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Eleftheria Maratos-Flier

March 27, 2023

Eleftheria Maratos-Flier is an American endocrinologist,[1] and emerita Professor of Medicine at Harvard Medical School,[2] best known for her expertise in the pathophysiology and prevention of obesity-related metabolic disorders,[3][4] and for her discoveries on the neuroendocrine control of feeding behaviour.[5][6] She is a contributing author to known textbooks and reviews in internal medicine,[7] endocrinology,[8] and physiology.[9] Her marriage with professor Jeffrey Flier, was noted by Forbes[10] as a lasting and productive bond between eminent medical scholars.[11] They have two adult daughters who are also physicians. She is also known as Terry Maratos-Flier.[12]

Education

In 1972, she graduated with a BA in Chemistry from New York University, New York, NY.[13] In 1976, she graduated as an MD from the Mount Sinai School of Medicine, New York, NY,[14] followed by internship and residency training in internal medicine at George Washington University Hospital, Washington, DC.[15] In Massachusetts (1978-1981), she pursued further residency training in internal medicine at Beth Israel Hospital, postdoctoral research fellowship at Harvard School of Public Health, and Clinical Fellowship at the Joslin Diabetes Center and Brigham and Women’s Hospital.[2][15]

Career

Since 1982 she has taught at Harvard Medical School, becoming a full Professor of Medicine from 2010 to 2018, when she became professor emerita.[16] She has been an associate member of the Broad Institute,[17] and a Principal Investigator of many NIH-funded research grants.[18] She has also been an attending endocrinologist at Beth Israel Deaconess Medical Center, where she still provides care for patients with metabolic disease.[19] From 2018, she has been Director, Translational Medicine, at Novartis Institutes of Biomedical Research, Cambridge, MA.,[20] recently moving to Alnylam to serve as a director of clinical research. She has authored more than 100 peer reviewed manuscripts,[21] most of them studying aspects of obesity and type II diabetes in experimental mouse models, and also in clinical disease. She also authored the obesity chapters of the 20th edition of Harrison's Principles of Internal Medicine (jointly with Jeffrey Flier),[7] and the 14th edition of Williams Textbook of Endocrinology.[8] In 2016, she contributed a seminal article to the Annual Review of Physiology on the physiology of Fibroblast Growth Factor 21.[9]

Awards

  • 1971 - Undergraduate Award in Analytical Chemistry from the ACS to outstanding undergraduate chemistry students.[13]
  • 2011 - Saul Horowitz Distinguished Alumni Award, given for outstanding achievements since graduation from the Icahn School of Medicine at Mount Sinai.[14]

Selected works

Maratos-Flier's research papers have been cited over 15,600 times.[21] Her most cited papers are:

  • Qu, Daqing; Ludwig, David S.; Gammeltoft, Steen; Piper, Megan; Pelleymounter, Mary Ann; Cullen, Mary Jane; Mathes, Wendy Foulds; Przypek, Jeanne; Kanarek, Robin; Maratos-Flier, Eleftheria (1996-03-01). "A role for melanin-concentrating hormone in the central regulation of feeding behaviour". Nature. 380 (6571): 243–247. doi:10.1038/380243a0.PMID 8637571.[6]
  • Ahima, Rexford S.; Prabakaran, Daniel; Mantzoros, Christos; Qu, Daqing; Lowell, Bradford; Maratos-Flier, Eleftheria; Flier, Jeffrey S. (1996-07-01). "Role of leptin in the neuroendocrine response to fasting". Nature. 382 (6588): 250–252. doi:10.1038/382250a0. PMID 8717038.[23]
  • Badman, Michael K.; Pissios, Pavlos; Kennedy, Adam R.; Koukos, George; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007-06-01). "Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States". Cell Metabolism. 5 (6): 426–437. doi:10.1016/j.cmet.2007.05.002. PMID 17550778.[24]
  • Fisher, ffolliott M.; Kleiner, Sandra; Douris, Nicholas; Fox, Elliott C.; Mepani, Rina J.; Verdeguer, Francisco; Wu, Jun; Kharitonenkov, Alexei; Flier, Jeffrey S.; Maratos-Flier, Eleftheria; Spiegelman, Bruce M. (2012-02-01). "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271–281. doi:10.1101/gad.177857.111. PMID 22302939[25]

