GADD45GIP1, also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome. It is essential for the translation of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides in mammalian mitochondria. CRIF1 interacts with low-sulfur (LSU) proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperoneTid1. The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain-specific CRIF1-deficient mice, which exhibited profound OXPHOS failure and marked neurodegeneration.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000179271 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033751 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Horikoshi N, Cong J, Kley N, Shenk T (Aug 1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene". Biochemical and Biophysical Research Communications. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
^Görnemann J, Hofmann TG, Will H, Müller M (Nov 2002). "Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins". Virology. 303 (1): 69–78. doi:10.1006/viro.2002.1670. PMID 12482659.
^"Entrez Gene: GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1".
^Kim SJ, Kwon M, Ryu MJ, Chung HK, Tadi S, Kim YK, et al. (2012). "CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane". Cell Metabolism. 16 (2): 274–283. doi:10.1016/j.cmet.2012.06.012. ISSN 1550-4131. PMID 22819524.
^ abcChung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M (Jul 2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". The Journal of Biological Chemistry. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.
Further readingedit
Ahn BH, Kim TH, Bae YS (Oct 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Molecules and Cells. 12 (2): 158–63. doi:10.1016/S1016-8478(23)17077-4. PMID 11710515.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC442147. PMID 15231747.
Park KC, Song KH, Chung HK, Kim H, Kim DW, Song JH, Hwang ES, Jung HS, Park SH, Bae I, Lee IK, Choi HS, Shong M (Jan 2005). "CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation". Molecular Endocrinology. 19 (1): 12–24. doi:10.1210/me.2004-0107. PMID 15459248.
Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS (Jan 2007). "Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation". Gene. 386 (1–2): 147–53. doi:10.1016/j.gene.2006.08.023. PMID 17069992.
Nakayama K, Nakayama N, Wang TL, Shih Ie-M (Sep 2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Research. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.
gadd45gip1, growth, arrest, damage, inducible, proteins, interacting, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3j7y, 3j9midentifiersaliases, ckbbp2, ckbetabp2, crif1, plinp, plinp, prg6, plin. Growth arrest and DNA damage inducible proteins interacting protein 1 is a protein that in humans is encoded by the GADD45GIP1 gene 5 6 7 GADD45GIP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3J7Y 3J9MIdentifiersAliasesGADD45GIP1 CKBBP2 CKbetaBP2 CRIF1 MRP L59 PLINP PLINP 1 PRG6 Plinp1 GADD45G interacting protein 1External IDsOMIM 605162 MGI 1914947 HomoloGene 33474 GeneCards GADD45GIP1Gene location Human Chr Chromosome 19 human 1 Band19p13 13Start12 953 119 bp 1 End12 957 223 bp 1 Gene location Mouse Chr Chromosome 8 mouse 2 Band8 8 C3Start85 558 151 bp 2 End85 562 111 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inleft ventriclegastrocnemius muscletriceps brachii muscleright adrenal glandamygdalaprefrontal cortexleft adrenal glandputamenascending aortanucleus accumbensTop expressed inleft lobe of liverdigastric muscleextraocular muscleinterventricular septumright ventricletemporal musclemyocardium of ventriclesternocleidomastoid muscleadrenal glandtriceps brachii muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein bindingCellular componentmitochondrial matrix mitochondrial ribosome nucleus mitochondrion ribosomeBiological processcell cycle mitochondrial translational elongation mitochondrial translational termination viral processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez90480102060EnsemblENSG00000179271ENSMUSG00000033751UniProtQ8TAE8Q9CR59RefSeq mRNA NM 052850NM 183358RefSeq protein NP 443082NP 899202Location UCSC Chr 19 12 95 12 96 MbChr 8 85 56 85 56 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseGADD45GIP1 also known as CRIF1 is newly identified de novo components in large subunit of mitoribosome It is essential for the translation of mitochondrial oxidative phosphorylation OXPHOS polypeptides in mammalian mitochondria CRIF1 interacts with low sulfur LSU proteins some of which surround the exit tunnel of the mitoribosome and also interacts with nascent OXPHOS polypeptides and the mitochondrial specific chaperone Tid1 The essential role of CRIF1 in mitochondrial synthesis and membrane integration of OXPHOS polypeptides was shown in brain specific CRIF1 deficient mice which exhibited profound OXPHOS failure and marked neurodegeneration 8 Interactions editGADD45GIP1 has been shown to interact with GADD45G 9 GADD45B 9 and GADD45A 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000179271 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000033751 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Horikoshi N Cong J Kley N Shenk T Aug 1999 Isolation of differentially expressed cDNAs from p53 dependent apoptotic cells activation of the human homologue of the Drosophila peroxidasin gene Biochemical and Biophysical Research Communications 261 3 864 9 doi 10 1006 bbrc 1999 1123 PMID 10441517 Gornemann J Hofmann TG Will H Muller M Nov 2002 Interaction of human papillomavirus type 16 L2 with cellular proteins identification of novel nuclear body associated proteins Virology 303 1 69 78 doi 10 1006 viro 2002 1670 PMID 12482659 Entrez Gene GADD45GIP1 growth arrest and DNA damage inducible gamma interacting protein 1 Kim SJ Kwon M Ryu MJ Chung HK Tadi S Kim YK et al 2012 CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane Cell Metabolism 16 2 274 283 doi 10 1016 j cmet 2012 06 012 ISSN 1550 4131 PMID 22819524 a b c Chung HK Yi YW Jung NC Kim D Suh JM Kim H Park KC Song JH Kim DW Hwang ES Yoon SH Bae YS Kim JM Bae I Shong M Jul 2003 CR6 interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle The Journal of Biological Chemistry 278 30 28079 88 doi 10 1074 jbc M212835200 PMID 12716909 Further reading editAhn BH Kim TH Bae YS Oct 2001 Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins Molecules and Cells 12 2 158 63 doi 10 1016 S1016 8478 23 17077 4 PMID 11710515 Lehner B Sanderson CM Jul 2004 A protein interaction framework for human mRNA degradation Genome Research 14 7 1315 23 doi 10 1101 gr 2122004 PMC 442147 PMID 15231747 Park KC Song KH Chung HK Kim H Kim DW Song JH Hwang ES Jung HS Park SH Bae I Lee IK Choi HS Shong M Jan 2005 CR6 interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation Molecular Endocrinology 19 1 12 24 doi 10 1210 me 2004 0107 PMID 15459248 Oh NS Yoon SH Lee WK Choi JY Min do S Bae YS Jan 2007 Phosphorylation of CKBBP2 CRIF1 by protein kinase CKII promotes cell proliferation Gene 386 1 2 147 53 doi 10 1016 j gene 2006 08 023 PMID 17069992 Nakayama K Nakayama N Wang TL Shih Ie M Sep 2007 NAC 1 controls cell growth and survival by repressing transcription of Gadd45GIP1 a candidate tumor suppressor Cancer Research 67 17 8058 64 doi 10 1158 0008 5472 CAN 07 1357 PMID 17804717 nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GADD45GIP1 amp oldid 1197840641, wikipedia, wiki, book, books, library,
