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Wikipedia

GGA1

April 10, 2024

ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.[5][6][7]

GGA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGGA1, golgi associated, gamma adaptin ear containing, ARF binding protein 1
External IDsOMIM: 606004 MGI: 2146207 HomoloGene: 39250 GeneCards: GGA1
Orthologs
SpeciesHumanMouse
Entrez

26088

106039

Ensembl

ENSG00000100083

ENSMUSG00000033128

UniProt

Q9UJY5

Q8R0H9

RefSeq (mRNA)

NM_145929

RefSeq (protein)

NP_001001560
NP_001166158
NP_001166159
NP_037497
NP_001350700

NP_666041

Location (UCSC)Chr 22: 37.61 – 37.63 MbChr 15: 78.76 – 78.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[8]

Interactions edit

GGA1 has been shown to interact with Sortilin 1,[9] BACE2,[10] RABEP1[11] and ARF3.[12][13]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100083 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033128 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
  6. ^ Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (May 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.
  7. ^ Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S (March 2006). "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles". J Biol Chem. 281 (11): 7253–9. doi:10.1074/jbc.M511313200. hdl:2445/176753. PMID 16407204.
  8. ^ "Entrez Gene: GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1".
  9. ^ Jacobsen, Linda; Madsen Peder; Nielsen Morten S; Geraerts Wijnand P M; Gliemann Jørgen; Smit August B; Petersen Claus M (January 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. ISSN 0014-5793. PMID 11821067. S2CID 21977507.
  10. ^ He, Xiangyuan; Chang Wan-Pin; Koelsch Gerald; Tang Jordan (July 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. ISSN 0014-5793. PMID 12135764.
  11. ^ Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986.
  12. ^ Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. ISSN 1059-1524. PMC 124144. PMID 12221117.
  13. ^ Boman, A L; Zhang C j; Zhu X; Kahn R A (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. ISSN 1059-1524. PMC 14844. PMID 10749927.

Further reading edit

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Boman AL, Zhang C, Zhu X, Kahn RA (2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol. Biol. Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
  • Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
  • Zhdankina O, Strand NL, Redmond JM, Boman AL (2001). "Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi". Yeast. 18 (1): 1–18. doi:10.1002/1097-0061(200101)18:1<1::AID-YEA644>3.0.CO;2-5. PMID 11124697. S2CID 10348751.
  • Puertollano R, Randazzo PA, Presley JF, et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
  • Puertollano R, Aguilar RC, Gorshkova I, et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID 11387475. S2CID 30836125.
  • Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". J. Biol. Chem. 276 (30): 28541–5. doi:10.1074/jbc.C100218200. PMID 11390366.
  • Jacobsen L, Madsen P, Nielsen MS, et al. (2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067. S2CID 21977507.
  • Shiba T, Takatsu H, Nogi T, et al. (2002). "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1". Nature. 415 (6874): 937–41. Bibcode:2002Natur.415..937S. doi:10.1038/415937a. PMID 11859376. S2CID 4395774.
  • Takatsu H, Yoshino K, Toda K, Nakayama K (2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". Biochem. J. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392.
  • Doray B, Bruns K, Ghosh P, Kornfeld SA (2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi:10.1073/pnas.082235699. PMC 123022. PMID 12060753.
  • He X, Chang WP, Koelsch G, Tang J (2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764.
  • Boman AL, Salo PD, Hauglund MJ, et al. (2003). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  • Mills IG, Praefcke GJ, Vallis Y, et al. (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMC 2172650. PMID 12538641.

