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Wikipedia

GRIK3

October 18, 2023

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.[5][6]

GRIK3
Identifiers
AliasesGRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3
External IDsOMIM: 138243 MGI: 95816 HomoloGene: 73901 GeneCards: GRIK3
Orthologs
SpeciesHumanMouse
Entrez

2899

14807

Ensembl

ENSG00000163873

ENSMUSG00000001985

UniProt

Q13003

B1AS29

RefSeq (mRNA)

NM_000831

NM_001081097

RefSeq (protein)

NP_000822

NP_001074566

Location (UCSC)Chr 1: 36.8 – 37.03 MbChr 4: 125.38 – 125.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.[6]

See also Edit

References Edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163873 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001985 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puranam RS, Eubanks JH, Heinemann SF, McNamara JO (Apr 1994). "Chromosomal localization of gene for human glutamate receptor subunit-7". Somat Cell Mol Genet. 19 (6): 581–8. doi:10.1007/BF01233385. PMID 8128318. S2CID 44460126.
  6. ^ a b "Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3".

Further reading Edit

  • Nutt SL, Hoo KH, Rampersad V, et al. (1995). "Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites". Recept. Channels. 2 (4): 315–26. PMID 7719709.
  • Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6". J. Biol. Chem. 269 (16): 11679–82. doi:10.1016/S0021-9258(17)32623-6. PMID 8163463.
  • Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Schiffer HH, Swanson GT, Masliah E, Heinemann SF (2001). "Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains". J. Neurosci. 20 (24): 9025–33. doi:10.1523/JNEUROSCI.20-24-09025.2000. PMC 6773004. PMID 11124978.
  • Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. doi:10.1016/S0014-5793(02)02361-X. PMID 11943148.
  • Begni S, Popoli M, Moraschi S, et al. (2002). "Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia". Mol. Psychiatry. 7 (4): 416–8. doi:10.1038/sj.mp.4000987. PMID 11986986.
  • Delorme R, Krebs MO, Chabane N, et al. (2004). "Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder". NeuroReport. 15 (4): 699–702. doi:10.1097/00001756-200403220-00025. PMID 15094479. S2CID 29816578.
  • Preuss UW, Zill P, Koller G, et al. (2006). "Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics". Pharmacogenomics J. 6 (1): 34–41. doi:10.1038/sj.tpj.6500343. PMID 16314883.
  • Samochowiec J, Grzywacz A, Kucharska-Mazur J, et al. (2006). "Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence". Neurosci. Lett. 396 (2): 159–62. doi:10.1016/j.neulet.2005.11.030. PMID 16356644. S2CID 23136504.
  • Schiffer HH, Heinemann SF (2007). "Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (1): 20–6. doi:10.1002/ajmg.b.30374. PMID 16958029.
  • Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.

