European Registry of Hereditary Pancreatitis and Pancreatic Cancer
May 01, 2024
The European Registry of Hereditary Pancreatitis and Pancreatic Cancer (EUROPAC) was started by John Neoptolemos and colleagues[1] in 1997 and has become the world’s most extensive study on hereditary pancreatic diseases. It enabled discovery of several genetic characteristics causative for hereditary pancreatitis and familial pancreatic cancer.[2][3][4][5]
It maintains a registry of families in whom there is thought to be an increased risk of pancreatic cancer. Studies have shown that an increased risk of cancer is inferred if two or more first-degree relatives have the condition. In addition to the Familial Pancreatic Cancer (FPC) registry, EUROPAC offers screening for early pancreatic cancer on a research basis in those deemed at high risk for the development of the condition. Screening for early pancreatic cancer involves several different blood tests and scans and is usually undertaken from the age of 40 in high-risk individuals.
The research team based in Liverpool includes Annabelle Boughey (EUROPAC Operations Manager), Paul Thomas (EUROPAC Coordinator) Phil Hopley (clinical research fellow), Professor Christopher Halloran (principal investigator) and Professor William Greenhalf (lead scientist).
Referencesedit
^Finch, Margaret D.; Howes, Nathan; Ellis, Ian; Mountford, Roger; Sutton, Robert; Raraty, Michael; Neoptolemos, John P. (1997). "Hereditary Pancreatitis and Familial Pancreatic Cancer". Digestion. 58 (6): 564–569. doi:10.1159/000201502. ISSN 0012-2823. PMID 9438603.
^Threadgold, J (2002-05-01). "The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease". Gut. 50 (5): 675–681. doi:10.1136/gut.50.5.675. ISSN 0017-5749. PMC1773194. PMID 11950815.
^Howes, Nathan; Lerch, Markus M.; Greenhalf, William; Stocken, Deborah D.; Ellis, Ian; Simon, Peter; Truninger, Kaspar; Ammann, Rudi; Cavallini, Giorgio; Charnley, Richard M.; Uomo, Generoso (March 2004). "Clinical and genetic characteristics of hereditary pancreatitis in Europe". Clinical Gastroenterology and Hepatology. 2 (3): 252–261. doi:10.1016/S1542-3565(04)00013-8. PMID 15017610.
^McFaul, C D (2006-02-01). "Anticipation in familial pancreatic cancer". Gut. 55 (2): 252–258. doi:10.1136/gut.2005.065045. ISSN 0017-5749. PMC1856528. PMID 15972300.
^Grocock, C. J.; Rebours, V.; Delhaye, M. N.; Andren-Sandberg, A.; Weiss, F. U.; Mountford, R.; Harcus, M. J.; Niemczyck, E.; Vitone, L. J.; Dodd, S.; Jorgensen, M. T. (2010-03-01). "The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families". Gut. 59 (3): 357–363. doi:10.1136/gut.2009.186817. ISSN 0017-5749. PMID 19951905. S2CID 983450.
european, registry, hereditary, pancreatitis, pancreatic, cancer, europac, started, john, neoptolemos, colleagues, 1997, become, world, most, extensive, study, hereditary, pancreatic, diseases, enabled, discovery, several, genetic, characteristics, causative, . The European Registry of Hereditary Pancreatitis and Pancreatic Cancer EUROPAC was started by John Neoptolemos and colleagues 1 in 1997 and has become the world s most extensive study on hereditary pancreatic diseases It enabled discovery of several genetic characteristics causative for hereditary pancreatitis and familial pancreatic cancer 2 3 4 5 Description editEUROPAC is based at the Royal Liverpool University Hospital and it is supported by grants from Cancer Research UK the European Union the National Institute for Health and Care Research NIHR Pancreatic Cancer UK NHS England and Cheshire and Merseyside Cancer Alliance It maintains a registry of families in whom there is thought to be an increased risk of pancreatic cancer Studies have shown that an increased risk of cancer is inferred if two or more first degree relatives have the condition In addition to the Familial Pancreatic Cancer FPC registry EUROPAC offers screening for early pancreatic cancer on a research basis in those deemed at high risk for the development of the condition Screening for early pancreatic cancer involves several different blood tests and scans and is usually undertaken from the age of 40 in high risk individuals Patients who have a family history of pancreatic cancer or pancreatitis may be eligible to join the study Referrals are made via genetic counsellors GPs other consultants or directly via email The research team based in Liverpool includes Annabelle Boughey EUROPAC Operations Manager Paul Thomas EUROPAC Coordinator Phil Hopley clinical research fellow Professor Christopher Halloran principal investigator and Professor William Greenhalf lead scientist References edit Finch Margaret D Howes Nathan Ellis Ian Mountford Roger Sutton Robert Raraty Michael Neoptolemos John P 1997 Hereditary Pancreatitis and Familial Pancreatic Cancer Digestion 58 6 564 569 doi 10 1159 000201502 ISSN 0012 2823 PMID 9438603 Threadgold J 2002 05 01 The N34S mutation of SPINK1 PSTI is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease Gut 50 5 675 681 doi 10 1136 gut 50 5 675 ISSN 0017 5749 PMC 1773194 PMID 11950815 Howes Nathan Lerch Markus M Greenhalf William Stocken Deborah D Ellis Ian Simon Peter Truninger Kaspar Ammann Rudi Cavallini Giorgio Charnley Richard M Uomo Generoso March 2004 Clinical and genetic characteristics of hereditary pancreatitis in Europe Clinical Gastroenterology and Hepatology 2 3 252 261 doi 10 1016 S1542 3565 04 00013 8 PMID 15017610 McFaul C D 2006 02 01 Anticipation in familial pancreatic cancer Gut 55 2 252 258 doi 10 1136 gut 2005 065045 ISSN 0017 5749 PMC 1856528 PMID 15972300 Grocock C J Rebours V Delhaye M N Andren Sandberg A Weiss F U Mountford R Harcus M J Niemczyck E Vitone L J Dodd S Jorgensen M T 2010 03 01 The variable phenotype of the p A16V mutation of cationic trypsinogen PRSS1 in pancreatitis families Gut 59 3 357 363 doi 10 1136 gut 2009 186817 ISSN 0017 5749 PMID 19951905 S2CID 983450 External links editOfficial website Portals nbsp Medicine nbsp Science nbsp Technology Retrieved from https en wikipedia org w index php title European Registry of Hereditary Pancreatitis and Pancreatic Cancer amp oldid 1198932776, wikipedia, wiki, book, books, library,
