fbpx
Wikipedia

Fel d 1

December 15, 2023

Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes.[2][3]

Allergen Fel d 1, chain 1 (P30438)
Identifiers
SymbolAllergen_Fel_d_I_chain1
InterProIPR006178
Allergen Fel d 1, chain 2 (P30440)
Crystallographic structure of the Fel d 1 dimer, the primary allergen present in cat saliva [1]
Identifiers
SymbolFeld-I_B
PfamPF09252
Pfam clanCL0370
InterProIPR015332
SCOP21puo / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens.[1] [4] The function of the protein for cats is unknown, but it causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response).

Variation in cats edit

Kittens produce less Fel d 1 than adult cats. Female cats produce a lower level of Fel d 1 than (unneutered) males,[5] while neutered males produce levels similar to those of females. Both intact and spayed females produce similar levels. Although females and neutered males produce Fel d 1 in lower levels, they still produce enough to cause allergic symptoms in sensitive individuals.

Researchers have been investigating reports from cat owners that certain breeds of cats either do not produce Fel d 1 or are thought to do so at significantly lower levels than other breeds. For instance, individual cats from the naturally occurring Siberian breed, native to the Siberian region for which the breed is named, have been shown to have genetic variants that result in a lower production of Fel d 1.[6] Another breed thought to have a possible genetic disposition not to produce this allergen or to produce less of it is the Balinese, an offshoot of the Siamese breed.[7] Several other breeds are widely referenced as causing a diminished immune reaction in cat allergy sufferers, including Sphynx, Russian Blue, Cornish Rex, Devon Rex, Siamese, Javanese, Oriental shorthair, Burmese, and Laperm.

Fairly reliable tests for their Fel d 1 protein production is available for individual cats, but research regarding entire breeds continues, hampered by the lack of a thoroughly accessible and accurate genetic test for production of the antigen.

Structure edit

The complete quaternary structure of Fel d 1 has been determined.[1] The allergen is a tetrameric glycoprotein consisting of two disulfide-linked heterodimers of chains 1 and 2. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides. Both chains share an all alpha-helical structure.[1]

Presence in other species edit

Proteins matching the InterPro family signature for Fel d 1 parts is widespread among Theria, a subclass of mammals[8] amongst the Theriiformes (the sister taxon to Yinotheria.) Theria includes the eutherians that includes the placental mammals and the metatherians that includes the marsupials. More specifically, the InterPro profiles link the two components of Fel d 1 to the rodent androgen-binding protein (ABP; not to be confused with the human SHBG), a salivary pheromone.[9][10]

A homolog of Fel d 1 protein is also present in the venom of the slow loris (Primate: Nycticebus). Slow lorises are one of only a few venomous mammals and the only known venomous primate. They possess a dual-composite venom of saliva and brachial gland exudate (BGE).[11] The BGE possesses a protein resembling Fel d 1, which may affect host species as an allergen as a constituent of the venom. It possess a communicative function.

See also edit

References edit

  1. ^ a b c d PDB: 1PUO​; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G (September 2003). "The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family". The Journal of Biological Chemistry. 278 (39): 37730–5. doi:10.1074/jbc.M304740200. PMID 12851385.
  2. ^ Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC (November 1991). "Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9690–4. Bibcode:1991PNAS...88.9690M. doi:10.1073/pnas.88.21.9690. PMC 52784. PMID 1946388.
  3. ^ Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL (April 1992). "Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat". Gene. 113 (2): 263–8. doi:10.1016/0378-1119(92)90405-E. PMID 1572548.
  4. ^ Dabrowski AJ, Van der Brempt X, Soler M, Seguret N, Lucciani P, Charpin D, Vervloet D (October 1990). "Cat skin as an important source of Fel d I allergen". The Journal of Allergy and Clinical Immunology. 86 (4 Pt 1): 462–5. doi:10.1016/S0091-6749(05)80200-3. PMID 2229808.
  5. ^ Jalil-Colome J, de Andrade AD, Birnbaum J, Casanova D, Mège JL, Lanteaume A, Charpin D, Vervloet D (July 1996). "Sex difference in Fel d 1 allergen production". The Journal of Allergy and Clinical Immunology. 98 (1): 165–8. doi:10.1016/s0091-6749(96)70238-5. PMID 8765830.
  6. ^ Sartore S, Landoni E, Maione S, Tarducci A, Borrelli A, Soglia D, et al. (December 2017). "Polymorphism Analysis of Ch1 and Ch2 Genes in the Siberian Cat". Veterinary Sciences. 4 (4): 63. doi:10.3390/vetsci4040063. PMC 5753643. PMID 29194349.
  7. ^ "Allergy to Cats - Cat DNA Test Kit | Basepaws". Allergy to Cats - Cat DNA Test Kit | Basepaws. Retrieved 2018-08-07.
  8. ^ Myers, P.; R. Espinosa; C. S. Parr; T. Jones; G. S. Hammond & T. A. Dewey. "Subclass Theria". Animal Diversity Web.
  9. ^ InterPro taxonomy view, IPR006178 and IPR015332
  10. ^ Durairaj R, Pageat P, Bienboire-Frosini C (2018). "Another cat and mouse game: Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches". PLOS ONE. 13 (5): e0197618. Bibcode:2018PLoSO..1397618D. doi:10.1371/journal.pone.0197618. PMC 5957422. PMID 29771985.
  11. ^ Nekaris KA, Moore RS, Rode EJ, Fry BG (September 2013). "Mad, bad and dangerous to know: the biochemistry, ecology and evolution of slow loris venom". The Journal of Venomous Animals and Toxins Including Tropical Diseases. 19 (1): 21. doi:10.1186/1678-9199-19-21. PMC 3852360. PMID 24074353.

