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Eva Neer

April 11, 2024

Eva Julia Neer (1937–2000) was an American physician (Columbia University P&S), biochemist, and cell-biology scientist who gained U.S. national research awards (FASEB, 1987; American Heart Association, 1996) for her discoveries on G-protein subunit structure and function. She described the physiological roles of these subunits as an integrated and versatile molecular system of signal transduction for membrane-receptor regulation of cell function. Her research concepts turned her into a world leader in G-protein studies and impinged widely on the general understanding of cell behavior.[1][2][3]

Eva Neer
Born
Eva Augenblick

1937
Warsaw, Poland
Died2000, age 62
Cambridge, Massachusetts
NationalityAmerican of Polish origin
EducationRadcliffe College, Columbia University
Known forG-protein subunit structure and function
SpouseRobert M. Neer
AwardsNational Academy of Sciences
Scientific career
FieldsBiochemist and cell-biologist
InstitutionsHarvard University

Biography edit

Born Eva Augenblick in Warsaw, came to New York at age eight with her parents and grew up in Queens and Scarsdale.[4] Neer's family fled Warsaw at war's onset in 1939, emigrated first to Brazil, and soon after to the U.S.. In Warsaw, her father had practiced private corporate law, which he was unable to pursue in the US, but her parents inspired in Neer her love for scholarly endeavors.[2] She graduated with honors from Bronxville High School in 1955, being awarded a Regent’s college scholarship by the State Education Department.[5] Eva Augenblick attended Radcliffe College and graduated from Barnard College in 1959. A list of student acquaintances of hers at high school and college would include notable achievers such as economist Fischer Black, psychologist Robert L. Helmreich,[6] and endocrinologist Robert M. Neer[7] whom she married.[8] Neer graduated as a physician at Columbia University in 1963. Three years later, she joined Harvard University where she worked continuously for more than three decades. Neer has been singled out for her "efforts to help women advance up the academic ladder".[9] She died of complications from breast cancer in 2000, survived by her husband and two sons, Robert and Richard.[10] A personal account of Neer´s professional life was given by her close colleague David E. Clapham in an obituary note.[11]

Academic career edit

Neer joined Harvard research staff in 1966. She was appointed Assistant Professor of Medicine in 1976, and full professor in 1991. She was ascribed to the Cardiology Division at Brigham and Women's Hospital. Neer served on the Board of Tutors in Biochemical Sciences at Harvard College, as well as on the Harvard Students Research Committee at the Harvard Medical School. She combined the tools of chemistry, biology, physics and molecular biology to explain how cells interpret the messages they get from light, hormones and neurotransmitters. The author of numerous papers, she was elected to both the U.S. National Academy of Sciences and the Institute of Medicine of the National Academy of Sciences and earned membership in the American Academy of Arts and Sciences and the Polish Institute of Arts and Sciences of America. She was honored with the FASEB prize for basic research in 1987 and the American Heart Association’s basic research prize in 1996. She was also an adviser to the National Institutes of Health.[1][2][3]

Research edit

Neer's early research, performed under the guidance of Guido Guidotti,[12] was devoted to study aspects of hemoglobin chemistry. These included the role of sulfhydryl groups of α and β chains on the quaternary conformation of the molecule. She showed their importance in subunit interface interaction and functional cooperativity for oxygen binding. This binding is an essential property for oxygen transport in blood and is often referred as Bohr effect.[13]

While still at Guidotti's lab, Neer undertook independent research on the biochemical mechanisms of vasopressin's action on kidney's distal tubules. She described the purification and kinetic properties of vasopressin-sensitive adenylate cyclase from rat renal medulla.[14] It would be later shown that vasopressin[15] acts through a G protein-coupled receptor. This was the topic of Neer's work for most of her research career.

