Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLSgene .[5] Wntless is a receptor for Wnt proteins in Wnt-secreting cells.[6]
^Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–8. doi:10.1038/jid.2012.407. PMC3594635. PMID 23190887.
^Chai, Guoliang; Szenker-Ravi, Emmanuelle; Chung, Changuk; Li, Zhen; Wang, Lu; Khatoo, Muznah; Marshall, Trevor; Jiang, Nan; Yang, Xiaoxu; McEvoy-Venneri, Jennifer; Stanley, Valentina (2021-09-29). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion". New England Journal of Medicine. 385 (14): 1292–1301. doi:10.1056/NEJMoa2033911. PMC9017221. PMID 34587386.
Further readingedit
Bänziger C, Soldini D, Schütt C, Zipperlen P, Hausmann G, Basler K (May 2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell. 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID 16678095. S2CID 7841408.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID 12975309.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
protein, wntless, homolog, commonly, known, wntless, encoded, humans, gene, wntless, receptor, proteins, secreting, cells, wlsidentifiersaliaseswls, c1orf139, gpr177, wntless, ligand, secretion, mediator, ligand, secretion, mediator, zksexternal, idsomim, 6115. Protein wntless homolog commonly known as Wntless is encoded in humans by the WLS gene 5 Wntless is a receptor for Wnt proteins in Wnt secreting cells 6 WLSIdentifiersAliasesWLS C1orf139 EVI GPR177 MRP mig 14 wntless Wnt ligand secretion mediator Wnt ligand secretion mediator ZKSExternal IDsOMIM 611514 MGI 1915401 HomoloGene 11779 GeneCards WLSGene location Human Chr Chromosome 1 human 1 Band1p31 3Start68 098 473 bp 1 End68 233 120 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 3 H4Start159 545 309 bp 2 End159 644 300 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumretinal pigment epitheliumcorpus epididymisgastric mucosaislet of Langerhansgallbladderoptic nerveendothelial cellbronchial epithelial cellcaput epididymisTop expressed incalvariamolarleft lung lobeolfactory epitheliumpineal glandmaxillary prominencecorneal stromaseminal vesiculabody of femurhandMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding Wnt protein binding mu type opioid receptor bindingCellular componentintegral component of membrane endocytic vesicle membrane endosome Golgi apparatus early endosome membrane membrane plasma membrane dendrite membrane trans Golgi network early endosome dendrite cytoplasm extracellular exosome cytoplasmic vesicle membrane endoplasmic reticulum membrane cytoplasmic vesicle Golgi membrane endoplasmic reticulumBiological processexocrine pancreas development positive regulation of canonical Wnt signaling pathway positive regulation of Wnt protein secretion mesoderm formation hindbrain development multicellular organism development positive regulation of Wnt signaling pathway positive regulation of I kappaB kinase NF kappaB signaling intracellular protein transport anterior posterior axis specification midbrain development Wnt signaling pathway Wnt protein secretionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez7997168151EnsemblENSG00000116729ENSMUSG00000028173UniProtQ5T9L3Q6DID7RefSeq mRNA NM 001002292NM 001193334NM 024911NM 026582NM 001356349NM 001356350RefSeq protein NP 001002292NP 001180263NP 079187NP 080858NP 001343278NP 001343279Location UCSC Chr 1 68 1 68 23 MbChr 3 159 55 159 64 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseWntless was shown to be a cargo for the retromer complex 6 It has been found essential for hair follicle induction 7 A homozygous missense mutation in the WLS gene was identified in Zaki syndrome 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000116729 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028173 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine WLS Protein wntless homolog Homo sapiens Human WLS gene amp protein www uniprot org Retrieved 30 May 2022 a b Eaton S January 2008 Retromer retrieves wntless Developmental Cell 14 1 4 6 doi 10 1016 j devcel 2007 12 014 PMID 18194646 Fu J Hsu W April 2013 Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis The Journal of Investigative Dermatology 133 4 890 8 doi 10 1038 jid 2012 407 PMC 3594635 PMID 23190887 Chai Guoliang Szenker Ravi Emmanuelle Chung Changuk Li Zhen Wang Lu Khatoo Muznah Marshall Trevor Jiang Nan Yang Xiaoxu McEvoy Venneri Jennifer Stanley Valentina 2021 09 29 A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion New England Journal of Medicine 385 14 1292 1301 doi 10 1056 NEJMoa2033911 PMC 9017221 PMID 34587386 Further reading editBanziger C Soldini D Schutt C Zipperlen P Hausmann G Basler K May 2006 Wntless a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells Cell 125 3 509 22 doi 10 1016 j cell 2006 02 049 PMID 16678095 S2CID 7841408 Otsuki T Ota T Nishikawa T Hayashi K Suzuki Y Yamamoto J Wakamatsu A Kimura K Sakamoto K Hatano N Kawai Y Ishii S Saito K Kojima S Sugiyama T Ono T Okano K Yoshikawa Y Aotsuka S Sasaki N Hattori A Okumura K Nagai K Sugano S Isogai T 2007 Signal sequence and keyword trap in silico for selection of full length human cDNAs encoding secretion or membrane proteins from oligo capped cDNA libraries DNA Research 12 2 117 26 doi 10 1093 dnares 12 2 117 PMID 16303743 Clark HF Gurney AL Abaya E Baker K Baldwin D Brush J Chen J Chow B Chui C Crowley C Currell B Deuel B Dowd P Eaton D Foster J Grimaldi C Gu Q Hass PE Heldens S Huang A Kim HS Klimowski L Jin Y Johnson S Lee J Lewis L Liao D Mark M Robbie E Sanchez C Schoenfeld J Seshagiri S Simmons L Singh J Smith V Stinson J Vagts A Vandlen R Watanabe C Wieand D Woods K Xie MH Yansura D Yi S Yu G Yuan J Zhang M Zhang Z Goddard A Wood WI Godowski P Gray A October 2003 The secreted protein discovery initiative SPDI a large scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment Genome Research 13 10 2265 70 doi 10 1101 gr 1293003 PMC 403697 PMID 12975309 Matsuda A Suzuki Y Honda G Muramatsu S Matsuzaki O Nagano Y Doi T Shimotohno K Harada T Nishida E Hayashi H Sugano S May 2003 Large scale identification and characterization of human genes that activate NF kappaB and MAPK signaling pathways Oncogene 22 21 3307 18 doi 10 1038 sj onc 1206406 PMID 12761501 See also editGPR177 receptor human at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Protein wntless homolog amp oldid 1171072836, wikipedia, wiki, book, books, library,