External links Edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

October 18, 2023
grik3, glutamate, receptor, ionotropic, kainate, protein, that, humans, encoded, gene, identifiersaliases, eaa5, glr7, glur7, gluk3, glur7a, glutamate, ionotropic, receptor, kainate, type, subunit, 3external, idsomim, 138243, 95816, homologene, 73901, genecard. Glutamate receptor ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene 5 6 GRIK3IdentifiersAliasesGRIK3 EAA5 GLR7 GLUR7 GluK3 GluR7a glutamate ionotropic receptor kainate type subunit 3External IDsOMIM 138243 MGI 95816 HomoloGene 73901 GeneCards GRIK3Gene location Human Chr Chromosome 1 human 1 Band1p34 3Start36 795 527 bp 1 End37 034 515 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 D2 2 4 58 91 cMStart125 384 493 bp 2 End125 607 966 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nervespinal gangliatrigeminal ganglionprefrontal cortexendothelial cellhypothalamuscingulate gyrusBrodmann area 9Brodmann area 23substantia nigraTop expressed inmedian eminencearcuate nucleuslateral hypothalamusventromedial nucleusmammillary bodyparaventricular nucleus of hypothalamusprimary motor cortexventral tegmental areasubstantia nigradorsomedial hypothalamic nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionkainate selective glutamate receptor activity adenylate cyclase inhibiting G protein coupled glutamate receptor activity ion channel activity extracellularly glutamate gated ion channel activity ligand gated ion channel activity ionotropic glutamate receptor activity G protein coupled receptor binding glutamate receptor activity signaling receptor activity ligand gated ion channel activity involved in regulation of presynaptic membrane potential transmitter gated ion channel activity involved in regulation of postsynaptic membrane potentialCellular componentintegral component of membrane postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction dendrite cytoplasm perikaryon dendrite terminal bouton axon kainate selective glutamate receptor complex presynaptic membrane glutamatergic synapseBiological processG protein coupled glutamate receptor signaling pathway glutamate receptor signaling pathway ion transport ion transmembrane transport negative regulation of synaptic transmission glutamatergic ionotropic glutamate receptor signaling pathway adenylate cyclase inhibiting G protein coupled glutamate receptor signaling pathway regulation of membrane potential excitatory postsynaptic potential synaptic transmission glutamatergic modulation of chemical synaptic transmission regulation of presynaptic membrane potential regulation of postsynaptic membrane potentialSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez289914807EnsemblENSG00000163873ENSMUSG00000001985UniProtQ13003B1AS29RefSeq mRNA NM 000831NM 001081097RefSeq protein NP 000822NP 001074566Location UCSC Chr 1 36 8 37 03 MbChr 4 125 38 125 61 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a protein that belongs to the ligand gated ionic channel family It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system RNA editing in the mRNA has been reported 6 Contents 1 See also 2 References 3 Further reading 4 External linksSee also EditKainate receptorReferences Edit a b c GRCh38 Ensembl release 89 ENSG00000163873 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000001985 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Puranam RS Eubanks JH Heinemann SF McNamara JO Apr 1994 Chromosomal localization of gene for human glutamate receptor subunit 7 Somat Cell Mol Genet 19 6 581 8 doi 10 1007 BF01233385 PMID 8128318 S2CID 44460126 a b Entrez Gene GRIK3 glutamate receptor ionotropic kainate 3 Further reading EditNutt SL Hoo KH Rampersad V et al 1995 Molecular characterization of the human EAA5 GluR7 receptor a high affinity kainate receptor with novel potential RNA editing sites Recept Channels 2 4 315 26 PMID 7719709 Roche KW Raymond LA Blackstone C Huganir RL 1994 Transmembrane topology of the glutamate receptor subunit GluR6 J Biol Chem 269 16 11679 82 doi 10 1016 S0021 9258 17 32623 6 PMID 8163463 Ripellino JA Neve RL Howe JR 1998 Expression and heteromeric interactions of non N methyl D aspartate glutamate receptor subunits in the developing and adult cerebellum Neuroscience 82 2 485 97 doi 10 1016 S0306 4522 97 00296 0 PMID 9466455 S2CID 23219004 Dias Neto E Correa RG Verjovski Almeida S et al 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags Proc Natl Acad Sci U S A 97 7 3491 6 Bibcode 2000PNAS 97 3491D doi 10 1073 pnas 97 7 3491 PMC 16267 PMID 10737800 Schiffer HH Swanson GT Masliah E Heinemann SF 2001 Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains J Neurosci 20 24 9025 33 doi 10 1523 JNEUROSCI 20 24 09025 2000 PMC 6773004 PMID 11124978 Enz R 2002 The actin binding protein Filamin A interacts with the metabotropic glutamate receptor type 7 FEBS Lett 514 2 3 184 8 doi 10 1016 S0014 5793 02 02361 X PMID 11943148 Begni S Popoli M Moraschi S et al 2002 Association between the ionotropic glutamate receptor kainate 3 GRIK3 ser310ala polymorphism and schizophrenia Mol Psychiatry 7 4 416 8 doi 10 1038 sj mp 4000987 PMID 11986986 Delorme R Krebs MO Chabane N et al 2004 Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder NeuroReport 15 4 699 702 doi 10 1097 00001756 200403220 00025 PMID 15094479 S2CID 29816578 Preuss UW Zill P Koller G et al 2006 Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics Pharmacogenomics J 6 1 34 41 doi 10 1038 sj tpj 6500343 PMID 16314883 Samochowiec J Grzywacz A Kucharska Mazur J et al 2006 Family based and case control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence Neurosci Lett 396 2 159 62 doi 10 1016 j neulet 2005 11 030 PMID 16356644 S2CID 23136504 Schiffer HH Heinemann SF 2007 Association of the human kainate receptor GluR7 gene GRIK3 with recurrent major depressive disorder Am J Med Genet B Neuropsychiatr Genet 144 1 20 6 doi 10 1002 ajmg b 30374 PMID 16958029 Kim JM Lee KH Jeon YJ et al 2007 Identification of genes related to Parkinson s disease using expressed sequence tags DNA Res 13 6 275 86 doi 10 1093 dnares dsl016 PMID 17213182 External links EditGRIK3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GRIK3 amp oldid 1170971694, wikipedia, wiki, book, books, library,

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