This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.[7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000169242 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027954 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Holzman LB, Marks RM, Dixit VM (Nov 1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein". Molecular and Cellular Biology. 10 (11): 5830–8. doi:10.1128/mcb.10.11.5830. PMC361366. PMID 2233719.
^Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Apr 1996). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics. 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976.
Pandey A, Lindberg RA, Dixit VM (Sep 1995). "Cell signalling. Receptor orphans find a family". Current Biology. 5 (9): 986–9. doi:10.1016/S0960-9822(95)00195-3. PMID 8542290. S2CID 13338632.
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annual Review of Neuroscience. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (Mar 1998). "The Eph family receptors and ligands". Pharmacology & Therapeutics. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
Holder N, Klein R (May 1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN9780123646002. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (Jul 2000). "Roles of Eph receptors and ephrins in segmental patterning". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC1692797. PMID 11128993.
Wilkinson DG (Mar 2001). "Multiple roles of EPH receptors and ephrins in neural development". Nature Reviews. Neuroscience. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
Mahadevan D, Thanki N, Singh J, McPhie P, Zangrilli D, Wang LM, Guerrero C, LeVine H, Humblet C, Saldanha J (Jul 1995). "Structural studies on the PH domains of Db1, Sos1, IRS-1, and beta ARK1 and their differential binding to G beta gamma subunits". Biochemistry. 34 (28): 9111–7. doi:10.1021/bi00028a021. PMID 7619809.
Kozlosky CJ, Maraskovsky E, McGrew JT, VandenBos T, Teepe M, Lyman SD, Srinivasan S, Fletcher FA, Gayle RB, Cerretti DP (Jan 1995). "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins". Oncogene. 10 (2): 299–306. PMID 7838529.
Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD (Nov 1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9. Bibcode:1994Sci...266..816D. doi:10.1126/science.7973638. PMID 7973638.
Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E (Aug 1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors". The EMBO Journal. 13 (16): 3757–62. doi:10.1002/j.1460-2075.1994.tb06685.x. PMC395287. PMID 8070404.
Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD (Jul 1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
Ephnomenclaturecommittee (Aug 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
Nagel W, Schilcher P, Zeitlmann L, Kolanus W (Aug 1998). "The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function". Molecular Biology of the Cell. 9 (8): 1981–94. doi:10.1091/mbc.9.8.1981. PMC25450. PMID 9693361.
March 16, 2024
ephrin, protein, that, humans, encoded, efna1, gene, efna1available, structurespdbortholog, search, pdbe, rcsblist, codes3hei, 3mbw, 3czuidentifiersaliasesefna1, ecklg, efl1, eplg1, lerk, lerk1, tnfaip4, gmanexternal, idsomim, 191164, 103236, homologene, 3262,. Ephrin A1 is a protein that in humans is encoded by the EFNA1 gene 5 6 7 EFNA1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3HEI 3MBW 3CZUIdentifiersAliasesEFNA1 B61 ECKLG EFL1 EPLG1 LERK 1 LERK1 TNFAIP4 Ephrin A1 GMANExternal IDsOMIM 191164 MGI 103236 HomoloGene 3262 GeneCards EFNA1Gene location Human Chr Chromosome 1 human 1 Band1q22Start155 127 876 bp 1 End155 134 899 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 F1 3 39 04 cMStart89 179 040 bp 2 End89 188 449 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of liverright lungskin of abdomenupper lobe of left lungleft lobe of thyroid glandright lobe of thyroid glandminor salivary glandparotid glandrectumduodenumTop expressed inlipleft lung loberight lung lobecolonduodenumcorneal stromajejunumproximal tubuleleft colonleft lobe of liverMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein binding signaling receptor binding ephrin receptor bindingCellular componentmembrane plasma membrane integral component of plasma membrane anchored component of membrane extracellular exosome intracellular anatomical structure extracellular region anchored component of plasma membraneBiological processregulation of cell adhesion mediated by integrin ephrin receptor signaling pathway aortic valve morphogenesis cell cell signaling negative regulation of transcription by RNA polymerase II regulation of angiogenesis mitral valve morphogenesis endocardial cushion to mesenchymal transition involved in heart valve formation regulation of blood vessel endothelial cell migration regulation of axonogenesis neuron differentiation notochord positive regulation of peptidyl tyrosine phosphorylation substrate adhesion dependent cell spreading cell migration negative regulation of epithelial to mesenchymal transition negative regulation of dendritic spine morphogenesis regulation of peptidyl tyrosine phosphorylation negative regulation of thymocyte apoptotic process MAPK cascade angiogenesis axon guidance positive regulation of protein phosphorylation negative regulation of MAPK cascade positive regulation of MAPK cascade protein stabilization positive regulation of protein tyrosine