Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7gene.[5][6] The gem-associated proteins are those found in the gems of Cajal bodies.
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000142252 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000044709 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcBaccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–31962. doi:10.1074/jbc.M203478200. PMID 12065586.
^ ab"Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7".
^Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–7545. doi:10.1074/jbc.M110141200. PMID 11748230.
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Further readingedit
Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–37016. doi:10.1074/jbc.M607505200. PMID 17023415.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (Oct 2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Human Molecular Genetics. 14 (20): 3099–3111. doi:10.1093/hmg/ddi343. PMID 16159890.
External linksedit
PDBe-KB provides an overview of all the structure information available in the PDB for Human Gem-associated protein 7
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.
associated, protein, protein, that, humans, encoded, gemin7, gene, associated, proteins, those, found, gems, cajal, bodies, gemin7available, structurespdbortholog, search, pdbe, rcsblist, codes1y96identifiersaliasesgemin7, sip3, nuclear, organelle, associated,. Gem associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene 5 6 The gem associated proteins are those found in the gems of Cajal bodies GEMIN7Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1Y96IdentifiersAliasesGEMIN7 SIP3 gem nuclear organelle associated protein 7External IDsOMIM 607419 MGI 1916981 HomoloGene 11668 GeneCards GEMIN7Gene location Human Chr Chromosome 19 human 1 Band19q13 32Start45 079 195 bp 1 End45 091 518 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 A3Start19 298 871 bp 2 End19 311 520 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed intibialis anterior musclemonocytegastrocnemius musclespleenright lobe of liverbody of stomachanterior pituitaryleft ventricleskin of abdomenlymph nodeTop expressed ininterventricular septumyolk saclipneural tubeskeletal muscle tissuetriceps brachii muscleproximal tubuleknee jointinternal carotid arteryexternal carotid arteryMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein bindingCellular componentcytoplasm cytosol nuclear body nucleus nucleoplasm SMN complex SMN Sm protein complex gemini of coiled bodiesBiological processmRNA splicing via spliceosome mRNA processing RNA splicing spliceosomal snRNP assembly import into nucleusSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez7976069731EnsemblENSG00000142252ENSMUSG00000044709UniProtQ9H840Q9CWY4RefSeq mRNA NM 001007269NM 001007270NM 024707NM 001319054NM 001319055NM 027189RefSeq protein NP 001007270NP 001007271NP 001305983NP 001305984NP 078983NP 081465Location UCSC Chr 19 45 08 45 09 MbChr 7 19 3 19 31 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further reading 5 External linksFunction editThe protein encoded by this gene is a component of the core SMN complex which is required for pre mRNA splicing in the nucleus The encoded protein is found in the nucleoplasm in nuclear gems Gemini of Cajal bodies and in the cytoplasm Three transcript variants encoding the same protein have been found for this gene 6 Interactions editGem associated protein 7 has been shown to interact with SMN1 5 7 and Gem associated protein 6 5 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000142252 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000044709 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c Baccon J Pellizzoni L Rappsilber J Mann M Dreyfuss G Aug 2002 Identification and characterization of Gemin7 a novel component of the survival of motor neuron complex The Journal of Biological Chemistry 277 35 31957 31962 doi 10 1074 jbc M203478200 PMID 12065586 a b Entrez Gene GEMIN7 gem nuclear organelle associated protein 7 Pellizzoni L Baccon J Rappsilber J Mann M Dreyfuss G Mar 2002 Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component The Journal of Biological Chemistry 277 9 7540 7545 doi 10 1074 jbc M110141200 PMID 11748230 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N et al Oct 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 1178 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Further reading editCarissimi C Saieva L Gabanella F Pellizzoni L Dec 2006 Gemin8 is required for the architecture and function of the survival motor neuron complex The Journal of Biological Chemistry 281 48 37009 37016 doi 10 1074 jbc M607505200 PMID 17023415 Stelzl U Worm U Lalowski M Haenig C Brembeck FH Goehler H Stroedicke M Zenkner M Schoenherr A Koeppen S Timm J Mintzlaff S Abraham C Bock N Kietzmann S Goedde A Toksoz E Droege A Krobitsch S Korn B Birchmeier W Lehrach H Wanker EE Sep 2005 A human protein protein interaction network a resource for annotating the proteome Cell 122 6 957 968 doi 10 1016 j cell 2005 08 029 hdl 11858 00 001M 0000 0010 8592 0 PMID 16169070 S2CID 8235923 Grimmler M Otter S Peter C Muller F Chari A Fischer U Oct 2005 Unrip a factor implicated in cap independent translation associates with the cytosolic SMN complex and influences its intracellular localization Human Molecular Genetics 14 20 3099 3111 doi 10 1093 hmg ddi343 PMID 16159890 External links editPDBe KB provides an overview of all the structure information available in the PDB for Human Gem associated protein 7 nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Gem associated protein 7 amp oldid 1193439177, wikipedia, wiki, book, books, library,
