Gleich's syndrome is a rare disease in which the body swells up episodically (angioedema), associated with raised antibodies of the IgM type and increased numbers of eosinophil granulocytes, a type of white blood cells, in the blood (eosinophilia). It was first described in 1984.[1]
Gleich's syndrome
Other names
Episodic angioedema with eosinophilia
Its cause is unknown, but it is unrelated to capillary leak syndrome (which may cause similar swelling episodes) and eosinophilia-myalgia syndrome (which features eosinophilia but alternative symptoms). Some studies have shown that edema attacks are associated with degranulation (release of enzymes and mediators from eosinophils), and others have demonstrated antibodies against endothelium (cells lining blood vessels) in the condition.[2]
Gleich's syndrome is not a form of the idiopathic hypereosinophilic syndrome in that there is little or no evidence that it leads to organ damage. Rather, recent studies report that a subset of T cells (a special form of lymphocyte blood cell) found in several Gleich syndrome patients have an abnormal immunophenotype, i.e. they express CD3-, CD4+ cluster of differentiation cell surface antigens. These same aberrant T cell immunophenotypes are found in lymphocyte-variant eosinophilia, a disease in which the aberrant T cells overproduce cytokines such as interleukin 5 which simulate the proliferation of eosinophil precursor cells and are thereby responsible for the eosinophilia. It is suggested that most forms of Gleich's syndrome are due to a similar aberrant T cell mechanism and are a subtype of lymphocyte-variant eosinophilia.[3]
Gleich syndrome has a good prognosis. Attack severity may improve with steroid treatment.[1][2]
Referencesedit
^ abGleich GJ, Schroeter AL, Marcoux JP, Sachs MI, O'Connell EJ, Kohler PF (1984). "Episodic angioedema associated with eosinophilia". N. Engl. J. Med. 310 (25): 1621–6. doi:10.1056/NEJM198406213102501. PMID 6727934.
^ abEmonet S, Kaya G, Hauser C (2000). "Gleich's syndrome". Ann Dermatol Venereol. 127 (6–7): 616–8. PMID 10930860.
^Boyer DF (2016). "Blood and Bone Marrow Evaluation for Eosinophilia". Archives of Pathology & Laboratory Medicine. 140 (10): 1060–7. doi:10.5858/arpa.2016-0223-RA. PMID 27684977.
December 15, 2023
gleich, syndrome, rare, disease, which, body, swells, episodically, angioedema, associated, with, raised, antibodies, type, increased, numbers, eosinophil, granulocytes, type, white, blood, cells, blood, eosinophilia, first, described, 1984, other, namesepisod. Gleich s syndrome is a rare disease in which the body swells up episodically angioedema associated with raised antibodies of the IgM type and increased numbers of eosinophil granulocytes a type of white blood cells in the blood eosinophilia It was first described in 1984 1 Gleich s syndromeOther namesEpisodic angioedema with eosinophiliaIts cause is unknown but it is unrelated to capillary leak syndrome which may cause similar swelling episodes and eosinophilia myalgia syndrome which features eosinophilia but alternative symptoms Some studies have shown that edema attacks are associated with degranulation release of enzymes and mediators from eosinophils and others have demonstrated antibodies against endothelium cells lining blood vessels in the condition 2 Gleich s syndrome is not a form of the idiopathic hypereosinophilic syndrome in that there is little or no evidence that it leads to organ damage Rather recent studies report that a subset of T cells a special form of lymphocyte blood cell found in several Gleich syndrome patients have an abnormal immunophenotype i e they express CD3 CD4 cluster of differentiation cell surface antigens These same aberrant T cell immunophenotypes are found in lymphocyte variant eosinophilia a disease in which the aberrant T cells overproduce cytokines such as interleukin 5 which simulate the proliferation of eosinophil precursor cells and are thereby responsible for the eosinophilia It is suggested that most forms of Gleich s syndrome are due to a similar aberrant T cell mechanism and are a subtype of lymphocyte variant eosinophilia 3 Gleich syndrome has a good prognosis Attack severity may improve with steroid treatment 1 2 References edit a b Gleich GJ Schroeter AL Marcoux JP Sachs MI O Connell EJ Kohler PF 1984 Episodic angioedema associated with eosinophilia N Engl J Med 310 25 1621 6 doi 10 1056 NEJM198406213102501 PMID 6727934 a b Emonet S Kaya G Hauser C 2000 Gleich s syndrome Ann Dermatol Venereol 127 6 7 616 8 PMID 10930860 Boyer DF 2016 Blood and Bone Marrow Evaluation for Eosinophilia Archives of Pathology amp Laboratory Medicine 140 10 1060 7 doi 10 5858 arpa 2016 0223 RA PMID 27684977 Retrieved from https en wikipedia org w index php title Gleich 27s syndrome amp oldid 993527629, wikipedia, wiki, book, books, library,