In order to dissect out different aspects of G protein messaging complexities Neer studied a variety of tissues including brain cortex, rat testis, pigeon erythrocytes, heart, brain, retina-rods. Some of her most cited research findings include:

  • Purification and properties of free and membrane-bound adenylate cyclase (1978)[16]
  • Size and detergent binding of adenylate cyclase from bovine cerebral cortex (1978)[17]
  • The site of α-chymotryptic activation of pigeon erythrocyte adenylate cyclase (1978)[18]
  • Calmodulin activates the isolated catalytic unit of brain adenylate cyclase (1981)[19]
  • Location and function of reactive sulfhydryl groups of α subunit 39 (1987)[20]
  • Action of G protein subunits on the cardiac muscarinic K+ channel (1987, 1988)[21][22]
  • Cloning and differential expression of α-subunit types in human tissues and cell types (1988)[23]
  • G-protein αs and αo synthesis in GH3 cells (1996)[24]
  • Structure-function aspects of activation of PLC by G protein subunits: site mutation studies. (1998)[25][26]

During the course of her career Neer authored a number of highly cited review articles on structural and functional aspects of G protein and its subunits. [27][28][29][30][31]

Awards and honors edit

References edit

  1. ^ a b "Professor of Medicine Eva J. Neer Dies at 62". Harvard Gazette. 2 March 2000. Retrieved 27 September 2017.
  2. ^ a b c . Harvard Gazette. 6 March 2003. Archived from the original on 2 January 2014. Retrieved 2 January 2014.
  3. ^ a b . BioMolecular Engineering Research Center. 21 February 2000. Archived from the original on 2 January 2014. Retrieved 2 January 2014.
  4. ^ Saxon, Wolfgang (26 February 2000). "Eva Julia Neer, 62, Biochemist Known for Work With Proteins". The New York Times. Retrieved 2 January 2014.
  5. ^ "HS,Yonkers,N.Y,May 13, 1955". Archives of the Yonkers NY Herald Statesman. Fultonhistory.com. Retrieved 2 January 2014.
  6. ^ [1][dead link]
  7. ^ . Archived from the original on 2 January 2014. Retrieved 2 January 2014.
  8. ^ Mehrling, Perry. . Dmmserver.com. Archived from the original on 4 March 2016. Retrieved 2 January 2014.
  9. ^ . Archived from the original on 2 January 2014. Retrieved 1 January 2014.
  10. ^ "Eva Julia Neer, 62, Biochemist, Heart Researcher". Chicago Tribune. 28 February 2000. Retrieved 2 January 2014.
  11. ^ Clapham, David E. (2000). "Remembering Eva Neer". Cell. 101 (3): 247–248. doi:10.1016/S0092-8674(02)71135-5.
  12. ^ . Molecular & Cellular Biology - Harvard University. Archived from the original on 15 November 2016. Retrieved 2 January 2014.
  13. ^ Neer, EJ; Guidotti, G (1970). "The recombination of α and β chains of human hemoglobin. Effect of sulfhydryl group modifications". J. Biol. Chem. 245 (3): 570–3. doi:10.1016/S0021-9258(18)63370-8. PMID 5412713.
  14. ^ Neer, EJ (1973). "The vasopressin-sensitive adenylate cyclase of the rat renal medulla". J. Biol. Chem. 248 (13): 4775–81. doi:10.1016/S0021-9258(19)43732-0. PMID 4352409.
  15. ^ Prat, AG; Ausiello, DA; Cantiello, HF (1993). "Vasopressin and protein kinase A activate G protein-sensitive epithelial Na+ channels". American Journal of Physiology. Cell Physiology. 265 (1 Pt 1): C218–23. doi:10.1152/ajpcell.1993.265.1.C218. PMID 8393279.
  16. ^ Neer, EJ (1978). "Physical and functional properties of adenylate cyclase from mature rat testis". J. Biol. Chem. 253 (16): 5808–12. doi:10.1016/S0021-9258(17)30340-X. PMID 670231.
  17. ^ Neer, EJ (1978). "Size and detergent binding of adenylate cyclase from bovine cerebral cortex". J. Biol. Chem. 253 (5): 1498–502. doi:10.1016/S0021-9258(17)34894-9. PMID 627551.