kinase activity positive regulation of amyloid beta formation positive regulation of aspartic type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of proteolysis involved in cellular protein catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez194213636EnsemblENSG00000169242ENSMUSG00000027954UniProtP20827P52793RefSeq mRNA NM 004428NM 182685NM 001162425NM 010107RefSeq protein NP 004419NP 872626NP 001155897NP 034237Location UCSC Chr 1 155 13 155 13 MbChr 3 89 18 89 19 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of the ephrin EPH family The ephrins and EPH related receptors comprise the largest subfamily of receptor protein tyrosine kinases and have been implicated in mediating developmental events especially in the nervous system and in erythropoiesis Based on their structures and sequence relationships ephrins are divided into the ephrin A EFNA class which are anchored to the membrane by a glycosylphosphatidylinositol linkage and the ephrin B EFNB class which are transmembrane proteins This gene encodes an EFNA class ephrin which binds to the EPHA2 EPHA4 EPHA5 EPHA6 and EPHA7 receptors Two transcript variants that encode different isoforms were identified through sequence analysis 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000169242 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000027954 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Holzman LB Marks RM Dixit VM Nov 1990 A novel immediate early response gene of endothelium is induced by cytokines and encodes a secreted protein Molecular and Cellular Biology 10 11 5830 8 doi 10 1128 mcb 10 11 5830 PMC 361366 PMID 2233719 Cerretti DP Lyman SD Kozlosky CJ Copeland NG Gilbert DJ Jenkins NA Valentine V Kirstein MN Shapiro DN Morris SW Apr 1996 The genes encoding the eph related receptor tyrosine kinase ligands LERK 1 EPLG1 Epl1 LERK 3 EPLG3 Epl3 and LERK 4 EPLG4 Epl4 are clustered on human chromosome 1 and mouse chromosome 3 Genomics 33 2 277 82 doi 10 1006 geno 1996 0192 PMID 8660976 a b Entrez Gene EFNA1 ephrin A1 Further reading editPandey A Lindberg RA Dixit VM Sep 1995 Cell signalling Receptor orphans find a family Current Biology 5 9 986 9 doi 10 1016 S0960 9822 95 00195 3 PMID 8542290 S2CID 13338632 Flanagan JG Vanderhaeghen P 1998 The ephrins and Eph receptors in neural development Annual Review of Neuroscience 21 309 45 doi 10 1146 annurev neuro 21 1 309 PMID 9530499 Zhou R Mar 1998 The Eph family receptors and ligands Pharmacology amp Therapeutics 77 3 151 81 doi 10 1016 S0163 7258 97 00112 5 PMID 9576626 Holder N Klein R May 1999 Eph receptors and ephrins effectors of morphogenesis Development 126 10 2033 44 doi 10 1242 dev 126 10 2033 PMID 10207129 Wilkinson DG 2000 Eph receptors and ephrins regulators of guidance and assembly International Review of Cytology 196 177 244 doi 10 1016 S0074 7696 00 96005 4 ISBN 9780123646002 PMID 10730216 Xu Q Mellitzer G Wilkinson DG Jul 2000 Roles of Eph receptors and ephrins in segmental patterning Philosophical Transactions of the Royal Society of London Series B Biological Sciences 355 1399 993 1002 doi 10 1098 rstb 2000 0635 PMC 1692797 PMID 11128993 Wilkinson DG Mar 2001 Multiple roles of EPH receptors and ephrins in neural development Nature Reviews Neuroscience 2 3 155 64 doi 10 1038 35058515 PMID 11256076 S2CID 205014301 Mahadevan D Thanki N Singh J McPhie P Zangrilli D Wang LM Guerrero C LeVine H Humblet C Saldanha J Jul 1995 Structural studies on the PH domains of Db1 Sos1 IRS 1 and beta ARK1 and their differential binding to G beta gamma subunits Biochemistry 34 28 9111 7 doi 10 1021 bi00028a021 PMID 7619809 Kozlosky CJ Maraskovsky E McGrew JT VandenBos T Teepe M Lyman SD Srinivasan S Fletcher FA Gayle RB Cerretti DP Jan 1995 Ligands for the receptor tyrosine kinases hek and elk isolation of cDNAs encoding a family of proteins Oncogene 10 2 299 306 PMID 7838529 Davis S Gale NW Aldrich TH Maisonpierre PC Lhotak V Pawson T Goldfarb M Yancopoulos GD Nov 1994 Ligands for EPH related receptor tyrosine kinases that require membrane attachment or clustering for activity Science 266 5186 816 9 Bibcode 1994Sci 266 816D doi 10 1126 science 7973638 PMID 7973638 Beckmann MP Cerretti DP Baum P Vanden Bos T James L Farrah T Kozlosky C Hollingsworth T Shilling H Maraskovsky E Aug 1994 Molecular characterization of a family of ligands for eph related tyrosine kinase receptors The EMBO Journal 13 16 3757 62 doi 10 1002 j 1460 2075 1994 tb06685 x PMC 395287 PMID 8070404 Gale NW Holland SJ Valenzuela DM Flenniken A Pan L Ryan TE Henkemeyer M Strebhardt K Hirai H Wilkinson DG Pawson T Davis S Yancopoulos GD Jul 1996 Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis Neuron 17 1 9 19 doi 10 1016 S0896 6273 00 80276 7 PMID 8755474 S2CID 1075856 Ephnomenclaturecommittee Aug 1997 Unified nomenclature for Eph family receptors and their ligands the ephrins Eph Nomenclature Committee Cell 90 3 403 4 doi 10 1016 S0092 8674 00 80500 0 PMID 9267020 S2CID 26773768 Nagel W Schilcher P Zeitlmann L Kolanus W Aug 1998 The PH domain and the polybasic c domain of cytohesin 1 cooperate specifically in plasma membrane association and cellular function Molecular Biology of the Cell 9 8 1981 94 doi 10 1091 mbc 9 8 1981 PMC 25450 PMID 9693361 Retrieved from https en wikipedia org w index php title Ephrin A1 amp oldid 1190502248, wikipedia, wiki, book, books, library,
