Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5gene.[5][6]
GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]
^Hall L, Williams K, Perry AC, Frayne J, Jury JA (July 1998). "The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract". Biochem. J. 333 (1): 5–9. doi:10.1042/bj3330005. PMC1219548. PMID 9639555.
Further readingedit
Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC2775832. PMID 19913121.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Perry AC, Jones R, Niang LS, et al. (1992). "Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon". Biochem. J. 285 (3): 863–70. doi:10.1042/bj2850863. PMC1132876. PMID 1386734.
Richard MJ, Guiraud P, Didier C, et al. (2001). "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation". Arch. Biochem. Biophys. 386 (2): 213–20. doi:10.1006/abbi.2000.2197. PMID 11368344.
Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor". Arch. Biochem. Biophys. 351 (1): 17–26. doi:10.1006/abbi.1997.0566. PMID 9501919.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Rejraji H, Vernet P, Drevet JR (2002). "GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations". Mol. Reprod. Dev. 63 (1): 96–103. doi:10.1002/mrd.10136. PMID 12211066. S2CID 8103049.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Choi J, Liu RM, Kundu RK, et al. (2000). "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice". J. Biol. Chem. 275 (5): 3693–8. doi:10.1074/jbc.275.5.3693. PMID 10652368.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Vernet P, Faure J, Dufaure JP, Drevet JR (1997). "Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase". Mol. Reprod. Dev. 47 (1): 87–98. doi:10.1002/(SICI)1098-2795(199705)47:1<87::AID-MRD12>3.0.CO;2-X. PMID 9110319. S2CID 20995200.
Price TO, Ercal N, Nakaoke R, Banks WA (2005). "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells". Brain Res. 1045 (1–2): 57–63. doi:10.1016/j.brainres.2005.03.031. PMID 15910762. S2CID 7362454.
Williams K, Frayne J, Hall L (1998). "Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract". Mol. Hum. Reprod. 4 (9): 841–8. doi:10.1093/molehr/4.9.841. PMID 9783843.
Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC2945168. PMID 20628086.
Moyer AM, Sun Z, Batzler AJ, et al. (2010). "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy". Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. doi:10.1158/1055-9965.EPI-09-0871. PMC2837367. PMID 20200426.
gpx5, glutathione, peroxidase, also, known, epididymal, secretory, glutathione, peroxidase, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2i3yidentifiersaliases, glutathione, peroxidase, eglp, gshpx, 5exter. Glutathione peroxidase 5 GPx 5 also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene 5 6 GPX5Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2I3YIdentifiersAliasesGPX5 HEL S 75p glutathione peroxidase 5 GPx 5 EGLP GSHPx 5External IDsOMIM 603435 MGI 104886 HomoloGene 1155 GeneCards GPX5Gene location Human Chr Chromosome 6 human 1 Band6p22 1Start28 525 881 bp 1 End28 534 955 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 A3 1 13 7 73 cMStart21 470 599 bp 2 End21 476 901 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insuperior frontal gyrusprefrontal cortexislet of Langerhansprostatecanal of the cervixbloodhuman musculoskeletal systemmuscle of leggastrocnemius musclehypothalamusTop expressed inmorulaentorhinal cortexwhite adipose tissueepidermisadrenal glandexocrine glandhepatobiliary systemlivergonadtesticleMore reference expression dataBioGPSn aGene ontologyMolecular functionoxidoreductase activity peroxidase activity glutathione peroxidase activityCellular componentsperm plasma membrane extracellular region extracellular spaceBiological processcellular oxidant detoxification response to oxidative stress lipid metabolism cellular response to oxidative stressSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez288014780EnsemblENSG00000257770ENSG00000224586ENSMUSG00000004344UniProtO75715P21765RefSeq mRNA NM 001509NM 003996NM 010343RefSeq protein NP 001500NP 003987NP 034473Location UCSC Chr 6 28 53 28 