This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium.[5]
Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC2775832. PMID 19913121.
Richard MJ, Guiraud P, Didier C, et al. (2001). "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation". Arch. Biochem. Biophys. 386 (2): 213–20. doi:10.1006/abbi.2000.2197. PMID 11368344.
Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor". Arch. Biochem. Biophys. 351 (1): 17–26. doi:10.1006/abbi.1997.0566. PMID 9501919.
Choi J, Liu RM, Kundu RK, et al. (2000). "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice". J. Biol. Chem. 275 (5): 3693–8. doi:10.1074/jbc.275.5.3693. PMID 10652368.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Price TO, Ercal N, Nakaoke R, Banks WA (2005). "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells". Brain Res. 1045 (1–2): 57–63. doi:10.1016/j.brainres.2005.03.031. PMID 15910762. S2CID 7362454.
Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC2945168. PMID 20628086.
Moyer AM, Sun Z, Batzler AJ, et al. (2010). "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy". Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. doi:10.1158/1055-9965.EPI-09-0871. PMC2837367. PMID 20200426.
gpx6, glutathione, peroxidase, enzyme, that, humans, encoded, gene, identifiersaliases, gpx5p, gpxp3, gshpx, dj1186n24, dj1186n24, glutathione, peroxidase, 6external, idsomim, 607913, 1922762, homologene, 130008, genecards, gene, location, human, chromosome, h. Glutathione peroxidase 6 GPx 6 is an enzyme that in humans is encoded by the GPX6 gene 5 6 GPX6IdentifiersAliasesGPX6 GPX5p GPXP3 GPx 6 GSHPx 6 dJ1186N24 dJ1186N24 1 glutathione peroxidase 6External IDsOMIM 607913 MGI 1922762 HomoloGene 130008 GeneCards GPX6Gene location Human Chr Chromosome 6 human 1 Band6p22 1Start28 503 296 bp 1 End28 528 215 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A3 1Start21 496 295 bp 2 End21 503 794 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inislet of Langerhanslungcolonwall of intestineTop expressed inolfactory epitheliumspermatidouter renal medullaseminiferous tubulesecondary oocytekidneyurethrainner stripe of outer renal medullaspermatocytemain bronchusMore reference expression dataBioGPSn aGene ontologyMolecular functionoxidoreductase activity glutathione peroxidase activity peroxidase activityCellular componentextracellular regionBiological processcellular oxidant detoxification response to oxidative stressSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez25720275512EnsemblENSG00000281185ENSG00000198704ENSMUSG00000004341UniProtP59796Q91WR8RefSeq mRNA NM 182701NM 145451RefSeq protein NP 874360NP 663426Location UCSC Chr 6 28 5 28 53 MbChr 13 21 5 21 5 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse This gene product belongs to the glutathione peroxidase family which functions in the detoxification of hydrogen peroxide It contains a selenocysteine Sec residue at its active site The selenocysteine is encoded by the UGA codon which normally signals translation termination The 3 UTR of Sec containing genes have a common stem loop structure the sec insertion sequence SECIS which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal Expression of this gene is restricted to embryos and adult olfactory epithelium 5 References edit a b c ENSG00000198704 GRCh38 Ensembl release 89 ENSG00000281185 ENSG00000198704 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004341 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene glutathione peroxidase 6 olfactory Kryukov GV Castellano S Novoselov SV Lobanov AV Zehtab O Guigo R Gladyshev VN May 2003 Characterization of mammalian selenoproteomes Science 300 5624 1439 43 Bibcode 2003Sci 300 1439K doi 10 1126 science 1083516 PMID 12775843 S2CID 10363908 Further reading editTalmud PJ Drenos F Shah S et al 2009 Gene centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip Am J Hum Genet 85 5 628 42 doi 10 1016 j ajhg 2009 10 014 PMC 2775832 PMID 19913121 Richard MJ Guiraud P Didier C et al 2001 Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake consequences on cellular resistance to UV A radiation Arch Biochem Biophys 386 2 213 20 doi 10 1006 abbi 2000 2197 PMID 11368344 Opalenik SR Ding Q Mallery SR Thompson JA 1998 Glutathione depletion associated with the HIV 1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor Arch Biochem Biophys 351 1 17 26 doi 10 1006 abbi 1997 0566 PMID 9501919 Choi J Liu RM Kundu RK et al 2000 Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat transgenic mice J Biol Chem 275 5 3693 8 doi 10 1074 jbc 275 5 3693 PMID 10652368 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Price TO Ercal N Nakaoke R Banks WA 2005 HIV 1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells Brain Res 1045 1 2 57 63 doi 10 1016 j brainres 2005 03 031 PMID 15910762 S2CID 7362454 Bailey SD Xie C Do R et al 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication DREAM study Diabetes Care 33 10 2250 3 doi 10 2337 dc10 0452 PMC 2945168 PMID 20628086 Moyer AM Sun Z Batzler AJ et al 2010 Glutathione pathway genetic polymorphisms and lung cancer survival after platinum based chemotherapy Cancer Epidemiol Biomarkers Prev 19 3 811 21 doi 10 1158 1055 9965 EPI 09 0871 PMC 2837367 PMID 20200426 Portal nbsp Biology nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GPX6 amp oldid 1142706206, wikipedia, wiki, book, books, library,
