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Wikipedia

EPS15

April 11, 2024

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.[5]

EPS15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPS15, AF-1P, AF1P, MLLT5, epidermal growth factor receptor pathway substrate 15
External IDsOMIM: 600051 MGI: 104583 HomoloGene: 128359 GeneCards: EPS15
Orthologs
SpeciesHumanMouse
Entrez

2060

13858

Ensembl

ENSG00000085832

ENSMUSG00000028552

UniProt

P42566

P42567

RefSeq (mRNA)

NM_001159969
NM_001981

NM_001159964
NM_007943

RefSeq (protein)

NP_001153441
NP_001972

NP_001153436
NP_031969

Location (UCSC)Chr 1: 51.35 – 51.52 MbChr 4: 109.14 – 109.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[6]

Interactions edit

EPS15 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085832 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028552 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wong WT, Kraus MH, Carlomagno F, Zelano A, Druck T, Croce CM, Huebner K, Di Fiore PP (Jun 1994). "The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32". Oncogene. 9 (6): 1591–7. PMID 8183552.
  6. ^ "Entrez Gene: EPS15 epidermal growth factor receptor pathway substrate 15".
  7. ^ Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H (June 1995). "The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R". J. Biol. Chem. 270 (25): 15341–7. doi:10.1074/jbc.270.25.15341. PMID 7797522.
  8. ^ Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (August 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
  9. ^ Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. doi:10.1074/jbc.275.20.15271. PMID 10809762.
  10. ^ Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14): 12513–21. doi:10.1074/jbc.M210843200. PMID 12551915.
  11. ^ Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP (December 1999). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport". J. Cell Biol. 147 (7): 1379–84. doi:10.1083/jcb.147.7.1379. PMC 2174238. PMID 10613896.
  12. ^ Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (July 1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441. PMID 10393179.

Further reading edit

  • Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H (1995). "The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R". J. Biol. Chem. 270 (25): 15341–7. doi:10.1074/jbc.270.25.15341. PMID 7797522.
  • Bernard OA, Mauchauffe M, Mecucci C, Van den Berghe H, Berger R (1994). "A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL". Oncogene. 9 (4): 1039–45. PMID 8134107.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein". J. Biol. Chem. 271 (20): 12111–6. doi:10.1074/jbc.271.20.12111. PMID 8662627.
  • Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T (1996). "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins". J. Biol. Chem. 271 (24): 14468–72. doi:10.1074/jbc.271.24.14468. PMID 8662907.
  • van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM (1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin". J. Cell Biol. 136 (4): 811–21. doi:10.1083/jcb.136.4.811. PMC 2132490. PMID 9049247.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Tebar F, Confalonieri S, Carter RE, Di Fiore PP, Sorkin A (1997). "Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region". J. Biol. Chem. 272 (24): 15413–8. doi:10.1074/jbc.272.24.15413. PMID 9182572.
  • Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
  • Cupers P, ter Haar E, Boll W, Kirchhausen T (1998). "Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15". J. Biol. Chem. 272 (52): 33430–4. doi:10.1074/jbc.272.52.33430. PMID 9407139.
  • Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler MH, Salcini AE, Di Fiore PP, De Camilli P (1998). "Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15". FEBS Lett. 419 (2–3): 175–80. doi:10.1016/S0014-5793(97)01451-8. PMID 9428629. S2CID 45186831.
  • Benmerah A, Lamaze C, Bègue B, Schmid SL, Dautry-Varsat A, Cerf-Bensussan N (1998). "AP-2/Eps15 interaction is required for receptor-mediated endocytosis". J. Cell Biol. 140 (5): 1055–62. doi:10.1083/jcb.140.5.1055. PMC 2132690. PMID 9490719.
  • de Beer T, Carter RE, Lobel-Rice KE, Sorkin A, Overduin M (1998). "Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain". Science. 281 (5381): 1357–60. Bibcode:1998Sci...281.1357D. doi:10.1126/science.281.5381.1357. PMID 9721102.
  • Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
  • Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett. 435 (2–3): 263–8. doi:10.1016/S0014-5793(98)01083-7. PMID 9762922. S2CID 83518205.
  • Sengar AS, Wang W, Bishay J, Cohen S, Egan SE (1999). "The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15". EMBO J. 18 (5): 1159–71. doi:10.1093/emboj/18.5.1159. PMC 1171207. PMID 10064583.
  • Poupon V, Bègue B, Gagnon J, Dautry-Varsat A, Cerf-Bensussan N, Benmerah A (1999). "Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase". J. Biol. Chem. 274 (27): 19188–94. doi:10.1074/jbc.274.27.19188. PMID 10383425.
  • Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441. PMID 10393179.
  • Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.