References

  1. ^ "Meet the 2020 Laureates: Eleftheria Maratos-Flier, MD". Endocrine News. 2020-03-05. Retrieved 2022-03-19.
  2. ^ a b "SSIB 2017 MARS Speakers". www.ssib.org. Retrieved 2022-03-19.
  3. ^ Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007). "What Fuels Fat". Scientific American. 297 (3): 72–81. Bibcode:2007SciAm.297c..72F. doi:10.1038/scientificamerican0907-72. PMID 17784627. Retrieved 2022-03-18.
  4. ^ "Can't resist candy? You may have this mutation". PBS NewsHour. 2017-05-08. Retrieved 2022-03-18.
  5. ^ Ahima, Rexford S.; Prabakaran, Daniel; Mantzoros, Christos; Qu, Daqing; Lowell, Bradford; Maratos-Flier, Eleftheria; Flier, Jeffrey S. (1996-07-01). "Role of leptin in the neuroendocrine response to fasting". Nature. 382 (6588): 250–252. Bibcode:1996Natur.382..250A. doi:10.1038/382250a0. ISSN 0028-0836. PMID 8717038. S2CID 4331304.
  6. ^ a b Qu, Daqing; Ludwig, David S.; Gammeltoft, Steen; Piper, Megan; Pelleymounter, Mary Ann; Cullen, Mary Jane; Mathes, Wendy Foulds; Przypek, Jeanne; Kanarek, Robin; Maratos-Flier, Eleftheria (1996-03-01). "A role for melanin-concentrating hormone in the central regulation of feeding behaviour". Nature. 380 (6571): 243–247. Bibcode:1996Natur.380..243Q. doi:10.1038/380243a0. ISSN 0028-0836. PMID 8637571. S2CID 42701304.
  7. ^ a b Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2018). Harrison's principles of internal medicine. Chapter 394: Pathobiology of Obesity (20th ed.). New York: McGraw Hill. ISBN 978-1-259-64403-0. OCLC 1029074059.
  8. ^ a b Maratos-Flier, Elephteria (2020). Obesity chapter in Williams textbook of endocrinology. Shlomo Melmed, Richard J. Auchus, Allison B. Goldfine, Ronald Koenig, Clifford J. Rosen, Robert Hardin Preceded by: Williams (14 ed.). Philadelphia, PA: Saunders. pp. 1567–1580, Obesity chapter. ISBN 978-0323555968. OCLC 1131863622.
  9. ^ a b Fisher, Ffolliott Martin; Maratos-Flier, Eleftheria (2016). "Understanding the Physiology of FGF21". Annual Review of Physiology. 78: 223–241. doi:10.1146/annurev-physiol-021115-105339. ISSN 1545-1585. PMID 26654352.
  10. ^ Shaywitz, David. "Power couples: common in medicine, rare in business?". Forbes. Retrieved 2022-03-02.
  11. ^ Flier, Jeffrey S. (2012-09-01). "Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21". The Yale Journal of Biology and Medicine. 85 (3): 405–414. ISSN 1551-4056. PMC 3447204. PMID 23012588.
