Fet3p is a multicopper oxidase (MCO)2 found in Saccharomyces cerevisiae with a structure consisting of three cupredoxin-like β-barrel domains and four copper ions located in three distinct metal sites (T1 in domain 3, T2, and the binuclear T3 at the interface between domains 1 and 3).[1][2] Fet3p is a type I membrane protein with an orientation that places the amino-terminal oxidase domain in the exocellular space (Nexo) and the carboxyl terminus in the cytoplasm (Ccyt).
Part of the ferroxidase reaction, Fet3p catalyzes the oxidation of Fe(II) to Fe(III) using O2 as substrate. The Fe(III) generated by Fet3p is a ligand for the iron permease, Ftr1p.
Referencesedit
^Sedlak, E.; Ziegler, L.; Kosman, D. J.; Wittung-Stafshede, P. (25 November 2008). "In vitro unfolding of yeast multicopper oxidase Fet3p variants reveals unique role of each metal site". Proceedings of the National Academy of Sciences. 105 (49): 19258–19263. Bibcode:2008PNAS..10519258S. doi:10.1073/pnas.0806431105. PMC2614749. PMID 19033465.
^Singh, A. (1 March 2006). "Assembly, Activation, and Trafficking of the Fet3p·Ftr1p High Affinity Iron Permease Complex in Saccharomyces cerevisiae". Journal of Biological Chemistry. 281 (19): 13355–13364. doi:10.1074/jbc.M512042200. PMID 16522632.
fet3p, multicopper, oxidase, found, saccharomyces, cerevisiae, with, structure, consisting, three, cupredoxin, like, barrel, domains, four, copper, ions, located, three, distinct, metal, sites, domain, binuclear, interface, between, domains, type, membrane, pr. Fet3p is a multicopper oxidase MCO 2 found in Saccharomyces cerevisiae with a structure consisting of three cupredoxin like b barrel domains and four copper ions located in three distinct metal sites T1 in domain 3 T2 and the binuclear T3 at the interface between domains 1 and 3 1 2 Fet3p is a type I membrane protein with an orientation that places the amino terminal oxidase domain in the exocellular space Nexo and the carboxyl terminus in the cytoplasm Ccyt Part of the ferroxidase reaction Fet3p catalyzes the oxidation of Fe II to Fe III using O2 as substrate The Fe III generated by Fet3p is a ligand for the iron permease Ftr1p References edit Sedlak E Ziegler L Kosman D J Wittung Stafshede P 25 November 2008 In vitro unfolding of yeast multicopper oxidase Fet3p variants reveals unique role of each metal site Proceedings of the National Academy of Sciences 105 49 19258 19263 Bibcode 2008PNAS 10519258S doi 10 1073 pnas 0806431105 PMC 2614749 PMID 19033465 Singh A 1 March 2006 Assembly Activation and Trafficking of the Fet3p Ftr1p High Affinity Iron Permease Complex in Saccharomyces cerevisiae Journal of Biological Chemistry 281 19 13355 13364 doi 10 1074 jbc M512042200 PMID 16522632 Portal nbsp Biology Retrieved from https en wikipedia org w index php title Fet3p amp oldid 1041216511, wikipedia, wiki, book, books, library,