April 11, 2024
eps15, epidermal, growth, factor, receptor, substrate, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1c07, 1eh2, 1f8h, 1ff1, 2iv9, 2jxc, 4rh5, 4rh9, 4rhg, 4s0g, 5jp2identifiersaliases, af1p, mllt5, epiderm. Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene 5 EPS15Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5JP2IdentifiersAliasesEPS15 AF 1P AF1P MLLT5 epidermal growth factor receptor pathway substrate 15External IDsOMIM 600051 MGI 104583 HomoloGene 128359 GeneCards EPS15Gene location Human Chr Chromosome 1 human 1 Band1p32 3Start51 354 263 bp 1 End51 519 266 bp 1 Gene location Mouse Chr Chromosome 4 mouse 2 Band4 4 C7Start109 137 465 bp 2 End109 245 014 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial cellsperminternal globus pallidusfrontal poleBrodmann area 23middle temporal gyruscorpus callosumponsorbitofrontal cortexBrodmann area 10Top expressed inRegion I of hippocampus propersubstantia nigracingulate gyrussciatic nerveventral tegmental arealateral geniculate nucleuscerebellar vermispontine nucleisubiculummedial geniculate nucleusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding SH3 domain binding metal ion binding polyubiquitin modification dependent protein binding protein binding cadherin binding identical protein binding cargo receptor activityCellular componentendosome clathrin coat of coated pit early endosome membrane membrane intracellular membrane bounded organelle plasma membrane aggresome ciliary membrane clathrin coated pit AP 2 adaptor complex clathrin coated vesicle basal plasma membrane apical plasma membrane early endosome cytoplasm cytosol synapse postsynapse glutamatergic synapseBiological processnegative regulation of epidermal growth factor receptor signaling pathway endocytosis epidermal growth factor receptor signaling pathway vesicle organization Golgi to endosome transport clathrin coat assembly protein transport viral entry into host cell receptor mediated endocytosis of virus by host cell cell population proliferation positive regulation of receptor recycling regulation of cell population proliferation endocytic recycling membrane organization viral process transport postsynaptic neurotransmitter receptor internalizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez206013858EnsemblENSG00000085832ENSMUSG00000028552UniProtP42566P42567RefSeq mRNA NM 001159969NM 001981NM 001159964NM 007943RefSeq protein NP 001153441NP 001972NP 001153436NP 031969Location UCSC Chr 1 51 35 51 52 MbChr 4 109 14 109 25 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editThis gene encodes a protein that is part of the EGFR pathway The protein is present at clathrin coated pits and is involved in receptor mediated endocytosis of EGF Notably this gene is rearranged with the HRX ALL MLL gene in acute myelogeneous leukemias Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized 6 Interactions editEPS15 has been shown to interact with CRK 7 EPN1 8 HGS 9 10 HRB 11 and REPS2 12 References edit a b c GRCh38 Ensembl release 89 ENSG00000085832 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028552 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wong WT Kraus MH Carlomagno F Zelano A Druck T Croce CM Huebner K Di Fiore PP Jun 1994 The human eps15 gene encoding a tyrosine kinase substrate is conserved in evolution and maps to 1p31 p32 Oncogene 9 6 1591 7 PMID 8183552 Entrez Gene EPS15 epidermal growth factor receptor pathway