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Emily Bernstein

February 29, 2024

Emily Bernstein is a professor at Mount Sinai School of Medicine known for her research on RNA interference, epigenetics, and cancer, especially melanoma.

Emily Bernstein
Alma materState University of New York at Stony Brook
Scientific career
InstitutionsMount Sinai College of Medicine
ThesisDicer, a novel RNase III, is required for RNA interference and development (2003)
Doctoral advisorGregory Hannon

Education and career edit

Bernstein received her B.S. from McGill University in 1998 and earned a Ph.D. from Stony Brook University in 2003.[1] Following her Ph.D. she was a postdoctoral researcher at Rockefeller University where she worked with David Allis.[2] In 2008 she moved to Mount Sinai School of Medicine where, as of 2022, she is a professor in the department of oncology and dermatology.[3]

Research edit

Bernstein is known for her research on RNA interference, epigenetics, and cell development. Her early research examined the enzyme Dicer, its role in cell development in mice,[4] and RNA interference.[5] While a postdoctoral researcher she examined linkages between non-coding RNA and chromatin[6][7] and DNA methylation.[8] Subsequently, she has worked on histones,[9][10] gene silencing,[11] and tumor cell development.[12][13] In 2022 her team discovered alterations to a gene which can lead to melanoma.[14][15]

Selected publications edit

  • Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. S2CID 4371481.
  • Hammond, Scott M.; Bernstein, Emily; Beach, David; Hannon, Gregory J. (2000). "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells". Nature. 404 (6775): 293–296. Bibcode:2000Natur.404..293H. doi:10.1038/35005107. ISSN 0028-0836. PMID 10749213. S2CID 9091863.
  • Goldberg, Aaron D.; Allis, C. David; Bernstein, Emily (2007-02-23). "Epigenetics: A Landscape Takes Shape". Cell. 128 (4): 635–638. doi:10.1016/j.cell.2007.02.006. ISSN 0092-8674. PMID 17320500. S2CID 16604496.
  • Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01). "Dicer is essential for mouse development". Nature Genetics. 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. S2CID 972721.

Awards and honors edit

In 2014 Bernstein received a young investigators award from the Pershing Square Foundation.[16]

