Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .[5]
ESRRB has been shown to be vital for the transition between a naïve pluripotent and primed pluripotent state in mammalian cells, and NANOG controls the expression of ESRRB in this scenario.[6]
ReferencesEdit
^ abcGRCh38: Ensembl release 89: ENSG00000119715 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021255 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Festuccia N, Halbritter F, Corsinotti A, Gagliardi A, Colby D, Tomlinson SR, Chambers I (November 2018). "Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation". The EMBO Journal. 37 (21): e95476. doi:10.15252/embj.201695476. PMC6213284. PMID 30275266.
Further readingEdit
Giguère V, Yang N, Segui P, Evans RM (January 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–94. Bibcode:1988Natur.331...91G. doi:10.1038/331091a0. PMID 3267207. S2CID 4275394.
Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V (October 1997). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene". Genomics. 45 (2): 320–326. doi:10.1006/geno.1997.4939. PMID 9344655.
Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, et al. (December 1997). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern". The Journal of Clinical Endocrinology and Metabolism. 82 (12): 4258–4265. doi:10.1210/jcem.82.12.4470. PMID 9398750.
Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, et al. (March 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–109. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (December 1999). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Molecular Endocrinology. 13 (12): 2151–2162. doi:10.1210/mend.13.12.0381. PMID 10598588.
Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE (April 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". Journal of Molecular Biology. 327 (4): 819–832. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265.
Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF (November 2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". The Journal of Comparative Neurology. 466 (2): 251–277. doi:10.1002/cne.10899. PMID 14528452. S2CID 86143014.
Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS (July 2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology. 145 (7): 3473–3486. doi:10.1210/en.2003-1682. PMID 15033914.
Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (August 2004). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB Journal. 18 (11): 1252–1254. doi:10.1096/fj.03-1088fje. PMID 15208259. S2CID 20159723.
Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, et al. (August 2004). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circulation Research. 95 (3): 269–275. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907.
Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA (February 2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". The Journal of Clinical Endocrinology and Metabolism. 90 (2): 1041–1046. doi:10.1210/jc.2004-1211. PMID 15536156.
Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, et al. (March 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–1844. doi:10.1210/jc.2004-1421. PMID 15598686.
Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB (February 2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". The Journal of Clinical Endocrinology and Metabolism. 91 (2): 569–579. doi:10.1210/jc.2004-1957. PMID 16332939.
estrogen, related, receptor, beta, also, known, esrrb, nr3b2, nuclear, receptor, subfamily, group, member, nuclear, receptor, that, humans, encoded, esrrb, estrogen, related, receptor, beta, gene, esrrbavailable, structurespdbortholog, search, pdbe, rcsblist, . Estrogen related receptor beta ERR b also known as ESRRB or NR3B2 nuclear receptor subfamily 3 group B member 2 is a nuclear receptor that in humans is encoded by the ESRRB Estrogen Related Receptor Beta gene 5 ESRRBAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1LO1IdentifiersAliasesESRRB DFNB35 ERR2 ERRb ESRL2 NR3B2 estrogen related receptor beta ERRbeta2 ERR beta 2 EsrrbExternal IDsOMIM 602167 MGI 1346832 HomoloGene 69108 GeneCards ESRRBGene location Human Chr Chromosome 14 human 1 Band14q24 3Start76 310 712 bp 1 End76 501 837 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 D2 12 40 49 cMStart86 407 891 bp 2 End86 568 402 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inkidneygastrocnemius muscleleft ventriclerenal medullabody of stomachskeletal muscle tissueretinal pigment epitheliumfundusganglionic eminenceprefrontal cortexTop expressed instria vascularisretinal pigment epitheliummorulablastocystsecondary oocyteooblasturethramale urethraampulla of semicircular canalouter nuclear layerMore reference expression dataBioGPSn aGene ontologyMolecular functionsteroid binding nuclear receptor activity zinc ion binding RNA polymerase II cis regulatory region sequence specific DNA binding DNA binding sequence specific DNA binding transcription factor binding metal ion binding steroid hormone receptor activity transcription coactivator activity protein binding RNA polymerase II complex binding cis regulatory region sequence specific DNA binding DNA binding transcription activator activity RNA polymerase II specific DNA binding transcription factor activity transcription factor activity RNA polymerase II distal enhancer sequence specific binding DNA binding transcription factor activity RNA polymerase II specific transcription factor activity RNA polymerase II core promoter proximal region sequence specific bindingCellular componentnucleus nucleoplasm condensed chromosome integrator complex chromosome cytoplasmBiological