Subtype-selective GAT3 inhibitors are known since 2015.[2]
The transporter and its effect on GABA concentrations in the amygdala has been implicated as a key player in the disease of alcoholism. In studies conducted on rat populations, reduction of GAT3 caused rats who formerly preferred sugar to prefer alcohol. Further, studies of deceased alcoholics show a decreased concentration of GAT3 in their brains.[3]
^Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ (2013). Principles of Neural Science (Fifth ed.). McGraw-Hill Companies. p. 296. ISBN978-0-07-139011-8.
^Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP (2015). "Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3". ACS Chem Neurosci. 6 (9): 1591–9. doi:10.1021/acschemneuro.5b00150. PMID 26154082.
^"A Landmark Study on the Origins of Alcoholism". 21 June 2018.
This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
gaba, transporter, type, gat3, uses, sodium, electrochemical, gradients, mediate, uptake, gaba, from, synaptic, cleft, surrounding, glial, cells, subtype, selective, gat3, inhibitors, known, since, 2015, transporter, effect, gaba, concentrations, amygdala, bee. GABA transporter type 3 GAT3 uses sodium Na electrochemical gradients to mediate uptake of GABA from the synaptic cleft by surrounding glial cells 1 Subtype selective GAT3 inhibitors are known since 2015 2 The transporter and its effect on GABA concentrations in the amygdala has been implicated as a key player in the disease of alcoholism In studies conducted on rat populations reduction of GAT3 caused rats who formerly preferred sugar to prefer alcohol Further studies of deceased alcoholics show a decreased concentration of GAT3 in their brains 3 See also editGABA transporter 1 GABA transporter 2 Solute carrier familyReferences edit Kandel ER Schwartz JH Jessell TM Siegelbaum SA Hudspeth AJ 2013 Principles of Neural Science Fifth ed McGraw Hill Companies p 296 ISBN 978 0 07 139011 8 Damgaard M Al Khawaja A Vogensen SB Jurik A Sijm M Lie ME Baek MI Rosenthal E Jensen AA Ecker GF Frolund B Wellendorph P Clausen RP 2015 Identification of the First Highly Subtype Selective Inhibitor of Human GABA Transporter GAT3 ACS Chem Neurosci 6 9 1591 9 doi 10 1021 acschemneuro 5b00150 PMID 26154082 A Landmark Study on the Origins of Alcoholism 21 June 2018 nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GABA transporter type 3 amp oldid 1045779274, wikipedia, wiki, book, books, library,