References edit

  1. ^ . 2022-05-15. Archived from the original on 15 May 2022. Retrieved 2022-05-15.
  2. ^ "Investigator | Bernstein Laboratory". Bernstein Laboratory |. 2015-04-16. Retrieved 2022-05-15.
  3. ^ "Emily Bernstein | Mount Sinai - New York". Mount Sinai Health System. Retrieved 2022-05-15.
  4. ^ Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01). "Dicer is essential for mouse development". Nature Genetics. 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. S2CID 972721.
  5. ^ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. S2CID 4371481.
  6. ^ Bernstein, Emily; Allis, C. David (2005-07-15). "RNA meets chromatin". Genes & Development. 19 (14): 1635–1655. doi:10.1101/gad.1324305. ISSN 0890-9369. PMID 16024654.
  7. ^ Bernstein, Emily; Duncan, Elizabeth M.; Masui, Osamu; Gil, Jesus; Heard, Edith; Allis, C. David (2006). "Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin". Molecular and Cellular Biology. 26 (7): 2560–2569. doi:10.1128/MCB.26.7.2560-2569.2006. ISSN 0270-7306. PMC 1430336. PMID 16537902.
  8. ^ Ooi, Steen K. T.; Qiu, Chen; Bernstein, Emily; Li, Keqin; Jia, Da; Yang, Zhe; Erdjument-Bromage, Hediye; Tempst, Paul; Lin, Shau-Ping; Allis, C. David; Cheng, Xiaodong (2007). "DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA". Nature. 448 (7154): 714–717. Bibcode:2007Natur.448..714O. doi:10.1038/nature05987. ISSN 0028-0836. PMC 2650820. PMID 17687327.
  9. ^ Gaspar-Maia, Alexandre; Qadeer, Zulekha A.; Hasson, Dan; Ratnakumar, Kajan; Adrian Leu, N.; Leroy, Gary; Liu, Shichong; Costanzi, Carl; Valle-Garcia, David; Schaniel, Christoph; Lemischka, Ihor (2013-06-26). "MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency". Nature Communications. 4 (1): 1565. Bibcode:2013NatCo...4.1565G. doi:10.1038/ncomms2582. ISSN 2041-1723. PMC 4055026. PMID 23463008.
  10. ^ Vardabasso, Chiara; Hasson, Dan; Ratnakumar, Kajan; Chung, Chi-Yeh; Duarte, Luis F.; Bernstein, Emily (2014). "Histone variants: emerging players in cancer biology". Cellular and Molecular Life Sciences. 71 (3): 379–404. doi:10.1007/s00018-013-1343-z. ISSN 1420-682X. PMC 4025945. PMID 23652611.
  11. ^ Chicas, Agustin; Kapoor, Avnish; Wang, Xiaowo; Aksoy, Ozlem; Evertts, Adam G.; Zhang, Michael Q.; Garcia, Benjamin A.; Bernstein, Emily; Lowe, Scott W. (2012-06-05). "H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence". Proceedings of the National Academy of Sciences. 109 (23): 8971–8976. Bibcode:2012PNAS..109.8971C. doi:10.1073/pnas.1119836109. ISSN 0027-8424. PMC 3384172. PMID 22615382.
  12. ^ Sosa, Maria Soledad; Parikh, Falguni; Maia, Alexandre Gaspar; Estrada, Yeriel; Bosch, Almudena; Bragado, Paloma; Ekpin, Esther; George, Ajish; Zheng, Yang; Lam, Hung-Ming; Morrissey, Colm (2015). "NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes". Nature Communications. 6 (1): 6170. Bibcode:2015NatCo...6.6170S. doi:10.1038/ncomms7170. ISSN 2041-1723. PMC 4313575. PMID 25636082.
  13. ^ Strub, Thomas; Ghiraldini, Flavia G.; Carcamo, Saul; Li, Man; Wroblewska, Aleksandra; Singh, Rajendra; Goldberg, Matthew S.; Hasson, Dan; Wang, Zichen; Gallagher, Stuart J.; Hersey, Peter (2018). "SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling". Nature Communications. 9 (1): 3440. Bibcode:2018NatCo...9.3440S. doi:10.1038/s41467-018-05966-z. ISSN 2041-1723. PMC 6109055. PMID 30143629.
  14. ^ "Scientists discover gene mutation that signals aggressive melanoma". ScienceDaily. April 6, 2022. Retrieved 2022-05-15.
  15. ^ Carcamo, Saul; Nguyen, Christie B.; Grossi, Elena; Filipescu, Dan; Alpsoy, Aktan; Dhiman, Alisha; Sun, Dan; Narang, Sonali; Imig, Jochen; Martin, Tiphaine C.; Parsons, Ramon (2022-04-05). "Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma". Cell Reports. 39 (1): 110637. doi:10.1016/j.celrep.2022.110637. ISSN 2211-1247. PMC 9013128. PMID 35385731.
  16. ^ Benson, Barbara (May 5, 2014). "Wall Street funds cancer-research up-and-comers". Crain's New York Business; New York. Vol. 30, no. 18. p. 22 – via ProQuest.

