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Wikipedia

Far upstream element-binding protein 1

April 11, 2024

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.[5][6]

FUBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFUBP1, FBP, FUBP, hDH V, far upstream element binding protein 1
External IDsOMIM: 603444 MGI: 1196294 HomoloGene: 48253 GeneCards: FUBP1
Orthologs
SpeciesHumanMouse
Entrez

8880

51886

Ensembl

ENSG00000162613

ENSMUSG00000028034

UniProt

Q96AE4

Q91WJ8

RefSeq (mRNA)

NM_001303433
NM_003902
NM_001376055
NM_001376056
NM_001376057

RefSeq (protein)

NP_001290362
NP_003893
NP_001362984
NP_001362985
NP_001362986

Location (UCSC)Chr 1: 77.94 – 77.98 MbChr 3: 151.92 – 151.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.[6]

Interactions edit

Far upstream element-binding protein 1 has been shown to interact with MAPK14[7] and SMN1.[8]

Clinical Significance edit

FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour.[9] CIC gene is also lost in the 1p/19q codeletion mutation.

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162613 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028034 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (April 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.
  6. ^ a b "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".
  7. ^ Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (July 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3). United States: 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782. S2CID 41006480.
  8. ^ Williams, B Y; Hamilton S L; Sarkar H K (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2). NETHERLANDS: 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235. S2CID 28330997.
  9. ^ Weller, Michael (8 December 2020). "EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood". Nature Reviews. Clinical Oncology. 18 (3): 170–186. doi:10.1038/s41571-020-00447-z. PMC 7904519. PMID 33293629.

Further reading edit

  • Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. PMID 10734235. S2CID 28330997.
  • Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol. Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
  • Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
  • He L, Weber A, Levens D (2000). "Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor". Nucleic Acids Res. 28 (22): 4558–65. doi:10.1093/nar/28.22.4558. PMC 113884. PMID 11071946.
  • Vindigni A, Ochem A, Triolo G, Falaschi A (2001). "Identification of human DNA helicase V with the far upstream element-binding protein". Nucleic Acids Res. 29 (5): 1061–7. doi:10.1093/nar/29.5.1061. PMC 29729. PMID 11222755.
  • Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum". Cell. 104 (3): 353–63. doi:10.1016/S0092-8674(01)00223-9. PMID 11239393.
  • Braddock DT, Louis JM, Baber JL, et al. (2002). "Structure and dynamics of KH domains from FBP bound to single-stranded DNA". Nature. 415 (6875): 1051–6. Bibcode:2002Natur.415.1051B. doi:10.1038/4151051a. PMID 11875576. S2CID 4401103.
  • Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782. S2CID 41006480.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kouzine F, Liu J, Sanford S, et al. (2004). "The dynamic response of upstream DNA to transcription-generated torsional stress". Nat. Struct. Mol. Biol. 11 (11): 1092–100. doi:10.1038/nsmb848. PMID 15502847. S2CID 28956216.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
  • Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
  • Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression". EMBO J. 25 (10): 2119–30. doi:10.1038/sj.emboj.7601101. PMC 1462968. PMID 16628215.
  • Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi:10.1074/jbc.C600041200. PMID 16672220.


 

