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Wikipedia

EXTL3

April 13, 2024

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.[5][6][7][8]

EXTL3
Identifiers
AliasesEXTL3, BOTV, EXTL1L, EXTR1, REGR, RPR, exostosin like glycosyltransferase 3, ISDNA
External IDsOMIM: 605744 MGI: 1860765 HomoloGene: 1103 GeneCards: EXTL3
Orthologs
SpeciesHumanMouse
Entrez

2137

54616

Ensembl

ENSG00000012232

ENSMUSG00000021978

UniProt

O43909

Q9WVL6
Q6P1H4

RefSeq (mRNA)

NM_001440

NM_018788
NM_001360385

RefSeq (protein)

NP_001431

Location (UCSC)Chr 8: 28.6 – 28.76 MbChr 14: 65.29 – 65.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000012232 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021978 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Van Hul W, Wuyts W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Bossuyt P, Willems PJ (Apr 1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family". Genomics. 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.
  6. ^ Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
  7. ^ Mizuno K, Irie S, Sato TA (Mar 2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha". Cell Signal. 13 (2): 125–30. doi:10.1016/S0898-6568(00)00144-3. PMID 11257457.
  8. ^ "Entrez Gene: EXTL3 exostoses (multiple)-like 3".

Further reading edit

  • Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family". Biochem. Biophys. Res. Commun. 243 (1): 61–6. doi:10.1006/bbrc.1997.8062. PMID 9473480.
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • McCormick C, Duncan G, Goutsos KT, Tufaro F (2000). "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. Bibcode:2000PNAS...97..668M. doi:10.1073/pnas.97.2.668. PMC 15388. PMID 10639137.
  • Kobayashi S, Akiyama T, Nata K, et al. (2000). "Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor". J. Biol. Chem. 275 (15): 10723–6. doi:10.1074/jbc.275.15.10723. PMID 10753861.
  • Kim BT, Kitagawa H, Tamura Ji J, et al. (2002). "Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation". J. Biol. Chem. 277 (16): 13659–65. doi:10.1074/jbc.M111630200. PMID 11832488.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Bishnupuri KS, Luo Q, Korzenik JR, et al. (2007). "Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes". Cancer Biol. Ther. 5 (12): 1714–20. doi:10.4161/cbt.5.12.3469. PMID 17106246.


 

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

April 13, 2024
extl3, exostosin, like, protein, that, humans, encoded, gene, identifiersaliases, botv, extl1l, extr1, regr, exostosin, like, glycosyltransferase, isdnaexternal, idsomim, 605744, 1860765, homologene, 1103, genecards, gene, location, human, chromosome, human, b. Exostosin like 3 is a protein that in humans is encoded by the EXTL3 gene 5 6 7 8 EXTL3IdentifiersAliasesEXTL3 BOTV EXTL1L EXTR1 REGR RPR exostosin like glycosyltransferase 3 ISDNAExternal IDsOMIM 605744 MGI 1860765 HomoloGene 1103 GeneCards EXTL3Gene location Human Chr Chromosome 8 human 1 Band8p21 1Start28 600 469 bp 1 End28 756 561 bp 1 Gene location Mouse Chr Chromosome 14 mouse 2 Band14 14 D1Start65 289 509 bp 2 End65 387 304 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed instromal cell of endometriumganglionic eminenceislet of Langerhansprefrontal cortexgastric mucosafrontal poleBrodmann area 10left ventriclesmooth muscle tissuemiddle frontal gyrusTop expressed inaortic valveascending aortainternal carotid arteryexternal carotid arteryrenal corpusclepiriform cortexentorhinal cortexatriumpineal glandvisual cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontransferase activity glucuronyl galactosyl proteoglycan 4 alpha N acetylglucosaminyltransferase activity metal ion binding glycosyltransferase activityCellular componentintegral component of membrane membrane endoplasmic reticulum endoplasmic reticulum membrane Golgi apparatusBiological processpositive regulation of cell growth IRE1 mediated unfolded protein response heparan sulfate proteoglycan biosynthetic process protein glycosylationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez213754616EnsemblENSG00000012232ENSMUSG00000021978UniProtO43909Q9WVL6Q6P1H4RefSeq mRNA NM 001440NM 018788NM 001360385RefSeq protein NP 001431NP 061258NP 001347314NP 001391867NP 001391868NP 001391869NP 001391870NP 001391871NP 001391872NP 001391873NP 001391874NP 001391875Location UCSC Chr 8 28 6 28 76 MbChr 14 65 29 65 39 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000012232 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021978 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Van Hul W Wuyts W Hendrickx J Speleman F Wauters J De Boulle K Van Roy N Bossuyt P Willems PJ Apr 1998 Identification of a third EXT like gene EXTL3 belonging to the EXT gene family Genomics 47 2 230 7 doi 10 1006 geno 1997 5101 PMID 9479495 Wuyts W Van Hul W Hendrickx J Speleman F Wauters J De Boulle K Van Roy N Van Agtmael T Bossuyt P Willems PJ Mar 1998 Identification and characterization of a novel member of the EXT gene family EXTL2 Eur J Hum Genet 5 6 382 9 doi 10 1159 000484796 PMID 9450183 Mizuno K Irie S Sato TA Mar 2001 Overexpression of EXTL3 EXTR1 enhances NF kappaB activity induced by TNF alpha Cell Signal 13 2 125 30 doi 10 1016 S0898 6568 00 00144 3 PMID 11257457 Entrez Gene EXTL3 exostoses multiple like 3 Further reading editSaito T Seki N Yamauchi M et al 1998 Structure chromosomal location and expression profile of EXTR1 and EXTR2 new members of the multiple exostoses gene family Biochem Biophys Res Commun 243 1 61 6 doi 10 1006 bbrc 1997 8062 PMID 9473480 Nagase T Ishikawa K Miyajima N et al 1998 Prediction of the coding sequences of unidentified human genes IX The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro DNA Res 5 1 31 9 doi 10 1093 dnares 5 1 31 PMID 9628581 McCormick C Duncan G Goutsos KT Tufaro F 2000 The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate Proc Natl Acad Sci U S A 97 2 668 73 Bibcode 2000PNAS 97 668M doi 10 1073 pnas 97 2 668 PMC 15388 PMID 10639137 Kobayashi S Akiyama T Nata K et al 2000 Identification of a receptor for reg regenerating gene protein a pancreatic beta cell regeneration factor J Biol Chem 275 15 10723 6 doi 10 1074 jbc 275 15 10723 PMID 10753861 Kim BT Kitagawa H Tamura Ji J et al 2002 Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N acetylglucosamine transferase in the heparan sulfate biosynthesis chain initiation and elongation J Biol Chem 277 16 13659 65 doi 10 1074 jbc M111630200 PMID 11832488 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Bishnupuri KS Luo Q Korzenik JR et al 2007 Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti apoptotic genes Cancer Biol Ther 5 12 1714 20 doi 10 4161 cbt 5 12 3469 PMID 17106246 nbsp This article on a gene on human chromosome 8 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title EXTL3 amp oldid 1115869286, wikipedia, wiki, book, books, library,

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