GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000173612 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000019905 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".
^Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. S2CID 469049.
^Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (December 2005). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC1435382. PMID 16199532.
^Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMC5079536. PMID 21425331.
^Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMC3000977. PMID 20947496.
^Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate. 72 (4): 399–409. doi:10.1002/pros.21442. PMC3183291. PMID 21681779.
Further readingEdit
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor". Gene. 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188.
Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628. S2CID 469049.
Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC1435382. PMID 16199532.
gprc6a, protein, coupled, receptor, family, group, member, protein, that, humans, encoded, gene, this, protein, functions, receptor, amino, acids, cations, calcium, osteocalcin, steroids, membrane, androgen, receptor, identifiersaliases, gpcr, ba86f4, protein,. G protein coupled receptor family C group 6 member A GPRC6A is a protein that in humans is encoded by the GPRC6A gene 5 This protein functions as a receptor of L a amino acids 6 cations e g calcium 7 osteocalcin 8 and steroids 9 It is a membrane androgen receptor GPRC6AIdentifiersAliasesGPRC6A GPCR bA86F4 3 G protein coupled receptor class C group 6 member AExternal IDsOMIM 613572 MGI 2429498 HomoloGene 17529 GeneCards GPRC6AGene location Human Chr Chromosome 6 human 1 Band6q22 1Start116 792 085 bp 1 End116 829 083 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 B3Start51 490 919 bp 2 End51 507 557 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insalivary glandminor salivary glandislet of Langerhanskidneyright adrenal glandleft adrenal glandrenal cortexprostatereproductive organgonadTop expressed inleft lung loberight lung lobeislet of LangerhansMore reference expression dataBioGPSn aGene ontologyMolecular functionG protein coupled receptor activity signal transducer activity signaling receptor activityCellular componentintegral component of membrane cell surface plasma membrane intracellular anatomical structure membrane integral component of plasma membraneBiological processresponse to amino acid calcium mediated signaling signal transduction G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez222545210198EnsemblENSG00000173612ENSMUSG00000019905UniProtQ5T6X5Q8K4Z6RefSeq mRNA NM 148963NM 001286354NM 001286355NM 153071RefSeq protein NP 001273283NP 001273284NP 683766NP 694711Location UCSC Chr 6 116 79 116 83 MbChr 10 51 49 51 51 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Clinical significance 2 See also 3 References 4 Further reading 5 External linksClinical significance EditGPRC6A has also been linked to prostate cancer progression and it has been shown to mediate rapid non genomic prostate cancer cell responses to testosterone 10 See also EditZIP9References Edit a b c GRCh38 Ensembl release 89 ENSG00000173612 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000019905 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene GPRC6A G protein coupled receptor family C group 6 member A Wellendorph P Hansen KB Balsgaard A Greenwood JR Egebjerg J Brauner Osborne H 2005 Deorphanization of GPRC6A a promiscuous L alpha amino acid receptor with preference for basic amino acids Mol Pharmacol 67 3 589 97 doi 10 1124 mol 104 007559 PMID 15576628 S2CID 469049 Pi M Faber P Ekema G Jackson PD Ting A Wang N Fontilla Poole M Mays RW Brunden KR Harrington JJ Quarles LD December 2005 Identification of a novel extracellular cation sensing G protein coupled receptor J Biol Chem 280 48 40201 9 doi 10 1074 jbc M505186200 PMC 1435382 PMID 16199532 Pi M Wu Y Quarles LD July 2011 GPRC6A mediates responses to osteocalcin in b cells in vitro and pancreas in vivo J Bone Miner Res 26 7 1680 3 doi 10 1002 jbmr 390 PMC 5079536 PMID 21425331 Pi M Parrill AL Quarles LD December 2010 GPRC6A mediates the non genomic effects of steroids J Biol Chem 285 51 39953 64 doi 10 1074 jbc M110 158063 PMC 3000977 PMID 20947496 Pi M Quarles LD June 2011 GPRC6A regulates prostate cancer progression Prostate 72 4 399 409 doi 10 1002 pros 21442 PMC 3183291 PMID 21681779 Further reading EditHarrington JJ Sherf B Rundlett S Jackson PD Perry R Cain S Leventhal C Thornton M Ramachandran R Whittington J Lerner L Costanzo D McElligott K Boozer S Mays R Smith E Veloso N Klika A Hess J Cothren K Lo K Offenbacher J Danzig J Ducar M 2001 Creation of genome wide protein expression libraries using random activation of gene expression Nat Biotechnol 19 5 440 5 doi 10 1038 88107 PMID 11329013 S2CID 25064683 Takeda S Kadowaki S Haga T Takaesu H Mitaku S 2002 Identification of G protein coupled receptor genes from the human genome sequence FEBS Lett 520 1 3 97 101 doi 10 1016 S0014 5793 02 02775 8 PMID 12044878 S2CID 7116392 Wellendorph P Brauner Osborne H 2004 Molecular cloning expression and sequence analysis of GPRC6A a novel family C G protein coupled receptor Gene 335 37 46 doi 10 1016 j gene 2004 03 003 PMID 15194188 Wellendorph P Hansen KB Balsgaard A Greenwood JR Egebjerg J Brauner Osborne H 2005 Deorphanization of GPRC6A a promiscuous L alpha amino acid receptor with preference for basic amino acids Mol Pharmacol 67 3 589 97 doi 10 1124 mol 104 007559 PMID 15576628 S2CID 469049 Pi M Faber P Ekema G Jackson PD Ting A Wang N Fontilla Poole M Mays RW Brunden KR Harrington JJ Quarles LD 2006 Identification of a novel extracellular cation sensing G protein coupled receptor J Biol Chem 280 48 40201 9 doi 10 1074 jbc M505186200 PMC 1435382 PMID 16199532 External links EditGPRC6A protein human at the U S National Library of Medicine Medical Subject Headings MeSH Calcium Sensing Receptors GPRC6 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GPRC6A amp oldid 1171069194, wikipedia, wiki, book, books, library,
