  11. ^ Eduardo Gaitan; Raymond, H. Lindsay; Robert D. Reichert; Sidney H. Ingbar; Robert C. Cooksey; Jim Legan; Edward F. Meydrech; John Hill; Ken Kubota (1989). "Antithyroid and Goitrogenic Effects of Millet: Role of C-Glycosylflavones". The Journal of Clinical Endocrinology & Metabolism. 68 (4): 707–714. doi:10.1210/jcem-68-4-707. PMID 2921306.

External links edit

  • Goitrogenic Substances in Food

April 10, 2024
goitrogen, substances, that, disrupt, production, thyroid, hormones, this, triggers, pituitary, release, thyroid, stimulating, hormone, which, then, promotes, growth, thyroid, tissue, eventually, leading, goiter, contents, drugs, chemicals, foods, also, refere. Goitrogens are substances that disrupt the production of thyroid hormones This triggers the pituitary to release thyroid stimulating hormone TSH which then promotes the growth of thyroid tissue eventually leading to goiter 1 Contents 1 Goitrogenic drugs and chemicals 2 Goitrogenic foods 3 See also 4 References 5 External linksGoitrogenic drugs and chemicals editChemicals that have been shown to have goitrogenic effects include Sulfadimethoxine Albon 2 propylthiouracil 3 potassium perchlorate 4 and iopanoic acid 5 Some oxazolidines such as goitrin 6 Ions such as thiocyanate 7 from cigarette smoking for example 8 and perchlorate decrease iodide uptake by competitive inhibition and as a consequence of reduced thyroxine and triiodothyronine secretion by the gland cause at low doses an increased release of thyrotropin by reduced negative feedback which then stimulates the gland citation needed Amiodarone inhibits peripheral conversion of thyroxine to triiodothyronine also interferes with thyroid hormone action citation needed Lithium inhibits thyroid hormone release citation needed Phenobarbitone phenytoin carbamazepine rifampin induce metabolic degradation of triiodothyronine T3 and thyroxine T4 citation needed Goitrogenic foods editFoods which have been demonstrated to have goitrogenic effects include soy cassava when crushed and not detoxified by soaking 7 vegetables in the genus Brassica such as broccoli and cabbage 9 page needed and other cruciferous vegetables 10 In places where iodine deficiency exists in tandem with millet being a major component of the diet millet consumption can contribute to thyroid enlargement which is the start of endemic goiter 11 See also editHypothyroidism Hyperthyroidism ThyroidReferences edit Bender David A 2009 Goitrogens A dictionary of food and nutrition 3rd ed Oxford Oxford University Press ISBN 9780199234875 Blackwell T Werdin R Eisenmenger M FitzSimmons M March 1989 Goitrogenic effects in offspring of swine fed sulfadimethoxine and ormetoprim in late gestation Journal of the American Veterinary Medical Association 194 4 519 523 Rosenfeld H Ornoy A Shechtman S Diav Citrin O 2009 Pregnancy outcome thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil a controlled cohort study Br J Clin Pharmacol 68 4 609 17 doi 10 1111 j 1365 2125 2009 03495 x PMC 2780286 PMID 19843064 Soldin OP Braverman LE Lamm SH 2001 Perchlorate Clinical Pharmacology and Human Health A Review Ther Drug Monit 23 4 316 31 doi 10 1097 00007691 200108000 00002 PMC 3640367 PMID 11477312 Andreucci M Solomon R Tasanarong A 2014 Side Effects of Radiographic Contrast Media Pathogenesis Risk Factors and Prevention Biomed Res Int 2014 741018 doi 10 1155 2014 741018 PMC 4034507 PMID 24895606 Verhoeven DT Verhagen H Goldbohm RA van den Brandt PA van Poppel G February 1997 A review of mechanisms underlying anticarcinogenicity by brassica vegetables Chem Biol Interact 103 2 79 129 doi 10 1016 S0009 2797 96 03745 3 PMID 9055870 a b Vanderpas J 2006 Nutritional epidemiology and thyroid hormone metabolism Annu Rev Nutr 26 293 322 doi 10 1146 annurev nutr 26 010506 103810 PMID 16704348 Erdogan MF 2003 Thiocyanate overload and thyroid disease BioFactors Review 19 3 4 107 11 doi 10 1002 biof 5520190302 PMID 14757960 Mitchell Richard Sheppard Kumar Vinay Abbas Abul K Fausto Nelson 2007 Robbins Basic Pathology 8th ed Philadelphia Saunders ISBN 978 1 4160 2973 1 Gaitan Eduardo July 1990 Goitrogens in Food and Water Annual Review of Nutrition 10 1 21 37 doi 10 1146 annurev nu 10 070190 000321 PMID 1696490 Eduardo Gaitan Raymond H Lindsay Robert D Reichert Sidney H Ingbar Robert C Cooksey Jim Legan Edward F Meydrech John Hill Ken Kubota 1989 Antithyroid and Goitrogenic Effects of Millet Role of C Glycosylflavones The Journal of Clinical Endocrinology amp Metabolism 68 4 707 714 doi 10 1210 jcem 68 4 707 PMID 2921306 External links editGoitrogenic Substances in Food Retrieved from https en wikipedia org w index php title Goitrogen amp oldid 1194083192, wikipedia, wiki, book, books, library,

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