  18. ^ Marshak, DR; Neer, EJ (1980). "The site of α-chymotryptic activation of pigeon erythrocyte adenylate cyclase". J. Biol. Chem. 255 (10): 4781–5. doi:10.1016/S0021-9258(19)85565-5. PMID 7372611.
  19. ^ Salter, RS; Krinks, MH; Klee, CB; Neer, EJ (1981). "Calmodulin activates the isolated catalytic unit of brain adenylate cyclase". J. Biol. Chem. 256 (19): 9830–3. doi:10.1016/S0021-9258(19)68703-X. PMID 6268633.
  20. ^ Winslow, JW; Bradley, JD; Smith, JA; Neer, EJ (1987). "Reactive sulfhydryl groups of α39, a guanine nucleotide-binding protein from brain. Location and function". J. Biol. Chem. 262 (10): 4501–7. doi:10.1016/S0021-9258(18)61220-7. PMID 3104318.
  21. ^ Logothetis, DE; Kurachi, Y; Galper, J; Neer, EJ; Clapham, DE (1987). "The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart". Nature. 325 (6102): 321–6. Bibcode:1987Natur.325..321L. doi:10.1038/325321a0. PMID 2433589. S2CID 4338529.
  22. ^ Logothetis, DE; Kim, DH; Northup, JK; Neer, EJ; Clapham, DE (1988). "Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel". Proc. Natl. Acad. Sci. USA. 85 (16): 5814–8. Bibcode:1988PNAS...85.5814L. doi:10.1073/pnas.85.16.5814. PMC 281855. PMID 2457901.
  23. ^ Kim, SY; Ang, SL; Bloch, DB; Bloch, KD; Kawahara, Y; Tolman, C; Lee, R; Seidman, JG; Neer, EJ (1988). "Identification of cDNA encoding an additional α subunit of a human GTP-binding protein: expression of three αi subtypes in human tissues and cell lines". Proc. Natl. Acad. Sci. USA. 85 (12): 4153–4257. Bibcode:1988PNAS...85.4153K. doi:10.1073/pnas.85.12.4153. PMC 280384. PMID 3132707.
  24. ^ Li, Y; Mende, U; Lewis, C; Neer, EJ (1996). "Maintenance of cellular levels of G-proteins: different efficiencies of αs and αo synthesis in GH3 cells". Biochem. J. 318 (Pt 3): 1071–7. doi:10.1042/bj3181071. PMC 1217725. PMID 8836158.
  25. ^ Panchenko, MP; Saxena, K; Li, Y; Charnecki, S; Sternweis, PM; Smith, TF; Gilman, AG; Kozasa, T; Neer, EJ (23 October 1998). "Sites important for PLCβ2 activation by the G Protein βγ subunit map to the sides of the β propeller structure". J. Biol. Chem. 273 (43): 28298–304. doi:10.1074/jbc.273.43.28298. PMID 9774453.
  26. ^ Li, Y; Sternweis, PM; Charnecki, S; Smith, TF; Gilman, AG; Neer, EJ; Kozasa, T (1998). "Sites for Gα binding on the G protein β subunit overlap with sites for regulation of phospholipase Cβ and adenylyl cyclase". J. Biol. Chem. 273 (26): 16265–72. doi:10.1074/jbc.273.26.16265. PMID 9632686.
  27. ^ Neer, EJ (1990). "Structural and functional studies of the Go protein". Soc. Gen. Physiol. Series. 45: 143–51. PMID 2116036.
  28. ^ Clapham, DE; Neer, EJ (1993). "New roles for G-protein beta gamma-dimers in transmembrane signalling". Nature. 365 (6445): 403–6. Bibcode:1993Natur.365..403C. doi:10.1038/365403a0. PMID 8413584. S2CID 4245662.
  29. ^ Neer, EJ (1995). "Heterotrimeric G proteins: organizers of transmembrane signals". Cell. 80 (2): 249–57. doi:10.1016/0092-8674(95)90407-7. PMID 7834744. S2CID 10095565.
  30. ^ Neer, EJ; Clapham, DE (1988). "Roles of G protein subunits in transmembrane signalling". Nature. 333 (6169): 129–34. Bibcode:1988Natur.333..129N. doi:10.1038/333129a0. PMID 3130578. S2CID 4256130.
  31. ^ Clapham, D. E.; Neer, E. J. (1997). . Annu. Rev. Pharmacol. Toxicol. 37: 167–203. doi:10.1146/annurev.pharmtox.37.1.167. PMID 9131251. Archived from the original on 13 July 2020. Retrieved 1 January 2014.
  32. ^ . Damon Runyon Cancer Research Foundation. Archived from the original on 2 January 2014. Retrieved 2 January 2014.
  33. ^ . Archived from the original on 2 February 2014. Retrieved 23 January 2014.

