The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell–cell and/or cell–matrix interactions necessary for normal growth control.[7]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000053522 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Madsen P, Rasmussen HH, Flint T, Gromov P, Kruse TA, Honore B, Vorum H, Celis JE (Apr 1995). "Cloning, expression, and chromosome mapping of human galectin-7". J Biol Chem. 270 (11): 5823–29. doi:10.1074/jbc.270.11.5823. PMID 7534301.
^Magnaldo T, Bernerd F, Darmon M (May 1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Polyak K, Xia Y, Zweier JL, et al. (1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID 9305847. S2CID 4429638.
Magnaldo T, Fowlis D, Darmon M (1998). "Galectin-7, a marker of all types of stratified epithelia". Differentiation. 63 (3): 159–68. doi:10.1046/j.1432-0436.1998.6330159.x. PMID 9697310.
Leonidas DD, Vatzaki EH, Vorum H, et al. (1998). "Structural basis for the recognition of carbohydrates by human galectin-7". Biochemistry. 37 (40): 13930–40. doi:10.1021/bi981056x. PMID 9760227. S2CID 27458839.
Bernerd F, Sarasin A, Magnaldo T (1999). "Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11329–34. Bibcode:1999PNAS...9611329B. doi:10.1073/pnas.96.20.11329. PMC18033. PMID 10500176.
Kuwabara I, Kuwabara Y, Yang RY, et al. (2002). "Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release". J. Biol. Chem. 277 (5): 3487–97. doi:10.1074/jbc.M109360200. PMID 11706006.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Cao Z, Said N, Wu HK, et al. (2003). "Galectin-7 as a potential mediator of corneal epithelial cell migration". Arch. Ophthalmol. 121 (1): 82–6. doi:10.1001/archopht.121.1.82. PMID 12523890.
Kopitz J, André S, von Reitzenstein C, et al. (2003). "Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells". Oncogene. 22 (40): 6277–88. doi:10.1038/sj.onc.1206631. PMID 13679866.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Saussez S, Cucu DR, Decaestecker C, et al. (2006). "Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer". Ann. Surg. Oncol. 13 (7): 999–1009. doi:10.1245/ASO.2006.08.033. PMID 16788763. S2CID 12521102.
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galectin, protein, that, humans, encoded, lgals7, gene, lgals7available, structurespdbortholog, search, pdbe, rcsblist, codes4uw5, 2gal, 4gal, 1bkz, 4uw4, 3zxe, 3gal, 3zxf, 4uw6, 4xbq, 5gal, 4uw3, 5h9s, 4y26, 5h9qidentifiersaliaseslgals7, gal7, lgals7a, galect. Galectin 7 is a protein that in humans is encoded by the LGALS7 gene 5 6 7 LGALS7Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4UW5 2GAL 4GAL 1BKZ 4UW4 3ZXE 3GAL 3ZXF 4UW6 4XBQ 5GAL 4UW3 5H9S 4Y26 5H9QIdentifiersAliasesLGALS7 GAL7 LGALS7A galectin 7External IDsOMIM 600615 MGI 1316742 HomoloGene 100509 GeneCards LGALS7Gene location Human Chr Chromosome 19 human 1 Band19q13 2Start38 770 968 bp 1 End38 773 517 bp 1 Gene location Mouse Chr Chromosome 7 mouse 2 Band7 7 B1Start28 563 278 bp 2 End28 565 709 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inskin of abdomenvaginaminor salivary glandright lungspleengastric mucosathymusfundusgastrocnemius muscleleft lobe of thyroid glandTop expressed inlipesophagussuperior surface of tongueskin of abdomenskin of backbelly cordepidermishair folliclecondylefossaMore reference expression dataBioGPSn aGene ontologyMolecular functioncarbohydrate bindingCellular componentcytoplasm extracellular region extracellular exosome nucleus extracellular spaceBiological processheterophilic cell cell adhesion via plasma membrane cell adhesion molecules apoptotic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez396316858EnsemblENSG00000283082ENSG00000205076ENSMUSG00000053522UniProtP47929O54974RefSeq