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

April 11, 2024
upstream, element, binding, protein, protein, that, humans, encoded, fubp1, gene, fubp1available, structurespdbortholog, search, pdbe, rcsblist, codes1j4w, 2kxh, 4lijidentifiersaliasesfubp1, fubp, upstream, element, binding, protein, 1external, idsomim, 603444. Far upstream element binding protein 1 is a protein that in humans is encoded by the FUBP1 gene 5 6 FUBP1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1J4W 2KXH 4LIJIdentifiersAliasesFUBP1 FBP FUBP hDH V far upstream element binding protein 1External IDsOMIM 603444 MGI 1196294 HomoloGene 48253 GeneCards FUBP1Gene location Human Chr Chromosome 1 human 1 Band1p31 1Start77 944 055 bp 1 End77 979 110 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 H3 3 77 05 cMStart151 916 059 bp 2 End151 942 463 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminenceAchilles tendonright uterine tubeleft lobe of thyroid glandright lobe of thyroid glandcanal of the cervixlymph nodetibial nerveanterior pituitaryright lungTop expressed inmaxillary prominencesomiteabdominal wallganglionic eminencethymushandprimitive streakdermisyolk saccerebellar cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding nucleic acid binding single stranded DNA binding DNA binding transcription factor activity DNA binding RNA bindingCellular componentnucleus nucleoplasmBiological processpositive regulation of gene expression regulation of transcription DNA templated transcription by RNA polymerase II transcription DNA templatedSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez888051886EnsemblENSG00000162613ENSMUSG00000028034UniProtQ96AE4Q91WJ8RefSeq mRNA NM 001303433NM 003902NM 001376055NM 001376056NM 001376057NM 057172NM 001355366NM 001355367NM 001355368NM 001355369NM 001355370NM 001355371NM 001355372NM 001355373NM 001355374RefSeq protein NP 001290362NP 003893NP 001362984NP 001362985NP 001362986NP 476513NP 001342295NP 001342296NP 001342297NP 001342298NP 001342299NP 001342300NP 001342301NP 001342302NP 001342303Location UCSC Chr 1 77 94 77 98 MbChr 3 151 92 151 94 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a ssDNA binding protein that activates the far upstream element FUSE of c myc and stimulates expression of c myc in undifferentiated cells Regulation of FUSE by FUBP occurs through single strand binding of FUBP to the non coding strand This protein has been shown to function as an ATP dependent DNA helicase 6 Contents 1 Interactions 2 Clinical Significance 3 References 4 Further readingInteractions editFar upstream element binding protein 1 has been shown to interact with MAPK14 7 and SMN1 8 Clinical Significance editFUBP1 gene deletion forms part of the 1p 19q codeletion mutation seen in oligodendroglioma a form of primary brain tumour 9 CIC gene is also lost in the 1p 19q codeletion mutation References edit a b c GRCh38 Ensembl release 89 ENSG00000162613 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028034 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Duncan R Bazar L Michelotti G Tomonaga T Krutzsch H Avigan M Levens D April 1994 A sequence specific single strand binding protein activates the far upstream element of c myc and defines a new DNA binding motif Genes Dev 8 4 465 80 doi 10 1101 gad 8 4 465 PMID 8125259 a b Entrez Gene FUBP1 far upstream element FUSE binding protein 1 Kim Min Jung Park Bum Joon Kang Young Sun Kim Hyoung June Park Jae Hyun Kang Jung Woo Lee Sang Won Han Jung Min Lee Han Woong Kim Sunghoon July 2003 Downregulation of FUSE binding protein and c myc by tRNA synthetase cofactor p38 is required for lung cell differentiation Nat Genet 34 3 United States 330 6 doi 10 1038 ng1182 ISSN 1061 4036 PMID 12819782 S2CID 41006480 Williams B Y Hamilton S L Sarkar H K March 2000 The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain FEBS Lett 470 2 NETHERLANDS 207 10 doi 10 1016 S0014 5793 00 01320 X ISSN 0014 5793 PMID 10734235 S2CID 28330997 Weller Michael 8 December 2020 EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood Nature Reviews Clinical Oncology 18 3 170 186 doi 10 1038 s41571 020 00447 z PMC 7904519 PMID 33293629 Further reading editWilliams BY Hamilton SL Sarkar HK 2000 The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain FEBS Lett 470 2 207 10 doi 10 1016 S0014 5793 00 01320 X PMID 10734235 S2CID 28330997 Liu J He L Collins I et al 2000 The FBP interacting repressor targets TFIIH to inhibit activated transcription Mol Cell 5 2 331 41 doi 10 1016 S1097 2765 00 80428 1 PMID 10882074 Markovtsov V Nikolic JM Goldman JA et al 2000 Cooperative assembly of an hnRNP complex induced by a tissue specific homolog of polypyrimidine tract binding protein Mol Cell Biol 20 20 7463 79 doi 10 1128 MCB 20 20 7463 7479 2000 PMC 86300 PMID 11003644 He L Weber A Levens D 2000 Nuclear targeting determinants of the far upstream element binding protein a c myc transcription factor Nucleic Acids Res 28 22 4558 65 doi 10 1093 nar 28 22 4558 PMC 113884 PMID 11071946 Vindigni A Ochem A Triolo G Falaschi A 2001 Identification of human DNA helicase V with the far upstream element binding protein Nucleic Acids Res 29 5 1061 7 doi 10 1093 nar 29 5 1061 PMC 29729 PMID 11222755 Liu J Akoulitchev S Weber A et al 2001 Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum Cell 104 3 353 63 doi 10 1016 S0092 8674 01 00223 9 PMID 11239393 Braddock DT Louis JM Baber JL et al 2002 Structure and dynamics of KH domains from FBP bound to single stranded DNA Nature 415 6875 1051 6 Bibcode 2002Natur 415 1051B doi 10 1038 4151051a PMID 11875576 S2CID 4401103 Rappsilber J Ryder U Lamond AI Mann M 2002 Large scale proteomic analysis of the human spliceosome Genome Res 12 8 1231 45 doi 10 1101 gr 473902 PMC 186633 PMID 12176931 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kim MJ Park BJ Kang YS et al 2003 Downregulation of FUSE binding protein and c myc by tRNA synthetase cofactor p38 is required for lung cell differentiation Nat Genet 34 3 330 6 doi 10 1038 ng1182 PMID 12819782 S2CID 41006480 Brandenberger R Wei H Zhang S et al 2005 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation Nat Biotechnol 22 6 707 16 doi 10 1038 nbt971 PMID 15146197 S2CID 27764390 Beausoleil SA Jedrychowski M Schwartz D et al 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Kouzine F Liu J Sanford S et al 2004 The dynamic response of upstream DNA to transcription generated torsional stress Nat Struct Mol Biol 11 11 1092 100 doi 10 1038 nsmb848 PMID 15502847 S2CID 28956216 Rush J Moritz A Lee KA et al 2005 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nat Biotechnol 23 1 94 101 doi 10 1038 nbt1046 PMID 15592455 S2CID 7200157 Stelzl U Worm U Lalowski M et al 2005 A human protein protein interaction network a resource for annotating the proteome Cell 122 6 957 68 doi 10 1016 j cell 2005 08 029 hdl 11858 00 001M 0000 0010 8592 0 PMID 16169070 Fautsch MP Vrabel AM Johnson DH 2006 The identification of myocilin associated proteins in the human trabecular meshwork Exp Eye Res 82 6 1046 52 doi 10 1016 j exer 2005 09 016 PMID 16289162 Liu J Kouzine F Nie Z et al 2006 The FUSE FBP FIR TFIIH system is a molecular machine programming a pulse of c myc expression EMBO J 25 10 2119 30 doi 10 1038 sj emboj 7601101 PMC 1462968 PMID 16628215 Ko HS Kim SW Sriram SR et al 2006 Identification of far upstream element binding protein 1 as an authentic Parkin substrate J Biol Chem 281 24 16193 6 doi 10 1074 jbc C600041200 PMID 16672220 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Far upstream element binding protein 1 amp oldid 1193771155, wikipedia, wiki, book, books, library,

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