Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BAgene.
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein receptor composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds.[5] The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. Binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury,[6] and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis.[7] This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard–Soulier syndromes and platelet-type von Willebrand disease.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000185245 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000050675 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lopez JA, Chung DW, Fujikawa K, Hagen FS, Papayannopoulou T, Roth GJ (August 1987). "Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein". Proceedings of the National Academy of Sciences of the United States of America. 84 (16): 5615–5619. Bibcode:1987PNAS...84.5615L. doi:10.1073/pnas.84.16.5615. PMC298913. PMID 3303030.
^Arya M, Anvari B, Romo GM, Cruz MA, Dong JF, McIntire LV, et al. (June 2002). "Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers". Blood. 99 (11): 3971–3977. doi:10.1182/blood-2001-11-0060. PMID 12010796. S2CID 24850350. Retrieved 2023-09-08.
^Jackson SP, Nesbitt WS, Kulkarni S (July 2003). "Signaling events underlying thrombus formation". Journal of Thrombosis and Haemostasis. 1 (7): 1602–1612. doi:10.1046/j.1538-7836.2003.00267.x. PMID 12871297. S2CID 22088432.
^Calverley DC, Kavanagh TJ, Roth GJ (February 1998). "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta". Blood. 91 (4): 1295–1303. doi:10.1182/blood.V91.4.1295. PMID 9454760.
^Du X, Fox JE, Pei S (March 1996). "Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha". The Journal of Biological Chemistry. 271 (13): 7362–7367. doi:10.1074/jbc.271.13.7362. PMID 8631758.
^Feng S, Christodoulides N, Reséndiz JC, Berndt MC, Kroll MH (January 2000). "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V". Blood. 95 (2): 551–557. doi:10.1182/blood.V95.2.551. PMID 10627461. S2CID 77799615.
^Takafuta T, Wu G, Murphy GF, Shapiro SS (July 1998). "Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha". The Journal of Biological Chemistry. 273 (28): 17531–17538. doi:10.1074/jbc.273.28.17531. PMID 9651345.
Further readingedit
Kunishima S, Kamiya T, Saito H (November 2002). "Genetic abnormalities of Bernard-Soulier syndrome". International Journal of Hematology. 76 (4): 319–327. doi:10.1007/BF02982690. PMID 12463594. S2CID 23635810.
Du X (May 2007). "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex". Current Opinion in Hematology. 14 (3): 262–269. doi:10.1097/MOH.0b013e3280dce51a. PMID 17414217. S2CID 39904506.
Clemetson KJ (July 2007). "A short history of platelet glycoprotein Ib complex". Thrombosis and Haemostasis. 98 (1): 63–68. doi:10.1160/th07-05-0327. PMID 17597992. S2CID 958810.
López JA, Ludwig EH, McCarthy BJ (May 1992). "Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications". The Journal of Biological Chemistry. 267 (14): 10055–10061. doi:10.1016/S0021-9258(19)50199-5. PMID 1577776.
Murata M, Furihata K, Ishida F, Russell SR, Ware J, Ruggeri ZM (June 1992). "Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness". Blood. 79 (11): 3086–3090. doi:10.1182/blood.V79.11.3086.3086. PMID 1586750.
Girma JP, Takahashi Y, Yoshioka A, Diaz J, Meyer D (October 1990). "Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib". Thrombosis and Haemostasis. 64 (2): 326–332. doi:10.1055/s-0038-1647310. PMID 1702906. S2CID 27425464.
Miller JL, Lyle VA, Cunningham D (January 1992). "Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease". Blood. 79 (2): 439–446. doi:10.1182/blood.V79.2.439.439. PMID 1730088.
Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE (January 1992). "Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane". The Journal of Biological Chemistry. 267 (1): 364–369. doi:10.1016/S0021-9258(18)48503-1. PMID 1730602.
Miller JL, Cunningham D, Lyle VA, Finch CN (June 1991). "Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease". Proceedings of the National Academy of Sciences of the United States of America. 88 (11): 4761–4765. Bibcode:1991PNAS...88.4761M. doi:10.1073/pnas.88.11.4761. PMC51746. PMID 2052556.
Hess D, Schaller J, Rickli EE, Clemetson KJ (July 1991). "Identification of the disulphide bonds in human platelet glycocalicin". European Journal of Biochemistry. 199 (2): 389–393. doi:10.1111/j.1432-1033.1991.tb16135.x. PMID 2070794.
