Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.[7]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000188763 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049551 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.
^Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.
Datta DV (May 1977). "Viral hepatitis (Chandigarh study)". The Journal of the Association of Physicians of India. 25 (5): 325–30. PMID 914765.
Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC21233. PMID 9192640.
Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (Aug 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC21479. PMID 9707618.
Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (Oct 2002). "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling". The Journal of Biological Chemistry. 277 (40): 37479–86. doi:10.1074/jbc.M205658200. PMID 12138115.
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE (May 2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". The Journal of Biological Chemistry. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT, Heasley LE, Nemenoff RA (Sep 2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.
External linksEdit
"Frizzled Receptors: FZD9". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
frizzled, protein, that, humans, encoded, fzd9, gene, also, been, designated, cd349, cluster, differentiation, fzd9identifiersaliasesfzd9, cd349, fzd3, frizzled, class, receptor, 9external, idsomim, 601766, 1313278, homologene, 2619, genecards, fzd9gene, locat. Frizzled 9 Fz 9 is a protein that in humans is encoded by the FZD9 gene 5 6 7 Fz 9 has also been designated as CD349 cluster of differentiation 349 FZD9IdentifiersAliasesFZD9 CD349 FZD3 frizzled class receptor 9External IDsOMIM 601766 MGI 1313278 HomoloGene 2619 GeneCards FZD9Gene location Human Chr Chromosome 7 human 1 Band7q11 23Start73 433 778 bp 1 End73 436 120 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 G2 5 75 08 cMStart135 277 792 bp 2 End135 280 084 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleamygdalacingulate gyrusprefrontal cortexhypothalamusputamenskeletal muscle tissuedorsolateral prefrontal cortexBrodmann area 9caudate nucleusTop expressed inribsoleus musclestria vascularisplantaris musclelarynxextensor digitorum longus musclethyroid cartilagenasal septumskeletal muscle tissuegastrocnemius muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein homodimerization activity signal transducer activity Wnt protein binding protein heterodimerization activity transmembrane signaling receptor activity G protein coupled receptor activity Wnt activated receptor activityCellular componentcytoplasm membrane plasma membrane cell surface perinuclear region of cytoplasm filopodium membrane endoplasmic reticulum membrane Golgi apparatus mitochondrial membrane integral component of membrane postsynapse glutamatergic synapseBiological processG protein coupled receptor signaling pathway Wnt signaling pathway nervous system development multicellular organism development cell surface receptor signaling pathway learning or memory neuroblast proliferation B cell differentiation signal transduction ossification release of cytochrome c from mitochondria positive regulation of bone mineralization positive regulation of apoptotic process negative regulation of neuron apoptotic process regulation of cytosolic calcium ion concentration negative regulation of mitochondrial depolarization negative regulation of necroptotic process positive regulation of canonical Wnt signaling pathway negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of skeletal muscle acetylcholine gated channel clustering negative regulation of skeletal muscle acetylcholine gated channel clustering bone regeneration positive regulation of neural precursor cell proliferation non canonical Wnt signaling pathway canonical Wnt signaling pathway postsynapse organization regulation of postsynaptic cytosolic calcium ion concentrationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez832614371EnsemblENSG00000188763ENSMUSG00000049551UniProtO00144Q9R216RefSeq mRNA NM 003508NM 010246RefSeq protein NP 003499NP 034376Location UCSC Chr 7 73 43 73 44 MbChr 5 135 28 135 28 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction EditMembers of the frizzled gene family encode 7 transmembrane domain proteins that are receptors for Wnt signaling proteins The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7 and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype FZD9 is expressed predominantly in brain testis eye skeletal muscle and kidney 7 References Edit a b c GRCh38 Ensembl release 89 ENSG00000188763 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000049551 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wang YK Samos CH Peoples R Perez Jurado LA Nusse R Francke U Mar 1997 A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11 23 Human Molecular Genetics 6 3 465 72 doi 10 1093 hmg 6 3 465 PMID 9147651 Wang YK Sporle R Paperna T Schughart K Francke U Apr 1999 Characterization and expression pattern of the frizzled gene Fzd9 the mouse homolog of FZD9 which is deleted in Williams Beuren syndrome Genomics 57 2 235 48 doi 10 1006 geno 1999 5773 PMID 10198163 a b Entrez Gene FZD9 frizzled homolog 9 Drosophila Further reading EditDatta DV May 1977 Viral hepatitis Chandigarh study The Journal of the Association of Physicians of India 25 5 325 30 PMID 914765 Finch PW He X Kelley MJ Uren A Schaudies RP Popescu NC Rudikoff S Aaronson SA Varmus HE Rubin JS Jun 1997 Purification and molecular cloning of a secreted Frizzled related antagonist of Wnt action Proceedings of the National Academy of Sciences of the United States of America 94 13 6770 5 Bibcode 1997PNAS 94 6770F doi 10 1073 pnas 94 13 6770 PMC 21233 PMID 9192640 Tanaka S Akiyoshi T Mori M Wands JR Sugimachi K Aug 1998 A novel frizzled gene identified in human esophageal carcinoma mediates APC beta catenin signals Proceedings of the National Academy of Sciences of the United States of America 95 17 10164 9 Bibcode 1998PNAS 9510164T doi 10 1073 pnas 95 17 10164 PMC 21479 PMID 9707618 Karasawa T Yokokura H Kitajewski J Lombroso PJ Oct 2002 Frizzled 9 is activated by Wnt 2 and functions in Wnt beta catenin signaling The Journal of Biological Chemistry 277 40 37479 86 doi 10 1074 jbc M205658200 PMID 12138115 Omoto S Hayashi T Kitahara K Takeuchi T Ueoka Y Jun 2004 Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations H69Y and C181R Ophthalmic Genetics 25 2 81 90 doi 10 1080 13816810490514270 PMID 15370539 S2CID 32817238 Winn RA Marek L Han SY Rodriguez K Rodriguez N Hammond M Van Scoyk M Acosta H Mirus J Barry N Bren Mattison Y Van Raay TJ Nemenoff RA Heasley LE May 2005 Restoration of Wnt 7a expression reverses non small cell lung cancer cellular transformation through frizzled 9 mediated growth inhibition and promotion of cell differentiation The Journal of Biological Chemistry 280 20 19625 34 doi 10 1074 jbc M409392200 PMID 15705594 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M Oct 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Winn RA Van Scoyk M Hammond M Rodriguez K Crossno JT Heasley LE Nemenoff RA Sep 2006 Antitumorigenic effect of Wnt 7a and Fzd 9 in non small cell lung cancer cells is mediated through ERK 5 dependent activation of peroxisome proliferator activated receptor gamma The Journal of Biological Chemistry 281 37 26943 50 doi 10 1074 jbc M604145200 PMID 16835228 External links Edit Frizzled Receptors FZD9 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology FZD9 protein human at the U S National Library of Medicine Medical Subject Headings MeSH This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Frizzled 9 amp oldid 1089417565, wikipedia, wiki, book, books, library,
