Overexpression of the GADD45 gene in the Drosophila melanogasternervous system significantly increases longevity.[4] This longevity increase can be attributed to more efficient recognition and repair of spontaneous DNA damages generated by physiological processes and environmental factors.
Gadd45b (MyD118) was discovered and characterized in the laboratories of Drs. Dan A. Liebermann and Barbara Hoffman in 1991.[6]
Gadd45g (CR6) was discovered and characterized in the laboratories of Drs. Kenneth Smith, Dan A. Liebermann, and Barbara Hoffman in 1993 and 1999.[7][8]
^Fornace, A.J.; Jackman, J.; Hollander, M.C.; Hoffman-Liebermann, B.; Liebermann, D.A. (1992). "Genotoxic-stress-response genes and growth-arrest genes: gadd, MyD, and other genes induced by treatments eliciting growth arrest". Annals of the New York Academy of Sciences. 663: 139–53. doi:10.1111/j.1749-6632.1992.tb38657.x. PMID 1482047. S2CID 37885339.
^Liebermann, D.A.; Hoffman, B. (2002). "Myeloid differentiation (MyD)/growth arrest DNA damage (GADD) genes in tumor suppression, immunity and inflammation". Leukemia. 16 (4): 527–41. doi:10.1038/sj.leu.2402477. PMID 11960329.
^Schüle KM, Leichsenring M, Andreani T, Vastolo V, Mallick M, Musheev MU, Karaulanov E, Niehrs C. GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells. Genes Dev. 2019 Jul 1;33(13-14):782-798. doi: 10.1101/gad.325696.119. Epub 2019 Jun 6. PMID 31171699
^Plyusnina EN, Shaposhnikov MV, Moskalev AA. Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system. Biogerontology. 2011 Jun;12(3):211-26. doi: 10.1007/s10522-010-9311-6. Epub 2010 Dec 9. PMID 21153055
^Fornace, A.J.; Alamo, I.; Hollander, M.C. (1988). "DNA damage-inducible transcripts in mammalian cells". Proceedings of the National Academy of Sciences. 85 (23): 8800–4. Bibcode:1988PNAS...85.8800F. doi:10.1073/pnas.85.23.8800. PMC282594. PMID 3194391.
^Abdollahi, A.; Lord, K.A.; Hoffman-Liebermann, B.; Liebermann, D.A. (1991). "Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines". Oncogene. 6 (1): 165–7. PMID 1899477.
^Zhang, W.; Bae, I.; Krishnaraju, K.; Azam, Naiyer; et al. (1999). "CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control". Oncogene. 18 (35): 4899–907. doi:10.1038/sj.onc.1202885. PMID 10490824.
^Beadling, C.; Johnson, K.W.; Smith, K.A. (1993). "Isolation of interleukin 2-induced immediate-early genes". Proceedings of the National Academy of Sciences. 90 (7): 2719–23. Bibcode:1993PNAS...90.2719B. doi:10.1073/pnas.90.7.2719. PMC46167. PMID 7681987.
gadd45, growth, arrest, damage, gadd45, genes, including, gadd45a, originally, termed, gadd45, gadd45b, originally, termed, myd118, gadd45g, originally, termed, implicated, stress, sensors, that, modulate, response, mammalian, cells, genotoxic, physiological, . The Growth Arrest and DNA Damage or gadd45 genes including GADD45A originally termed gadd45 GADD45B originally termed MyD118 and GADD45G originally termed CR6 are implicated as stress sensors that modulate the response of mammalian cells to genotoxic physiological stress and modulate tumor formation Gadd45 proteins interact with other proteins implicated in stress responses including PCNA p21 Cdc2 CyclinB1 MEKK4 and p38 kinase 1 2 GADD45 proteins regulate differentiation at the two cell stage of embryogenesis a key stage of zygotic genome activation 3 GADD45 likely acts by promoting TET mediated DNA demethylation leading to the induction of expression of genes necessary for zygote activation Overexpression of the GADD45 gene in the Drosophila melanogaster nervous system significantly increases longevity 4 This longevity increase can be attributed to more efficient recognition and repair of spontaneous DNA damages generated by physiological processes and environmental factors Contents 1 History 2 See also 3 References 4 External linksHistory editGadd45a was discovered and characterized in the laboratory of Dr Albert J Fornace Jr in 1988 5 Gadd45b MyD118 was discovered and characterized in the laboratories of Drs Dan A Liebermann and Barbara Hoffman in 1991 6 Gadd45g CR6 was discovered and characterized in the laboratories of Drs Kenneth Smith Dan A Liebermann and Barbara Hoffman in 1993 and 1999 7 8 See also editGADD45A GADD45B GADD45GReferences edit Fornace A J Jackman J Hollander M C Hoffman Liebermann B Liebermann D A 1992 Genotoxic stress response genes and growth arrest genes gadd MyD and other genes induced by treatments eliciting growth arrest Annals of the New York Academy of Sciences 663 139 53 doi 10 1111 j 1749 6632 1992 tb38657 x PMID 1482047 S2CID 37885339 Liebermann D A Hoffman B 2002 Myeloid differentiation MyD growth arrest DNA damage GADD genes in tumor suppression immunity and inflammation Leukemia 16 4 527 41 doi 10 1038 sj leu 2402477 PMID 11960329 Schule KM Leichsenring M Andreani T Vastolo V Mallick M Musheev MU Karaulanov E Niehrs C GADD45 promotes locus specific DNA demethylation and 2C cycling in embryonic stem cells Genes Dev 2019 Jul 1 33 13 14 782 798 doi 10 1101 gad 325696 119 Epub 2019 Jun 6 PMID 31171699 Plyusnina EN Shaposhnikov MV Moskalev AA Increase of Drosophila melanogaster lifespan due to D GADD45 overexpression in the nervous system Biogerontology 2011 Jun 12 3 211 26 doi 10 1007 s10522 010 9311 6 Epub 2010 Dec 9 PMID 21153055 Fornace A J Alamo I Hollander M C 1988 DNA damage inducible transcripts in mammalian cells Proceedings of the National Academy of Sciences 85 23 8800 4 Bibcode 1988PNAS 85 8800F doi 10 1073 pnas 85 23 8800 PMC 282594 PMID 3194391 Abdollahi A Lord K A Hoffman Liebermann B Liebermann D A 1991 Sequence and expression of a cDNA encoding MyD118 a novel myeloid differentiation primary response gene induced by multiple cytokines Oncogene 6 1 165 7 PMID 1899477 Zhang W Bae I Krishnaraju K Azam Naiyer et al 1999 CR6 A third member in the MyD118 and Gadd45 gene family which functions in negative growth control Oncogene 18 35 4899 907 doi 10 1038 sj onc 1202885 PMID 10490824 Beadling C Johnson K W Smith K A 1993 Isolation of interleukin 2 induced immediate early genes Proceedings of the National Academy of Sciences 90 7 2719 23 Bibcode 1993PNAS 90 2719B doi 10 1073 pnas 90 7 2719 PMC 46167 PMID 7681987 External links editGADD45 protein at the U S National Library of Medicine Medical Subject Headings MeSH nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Gadd45 amp oldid 1170971548, wikipedia, wiki, book, books, library,