  12. ^ "ORCID". orcid.org. Retrieved 2022-03-02.
  13. ^ a b "American Chemical Society Award Winners, Washington, D.C." Analytical Chemistry. 43 (12): 63A–73A. 1971-10-01. doi:10.1021/ac60306a706. ISSN 0003-2700.
  14. ^ a b "Alumni Award Recipients". alumni.icahn.mssm.edu. Retrieved 2022-03-19.
  15. ^ a b "Eleftheria Maratos-Flier, MD".
  16. ^ "New Appointments to Full Professor (12/22/10)". hms.harvard.edu. Retrieved 2022-03-19.
  17. ^ "Team". Broad Institute. 2008-04-23. Retrieved 2022-03-19.
  18. ^ "Eleftheria Maratos-Flier". grantome.com.
  19. ^ "Meet Our Endocrinology, Diabetes and Metabolism Experts". www.bidmc.org. Retrieved 2022-03-19.
  20. ^ Rader, Daniel J.; Maratos-Flier, Eleftheria; Nguyen, Amanda; Hom, Doug; Ferriere, Michael; Li, Yifang; Kompa, Jill; Martic, Miljen; Hinder, Markus; Basson, Craig T.; Yowe, David (2022-01-01). "LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia". The Journal of Clinical Endocrinology and Metabolism. 107 (1): e57–e70. doi:10.1210/clinem/dgab624. ISSN 1945-7197. PMC 8914500. PMID 34431493.
  21. ^ a b "Scopus preview - Maratos-Flier, Eleftheria - Author details - Scopus". www.scopus.com. Retrieved 2022-03-19.
  22. ^ "An Appetite for Research: Q&A with Eleftheria Maratos-Flier, MD". Endocrine News. 2020-10-05. Retrieved 2022-03-02.
  23. ^ Ahima, Rexford S.; Prabakaran, Daniel; Mantzoros, Christos; Qu, Daqing; Lowell, Bradford; Maratos-Flier, Eleftheria; Flier, Jeffrey S. (1996-07-01). "Role of leptin in the neuroendocrine response to fasting". Nature. 382 (6588): 250–252. Bibcode:1996Natur.382..250A. doi:10.1038/382250a0. ISSN 0028-0836. PMID 8717038. S2CID 4331304.
  24. ^ Badman, Michael K.; Pissios, Pavlos; Kennedy, Adam R.; Koukos, George; Flier, Jeffrey S.; Maratos-Flier, Eleftheria (2007-06-01). "Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States". Cell Metabolism. 5 (6): 426–437. doi:10.1016/j.cmet.2007.05.002. PMID 17550778.
  25. ^ Fisher, ffolliott M.; Kleiner, Sandra; Douris, Nicholas; Fox, Elliott C.; Mepani, Rina J.; Verdeguer, Francisco; Wu, Jun; Kharitonenkov, Alexei; Flier, Jeffrey S.; Maratos-Flier, Eleftheria; Spiegelman, Bruce M. (2012-02-01). "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271–281. doi:10.1101/gad.177857.111. ISSN 0890-9369. PMC 3278894. PMID 22302939.

