Gillian Griffiths, FMedSciFRS is a British cell biologist and immunologist. Griffiths was one of the first to show that immune cells have specialised mechanisms of secretion, and identified proteins and mechanisms that control cytotoxic T lymphocyte secretion.[1] Griffiths is Professor of Cell Biology and Immunology at the University of Cambridge and is the Director of the Cambridge Institute for Medical Research.[1][2][3][4][5][6]
When she was young, Griffiths initially thought she might like to be an ecologist. However, she began her scientific career at University College London by studying immunology. She continued in the subject, undertaking her PhD at the MRC Laboratory of Molecular Biology in Cambridge supervised by César Milstein.[7]
Gillian Griffiths has made key contributions to the fields of both cell biology and immunology, introducing important new concepts into both fields. Gillian Griffiths was one of the first to show that immune cells used specialised mechanisms of secretion, identifying the proteins and mechanisms controlling secretion from cytotoxic T lymphocytes by studying human genetic diseases and biochemical approaches. Her work has identified a new and unexpected role for the centrosome in exocytosis, and revealed that centrosome docking at the plasma membrane provides a focal point for exocytosis and endocytosis. Her work is both elegant and insightful.[1]
^ abc. The Royal Society. Archived from the original on 20 June 2019. Retrieved 11 October 2013.
^Stinchcombe, J. C.; Salio, M; Cerundolo, V; Pende, D; Arico, M; Griffiths, G. M. (2011). "Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems". BMC Biology. 9: 45. doi:10.1186/1741-7007-9-45. PMC3149597. PMID 21711522.
^Tsun, A; Qureshi, I; Stinchcombe, J. C.; Jenkins, M. R.; de la Roche, M; Kleczkowska, J; Zamoyska, R; Griffiths, G. M. (2011). "Centrosome docking at the immunological synapse is controlled by Lck signaling". The Journal of Cell Biology. 192 (4): 663–74. doi:10.1083/jcb.201008140. PMC3044125. PMID 21339332.
^Griffiths, G. M.; Tsun, A.; Stinchcombe, J. C. (2010). "The immunological synapse: A focal point for endocytosis and exocytosis". The Journal of Cell Biology. 189 (3): 399–406. doi:10.1083/jcb.201002027. PMC2867296. PMID 20439993.
^Cetica, V; Santoro, A; Gilmour, K. C.; Sieni, E; Beutel, K; Pende, D; Marcenaro, S; Koch, F; Grieve, S; Wheeler, R; Zhao, F; Zur Stadt, U; Griffiths, G. M.; Aricò, M (2010). "STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5". Journal of Medical Genetics. 47 (9): 595–600. doi:10.1136/jmg.2009.075341. PMC4115259. PMID 20798128.
^Gillian Griffiths's publications indexed by the Scopus bibliographic database. (subscription required)
^Sedwick, C. (2013). "Gillian Griffiths: How T cells get on target". The Journal of Cell Biology. 200 (1): 4–5. doi:10.1083/jcb.2001pi. PMC3542799. PMID 23295346.
^"Buchanan Medallist 2019". Royal Society. Retrieved 5 October 2019.
External linksedit
Under the Microscope Killer T-cells video
March 17, 2024
gillian, griffiths, fmedsci, british, cell, biologist, immunologist, griffiths, first, show, that, immune, cells, have, specialised, mechanisms, secretion, identified, proteins, mechanisms, that, control, cytotoxic, lymphocyte, secretion, griffiths, professor,. Gillian Griffiths FMedSci FRS is a British cell biologist and immunologist Griffiths was one of the first to show that immune cells have specialised mechanisms of secretion and identified proteins and mechanisms that control cytotoxic T lymphocyte secretion 1 Griffiths is Professor of Cell Biology and Immunology at the University of Cambridge and is the Director of the Cambridge Institute for Medical Research 1 2 3 4 5 6 Gillian GriffithsBornGillian M GriffithsAlma materUniversity College London BSc University of Cambridge PhD AwardsFMedSci FRS 2013 Buchanan Medal 2019 Scientific careerFieldsImmunology cell biologyInstitutionsCambridge Institute for Medical Research Laboratory of Molecular BiologyThesisMolecular analysis of the immune response 1983 Doctoral advisorCesar MilsteinWebsitemed wbr cam wbr ac wbr uk wbr griffiths Contents 1 Education 2 Awards and honours 3 References 4 External linksEducation editWhen she was young Griffiths initially thought she might like to be an ecologist However she began her scientific career at University College London by studying immunology She continued in the subject undertaking her PhD at the MRC Laboratory of Molecular Biology in Cambridge supervised by Cesar Milstein 7 Awards and honours editGriffiths holds a Wellcome Trust Principal Research Fellowship and she is a Fellow at King s College Cambridge Griffiths was elected a Fellow of the Royal Society in 2013 Her nomination for the Royal Society readsGillian Griffiths has made key contributions to the fields of both cell biology and immunology introducing important new concepts into both fields Gillian Griffiths was one of the first to show that immune cells used specialised mechanisms of secretion identifying the proteins and mechanisms controlling secretion from cytotoxic T lymphocytes by studying human genetic diseases and biochemical approaches Her work has identified a new and unexpected role for the centrosome in exocytosis and revealed that centrosome docking at the plasma membrane provides a focal point for exocytosis and endocytosis Her work is both elegant and insightful 1 2019 Awarded the Buchanan Medal of the Royal Society 8 References edit a b c Professor Gillian Griffiths FMedSci FRS The Royal Society Archived from the original on 20 June 2019 Retrieved 11 October 2013 Stinchcombe J C Salio M Cerundolo V Pende D Arico M Griffiths G M 2011 Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems BMC Biology 9 45 doi 10 1186 1741 7007 9 45 PMC 3149597 PMID 21711522 Tsun A Qureshi I Stinchcombe J C Jenkins M R de la Roche M Kleczkowska J Zamoyska R Griffiths G M 2011 Centrosome docking at the immunological synapse is controlled by Lck signaling The Journal of Cell Biology 192 4 663 74 doi 10 1083 jcb 201008140 PMC 3044125 PMID 21339332 Griffiths G M Tsun A Stinchcombe J C 2010 The immunological synapse A focal point for endocytosis and exocytosis The Journal of Cell Biology 189 3 399 406 doi 10 1083 jcb 201002027 PMC 2867296 PMID 20439993 Cetica V Santoro A Gilmour K C Sieni E Beutel K Pende D Marcenaro S Koch F Grieve S Wheeler R Zhao F Zur Stadt U Griffiths G M Arico M 2010 STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5 Journal of Medical Genetics 47 9 595 600 doi 10 1136 jmg 2009 075341 PMC 4115259 PMID 20798128 Gillian Griffiths s publications indexed by the Scopus bibliographic database subscription required Sedwick C 2013 Gillian Griffiths How T cells get on target The Journal of Cell Biology 200 1 4 5 doi 10 1083 jcb 2001pi PMC 3542799 PMID 23295346 Buchanan Medallist 2019 Royal Society Retrieved 5 October 2019 External links editUnder the Microscope Killer T cells video Retrieved from https en wikipedia org w index php title Gillian Griffiths amp oldid 1188182978, wikipedia, wiki, book, books, library,