Du X, Beutler L, Ruan C, Castaldi PA, Berndt MC (May 1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524–1527. doi:10.1182/blood.V69.5.1524.1524. PMID 2436691.
Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Berndt MC (October 1989). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry. 28 (21): 8317–8326. doi:10.1021/bi00447a009. PMID 2557900.
Wenger RH, Wicki AN, Kieffer N, Adolph S, Hameister H, Clemetson KJ (December 1989). "The 5' flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha". Gene. 85 (2): 517–524. doi:10.1016/0378-1119(89)90446-0. PMID 2628181.
Wenger RH, Kieffer N, Wicki AN, Clemetson KJ (October 1988). "Structure of the human blood platelet membrane glycoprotein Ib alpha gene". Biochemical and Biophysical Research Communications. 156 (1): 389–395. doi:10.1016/S0006-291X(88)80853-2. PMID 2845978.
Wicki AN, Clemetson KJ (November 1985). "Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin". European Journal of Biochemistry. 153 (1): 1–11. doi:10.1111/j.1432-1033.1985.tb09259.x. PMID 2933256.
Adelman B, Michelson AD, Greenberg J, Handin RI (December 1986). "Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions". Blood. 68 (6): 1280–1284. doi:10.1182/blood.V68.6.1280.1280. PMID 2946332.
Lopez JA, Chung DW, Fujikawa K, Hagen FS, Papayannopoulou T, Roth GJ (August 1987). "Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein". Proceedings of the National Academy of Sciences of the United States of America. 84 (16): 5615–5619. Bibcode:1987PNAS...84.5615L. doi:10.1073/pnas.84.16.5615. PMC298913. PMID 3303030.
Lopez JA, Chung DW, Fujikawa K, Hagen FS, Davie EW, Roth GJ (April 1988). "The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence". Proceedings of the National Academy of Sciences of the United States of America. 85 (7): 2135–2139. Bibcode:1988PNAS...85.2135L. doi:10.1073/pnas.85.7.2135. PMC279943. PMID 3353370.
Titani K, Takio K, Handa M, Ruggeri ZM (August 1987). "Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib". Proceedings of the National Academy of Sciences of the United States of America. 84 (16): 5610–5614. Bibcode:1987PNAS...84.5610T. doi:10.1073/pnas.84.16.5610. PMC298912. PMID 3497398.
Harmon JT, Jamieson GA (October 1986). "The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets". The Journal of Biological Chemistry. 261 (28): 13224–13229. doi:10.1016/S0021-9258(18)69294-4. PMID 3759960.
gp1ba, platelet, glycoprotein, alpha, chain, also, known, glycoprotein, platelet, alpha, polypeptide, cd42b, cluster, differentiation, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1gwb, 1m0z, 1m10, 1ook, . Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib platelet alpha polypeptide or CD42b Cluster of Differentiation 42b is a protein that in humans is encoded by the GP1BA gene GP1BAAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6IdentifiersAliasesGP1BA BDPLT1 BDPLT3 BSS CD42B CD42b alpha DBPLT3 GP1B GPIbA VWDP GPIbalpha glycoprotein Ib platelet alpha subunit glycoprotein Ib platelet subunit alphaExternal IDsOMIM 606672 MGI 1333744 HomoloGene 143 GeneCards GP1BAGene location Human Chr Chromosome 17 human 1 Band17p13 2Start4 932 277 bp 1 End4 935 023 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 B3 11 43 2 cMStart70 529 948 bp 2 End70 532 862 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytelymph nodesecondary oocytetrabecular bonebloodbone marrow cellstibialis anterior muscleappendixthymusoptic nerveTop expressed inbloodyolk sacspleenmorularight ventriclesubmandibular glandabdominal wallbody of femurlipskeletal muscle tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein kinase inhibitor activity thrombin activated receptor activity protein bindingCellular componentcytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane cell surface anchored component of external side of plasma membrane extracellular exosome extracellular space extracellular matrixBiological processblood coagulation intrinsic pathway hemostasis fibrinolysis negative regulation of protein kinase activity cytokine mediated signaling pathway blood coagulation platelet activation cell surface receptor signaling pathway cell adhesion cell morphogenesis regulation of blood coagulation negative