This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000151876 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022184 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abCenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
^Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
^ abEwing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
^Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
Further readingedit
Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet. Cell Genet. 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603. S2CID 431704.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC514446. PMID 15302935.
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC525538. PMID 15520277.
Lee TH, Perrem K, Harper JW, Lu KP, Zhou XZ (2006). "The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance". J. Biol. Chem. 281 (2): 759–68. doi:10.1074/jbc.M509855200. PMID 16275645.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID 16344560.
Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD (2006). "The ETS Protein MEF Is Regulated by Phosphorylation-Dependent Proteolysis via the Protein-Ubiquitin Ligase SCFSkp2". Mol. Cell. Biol. 26 (8): 3114–23. doi:10.1128/MCB.26.8.3114-3123.2006. PMC1446966. PMID 16581786.
Lin DI, Barbash O, Kumar KG, Weber JD, Harper JW, Klein-Szanto AJ, Rustgi A, Fuchs SY, Diehl JA (2006). "Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αBcrystallin complex". Mol. Cell. 24 (3): 355–66. doi:10.1016/j.molcel.2006.09.007. PMC1702390. PMID 17081987.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.
fbxo4, only, protein, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3l2o, 3l82identifiersaliases, fbx4, protein, 4external, idsomim, 609090, 2146220, homologene, 8134, genecards, gene, location, human, chr. F box only protein 4 is a protein that in humans is encoded by the FBXO4 gene 5 6 7 FBXO4Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3L2O 3L82IdentifiersAliasesFBXO4 FBX4 F box protein 4External IDsOMIM 609090 MGI 2146220 HomoloGene 8134 GeneCards FBXO4Gene location Human Chr Chromosome 5 human 1 Band5p13 1Start41 925 254 bp 1 End41 941 743 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 15 A1Start3 994 927 bp 2 End4 009 055 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendonbody of pancreasgastric mucosaright uterine tubetibial nerveright lobe of thyroid glandright lobe of liverleft lobe of thyroid glandspleensubcutaneous adipose tissueTop expressed insacculeciliary bodyproximal tubulesubcutaneous adipose tissuewhite adipose tissuespermatocyteduodenumcalvariaascending aortaendocardial cushionMore reference expression dataBioGPSn aGene ontologyMolecular functionprotein binding protein homodimerization activity ubiquitin protein ligase activity ubiquitin protein transferase activityCellular componentubiquitin ligase complex cytosol SCF ubiquitin ligase complex cytoplasmBiological processSCF dependent proteasomal ubiquitin dependent protein catabolic process telomere maintenance positive regulation of protein ubiquitination ubiquitin dependent protein catabolic process protein polyubiquitination common myeloid progenitor cell proliferation protein destabilization positive regulation of protein polyubiquitination human ageing negative regulation of fibroblast proliferation cellular response to ionizing radiation cellular homeostasis regulation of DNA damage checkpoint negative regulation of protein localization to nucleus posttranscriptional regulation of gene expression protein ubiquitination regulation of protein stability positive regulation of telomere maintenance via telomerase post translational protein modificationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez26272106052EnsemblENSG00000151876ENSMUSG00000022184UniProtQ9UKT5Q8CHQ0RefSeq mRNA NM 001297437NM 012176NM 033484NM 134099RefSeq protein NP 001284366NP 036308NP 277019NP 598860Location UCSC Chr 5 41 93 41 94 MbChr 15 3 99 4 01 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis gene encodes a member of the F box protein family which is characterized by an approximately 40 amino acid motif the F box The F box proteins constitute one of the four subunits of the ubiquitin ligase complex called SCFs SKP1 cullin F box which function in phosphorylation dependent ubiquitination The F box proteins are divided into 3 classes Fbws containing WD 40 domains Fbls containing leucine rich repeats and Fbxs containing either different protein protein interaction modules or no recognizable motifs The protein encoded by this gene belongs to the Fbxs class Alternative splicing of this gene generates 2 transcript variants 7 Interactions editFBXO4 has been shown to interact with CUL1 5 8 and SKP1A 8 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000151876 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000022184 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Cenciarelli C Chiaur DS Guardavaccaro D Parks W Vidal M Pagano M Dec 1999 Identification of a family of human F box proteins Curr Biol 9 20 1177 9 doi 10 1016 S0960 9822 00 80020 2 PMID 10531035 S2CID 7467493 Winston JT Koepp DM Zhu C Elledge SJ Harper JW Dec 1999 A family of mammalian F box proteins Curr Biol 9 20 1180 2 doi 10 1016 S0960 9822 00 80021 4 PMID 10531037 S2CID 14341845 a b Entrez Gene FBXO4 F box protein 4 a b Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Cenciarelli C Chiaur DS Guardavaccaro D Parks W Vidal M Pagano M Oct 1999 Identification of a family of human F box proteins Curr Biol 9 20 1177 9 doi 10 1016 S0960 9822 00 80020 2 PMID 10531035 S2CID 7467493 Further reading editChiaur DS Murthy S Cenciarelli C Parks W Loda M Inghirami G Demetrick D Pagano M 2000 Five human genes encoding F box proteins chromosome mapping and analysis in human tumors Cytogenet Cell Genet 88 3 4 255 8 doi 10 1159 000015532 PMID 10828603 S2CID 431704 Beausoleil SA Jedrychowski M Schwartz D Elias JE Villen J Li J Cohn MA Cantley LC Gygi SP 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Jin J Cardozo T Lovering RC Elledge SJ Pagano M Harper JW 2005 Systematic analysis and nomenclature of mammalian F box proteins Genes Dev 18 21 2573 80 doi 10 1101 gad 1255304 PMC 525538 PMID 15520277 Lee TH Perrem K Harper JW Lu KP Zhou XZ 2006 The F box protein FBX4 targets PIN2 TRF1 for ubiquitin mediated degradation and regulates telomere maintenance J Biol Chem 281 2 759 68 doi 10 1074 jbc M509855200 PMID 16275645 Kimura K Wakamatsu A Suzuki Y Ota T Nishikawa T Yamashita R Yamamoto J Sekine M Tsuritani K Wakaguri H Ishii S Sugiyama T Saito K Isono Y Irie R Kushida N Yoneyama T Otsuka R Kanda K Yokoi T Kondo H Wagatsuma M Murakawa K Ishida S Ishibashi T Takahashi Fujii A Tanase T Nagai K Kikuchi H Nakai K Isogai T Sugano S 2006 Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Liu Y Hedvat CV Mao S Zhu XH Yao J Nguyen H Koff A Nimer SD 2006 The ETS Protein MEF Is Regulated by Phosphorylation Dependent Proteolysis via the Protein Ubiquitin Ligase SCFSkp2 Mol Cell Biol 26 8 3114 23 doi 10 1128 MCB 26 8 3114 3123 2006 PMC 1446966 PMID 16581786 Lin DI Barbash O Kumar KG Weber JD Harper JW Klein Szanto AJ Rustgi A Fuchs SY Diehl JA 2006 Phosphorylation dependent ubiquitination of cyclin D1 by the SCFFBX4 aBcrystallin complex Mol Cell 24 3 355 66 doi 10 1016 j molcel 2006 09 007 PMC 1702390 PMID 17081987 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title FBXO4 amp oldid 1116588160, wikipedia, wiki, book, books, library,