Further reading edit

  • Bonnet B, Messaoudi K, Jacomet F, Michaud E, Fauquert JL, Caillaud D, Evrard B (2018). "An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen". Allergy, Asthma, and Clinical Immunology. 14: 14. doi:10.1186/s13223-018-0239-8. PMC 5891966. PMID 29643919.
This article incorporates text from the public domain Pfam and InterPro: IPR015332

December 15, 2023
secretoglobin, protein, complex, that, cats, encoded, chain, chain, genes, allergen, chain, p30438, identifierssymbolallergen, chain1interproipr006178allergen, chain, p30440, crystallographic, structure, dimer, primary, allergen, present, saliva, identifierssy. Fel d 1 is a secretoglobin protein complex that in cats is encoded by the CH1 chain 1 Fel d 1 A and CH2 chain 2 Fel d 1 B genes 2 3 Allergen Fel d 1 chain 1 P30438 IdentifiersSymbolAllergen Fel d I chain1InterProIPR006178Allergen Fel d 1 chain 2 P30440 Crystallographic structure of the Fel d 1 dimer the primary allergen present in cat saliva 1 IdentifiersSymbolFeld I BPfamPF09252Pfam clanCL0370InterProIPR015332SCOP21puo SCOPe SUPFAMAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryAmong cats Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin It is the primary allergen present on cats and kittens 1 4 The function of the protein for cats is unknown but it causes an IgG or IgE reaction in sensitive humans either as an allergic or asthmatic response Contents 1 Variation in cats 2 Structure 3 Presence in other species 4 See also 5 References 6 Further readingVariation in cats editKittens produce less Fel d 1 than adult cats Female cats produce a lower level of Fel d 1 than unneutered males 5 while neutered males produce levels similar to those of females Both intact and spayed females produce similar levels Although females and neutered males produce Fel d 1 in lower levels they still produce enough to cause allergic symptoms in sensitive individuals Researchers have been investigating reports from cat owners that certain breeds of cats either do not produce Fel d 1 or are thought to do so at significantly lower levels than other breeds For instance individual cats from the naturally occurring Siberian breed native to the Siberian region for which the breed is named have been shown to have genetic variants that result in a lower production of Fel d 1 6 Another breed thought to have a possible genetic disposition not to produce this allergen or to produce less of it is the Balinese an offshoot of the Siamese breed 7 Several other breeds are widely referenced as causing a diminished immune reaction in cat allergy sufferers including Sphynx Russian Blue Cornish Rex Devon Rex Siamese Javanese Oriental shorthair Burmese and Laperm Fairly reliable tests for their Fel d 1 protein production is available for individual cats but research regarding entire breeds continues hampered by the lack of a thoroughly accessible and accurate genetic test for production of the antigen Structure editThe complete quaternary structure of Fel d 1 has been determined 1 The allergen is a tetrameric glycoprotein consisting of two disulfide linked heterodimers of chains 1 and 2 Fel d 1 chains 1 and 2 share structural similarity with uteroglobin a secretoglobin superfamily member chain 2 is a glycoprotein with N linked oligosaccharides Both chains share an all alpha helical structure 1 Presence in other species editProteins matching the InterPro family signature for Fel d 1 parts is widespread among Theria a subclass of mammals 8 amongst the Theriiformes the sister taxon to Yinotheria Theria includes the eutherians that includes the placental mammals and