regulation of receptor signaling pathway via JAK STAT thrombin activated receptor signaling pathway platelet aggregation regulation of megakaryocyte differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez281114723EnsemblENSG00000185245ENSMUSG00000050675UniProtP07359O35930RefSeq mRNA NM 000173NM 010326RefSeq protein NP 000164NP 034456Location UCSC Chr 17 4 93 4 94 MbChr 11 70 53 70 53 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunction editGlycoprotein Ib GP Ib is a platelet surface membrane glycoprotein receptor composed of a heterodimer an alpha chain and a beta chain that are linked by disulfide bonds 5 The Gp Ib functions as a receptor for von Willebrand factor VWF The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib IX V complex Binding of the GP Ib IX V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury 6 and also initiates signaling events within the platelet that lead to enhanced platelet activation thrombosis and hemostasis 7 This gene encodes the alpha subunit Several polymorphisms and mutations have been described in this gene some of which are the cause of Bernard Soulier syndromes and platelet type von Willebrand disease 8 Interactions editGP1BA has been shown to interact with YWHAZ 9 10 11 and FLNB 12 See also editCluster of differentiationReferences edit a b c GRCh38 Ensembl release 89 ENSG00000185245 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000050675 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lopez JA Chung DW Fujikawa K Hagen FS Papayannopoulou T Roth GJ August 1987 Cloning of the alpha chain of human platelet glycoprotein Ib a transmembrane protein with homology to leucine rich alpha 2 glycoprotein Proceedings of the National Academy of Sciences of the United States of America 84 16 5615 5619 Bibcode 1987PNAS 84 5615L doi 10 1073 pnas 84 16 5615 PMC 298913 PMID 3303030 Arya M Anvari B Romo GM Cruz MA Dong JF McIntire LV et al June 2002 Ultralarge multimers of von Willebrand factor form spontaneous high strength bonds with the platelet glycoprotein Ib IX complex studies using optical tweezers Blood 99 11 3971 3977 doi 10 1182 blood 2001 11 0060 PMID 12010796 S2CID 24850350 Retrieved 2023 09 08 Jackson SP Nesbitt WS Kulkarni S July 2003 Signaling events underlying thrombus formation Journal of Thrombosis and Haemostasis 1 7 1602 1612 doi 10 1046 j 1538 7836 2003 00267 x PMID 12871297 S2CID 22088432 Entrez Gene GP1BA glycoprotein Ib platelet alpha polypeptide Calverley DC Kavanagh TJ Roth GJ February 1998 Human signaling protein 14 3 3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta Blood 91 4 1295 1303 doi 10 1182 blood V91 4 1295 PMID 9454760 Du X Fox JE Pei S March 1996 Identification of a binding sequence for the 14 3 3 protein within the cytoplasmic domain of the adhesion receptor platelet glycoprotein Ib alpha The Journal of Biological Chemistry 271 13 7362 7367 doi 10 1074 jbc 271 13 7362 PMID 8631758 Feng S Christodoulides N Resendiz JC Berndt MC Kroll MH January 2000 Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14 3 3zeta binding to GpIb IX V Blood 95 2 551 557 doi 10 1182 blood V95 2 551 PMID 10627461 S2CID 77799615 Takafuta T Wu G Murphy GF Shapiro SS July 1998 Human beta filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha The Journal of Biological Chemistry 273 28 17531 17538 doi 10 1074 jbc 273 28 17531 PMID 9651345 Further reading editKunishima S Kamiya T Saito H November 2002 Genetic abnormalities of Bernard Soulier syndrome International Journal of Hematology 76 4 319 327 doi 10 1007 BF02982690 PMID 12463594 S2CID 23635810 Du X May 2007 Signaling and regulation of the platelet glycoprotein Ib IX V complex Current Opinion in Hematology 14 3 262 269 doi 10 1097 MOH 0b013e3280dce51a PMID 17414217 S2CID 39904506 Clemetson KJ July 2007 A short history of platelet glycoprotein Ib complex Thrombosis and Haemostasis 98 1 63 68 doi 10 1160 th07 05 0327 PMID 17597992 S2CID 958810 Lopez JA Ludwig EH McCarthy BJ May 1992 Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13 amino acid sequence in the mucin like macroglycopeptide region Structure function implications The Journal of Biological Chemistry 267 14 10055 10061 doi 10 1016 S0021 9258 19 50199 5 PMID 