^ abcBagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA (August 2014). "Recent progress in sodium channel modulators for pain". Bioorganic & Medicinal Chemistry Letters. 24 (16): 3690–3699. doi:10.1016/j.bmcl.2014.06.038. PMID 25060923.
^ abAli Z, Palmer JE, Goli V (2013). "Anticonvulsants: Clinical". In McMahon S, Koltzenburg M, Tracey I, Turk DC (eds.). Wall & Melzack's Textbook of Pain (6 ed.). Elsevier Health Sciences. p. 508. ISBN978-0-7020-4059-7. OCLC 1008841684.
^ ab. Xenon Pharma. Archived from the original on 15 July 2013.
^ ab. Xenon Pharma. 11 December 2012. Archived from the original on 26 July 2014. Retrieved 2014-07-20.
funapide, former, developmental, code, names, 45070, xen402, novel, analgesic, under, development, xenon, pharmaceuticals, formerly, partnership, with, teva, pharmaceutical, industries, treatment, variety, chronic, pain, conditions, including, osteoarthritis, . Funapide INN former developmental code names TV 45070 and XEN402 is a novel analgesic under development by Xenon Pharmaceuticals formerly in partnership with Teva Pharmaceutical Industries for the treatment of a variety of chronic pain conditions including osteoarthritis neuropathic pain postherpetic neuralgia and erythromelalgia as well as dental pain 1 2 3 4 It acts as a small molecule Nav1 7 and Nav1 8 voltage gated sodium channel blocker 1 2 4 Funapide is being evaluated in humans in both oral and topical formulations and as of July 2014 has reached phase IIb clinical trials 1 3 FunapideClinical dataRoutes ofadministrationBy mouth topicalATC codeNoneIdentifiersIUPAC name 7S 1 5 trifluoromethyl furan 2 yl methyl spiro 6H furo 2 3 f 1 3 benzodioxole 7 3 indole 2 oneCAS Number1259933 16 8 YPubChem CID49836093ChemSpider34500834UNIIA5595LHJ2LKEGGD11156Chemical and physical dataFormulaC 22H 14F 3N O 5Molar mass429 351 g mol 13D model JSmol Interactive imageSMILES C1C2 C3 CC CC C3N C2 O CC4 CC C O4 C F F F C5 CC6 C C C5O1 OCO6InChI InChI 1S C22H14F3NO5 c23 22 24 25 19 6 5 12 31 19 9 26 15 4 2 1 3 13 15 21 20 26 27 10 28 16 8 18 17 7 14 16 21 29 11 30 18 h1 8H 9 11H2 t21 m0 s1Key NEBUOXBYNAHKFV NRFANRHFSA NSee also editList of investigational analgesicsReferences edit a b c Bagal SK Chapman ML Marron BE Prime R Storer RI Swain NA August 2014 Recent progress in sodium channel modulators for pain Bioorganic amp Medicinal Chemistry Letters 24 16 3690 3699 doi 10 1016 j bmcl 2014 06 038 PMID 25060923 a b Ali Z Palmer JE Goli V 2013 Anticonvulsants Clinical In McMahon S Koltzenburg M Tracey I Turk DC eds Wall amp Melzack s Textbook of Pain 6 ed Elsevier Health Sciences p 508 ISBN 978 0 7020 4059 7 OCLC 1008841684 a b TV 45070 A Small Molecule for the Treatment of the Orphan Disease EM and Other Pain Disorders Xenon Pharma Archived from the original on 15 July 2013 a b Teva and Xenon Announce Teva s World Wide License of Xenon s Pain Drug XEN402 Xenon Pharma 11 December 2012 Archived from the original on 26 July 2014 Retrieved 2014 07 20 External links edit Funapide Flexion Therapeutics AdisInsight Springer Nature Switzerland AG nbsp This analgesic related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Funapide amp oldid 1204970240, wikipedia, wiki, book, books, library,