External links edit

  • Emily Bernstein publications indexed by Google Scholar
  • Emily Bernstein PhD - 2014 Pershing Square Sohn Prize Winner on YouTube, May 14, 2016

February 29, 2024
emily, bernstein, professor, mount, sinai, school, medicine, known, research, interference, epigenetics, cancer, especially, melanoma, alma, materstate, university, york, stony, brookscientific, careerinstitutionsmount, sinai, college, medicinethesisdicer, nov. Emily Bernstein is a professor at Mount Sinai School of Medicine known for her research on RNA interference epigenetics and cancer especially melanoma Emily BernsteinAlma materState University of New York at Stony BrookScientific careerInstitutionsMount Sinai College of MedicineThesisDicer a novel RNase III is required for RNA interference and development 2003 Doctoral advisorGregory Hannon Contents 1 Education and career 2 Research 3 Selected publications 4 Awards and honors 5 References 6 External linksEducation and career editBernstein received her B S from McGill University in 1998 and earned a Ph D from Stony Brook University in 2003 1 Following her Ph D she was a postdoctoral researcher at Rockefeller University where she worked with David Allis 2 In 2008 she moved to Mount Sinai School of Medicine where as of 2022 she is a professor in the department of oncology and dermatology 3 Research editBernstein is known for her research on RNA interference epigenetics and cell development Her early research examined the enzyme Dicer its role in cell development in mice 4 and RNA interference 5 While a postdoctoral researcher she examined linkages between non coding RNA and chromatin 6 7 and DNA methylation 8 Subsequently she has worked on histones 9 10 gene silencing 11 and tumor cell development 12 13 In 2022 her team discovered alterations to a gene which can lead to melanoma 14 15 Selected publications editBernstein Emily Caudy Amy A Hammond Scott M Hannon Gregory J 2001 Role for a bidentate ribonuclease in the initiation step of RNA interference Nature 409 6818 363 366 doi 10 1038 35053110 ISSN 0028 0836 PMID 11201747 S2CID 4371481 Hammond Scott M Bernstein Emily Beach David Hannon Gregory J 2000 An RNA directed nuclease mediates post transcriptional gene silencing in Drosophila cells Nature 404 6775 293 296 Bibcode 2000Natur 404 293H doi 10 1038 35005107 ISSN 0028 0836 PMID 10749213 S2CID 9091863 Goldberg Aaron D Allis C David Bernstein Emily 2007 02 23 Epigenetics A Landscape Takes Shape Cell 128 4 635 638 doi 10 1016 j cell 2007 02 006 ISSN 0092 8674 PMID 17320500 S2CID 16604496 Bernstein Emily Kim Sang Yong Carmell Michelle A Murchison Elizabeth P Alcorn Heather Li Mamie Z Mills Alea A Elledge Stephen J Anderson Kathryn V Hannon Gregory J 2003 11 01 Dicer is essential for mouse development Nature Genetics 35 3 215 217 doi 10 1038 ng1253 ISSN 1061 4036 PMID 14528307 S2CID 972721 Awards and honors editIn 2014 Bernstein received a young investigators award from the Pershing Square Foundation 16 References edit Speakers 2022 05 15 Archived from the original on 15 May 2022 Retrieved 2022 05 15 Investigator Bernstein Laboratory Bernstein Laboratory 2015 04 16 Retrieved 2022 05 15 Emily Bernstein Mount Sinai New York Mount Sinai Health System Retrieved 2022 05 15 Bernstein Emily Kim Sang Yong Carmell Michelle A Murchison Elizabeth P Alcorn Heather Li Mamie Z Mills Alea A Elledge Stephen J Anderson Kathryn V Hannon Gregory J 2003 11 01 Dicer is essential for mouse development Nature Genetics 35 3 215 217 doi 10 1038 ng1253 ISSN 1061 4036 PMID 14528307 S2CID 972721 Bernstein Emily Caudy Amy A Hammond Scott M Hannon Gregory