processregulation of transcription DNA templated positive regulation of transcription by RNA polymerase II embryonic placenta development transcription DNA templated steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter intracellular receptor signaling pathway stem cell population maintenance negative regulation of transcription by RNA polymerase II cell population proliferation stem cell division cell dedifferentiation photoreceptor cell maintenance positive regulation of transcription DNA templated inner ear development positive regulation of transcription involved in G1 S transition of mitotic cell cycle positive regulation of transcription involved in G2 M transition of mitotic cell cycle positive regulation of stem cell population maintenance regulation of stem cell division negative regulation of stem cell differentiation positive regulation of glycogen biosynthetic process positive regulation of glycolytic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez210326380EnsemblENSG00000119715ENSMUSG00000021255UniProtO95718Q61539RefSeq mRNA NM 004452NM 001379180NM 001159500NM 011934RefSeq protein NP 004443NP 001366109NP 001152972NP 036064Location UCSC Chr 14 76 31 76 5 MbChr 12 86 41 86 57 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction EditESRRB has been shown to be vital for the transition between a naive pluripotent and primed pluripotent state in mammalian cells and NANOG controls the expression of ESRRB in this scenario 6 References Edit a b c GRCh38 Ensembl release 89 ENSG00000119715 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021255 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene ESRRB estrogen related receptor beta Festuccia N Halbritter F Corsinotti A Gagliardi A Colby D Tomlinson SR Chambers I November 2018 Esrrb extinction triggers dismantling of naive pluripotency and marks commitment to differentiation The EMBO Journal 37 21 e95476 doi 10 15252 embj 201695476 PMC 6213284 PMID 30275266 Further reading EditGiguere V Yang N Segui P Evans RM January 1988 Identification of a new class of steroid hormone receptors Nature 331 6151 91 94 Bibcode 1988Natur 331 91G doi 10 1038 331091a0 PMID 3267207 S2CID 4275394 Sladek R Beatty B Squire J Copeland NG Gilbert DJ Jenkins NA Giguere V October 1997 Chromosomal mapping of the human and murine orphan receptors ERRalpha ESRRA and ERRbeta ESRRB and identification of a novel human ERRalpha related pseudogene Genomics 45 2 320 326 doi 10 1006 geno 1997 4939 PMID 9344655 Enmark E Pelto Huikko M Grandien K Lagercrantz S Lagercrantz J Fried G et al December 1997 Human estrogen receptor beta gene structure chromosomal localization and expression pattern The Journal of Clinical Endocrinology and Metabolism 82 12 4258 4265 doi 10 1210 jcem 82 12 4470 PMID 9398750 Chen F Zhang Q McDonald T Davidoff MJ Bailey W Bai C et al March 1999 Identification of two hERR2 related novel nuclear receptors utilizing bioinformatics and inverse PCR Gene 228 1 2 101 109 doi 10 1016 S0378 1119 98 00619 2 PMID 10072763 Xie W Hong H Yang NN Lin RJ Simon CM Stallcup MR Evans RM December 1999 Constitutive activation of transcription and binding of coactivator by estrogen related receptors 1 and 2 Molecular Endocrinology 13 12 2151 2162 doi 10 1210 mend 13 12 0381 PMID 10598588 Gearhart MD Holmbeck SM Evans RM Dyson HJ Wright PE April 2003 Monomeric complex of human orphan estrogen related receptor 2 with DNA a pseudo dimer interface mediates extended half site recognition Journal of Molecular Biology 327 4 819 832 doi 10 1016 S0022 2836 03 00183 9 PMID 12654265 Kruijver FP Balesar R Espila AM Unmehopa UA Swaab DF November 2003 Estrogen receptor beta distribution in the human hypothalamus similarities and differences with ER alpha distribution The Journal of Comparative Neurology 466 2 251 277 doi 10 1002 cne 10899 PMID 14528452 S2CID 86143014 Stossi F Barnett DH Frasor J Komm B Lyttle CR Katzenellenbogen BS July 2004 Transcriptional profiling of estrogen regulated gene expression via estrogen receptor ER alpha or ERbeta in human osteosarcoma cells distinct and common target genes for these receptors Endocrinology 145 7 3473 3486 doi 10 1210 en 2003 1682 PMID 15033914 Verdier Sevrain S Yaar M Cantatore J Traish A Gilchrest BA August 2004 Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism FASEB Journal 18 11 1252 1254 doi 10 1096 fj 03 1088fje PMID 15208259 S2CID 20159723 Smith LH Coats SR Qin H Petrie MS Covington JW Su M et al August 2004 Differential and opposing regulation of PAI 1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells Circulation Research 95 3 269 275 doi 10 1161 01 RES 0000136521 70093 f1 PMID 15217907 Liu PY Christian RC Ruan M Miller VM Fitzpatrick LA February 2005 Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease The Journal of Clinical Endocrinology and Metabolism 90 2 1041 1046 doi 10 1210 jc 2004 1211 PMID 15536156 Cheung CP Yu S Wong KB Chan LW Lai FM Wang X et al March 2005 Expression and functional study of estrogen receptor related receptors in human prostatic cells and tissues The Journal of Clinical Endocrinology and Metabolism 90 3 1830 1844 doi 10 1210 jc 2004 1421 PMID 15598686 Zhou W Liu Z Wu J Liu JH Hyder SM Antoniou E Lubahn DB February 2006 Identification and characterization of two novel splicing isoforms of human estrogen related receptor beta The Journal of Clinical Endocrinology and Metabolism 91 2 569 579 doi 10 1210 jc 2004 1957 PMID 16332939 This article incorporates text from the United States National Library of Medicine which is in the public domain This 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