the metatherians that includes the marsupials More specifically the InterPro profiles link the two components of Fel d 1 to the rodent androgen binding protein ABP not to be confused with the human SHBG a salivary pheromone 9 10 A homolog of Fel d 1 protein is also present in the venom of the slow loris Primate Nycticebus Slow lorises are one of only a few venomous mammals and the only known venomous primate They possess a dual composite venom of saliva and brachial gland exudate BGE 11 The BGE possesses a protein resembling Fel d 1 which may affect host species as an allergen as a constituent of the venom It possess a communicative function See also editAllergy to cats Fel d 4 Slow lorisReferences edit a b c d PDB 1PUO Kaiser L Gronlund H Sandalova T Ljunggren HG van Hage Hamsten M Achour A Schneider G September 2003 The crystal structure of the major cat allergen Fel d 1 a member of the secretoglobin family The Journal of Biological Chemistry 278 39 37730 5 doi 10 1074 jbc M304740200 PMID 12851385 Morgenstern JP Griffith IJ Brauer AW Rogers BL Bond JF Chapman MD Kuo MC November 1991 Amino acid sequence of Fel dI the major allergen of the domestic cat protein sequence analysis and cDNA cloning Proceedings of the National Academy of Sciences of the United States of America 88 21 9690 4 Bibcode 1991PNAS 88 9690M doi 10 1073 pnas 88 21 9690 PMC 52784 PMID 1946388 Griffith IJ Craig S Pollock J Yu XB Morgenstern JP Rogers BL April 1992 Expression and genomic structure of the genes encoding FdI the major allergen from the domestic cat Gene 113 2 263 8 doi 10 1016 0378 1119 92 90405 E PMID 1572548 Dabrowski AJ Van der Brempt X Soler M Seguret N Lucciani P Charpin D Vervloet D October 1990 Cat skin as an important source of Fel d I allergen The Journal of Allergy and Clinical Immunology 86 4 Pt 1 462 5 doi 10 1016 S0091 6749 05 80200 3 PMID 2229808 Jalil Colome J de Andrade AD Birnbaum J Casanova D Mege JL Lanteaume A Charpin D Vervloet D July 1996 Sex difference in Fel d 1 allergen production The Journal of Allergy and Clinical Immunology 98 1 165 8 doi 10 1016 s0091 6749 96 70238 5 PMID 8765830 Sartore S Landoni E Maione S Tarducci A Borrelli A Soglia D et al December 2017 Polymorphism Analysis of Ch1 and Ch2 Genes in the Siberian Cat Veterinary Sciences 4 4 63 doi 10 3390 vetsci4040063 PMC 5753643 PMID 29194349 Allergy to Cats Cat DNA Test Kit Basepaws Allergy to Cats Cat DNA Test Kit Basepaws Retrieved 2018 08 07 Myers P R Espinosa C S Parr T Jones G S Hammond amp T A Dewey Subclass Theria Animal Diversity Web InterPro taxonomy view IPR006178 and IPR015332 Durairaj R Pageat P Bienboire Frosini C 2018 Another cat and mouse game Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches PLOS ONE 13 5 e0197618 Bibcode 2018PLoSO 1397618D doi 10 1371 journal pone 0197618 PMC 5957422 PMID 29771985 Nekaris KA Moore RS Rode EJ Fry BG September 2013 Mad bad and dangerous to know the biochemistry ecology and evolution of slow loris venom The Journal of Venomous Animals and Toxins Including Tropical Diseases 19 1 21 doi 10 1186 1678 9199 19 21 PMC 3852360 PMID 24074353 Further reading editBonnet B Messaoudi K Jacomet F Michaud E Fauquert JL Caillaud D Evrard B 2018 An update on molecular cat allergens Fel d 1 and what else Chapter 1 Fel d 1 the major cat allergen Allergy Asthma and Clinical Immunology 14 14 doi 10 1186 s13223 018 0239 8 PMC 5891966 PMID 29643919 This article incorporates text from the public domain Pfam and InterPro IPR015332 Retrieved from https en wikipedia org w index php title Fel d 1 amp oldid 1188012375, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.