1577776 Murata M Furihata K Ishida F Russell SR Ware J Ruggeri ZM June 1992 Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness Blood 79 11 3086 3090 doi 10 1182 blood V79 11 3086 3086 PMID 1586750 Girma JP Takahashi Y Yoshioka A Diaz J Meyer D October 1990 Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane glycoprotein Ib Thrombosis and Haemostasis 64 2 326 332 doi 10 1055 s 0038 1647310 PMID 1702906 S2CID 27425464 Miller JL Lyle VA Cunningham D January 1992 Mutation of leucine 57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard Soulier disease Blood 79 2 439 446 doi 10 1182 blood V79 2 439 439 PMID 1730088 Modderman PW Admiraal LG Sonnenberg A von dem Borne AE January 1992 Glycoproteins V and Ib IX form a noncovalent complex in the platelet membrane The Journal of Biological Chemistry 267 1 364 369 doi 10 1016 S0021 9258 18 48503 1 PMID 1730602 Miller JL Cunningham D Lyle VA Finch CN June 1991 Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet type von Willebrand disease Proceedings of the National Academy of Sciences of the United States of America 88 11 4761 4765 Bibcode 1991PNAS 88 4761M doi 10 1073 pnas 88 11 4761 PMC 51746 PMID 2052556 Hess D Schaller J Rickli EE Clemetson KJ July 1991 Identification of the disulphide bonds in human platelet glycocalicin European Journal of Biochemistry 199 2 389 393 doi 10 1111 j 1432 1033 1991 tb16135 x PMID 2070794 Du X Beutler L Ruan C Castaldi PA Berndt MC May 1987 Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane Blood 69 5 1524 1527 doi 10 1182 blood V69 5 1524 1524 PMID 2436691 Andrews RK Booth WJ Gorman JJ Castaldi PA Berndt MC October 1989 Purification of botrocetin from Bothrops jararaca venom Analysis of the botrocetin mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib IX complex Biochemistry 28 21 8317 8326 doi 10 1021 bi00447a009 PMID 2557900 Wenger RH Wicki AN Kieffer N Adolph S Hameister H Clemetson KJ December 1989 The 5 flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ib alpha Gene 85 2 517 524 doi 10 1016 0378 1119 89 90446 0 PMID 2628181 Wenger RH Kieffer N Wicki AN Clemetson KJ October 1988 Structure of the human blood platelet membrane glycoprotein Ib alpha gene Biochemical and Biophysical Research Communications 156 1 389 395 doi 10 1016 S0006 291X 88 80853 2 PMID 2845978 Wicki AN Clemetson KJ November 1985 Structure and function of platelet membrane glycoproteins Ib and V Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin European Journal of Biochemistry 153 1 1 11 doi 10 1111 j 1432 1033 1985 tb09259 x PMID 2933256 Adelman B Michelson AD Greenberg J Handin RI December 1986 Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine binding regions Blood 68 6 1280 1284 doi 10 1182 blood V68 6 1280 1280 PMID 2946332 Lopez JA Chung DW Fujikawa K Hagen FS Papayannopoulou T Roth GJ August 1987 Cloning of the alpha chain of human platelet glycoprotein Ib a transmembrane protein with homology to leucine rich alpha 2 glycoprotein Proceedings of the National Academy of Sciences of the United States of America 84 16 5615 5619 Bibcode 1987PNAS 84 5615L doi 10 1073 pnas 84 16 5615 PMC 298913 PMID 3303030 Lopez JA Chung DW Fujikawa K Hagen FS Davie EW Roth GJ April 1988 The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine rich amino acid sequence Proceedings of the National Academy of Sciences of the United States of America 85 7 2135 2139 Bibcode 1988PNAS 85 2135L doi 10 1073 pnas 85 7 2135 PMC 279943 PMID 3353370 Titani K Takio K Handa M Ruggeri ZM August 1987 Amino acid sequence of the von Willebrand factor binding domain of platelet membrane glycoprotein Ib Proceedings of the National Academy of Sciences of the United States of America 84 16 5610 5614 Bibcode 1987PNAS 84 5610T doi 10 1073 pnas 84 16 5610 PMC 298912 PMID 3497398 Harmon JT Jamieson GA October 1986 The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin A soluble radioreceptor assay for the interaction of thrombin with platelets The Journal of Biological Chemistry 261 28 13224 13229 doi 10 1016 S0021 9258 18 69294 4 PMID 3759960 External links editGP1BA protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GP1BA amp oldid 1184081125, wikipedia, wiki, book, books, library,
