This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000125447 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020740 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abDell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (April 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". The Journal of Cell Biology. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC2175099. PMID 10747089.
^ abBoman AL, Zhang C, Zhu X, Kahn RA (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC14844. PMID 10749927.
^Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.
^Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC124144. PMID 12221117.
Further readingEdit
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (April 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC2175106. PMID 10747088.
Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.
Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS (June 2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID 11387475. S2CID 30836125.
Takatsu H, Yoshino K, Toda K, Nakayama K (July 2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". The Biochemical Journal. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC1222692. PMID 11950392.
Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS (July 2002). "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism". Nature Structural Biology. 9 (7): 532–6. doi:10.1038/nsb807. PMID 12032548. S2CID 23740463.
Doray B, Bruns K, Ghosh P, Kornfeld SA (June 2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi:10.1073/pnas.082235699. PMC123022. PMID 12060753.
Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (September 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC2173151. PMID 12213833.
Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S (September 2002). "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network". Science. 297 (5587): 1700–3. Bibcode:2002Sci...297.1700D. doi:10.1126/science.1075327. PMID 12215646. S2CID 8810528.
Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC124144. PMID 12221117.
Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC140067. PMID 12505986.
Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y (July 2003). "Predominant expression of the short form of GGA3 in human cell lines and tissues". Biochemical and Biophysical Research Communications. 306 (3): 687–92. doi:10.1016/S0006-291X(03)01032-5. PMID 12810073.
He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J (October 2003). "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry. 42 (42): 12174–80. doi:10.1021/bi035199h. PMID 14567678.
Ghosh P, Griffith J, Geuze HJ, Kornfeld S (November 2003). "Mammalian GGAs act together to sort mannose 6-phosphate receptors". The Journal of Cell Biology. 163 (4): 755–66. doi:10.1083/jcb.200308038. PMC2173681. PMID 14638859.
Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K (February 2004). "GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination". The Journal of Biological Chemistry. 279 (8): 7105–11. doi:10.1074/jbc.M311702200. PMID 14660606.
This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.
gga3, ribosylation, factor, binding, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1jpl, 1juq, 1lf8, 1p4u, 1wr6, 1yd8identifiersaliases, golgi, associated, gamma, adaptin, containing, binding, pro. ADP ribosylation factor binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene 5 6 GGA3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8IdentifiersAliasesGGA3 golgi associated gamma adaptin ear containing ARF binding protein 3External IDsOMIM 606006 MGI 2384159 HomoloGene 121703 GeneCards GGA3Gene location Human Chr Chromosome 17 human 1 Band17q25 1Start75 236 599 bp 1 End75 262 363 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 E2Start115 475 081 bp 2 End115 494 877 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insural nervepylorusgastric mucosaspleenmonocytenipplelymph nodeupper lobe of left lungfundustransverse colonTop expressed insecondary oocytesuperior frontal gyruscerebellar cortexyolk sacfacial motor nucleusthymusanterior horn of spinal cordpiriform cortexsuperior cervical ganglionsuperior colliculusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding ubiquitin bindingCellular componentendosome trans Golgi network endosome membrane intracellular anatomical structure membrane clathrin adaptor complex Golgi apparatus early endosome membrane recycling endosome membrane early endosome recycling endosomeBiological processprotein transport intracellular protein transport positive regulation of protein catabolic process vesicle mediated transport protein localization to lysosome regulation of protein stability protein destabilization endocytic recycling protein localization to cell surface Golgi to plasma membrane protein transport negative regulation of amyloid beta formationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez23163260302EnsemblENSG00000125447ENSMUSG00000020740UniProtQ9NZ52Q8BMI3RefSeq mRNA NM 001172703NM 001172704NM 001291641NM 001291642NM 014001NM 138619NM 001252067NM 173048RefSeq protein NP 001166174NP 001166175NP 001278570NP 001278571NP 054720NP 619525NP 001238996NP 766636Location UCSC Chr 17 75 24 75 26 MbChr 11 115 48 115 49 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the Golgi localized gamma adaptin ear containing ARF binding GGA family This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans Golgi network and the lysosome These proteins share an amino terminal VHS domain which mediates sorting of the mannose 6 phosphate receptors at the trans Golgi network They also contain a carboxy terminal region with homology to the ear domain of gamma adaptins Alternative splicing of this gene results in two transcript variants 7 Interactions EditGGA3 has been shown to interact with ARF1 5 8 and ARF3 6 9 References Edit a b c GRCh38 Ensembl