April 10, 2024
gga1, ribosylation, factor, binding, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1j2j, 1jwf, 1jwg, 1na8, 1naf, 1nwm, 1o3x, 1om9, 1oxz, 1py1, 1ujj, 1ujk, 1x79, 2dwx, 2dwy, 3g2s, 3g2t, 3g2u, 3g2v,. ADP ribosylation factor binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene 5 6 7 GGA1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1J2J 1JWF 1JWG 1NA8 1NAF 1NWM 1O3X 1OM9 1OXZ 1PY1 1UJJ 1UJK 1X79 2DWX 2DWY 3G2S 3G2T 3G2U 3G2V 3G2WIdentifiersAliasesGGA1 golgi associated gamma adaptin ear containing ARF binding protein 1External IDsOMIM 606004 MGI 2146207 HomoloGene 39250 GeneCards GGA1Gene location Human Chr Chromosome 22 human 1 Band22q13 1Start37 608 725 bp 1 End37 633 564 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 E1Start78 761 390 bp 2 End78 778 785 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic ductal cellendothelial cellright uterine tubepituitary glandanterior pituitaryright lobe of thyroid glandtibialis anterior muscleleft lobe of thyroid glandspleenparotid glandTop expressed inlippyloric antrumyolk sacsuperior frontal gyrusesophaguscerebellar cortexinternal carotid arteryspermatocyteduodenumcrypt of lieberkuhn of small intestineMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding protein heterodimerization activity molecular functionCellular componentendosome Golgi apparatus endosome membrane intracellular anatomical structure membrane intracellular membrane bounded organelle clathrin adaptor complex nucleoplasm early endosome membrane early endosome cytosol protein containing complexBiological processprotein transport intracellular protein transport toxin transport positive regulation of protein catabolic process vesicle mediated transport transport Golgi to plasma membrane transport protein localization protein localization to cell surface retrograde transport endosome to Golgi Golgi to plasma membrane protein transport protein localization to ciliary membraneSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez26088106039EnsemblENSG00000100083ENSMUSG00000033128UniProtQ9UJY5Q8R0H9RefSeq mRNA NM 001001560NM 001001561NM 001172687NM 001172688NM 013365NM 001363771NM 145929RefSeq protein NP 001001560NP 001166158NP 001166159NP 037497NP 001350700NP 666041Location UCSC Chr 22 37 61 37 63 MbChr 15 78 76 78 78 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the Golgi localized gamma adaptin ear containing ARF binding GGA protein family Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans Golgi network and the lysosome These proteins share an amino terminal VHS domain which mediates sorting of the mannose 6 phosphate receptors at the trans Golgi network They also contain a carboxy terminal region with homology to the ear domain of gamma adaptins Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene 8 Interactions editGGA1 has been shown to interact with Sortilin 1 9 BACE2 10 RABEP1 11 and ARF3 12 13 References edit a b c GRCh38 Ensembl release 89 ENSG00000100083 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000033128 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Hirst J Lui WW Bright NA Totty N Seaman MN Robinson MS May 2000 A family of proteins with gamma adaptin and VHS domains that facilitate trafficking between the trans Golgi network and the vacuole lysosome J Cell Biol 149 1 67 80 doi 10 1083 jcb 149 1 67 PMC 2175106 PMID 10747088 Dell Angelica EC Puertollano R Mullins C Aguilar RC Vargas JD Hartnell LM Bonifacino JS May 2000 GGAs a family of ADP ribosylation factor binding proteins related to adaptors and associated with the Golgi complex J Cell Biol 149 1 81 94 doi 10 1083 jcb 149 1 81 PMC 2175099 PMID 10747089 Xie L Boyle D Sanford D Scherer PE Pessin JE Mora S March 2006 Intracellular trafficking and secretion of adiponectin is dependent on GGA coated vesicles J Biol Chem 281 11 7253 9 doi 10 1074 jbc M511313200 hdl 2445 176753 PMID 16407204 Entrez Gene GGA1 golgi associated gamma adaptin ear containing ARF binding protein 1 Jacobsen Linda Madsen Peder Nielsen Morten S Geraerts Wijnand P M Gliemann Jorgen Smit August B Petersen Claus M January 2002 The sorLA cytoplasmic domain interacts with GGA1 and 2 and defines minimum requirements for GGA binding FEBS Lett 511 1 3 155 8 doi 10 1016 S0014 5793 01 03299 9 ISSN 0014 5793 PMID 11821067 S2CID 21977507 He Xiangyuan Chang Wan Pin Koelsch Gerald Tang Jordan July 2002 Memapsin 2 beta secretase cytosolic domain binds to the VHS domains of GGA1 and GGA2 implications