March 27, 2023
eleftheria, maratos, flier, american, endocrinologist, emerita, professor, medicine, harvard, medical, school, best, known, expertise, pathophysiology, prevention, obesity, related, metabolic, disorders, discoveries, neuroendocrine, control, feeding, behaviour. Eleftheria Maratos Flier is an American endocrinologist 1 and emerita Professor of Medicine at Harvard Medical School 2 best known for her expertise in the pathophysiology and prevention of obesity related metabolic disorders 3 4 and for her discoveries on the neuroendocrine control of feeding behaviour 5 6 She is a contributing author to known textbooks and reviews in internal medicine 7 endocrinology 8 and physiology 9 Her marriage with professor Jeffrey Flier was noted by Forbes 10 as a lasting and productive bond between eminent medical scholars 11 They have two adult daughters who are also physicians She is also known as Terry Maratos Flier 12 Contents 1 Education 2 Career 2 1 Awards 3 Selected works 4 ReferencesEducation EditIn 1972 she graduated with a BA in Chemistry from New York University New York NY 13 In 1976 she graduated as an MD from the Mount Sinai School of Medicine New York NY 14 followed by internship and residency training in internal medicine at George Washington University Hospital Washington DC 15 In Massachusetts 1978 1981 she pursued further residency training in internal medicine at Beth Israel Hospital postdoctoral research fellowship at Harvard School of Public Health and Clinical Fellowship at the Joslin Diabetes Center and Brigham and Women s Hospital 2 15 Career EditSince 1982 she has taught at Harvard Medical School becoming a full Professor of Medicine from 2010 to 2018 when she became professor emerita 16 She has been an associate member of the Broad Institute 17 and a Principal Investigator of many NIH funded research grants 18 She has also been an attending endocrinologist at Beth Israel Deaconess Medical Center where she still provides care for patients with metabolic disease 19 From 2018 she has been Director Translational Medicine at Novartis Institutes of Biomedical Research Cambridge MA 20 recently moving to Alnylam to serve as a director of clinical research She has authored more than 100 peer reviewed manuscripts 21 most of them studying aspects of obesity and type II diabetes in experimental mouse models and also in clinical disease She also authored the obesity chapters of the 20th edition of Harrison s Principles of Internal Medicine jointly with Jeffrey Flier 7 and the 14th edition of Williams Textbook of Endocrinology 8 In 2016 she contributed a seminal article to the Annual Review of Physiology on the physiology of Fibroblast Growth Factor 21 9 Awards Edit 1971 Undergraduate Award in Analytical Chemistry from the ACS to outstanding undergraduate chemistry students 13 2011 Saul Horowitz Distinguished Alumni Award given for outstanding achievements since graduation from the Icahn School of Medicine at Mount Sinai 14 2020 Roy O Greep Award for Outstanding Research given by the Endocrine Society 22 Selected works EditMaratos Flier s research papers have been cited over 15 600 times 21 Her most cited papers are Qu Daqing Ludwig David S Gammeltoft Steen Piper Megan Pelleymounter Mary Ann Cullen Mary Jane Mathes Wendy Foulds Przypek Jeanne Kanarek Robin Maratos Flier Eleftheria 1996 03 01 A role for melanin concentrating hormone in the central regulation of feeding behaviour Nature 380 6571 243 247 doi 10 1038 380243a0 PMID 8637571 6 Ahima Rexford S Prabakaran Daniel Mantzoros Christos Qu Daqing Lowell Bradford Maratos Flier Eleftheria Flier Jeffrey S 1996 07 01 Role of leptin in the neuroendocrine response to fasting Nature 382 6588 250 252 doi 10 1038 382250a0 PMID 8717038 23 Badman Michael K Pissios Pavlos Kennedy Adam R Koukos George Flier Jeffrey S Maratos Flier Eleftheria 2007 06 01 Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARa and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States Cell Metabolism 5 6 426 437 doi 10 1016 j cmet 2007 05 002 PMID 17550778 24 Fisher ffolliott M Kleiner Sandra Douris Nicholas Fox Elliott C Mepani Rina J Verdeguer Francisco Wu Jun Kharitonenkov Alexei Flier Jeffrey S Maratos Flier Eleftheria Spiegelman Bruce M 2012 02 01 FGF21 regulates PGC 1a and browning of white adipose tissues in adaptive thermogenesis Genes amp Development 26 3 271 281 doi 10 1101 gad 177857 111 PMID 22302939 25 References Edit