External links edit

  • MOLECULAR MIDDLEMEN
  • Eva Neer papers, 1960-2002 (inclusive), 1980-1999 (bulk). H MS c391. Harvard Medical Library, Francis A. Countway Library of Medicine, Boston, Mass.
  • Robert Neer, Thomas Michel, and Robert J. Lefkowitz, "Eva J. Neer", Biographical Memoirs of the National Academy of Sciences (2021)

April 11, 2024
neer, julia, neer, 1937, 2000, american, physician, columbia, university, biochemist, cell, biology, scientist, gained, national, research, awards, faseb, 1987, american, heart, association, 1996, discoveries, protein, subunit, structure, function, described, . Eva Julia Neer 1937 2000 was an American physician Columbia University P amp S biochemist and cell biology scientist who gained U S national research awards FASEB 1987 American Heart Association 1996 for her discoveries on G protein subunit structure and function She described the physiological roles of these subunits as an integrated and versatile molecular system of signal transduction for membrane receptor regulation of cell function Her research concepts turned her into a world leader in G protein studies and impinged widely on the general understanding of cell behavior 1 2 3 Eva NeerBornEva Augenblick1937Warsaw PolandDied2000 age 62Cambridge MassachusettsNationalityAmerican of Polish originEducationRadcliffe College Columbia UniversityKnown forG protein subunit structure and functionSpouseRobert M NeerAwardsNational Academy of SciencesScientific careerFieldsBiochemist and cell biologistInstitutionsHarvard University Contents 1 Biography 2 Academic career 3 Research 4 Awards and honors 5 References 6 External linksBiography editBorn Eva Augenblick in Warsaw came to New York at age eight with her parents and grew up in Queens and Scarsdale 4 Neer s family fled Warsaw at war s onset in 1939 emigrated first to Brazil and soon after to the U S In Warsaw her father had practiced private corporate law which he was unable to pursue in the US but her parents inspired in Neer her love for scholarly endeavors 2 She graduated with honors from Bronxville High School in 1955 being awarded a Regent s college scholarship by the State Education Department 5 Eva Augenblick attended Radcliffe College and graduated from Barnard College in 1959 A list of student acquaintances of hers at high school and college would include notable achievers such as economist Fischer Black psychologist Robert L Helmreich 6 and endocrinologist Robert M Neer 7 whom she married 8 Neer graduated as a physician at Columbia University in 1963 Three years later she joined Harvard University where she worked continuously for more than three decades Neer has been singled out for her efforts to help women advance up the academic ladder 9 She died of complications from breast cancer in 2000 survived by her husband and two sons Robert and Richard 10 A personal account of Neer s professional life was given by her close colleague David E Clapham in an obituary note 11 Academic career editNeer joined Harvard research staff in 1966 She was appointed Assistant Professor of Medicine in 1976 and full professor in 1991 She was ascribed to the Cardiology Division at Brigham and Women s Hospital Neer served on the Board of Tutors in Biochemical Sciences at Harvard College as well as on the Harvard Students Research Committee at the Harvard Medical School She combined the tools of chemistry biology physics and molecular biology to explain how cells interpret the messages they get from light hormones and neurotransmitters The author of numerous papers she was elected to both the U S National Academy of Sciences and the Institute of Medicine of the National Academy of Sciences and earned membership in the American Academy of Arts and Sciences and the Polish Institute of Arts and Sciences of America She was honored with the FASEB prize for basic research in 1987 and the American Heart Association s basic research prize in 1996 She was also an adviser to the National Institutes of Health 1 2 3 Research editNeer s early research performed under the guidance of Guido Guidotti 12 was devoted to study aspects of hemoglobin chemistry These included the role of sulfhydryl groups of a and b chains on the quaternary conformation of the molecule