53 MbChr 13 21 47 21 48 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse GPx 5 belongs to the glutathione peroxidase family It is specifically expressed in the epididymis in the mammalian male reproductive tract and is androgen regulated Unlike mRNAs for other characterized glutathione peroxidases this mRNA does not contain a selenocysteine UGA codon Thus the encoded protein is selenium independent and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and or preventing premature acrosome reaction Alternatively spliced transcript variants encoding different isoforms have been described for this gene 5 References edit a b c ENSG00000224586 GRCh38 Ensembl release 89 ENSG00000257770 ENSG00000224586 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004344 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene glutathione peroxidase 5 epididymal androgen related protein Hall L Williams K Perry AC Frayne J Jury JA July 1998 The majority of human glutathione peroxidase type 5 GPX5 transcripts are incorrectly spliced implications for the role of GPX5 in the male reproductive tract Biochem J 333 1 5 9 doi 10 1042 bj3330005 PMC 1219548 PMID 9639555 Further reading editTalmud PJ Drenos F Shah S et al 2009 Gene centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip Am J Hum Genet 85 5 628 42 doi 10 1016 j ajhg 2009 10 014 PMC 2775832 PMID 19913121 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 11 Bibcode 2003Natur 425 805M doi 10 1038 nature02055 PMID 14574404 Perry AC Jones R Niang LS et al 1992 Genetic evidence for an androgen regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon Biochem J 285 3 863 70 doi 10 1042 bj2850863 PMC 1132876 PMID 1386734 Richard MJ Guiraud P Didier C et al 2001 Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake consequences on cellular resistance to UV A radiation Arch Biochem Biophys 386 2 213 20 doi 10 1006 abbi 2000 2197 PMID 11368344 Opalenik SR Ding Q Mallery SR Thompson JA 1998 Glutathione depletion associated with the HIV 1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor Arch Biochem Biophys 351 1 17 26 doi 10 1006 abbi 1997 0566 PMID 9501919 Hartley JL Temple GF Brasch MA 2000 DNA cloning using in vitro site specific recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Rejraji H Vernet P Drevet JR 2002 GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations Mol Reprod Dev 63 1 96 103 doi 10 1002 mrd 10136 PMID 12211066 S2CID 8103049 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Choi J Liu RM Kundu RK et al 2000 Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat transgenic mice J Biol Chem 275 5 3693 8 doi 10 1074 jbc 275 5 3693 PMID 10652368 Kimura K Wakamatsu A Suzuki Y et al 2006 Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Vernet P Faure J Dufaure JP Drevet JR 1997 Tissue and developmental distribution dependence upon testicular factors and attachment to spermatozoa of GPX5 a murine epididymis specific glutathione peroxidase Mol Reprod Dev 47 1 87 98 doi 10 1002 SICI 1098 2795 199705 47 1 lt 87 AID MRD12 gt 3 0 CO 2 X PMID 9110319 S2CID 20995200 Price TO Ercal N Nakaoke R Banks WA 2005 HIV 1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells Brain Res 1045 1 2 57 63 doi 10 1016 j brainres 2005 03 031 PMID 15910762 S2CID 7362454 Williams K Frayne J Hall L 1998 Expression of extracellular glutathione peroxidase type 5 GPX5 in the rat male reproductive tract Mol Hum Reprod 4 9 841 8 doi 10 1093 molehr 4 9 841 PMID 9783843 Bailey SD Xie C Do R et al 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication DREAM study Diabetes Care 33 10 2250 3 doi 10 2337 dc10 0452 PMC 2945168 PMID 20628086 Moyer AM Sun Z Batzler AJ et al 2010 Glutathione pathway genetic polymorphisms and lung cancer survival after platinum based chemotherapy Cancer Epidemiol Biomarkers Prev 19 3 811 21 doi 10 1158 1055 9965 EPI 09 0871 PMC 2837367 PMID 20200426 Portal nbsp Biology nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GPX5 amp oldid 1142706198, wikipedia, wiki, book, 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