release 89 ENSG00000125447 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020740 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Dell Angelica EC Puertollano R Mullins C Aguilar RC Vargas JD Hartnell LM Bonifacino JS April 2000 GGAs a family of ADP ribosylation factor binding proteins related to adaptors and associated with the Golgi complex The Journal of Cell Biology 149 1 81 94 doi 10 1083 jcb 149 1 81 PMC 2175099 PMID 10747089 a b Boman AL Zhang C Zhu X Kahn RA April 2000 A family of ADP ribosylation factor effectors that can alter membrane transport through the trans Golgi Molecular Biology of the Cell 11 4 1241 55 doi 10 1091 mbc 11 4 1241 PMC 14844 PMID 10749927 Entrez Gene GGA3 golgi associated gamma adaptin ear containing ARF binding protein 3 Puertollano R Randazzo PA Presley JF Hartnell LM Bonifacino JS April 2001 The GGAs promote ARF dependent recruitment of clathrin to the TGN Cell 105 1 93 102 doi 10 1016 S0092 8674 01 00299 9 PMID 11301005 S2CID 1158816 Boman AL Salo PD Hauglund MJ Strand NL Rensink SJ Zhdankina O September 2002 ADP ribosylation factor ARF interaction is not sufficient for yeast GGA protein function or localization Molecular Biology of the Cell 13 9 3078 95 doi 10 1091 mbc E02 02 0078 PMC 124144 PMID 12221117 Further reading EditNagase T Seki N Tanaka A Ishikawa K Nomura N August 1995 Prediction of the coding sequences of unidentified human genes IV The coding sequences of 40 new genes KIAA0121 KIAA0160 deduced by analysis of cDNA clones from human cell line KG 1 DNA Research 2 4 167 74 199 210 doi 10 1093 dnares 2 4 167 PMID 8590280 Hirst J Lui WW Bright NA Totty N Seaman MN Robinson MS April 2000 A family of proteins with gamma adaptin and VHS domains that facilitate trafficking between the trans Golgi network and the vacuole lysosome The Journal of Cell Biology 149 1 67 80 doi 10 1083 jcb 149 1 67 PMC 2175106 PMID 10747088 Takatsu H Yoshino K Nakayama K May 2000 Adaptor gamma ear homology domain conserved in gamma adaptin and GGA proteins that interact with gamma synergin Biochemical and Biophysical Research Communications 271 3 719 25 doi 10 1006 bbrc 2000 2700 PMID 10814529 Puertollano R Randazzo PA Presley JF Hartnell LM Bonifacino JS April 2001 The GGAs promote ARF dependent recruitment of clathrin to the TGN Cell 105 1 93 102 doi 10 1016 S0092 8674 01 00299 9 PMID 11301005 S2CID 1158816 Puertollano R Aguilar RC Gorshkova I Crouch RJ Bonifacino JS June 2001 Sorting of mannose 6 phosphate receptors mediated by the GGAs Science 292 5522 1712 6 Bibcode 2001Sci 292 1712P doi 10 1126 science 1060750 PMID 11387475 S2CID 30836125 Misra S Puertollano R Kato Y Bonifacino JS Hurley JH February 2002 Structural basis for acidic cluster dileucine sorting signal recognition by VHS domains Nature 415 6874 933 7 Bibcode 2002Natur 415 933M doi 10 1038 415933a PMID 11859375 S2CID 4430757 Takatsu H Yoshino K Toda K Nakayama K July 2002 GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP ribosylation factors The Biochemical Journal 365 Pt 2 369 78 doi 10 1042 BJ20020428 PMC 1222692 PMID 11950392 Kato Y Misra S Puertollano R Hurley JH Bonifacino JS July 2002 Phosphoregulation of sorting signal VHS domain interactions by a direct electrostatic mechanism Nature Structural Biology 9 7 532 6 doi 10 1038 nsb807 PMID 12032548 S2CID 23740463 Doray B Bruns K Ghosh P Kornfeld SA June 2002 Autoinhibition of the ligand binding site of GGA1 3 VHS domains by an internal acidic cluster dileucine motif Proceedings of the National Academy of Sciences of the United States of America 99 12 8072 7 Bibcode 2002PNAS 99 8072D doi 10 1073 pnas 082235699 PMC 123022 PMID 12060753 Wasiak S Legendre Guillemin V Puertollano R Blondeau F Girard M de Heuvel E Boismenu D Bell AW Bonifacino JS McPherson PS September 2002 Enthoprotin a novel clathrin associated protein identified through subcellular proteomics The Journal of Cell Biology 158 5 855 62 doi 10 1083 jcb 200205078 PMC 2173151 PMID 12213833 Doray B Ghosh P Griffith J Geuze HJ Kornfeld S September 2002 Cooperation of GGAs and AP 1 in packaging MPRs at the trans Golgi network Science 297 5587 1700 3 Bibcode 2002Sci 297 1700D doi 10 1126 science 1075327 PMID 12215646 S2CID 8810528 Boman AL Salo PD Hauglund MJ Strand NL Rensink SJ Zhdankina O September 2002 ADP ribosylation factor ARF interaction is not sufficient for yeast GGA protein function or localization Molecular Biology of the Cell 13 9 3078 95 doi 10 1091 mbc E02 02 0078 PMC 124144 PMID 12221117 Mattera R Arighi CN Lodge R Zerial M Bonifacino JS January 2003 Divalent interaction of the GGAs with the Rabaptin 5 Rabex 5 complex The EMBO Journal 22 1 78 88 doi 10 1093 emboj cdg015 PMC 140067 PMID 12505986 Wakasugi M Waguri S Kametaka S Tomiyama Y Kanamori S Shiba Y Nakayama K Uchiyama Y July 2003 Predominant expression of the short form of GGA3 in human cell lines and tissues Biochemical and Biophysical Research Communications 306 3 687 92 doi 10 1016 S0006 291X 03 01032 5 PMID 12810073 He X Zhu G Koelsch G Rodgers KK Zhang XC Tang J October 2003 Biochemical and structural characterization of the interaction of memapsin 2 beta secretase cytosolic domain with the VHS domain of GGA proteins Biochemistry 42 42 12174 80 doi 10 1021 bi035199h PMID 14567678 Ghosh P Griffith J Geuze HJ Kornfeld S November 2003 Mammalian GGAs act together to sort mannose 6 phosphate receptors The Journal of Cell Biology 163 4 755 66 doi 10 1083 jcb 200308038 PMC 2173681 PMID 14638859 Shiba Y Katoh Y Shiba T Yoshino K Takatsu H Kobayashi H Shin HW Wakatsuki S Nakayama K February 2004 GAT GGA and Tom1 domain responsible for ubiquitin binding and ubiquitination The Journal of Biological Chemistry 279 8 7105 11 doi 10 1074 jbc M311702200 PMID 14660606 This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GGA3 amp oldid 1079572614, wikipedia, wiki, book, books, library,