She showed their importance in subunit interface interaction and functional cooperativity for oxygen binding This binding is an essential property for oxygen transport in blood and is often referred as Bohr effect 13 While still at Guidotti s lab Neer undertook independent research on the biochemical mechanisms of vasopressin s action on kidney s distal tubules She described the purification and kinetic properties of vasopressin sensitive adenylate cyclase from rat renal medulla 14 It would be later shown that vasopressin 15 acts through a G protein coupled receptor This was the topic of Neer s work for most of her research career In order to dissect out different aspects of G protein messaging complexities Neer studied a variety of tissues including brain cortex rat testis pigeon erythrocytes heart brain retina rods Some of her most cited research findings include Purification and properties of free and membrane bound adenylate cyclase 1978 16 Size and detergent binding of adenylate cyclase from bovine cerebral cortex 1978 17 The site of a chymotryptic activation of pigeon erythrocyte adenylate cyclase 1978 18 Calmodulin activates the isolated catalytic unit of brain adenylate cyclase 1981 19 Location and function of reactive sulfhydryl groups of a subunit 39 1987 20 Action of G protein subunits on the cardiac muscarinic K channel 1987 1988 21 22 Cloning and differential expression of a subunit types in human tissues and cell types 1988 23 G protein as and ao synthesis in GH3 cells 1996 24 Structure function aspects of activation of PLC by G protein subunits site mutation studies 1998 25 26 During the course of her career Neer authored a number of highly cited review articles on structural and functional aspects of G protein and its subunits 27 28 29 30 31 Awards and honors editDamon Runyon Fellowship from the Cancer Research Foundation in 1973 32 American Heart Association Research Achievement Award for Basic Research 1996 together with David E Clapham FASEB Excellence in Science Award 1998 Elected to the National Academy of Sciences 1998 Elected to the Institute of Medicine of the National Academy of Sciences 1998 Earned membership in the American Academy of Arts and Sciences 1997 Posthumously honored by Harvard Medical School by establishing the Eva Neer Memorial Lecture 33 References edit a b Professor of Medicine Eva J Neer Dies at 62 Harvard Gazette 2 March 2000 Retrieved 27 September 2017 a b c Remembering Dr Eva Neer read at the Faculty of Medicine meeting on Dec 18 2002 Harvard Gazette 6 March 2003 Archived from the original on 2 January 2014 Retrieved 2 January 2014 a b Dr Eva J Neer in memorial BioMolecular Engineering Research Center 21 February 2000 Archived from the original on 2 January 2014 Retrieved 2 January 2014 Saxon Wolfgang 26 February 2000 Eva Julia Neer 62 Biochemist Known for Work With Proteins The New York Times Retrieved 2 January 2014 HS Yonkers N Y May 13 1955 Archives of the Yonkers NY Herald Statesman Fultonhistory com Retrieved 2 January 2014 1 dead link Dr Robert M Neer MD Boston MA Internal Medicine Healthgrades com Archived from the original on 2 January 2014 Retrieved 2 January 2014 Mehrling Perry Fischer Black and the Revolutionary Idea of Finance Dmmserver com Archived from the original on 4 March 2016 Retrieved 2 January 2014 Professor of Medicine Eva J Neer Dies at 62 Archived from the original on 2 January 2014 Retrieved 1 January 2014 Eva Julia Neer 62 Biochemist Heart Researcher Chicago Tribune 28 February 2000 Retrieved 2 January 2014 Clapham David E 2000 Remembering Eva Neer Cell 101 3 247 248 doi 10 1016 S0092 8674 02 71135 5 Guido Guidotti Molecular amp Cellular Biology Harvard University Archived from the original on 15 November 2016 Retrieved 2 January 2014 Neer EJ Guidotti G 1970 The recombination of a and b chains of human hemoglobin Effect of sulfhydryl group modifications J Biol Chem 245 3 570 3 doi 10 1016 S0021 9258 18 63370 8 PMID 5412713 Neer EJ 1973 The vasopressin sensitive adenylate cyclase of the rat renal medulla J Biol Chem 248 13 4775 81 doi 10 1016 S0021 9258 19 43732 0 PMID 4352409 Prat AG Ausiello DA Cantiello HF 1993 Vasopressin and protein kinase A activate G protein sensitive epithelial Na channels