Meet the 2020 Laureates Eleftheria Maratos Flier MD Endocrine News 2020 03 05 Retrieved 2022 03 19 a b SSIB 2017 MARS Speakers www ssib org Retrieved 2022 03 19 Flier Jeffrey S Maratos Flier Eleftheria 2007 What Fuels Fat Scientific American 297 3 72 81 Bibcode 2007SciAm 297c 72F doi 10 1038 scientificamerican0907 72 PMID 17784627 Retrieved 2022 03 18 Can t resist candy You may have this mutation PBS NewsHour 2017 05 08 Retrieved 2022 03 18 Ahima Rexford S Prabakaran Daniel Mantzoros Christos Qu Daqing Lowell Bradford Maratos Flier Eleftheria Flier Jeffrey S 1996 07 01 Role of leptin in the neuroendocrine response to fasting Nature 382 6588 250 252 Bibcode 1996Natur 382 250A doi 10 1038 382250a0 ISSN 0028 0836 PMID 8717038 S2CID 4331304 a b Qu Daqing Ludwig David S Gammeltoft Steen Piper Megan Pelleymounter Mary Ann Cullen Mary Jane Mathes Wendy Foulds Przypek Jeanne Kanarek Robin Maratos Flier Eleftheria 1996 03 01 A role for melanin concentrating hormone in the central regulation of feeding behaviour Nature 380 6571 243 247 Bibcode 1996Natur 380 243Q doi 10 1038 380243a0 ISSN 0028 0836 PMID 8637571 S2CID 42701304 a b Flier Jeffrey S Maratos Flier Eleftheria 2018 Harrison s principles of internal medicine Chapter 394 Pathobiology of Obesity 20th ed New York McGraw Hill ISBN 978 1 259 64403 0 OCLC 1029074059 a b Maratos Flier Elephteria 2020 Obesity chapter in Williams textbook of endocrinology Shlomo Melmed Richard J Auchus Allison B Goldfine Ronald Koenig Clifford J Rosen Robert Hardin Preceded by Williams 14 ed Philadelphia PA Saunders pp 1567 1580 Obesity chapter ISBN 978 0323555968 OCLC 1131863622 a b Fisher Ffolliott Martin Maratos Flier Eleftheria 2016 Understanding the Physiology of FGF21 Annual Review of Physiology 78 223 241 doi 10 1146 annurev physiol 021115 105339 ISSN 1545 1585 PMID 26654352 Shaywitz David Power couples common in medicine rare in business Forbes Retrieved 2022 03 02 Flier Jeffrey S 2012 09 01 Hormone resistance in diabetes and obesity insulin leptin and FGF21 The Yale Journal of Biology and Medicine 85 3 405 414 ISSN 1551 4056 PMC 3447204 PMID 23012588 ORCID orcid org Retrieved 2022 03 02 a b American Chemical Society Award Winners Washington D C Analytical Chemistry 43 12 63A 73A 1971 10 01 doi 10 1021 ac60306a706 ISSN 0003 2700 a b Alumni Award Recipients alumni icahn mssm edu Retrieved 2022 03 19 a b Eleftheria Maratos Flier MD New Appointments to Full Professor 12 22 10 hms harvard edu Retrieved 2022 03 19 Team Broad Institute 2008 04 23 Retrieved 2022 03 19 Eleftheria Maratos Flier grantome com Meet Our Endocrinology Diabetes and Metabolism Experts www bidmc org Retrieved 2022 03 19 Rader Daniel J Maratos Flier Eleftheria Nguyen Amanda Hom Doug Ferriere Michael Li Yifang Kompa Jill Martic Miljen Hinder Markus Basson Craig T Yowe David 2022 01 01 LLF580 an FGF21 Analog Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia The Journal of Clinical Endocrinology and Metabolism 107 1 e57 e70 doi 10 1210 clinem dgab624 ISSN 1945 7197 PMC 8914500 PMID 34431493 a b Scopus preview Maratos Flier Eleftheria Author details Scopus www scopus com Retrieved 2022 03 19 An Appetite for Research Q amp A with Eleftheria Maratos Flier MD Endocrine News 2020 10 05 Retrieved 2022 03 02 Ahima Rexford S Prabakaran Daniel Mantzoros Christos Qu Daqing Lowell Bradford Maratos Flier Eleftheria Flier Jeffrey S 1996 07 01 Role of leptin in the neuroendocrine response to fasting Nature 382 6588 250 252 Bibcode 1996Natur 382 250A doi 10 1038 382250a0 ISSN 0028 0836 PMID 8717038 S2CID 4331304 Badman Michael K Pissios Pavlos Kennedy Adam R Koukos George Flier Jeffrey S Maratos Flier Eleftheria 2007 06 01 Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARa and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States Cell Metabolism 5 6 426 437 doi 10 1016 j cmet 2007 05 002 PMID 17550778 Fisher ffolliott M Kleiner Sandra Douris Nicholas Fox Elliott C Mepani Rina J Verdeguer Francisco Wu Jun Kharitonenkov Alexei Flier Jeffrey S Maratos Flier Eleftheria Spiegelman Bruce M 2012 02 01 FGF21 regulates PGC 1a and browning of white adipose tissues in adaptive thermogenesis Genes amp Development 26 3 271 281 doi 10 1101 gad 177857 111 ISSN 0890 9369 PMC 3278894 PMID 22302939 Retrieved from https en wikipedia org w index php title Eleftheria Maratos Flier amp oldid 1138907187, wikipedia, wiki, book, books, library,

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