on the endocytosis mechanism of memapsin 2 FEBS Lett 524 1 3 183 7 doi 10 1016 S0014 5793 02 03052 1 ISSN 0014 5793 PMID 12135764 Mattera Rafael Arighi Cecilia N Lodge Robert Zerial Marino Bonifacino Juan S January 2003 Divalent interaction of the GGAs with the Rabaptin 5 Rabex 5 complex EMBO J 22 1 78 88 doi 10 1093 emboj cdg015 ISSN 0261 4189 PMC 140067 PMID 12505986 Boman Annette L Salo Paul D Hauglund Melissa J Strand Nicole L Rensink Shelly J Zhdankina Olga September 2002 ADP ribosylation factor ARF interaction is not sufficient for yeast GGA protein function or localization Mol Biol Cell 13 9 3078 95 doi 10 1091 mbc E02 02 0078 ISSN 1059 1524 PMC 124144 PMID 12221117 Boman A L Zhang C j Zhu X Kahn R A April 2000 A family of ADP ribosylation factor effectors that can alter membrane transport through the trans Golgi Mol Biol Cell 11 4 1241 55 doi 10 1091 mbc 11 4 1241 ISSN 1059 1524 PMC 14844 PMID 10749927 Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Dunham I Shimizu N Roe BA et al 1999 The DNA sequence of human chromosome 22 Nature 402 6761 489 95 Bibcode 1999Natur 402 489D doi 10 1038 990031 PMID 10591208 Boman AL Zhang C Zhu X Kahn RA 2000 A family of ADP ribosylation factor effectors that can alter membrane transport through the trans Golgi Mol Biol Cell 11 4 1241 55 doi 10 1091 mbc 11 4 1241 PMC 14844 PMID 10749927 Takatsu H Yoshino K Nakayama K 2000 Adaptor gamma ear homology domain conserved in gamma adaptin and GGA proteins that interact with gamma synergin Biochem Biophys Res Commun 271 3 719 25 doi 10 1006 bbrc 2000 2700 PMID 10814529 Zhdankina O Strand NL Redmond JM Boman AL 2001 Yeast GGA proteins interact with GTP bound Arf and facilitate transport through the Golgi Yeast 18 1 1 18 doi 10 1002 1097 0061 200101 18 1 lt 1 AID YEA644 gt 3 0 CO 2 5 PMID 11124697 S2CID 10348751 Puertollano R Randazzo PA Presley JF et al 2001 The GGAs promote ARF dependent recruitment of clathrin to the TGN Cell 105 1 93 102 doi 10 1016 S0092 8674 01 00299 9 PMID 11301005 Puertollano R Aguilar RC Gorshkova I et al 2001 Sorting of mannose 6 phosphate receptors mediated by the GGAs Science 292 5522 1712 6 Bibcode 2001Sci 292 1712P doi 10 1126 science 1060750 PMID 11387475 S2CID 30836125 Takatsu H Katoh Y Shiba Y Nakayama K 2001 Golgi localizing gamma adaptin ear homology domain ADP ribosylation factor binding GGA proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p Hrs STAM VHS domains J Biol Chem 276 30 28541 5 doi 10 1074 jbc C100218200 PMID 11390366 Jacobsen L Madsen P Nielsen MS et al 2002 The sorLA cytoplasmic domain interacts with GGA1 and 2 and defines minimum requirements for GGA binding FEBS Lett 511 1 3 155 8 doi 10 1016 S0014 5793 01 03299 9 PMID 11821067 S2CID 21977507 Shiba T Takatsu H Nogi T et al 2002 Structural basis for recognition of acidic cluster dileucine sequence by GGA1 Nature 415 6874 937 41 Bibcode 2002Natur 415 937S doi 10 1038 415937a PMID 11859376 S2CID 4395774 Takatsu H Yoshino K Toda K Nakayama K 2002 GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP ribosylation factors Biochem J 365 Pt 2 369 78 doi 10 1042 BJ20020428 PMC 1222692 PMID 11950392 Doray B Bruns K Ghosh P Kornfeld SA 2002 Autoinhibition of the ligand binding site of GGA1 3 VHS domains by an internal acidic cluster dileucine motif Proc Natl Acad Sci U S A 99 12 8072 7 Bibcode 2002PNAS 99 8072D doi 10 1073 pnas 082235699 PMC 123022 PMID 12060753 He X Chang WP Koelsch G Tang J 2002 Memapsin 2 beta secretase cytosolic domain binds to the VHS domains of GGA1 and GGA2 implications on the endocytosis mechanism of memapsin 2 FEBS Lett 524 1 3 183 7 doi 10 1016 S0014 5793 02 03052 1 PMID 12135764 Boman AL Salo PD Hauglund MJ et al 2003 ADP ribosylation factor ARF interaction is not sufficient for yeast GGA protein function or localization Mol Biol Cell 13 9 3078 95 doi 10 1091 mbc E02 02 0078 PMC 124144 PMID 12221117 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Mattera R Arighi CN Lodge R et al 2003 Divalent interaction of the GGAs with the Rabaptin 5 Rabex 5 complex EMBO J 22 1 78 88 doi 10 1093 emboj cdg015 PMC 140067 PMID 12505986 Mills IG Praefcke GJ Vallis Y et al 2003 EpsinR an AP1 clathrin interacting protein involved in vesicle trafficking J Cell Biol 160 2 213 22 doi 10 1083 jcb 200208023 PMC 2172650 PMID 12538641 Retrieved from https en wikipedia org w index php title GGA1 amp oldid 1193610824, wikipedia, wiki, book, books, library,

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