American Journal of Physiology Cell Physiology 265 1 Pt 1 C218 23 doi 10 1152 ajpcell 1993 265 1 C218 PMID 8393279 Neer EJ 1978 Physical and functional properties of adenylate cyclase from mature rat testis J Biol Chem 253 16 5808 12 doi 10 1016 S0021 9258 17 30340 X PMID 670231 Neer EJ 1978 Size and detergent binding of adenylate cyclase from bovine cerebral cortex J Biol Chem 253 5 1498 502 doi 10 1016 S0021 9258 17 34894 9 PMID 627551 Marshak DR Neer EJ 1980 The site of a chymotryptic activation of pigeon erythrocyte adenylate cyclase J Biol Chem 255 10 4781 5 doi 10 1016 S0021 9258 19 85565 5 PMID 7372611 Salter RS Krinks MH Klee CB Neer EJ 1981 Calmodulin activates the isolated catalytic unit of brain adenylate cyclase J Biol Chem 256 19 9830 3 doi 10 1016 S0021 9258 19 68703 X PMID 6268633 Winslow JW Bradley JD Smith JA Neer EJ 1987 Reactive sulfhydryl groups of a39 a guanine nucleotide binding protein from brain Location and function J Biol Chem 262 10 4501 7 doi 10 1016 S0021 9258 18 61220 7 PMID 3104318 Logothetis DE Kurachi Y Galper J Neer EJ Clapham DE 1987 The bg subunits of GTP binding proteins activate the muscarinic K channel in heart Nature 325 6102 321 6 Bibcode 1987Natur 325 321L doi 10 1038 325321a0 PMID 2433589 S2CID 4338529 Logothetis DE Kim DH Northup JK Neer EJ Clapham DE 1988 Specificity of action of guanine nucleotide binding regulatory protein subunits on the cardiac muscarinic K channel Proc Natl Acad Sci USA 85 16 5814 8 Bibcode 1988PNAS 85 5814L doi 10 1073 pnas 85 16 5814 PMC 281855 PMID 2457901 Kim SY Ang SL Bloch DB Bloch KD Kawahara Y Tolman C Lee R Seidman JG Neer EJ 1988 Identification of cDNA encoding an additional a subunit of a human GTP binding protein expression of three ai subtypes in human tissues and cell lines Proc Natl Acad Sci USA 85 12 4153 4257 Bibcode 1988PNAS 85 4153K doi 10 1073 pnas 85 12 4153 PMC 280384 PMID 3132707 Li Y Mende U Lewis C Neer EJ 1996 Maintenance of cellular levels of G proteins different efficiencies of as and ao synthesis in GH3 cells Biochem J 318 Pt 3 1071 7 doi 10 1042 bj3181071 PMC 1217725 PMID 8836158 Panchenko MP Saxena K Li Y Charnecki S Sternweis PM Smith TF Gilman AG Kozasa T Neer EJ 23 October 1998 Sites important for PLCb2 activation by the G Protein bg subunit map to the sides of the b propeller structure J Biol Chem 273 43 28298 304 doi 10 1074 jbc 273 43 28298 PMID 9774453 Li Y Sternweis PM Charnecki S Smith TF Gilman AG Neer EJ Kozasa T 1998 Sites for Ga binding on the G protein b subunit overlap with sites for regulation of phospholipase Cb and adenylyl cyclase J Biol Chem 273 26 16265 72 doi 10 1074 jbc 273 26 16265 PMID 9632686 Neer EJ 1990 Structural and functional studies of the Go protein Soc Gen Physiol Series 45 143 51 PMID 2116036 Clapham DE Neer EJ 1993 New roles for G protein beta gamma dimers in transmembrane signalling Nature 365 6445 403 6 Bibcode 1993Natur 365 403C doi 10 1038 365403a0 PMID 8413584 S2CID 4245662 Neer EJ 1995 Heterotrimeric G proteins organizers of transmembrane signals Cell 80 2 249 57 doi 10 1016 0092 8674 95 90407 7 PMID 7834744 S2CID 10095565 Neer EJ Clapham DE 1988 Roles of G protein subunits in transmembrane signalling Nature 333 6169 129 34 Bibcode 1988Natur 333 129N doi 10 1038 333129a0 PMID 3130578 S2CID 4256130 Clapham D E Neer E J 1997 G protein bg subunits Annu Rev Pharmacol Toxicol 37 167 203 doi 10 1146 annurev pharmtox 37 1 167 PMID 9131251 Archived from the original on 13 July 2020 Retrieved 1 January 2014 Damon Runyon Fellows Grantees by award year 70s Damon Runyon Cancer Research Foundation Archived from the original on 2 January 2014 Retrieved 2 January 2014 The M D Ph D Program at Harvard Medical School Archived from the original on 2 February 2014 Retrieved 23 January 2014 External links editMOLECULAR MIDDLEMEN Eva Neer papers 1960 2002 inclusive 1980 1999 bulk H MS c391 Harvard Medical Library Francis A Countway Library of Medicine Boston Mass Robert Neer Thomas Michel and Robert J Lefkowitz Eva J Neer Biographical Memoirs of the National Academy of Sciences 2021 Retrieved from https en wikipedia org w index php title Eva Neer amp oldid 1214808592, wikipedia, wiki, book, books, library,

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