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Wikipedia

GABRR2

January 01, 1970

Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.[5][6]

GABRR2
Identifiers
AliasesGABRR2, gamma-aminobutyric acid type A receptor rho2 subunit, gamma-aminobutyric acid type A receptor subunit rho2
External IDsOMIM: 137162 MGI: 95626 HomoloGene: 20471 GeneCards: GABRR2
Orthologs
SpeciesHumanMouse
Entrez

2570

14409

Ensembl

ENSG00000111886

ENSMUSG00000023267

UniProt

P28476

P56476

RefSeq (mRNA)

NM_002043

NM_008076

RefSeq (protein)

NP_002034

NP_032102

Location (UCSC)Chr 6: 89.25 – 89.32 MbChr 4: 33.06 – 33.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family.[6]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111886 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023267 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics. 12 (4): 801–806. doi:10.1016/0888-7543(92)90312-G. PMID 1315307.
  6. ^ a b "Entrez Gene: GABRR2 gamma-aminobutyric acid (GABA) receptor, rho 2".

Further reading edit

  • Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction". J. Biol. Chem. 272 (21): 13750–13757. doi:10.1074/jbc.272.21.13750. PMID 9153229.
  • Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716. S2CID 12933301.
  • Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
  • Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–8650. doi:10.1523/jneurosci.20-23-08643.2000. PMC 6773065. PMID 11102469.
  • Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–246. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859. S2CID 54402119.
  • Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. doi:10.1074/jbc.M205162200. PMID 12431995.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gamel-Didelon K, Kunz L, Fohr KJ, et al. (2003). "Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells". J. Biol. Chem. 278 (22): 20192–20195. doi:10.1074/jbc.M301729200. PMID 12660236.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 

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January 01, 1970
gabrr2, gamma, aminobutyric, acid, receptor, subunit, protein, that, humans, encoded, gene, identifiersaliases, gamma, aminobutyric, acid, type, receptor, rho2, subunit, gamma, aminobutyric, acid, type, receptor, subunit, rho2external, idsomim, 137162, 95626, . Gamma aminobutyric acid receptor subunit rho 2 is a protein that in humans is encoded by the GABRR2 gene 5 6 GABRR2IdentifiersAliasesGABRR2 gamma aminobutyric acid type A receptor rho2 subunit gamma aminobutyric acid type A receptor subunit rho2External IDsOMIM 137162 MGI 95626 HomoloGene 20471 GeneCards GABRR2Gene location Human Chr Chromosome 6 human 1 Band6q15Start89 254 464 bp 1 End89 315 299 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 A5 4 14 64 cMStart33 062 999 bp 2 End33 095 865 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed invena cavaskeletal muscle tissuedeltoid musclespermtibialis anterior musclespleensmooth muscle tissuebloodgastrocnemius musclelymph nodeTop expressed inbloodsuperior colliculuscerebellar cortexsuperior frontal gyrusskeletal muscle tissuesubmandibular glandquadriceps femoris musclemeningesesophagusthymusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionchloride channel activity extracellular ligand gated ion channel activity GABA A receptor activity ion channel activity transmembrane signaling receptor activity protein domain specific binding transmitter gated ion channel activity involved in regulation of postsynaptic membrane potentialCellular componentintegral component of membrane GABA A receptor complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction neuron projection GABA ergic synapseBiological processgamma aminobutyric acid signaling pathway chloride transmembrane transport ion transport chloride transport signal transduction visual perception chemical synaptic transmission ion transmembrane transport regulation of membrane potential nervous system process regulation of postsynaptic membrane potentialSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez257014409EnsemblENSG00000111886ENSMUSG00000023267UniProtP28476P56476RefSeq mRNA NM 002043NM 008076RefSeq protein NP 002034NP 032102Location UCSC Chr 6 89 25 89 32 MbChr 4 33 06 33 1 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors which are ligand gated chloride channels GABRR2 is a member of the rho subunit family 6 Contents 1 See also 2 References 3 Further reading 4 External linksSee also editGABAA r receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000111886 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000023267 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cutting GR Curristin S Zoghbi H O Hara B Seldin MF Uhl GR May 1992 Identification of a putative gamma aminobutyric acid GABA receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 GABRR2 and rho1 GABRR1 to human chromosome 6q14 q21 and mouse chromosome 4 Genomics 12 4 801 806 doi 10 1016 0888 7543 92 90312 G PMID 1315307 a b Entrez Gene GABRR2 gamma aminobutyric acid GABA receptor rho 2 Further reading editHackam AS Wang TL Guggino WB Cutting GR 1997 The N terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction J Biol Chem 272 21 13750 13757 doi 10 1074 jbc 272 21 13750 PMID 9153229 Kusama T Hatama K Sakurai M et al 1999 Consensus phosphorylation sites of human GABA c GABArho receptors are not critical for inhibition by protein kinase C activation Neurosci Lett 255 1 17 20 doi 10 1016 S0304 3940 98 00696 X PMID 9839716 S2CID 12933301 Bailey ME Albrecht BE Johnson KJ Darlison MG 1999 Genetic linkage and radiation hybrid mapping of the three human GABA C receptor rho subunit genes GABRR1 GABRR2 and GABRR3 Biochim Biophys Acta 1447 2 3 307 312 doi 10 1016 S0167 4781 99 00167 0 PMID 10542332 Billups D Hanley JG Orme M et al 2001 GABAC receptor sensitivity is modulated by interaction with MAP1B J Neurosci 20 23 8643 8650 doi 10 1523 jneurosci 20 23 08643 2000 PMC 6773065 PMID 11102469 Sedelnikova A Weiss DS 2002 Phosphorylation of the recombinant rho1 GABA receptor Int J Dev Neurosci 20 3 5 237 246 doi 10 1016 S0736 5748 02 00037 0 PMID 12175859 S2CID 54402119 Croci C Brandstatter JH Enz R 2003 ZIP3 a new splice variant of the PKC zeta interacting protein family binds to GABAC receptors PKC zeta and Kv beta 2 J Biol Chem 278 8 6128 6135 doi 10 1074 jbc M205162200 PMID 12431995 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 16903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gamel Didelon K Kunz L Fohr KJ et al 2003 Molecular and physiological evidence for functional gamma aminobutyric acid GABA C receptors in growth hormone secreting cells J Biol Chem 278 22 20192 20195 doi 10 1074 jbc M301729200 PMID 12660236 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 811 Bibcode 2003Natur 425 805M doi 10 1038 nature02055 PMID 14574404 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 2127 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 External links editGABRR2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GABRR2 amp oldid 1116929815, wikipedia, wiki, book, books, library,

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