mRNA NM 002307NM 008496RefSeq protein NP 002298NP 001035972n aLocation UCSC Chr 19 38 77 38 77 MbChr 7 28 56 28 57 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThe galectins are a family of beta galactoside binding proteins implicated in modulating cell cell and cell matrix interactions Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes It is expressed at all stages of epidermal differentiation i e in basal and suprabasal layers It is moderately repressed by retinoic acid The protein was found mainly in stratified squamous epithelium The antigen localized to basal keratinocytes although it was also found albeit at lower levels in the suprabasal layers where it concentrated to areas of cell to cell contact The cellular localization and its striking down regulation in cultured keratinocytes imply a role in cell cell and or cell matrix interactions necessary for normal growth control 7 References Edit a b c ENSG00000205076 GRCh38 Ensembl release 89 ENSG00000283082 ENSG00000205076 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000053522 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Madsen P Rasmussen HH Flint T Gromov P Kruse TA Honore B Vorum H Celis JE Apr 1995 Cloning expression and chromosome mapping of human galectin 7 J Biol Chem 270 11 5823 29 doi 10 1074 jbc 270 11 5823 PMID 7534301 Magnaldo T Bernerd F Darmon M May 1995 Galectin 7 a human 14 kDa S lectin specifically expressed in keratinocytes and sensitive to retinoic acid Dev Biol 168 2 259 71 doi 10 1006 dbio 1995 1078 PMID 7729568 a b Entrez Gene LGALS7 lectin galactoside binding soluble 7 galectin 7 Further reading EditBonaldo MF Lennon G Soares MB 1997 Normalization and subtraction two approaches to facilitate gene discovery Genome Res 6 9 791 806 doi 10 1101 gr 6 9 791 PMID 8889548 Polyak K Xia Y Zweier JL et al 1997 A model for p53 induced apoptosis Nature 389 6648 300 5 Bibcode 1997Natur 389 300P doi 10 1038 38525 PMID 9305847 S2CID 4429638 Magnaldo T Fowlis D Darmon M 1998 Galectin 7 a marker of all types of stratified epithelia Differentiation 63 3 159 68 doi 10 1046 j 1432 0436 1998 6330159 x PMID 9697310 Leonidas DD Vatzaki EH Vorum H et al 1998 Structural basis for the recognition of carbohydrates by human galectin 7 Biochemistry 37 40 13930 40 doi 10 1021 bi981056x PMID 9760227 S2CID 27458839 Bernerd F Sarasin A Magnaldo T 1999 Galectin 7 overexpression is associated with the apoptotic process in UVB induced sunburn keratinocytes Proc Natl Acad Sci U S A 96 20 11329 34 Bibcode 1999PNAS 9611329B doi 10 1073 pnas 96 20 11329 PMC 18033 PMID 10500176 Kuwabara I Kuwabara Y Yang RY et al 2002 Galectin 7 PIG1 exhibits pro apoptotic function through JNK activation and mitochondrial cytochrome c release J Biol Chem 277 5 3487 97 doi 10 1074 jbc M109360200 PMID 11706006 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Cao Z Said N Wu HK et al 2003 Galectin 7 as a potential mediator of corneal epithelial cell migration Arch Ophthalmol 121 1 82 6 doi 10 1001 archopht 121 1 82 PMID 12523890 Kopitz J Andre S von Reitzenstein C et al 2003 Homodimeric galectin 7 p53 induced gene 1 is a negative growth regulator for human neuroblastoma cells Oncogene 22 40 6277 88 doi 10 1038 sj onc 1206631 PMID 13679866 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Saussez S Cucu DR Decaestecker C et al 2006 Galectin 7 p53 induced gene 1 a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer Ann Surg Oncol 13 7 999 1009 doi 10 1245 ASO 2006 08 033 PMID 16788763 S2CID 12521102 This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Galectin 7 amp oldid 1113054586, wikipedia, wiki, book, books, library,