J 2001 Role for a bidentate ribonuclease in the initiation step of RNA interference Nature 409 6818 363 366 doi 10 1038 35053110 ISSN 0028 0836 PMID 11201747 S2CID 4371481 Bernstein Emily Allis C David 2005 07 15 RNA meets chromatin Genes amp Development 19 14 1635 1655 doi 10 1101 gad 1324305 ISSN 0890 9369 PMID 16024654 Bernstein Emily Duncan Elizabeth M Masui Osamu Gil Jesus Heard Edith Allis C David 2006 Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin Molecular and Cellular Biology 26 7 2560 2569 doi 10 1128 MCB 26 7 2560 2569 2006 ISSN 0270 7306 PMC 1430336 PMID 16537902 Ooi Steen K T Qiu Chen Bernstein Emily Li Keqin Jia Da Yang Zhe Erdjument Bromage Hediye Tempst Paul Lin Shau Ping Allis C David Cheng Xiaodong 2007 DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA Nature 448 7154 714 717 Bibcode 2007Natur 448 714O doi 10 1038 nature05987 ISSN 0028 0836 PMC 2650820 PMID 17687327 Gaspar Maia Alexandre Qadeer Zulekha A Hasson Dan Ratnakumar Kajan Adrian Leu N Leroy Gary Liu Shichong Costanzi Carl Valle Garcia David Schaniel Christoph Lemischka Ihor 2013 06 26 MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency Nature Communications 4 1 1565 Bibcode 2013NatCo 4 1565G doi 10 1038 ncomms2582 ISSN 2041 1723 PMC 4055026 PMID 23463008 Vardabasso Chiara Hasson Dan Ratnakumar Kajan Chung Chi Yeh Duarte Luis F Bernstein Emily 2014 Histone variants emerging players in cancer biology Cellular and Molecular Life Sciences 71 3 379 404 doi 10 1007 s00018 013 1343 z ISSN 1420 682X PMC 4025945 PMID 23652611 Chicas Agustin Kapoor Avnish Wang Xiaowo Aksoy Ozlem Evertts Adam G Zhang Michael Q Garcia Benjamin A Bernstein Emily Lowe Scott W 2012 06 05 H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma mediated gene silencing during cellular senescence Proceedings of the National Academy of Sciences 109 23 8971 8976 Bibcode 2012PNAS 109 8971C doi 10 1073 pnas 1119836109 ISSN 0027 8424 PMC 3384172 PMID 22615382 Sosa Maria Soledad Parikh Falguni Maia Alexandre Gaspar Estrada Yeriel Bosch Almudena Bragado Paloma Ekpin Esther George Ajish Zheng Yang Lam Hung Ming Morrissey Colm 2015 NR2F1 controls tumour cell dormancy via SOX9 and RARb driven quiescence programmes Nature Communications 6 1 6170 Bibcode 2015NatCo 6 6170S doi 10 1038 ncomms7170 ISSN 2041 1723 PMC 4313575 PMID 25636082 Strub Thomas Ghiraldini Flavia G Carcamo Saul Li Man Wroblewska Aleksandra Singh Rajendra Goldberg Matthew S Hasson Dan Wang Zichen Gallagher Stuart J Hersey Peter 2018 SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling Nature Communications 9 1 3440 Bibcode 2018NatCo 9 3440S doi 10 1038 s41467 018 05966 z ISSN 2041 1723 PMC 6109055 PMID 30143629 Scientists discover gene mutation that signals aggressive melanoma ScienceDaily April 6 2022 Retrieved 2022 05 15 Carcamo Saul Nguyen Christie B Grossi Elena Filipescu Dan Alpsoy Aktan Dhiman Alisha Sun Dan Narang Sonali Imig Jochen Martin Tiphaine C Parsons Ramon 2022 04 05 Altered BAF occupancy and transcription factor dynamics in PBAF deficient melanoma Cell Reports 39 1 110637 doi 10 1016 j celrep 2022 110637 ISSN 2211 1247 PMC 9013128 PMID 35385731 Benson Barbara May 5 2014 Wall Street funds cancer research up and comers Crain s New York Business New York Vol 30 no 18 p 22 via ProQuest External links editEmily Bernstein publications indexed by Google Scholar Emily Bernstein PhD 2014 Pershing Square Sohn Prize Winner on YouTube May 14 2016 Retrieved from https en wikipedia org w index php title Emily Bernstein amp oldid 1203063694, wikipedia, wiki, book, books, library,

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