substrate 15 Schumacher C Knudsen BS Ohuchi T Di Fiore PP Glassman RH Hanafusa H June 1995 The SH3 domain of Crk binds specifically to a conserved proline rich motif in Eps15 and Eps15R J Biol Chem 270 25 15341 7 doi 10 1074 jbc 270 25 15341 PMID 7797522 Chen H Fre S Slepnev VI Capua MR Takei K Butler MH Di Fiore PP De Camilli P August 1998 Epsin is an EH domain binding protein implicated in clathrin mediated endocytosis Nature 394 6695 793 7 Bibcode 1998Natur 394 793C doi 10 1038 29555 PMID 9723620 S2CID 4430975 Bean AJ Davanger S Chou MF Gerhardt B Tsujimoto S Chang Y May 2000 Hrs 2 regulates receptor mediated endocytosis via interactions with Eps15 J Biol Chem 275 20 15271 8 doi 10 1074 jbc 275 20 15271 PMID 10809762 Bache KG Raiborg C Mehlum A Stenmark H April 2003 STAM and Hrs are subunits of a multivalent ubiquitin binding complex on early endosomes J Biol Chem 278 14 12513 21 doi 10 1074 jbc M210843200 PMID 12551915 Doria M Salcini AE Colombo E Parslow TG Pelicci PG Di Fiore PP December 1999 The eps15 homology EH domain based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport J Cell Biol 147 7 1379 84 doi 10 1083 jcb 147 7 1379 PMC 2174238 PMID 10613896 Nakashima S Morinaka K Koyama S Ikeda M Kishida M Okawa K Iwamatsu A Kishida S Kikuchi A July 1999 Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors EMBO J 18 13 3629 42 doi 10 1093 emboj 18 13 3629 PMC 1171441 PMID 10393179 Further reading editSchumacher C Knudsen BS Ohuchi T Di Fiore PP Glassman RH Hanafusa H 1995 The SH3 domain of Crk binds specifically to a conserved proline rich motif in Eps15 and Eps15R J Biol Chem 270 25 15341 7 doi 10 1074 jbc 270 25 15341 PMID 7797522 Bernard OA Mauchauffe M Mecucci C Van den Berghe H Berger R 1994 A novel gene AF 1p fused to HRX in t 1 11 p32 q23 is not related to AF 4 AF 9 nor ENL Oncogene 9 4 1039 45 PMID 8134107 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Benmerah A Begue B Dautry Varsat A Cerf Bensussan N 1996 The ear of alpha adaptin interacts with the COOH terminal domain of the Eps 15 protein J Biol Chem 271 20 12111 6 doi 10 1074 jbc 271 20 12111 PMID 8662627 Matsuda M Ota S Tanimura R Nakamura H Matuoka K Takenawa T Nagashima K Kurata T 1996 Interaction between the amino terminal SH3 domain of CRK and its natural target proteins J Biol Chem 271 24 14468 72 doi 10 1074 jbc 271 24 14468 PMID 8662907 van Delft S Schumacher C Hage W Verkleij AJ van Bergen en Henegouwen PM 1997 Association and colocalization of Eps15 with adaptor protein 2 and clathrin J Cell Biol 136 4 811 21 doi 10 1083 jcb 136 4 811 PMC 2132490 PMID 9049247 Yu W Andersson B Worley KC Muzny DM Ding Y Liu W Ricafrente JY Wentland MA Lennon G Gibbs RA 1997 Large scale concatenation cDNA sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Tebar F Confalonieri S Carter RE Di Fiore PP Sorkin A 1997 Eps15 is constitutively oligomerized due to homophilic interaction of its coiled coil region J Biol Chem 272 24 15413 8 doi 10 1074 jbc 272 24 15413 PMID 9182572 Salcini AE Confalonieri S Doria M Santolini E Tassi E Minenkova O Cesareni G Pelicci PG Di Fiore PP 1997 Binding specificity and in vivo targets of the EH domain a novel protein protein interaction module Genes Dev 11 17 2239 49 doi 10 1101 gad 11 17 2239 PMC 275390 PMID 9303539 Cupers P ter Haar E Boll W Kirchhausen T 1998 Parallel dimers and anti parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15 J Biol Chem 272 52 33430 4 doi 10 1074 jbc 272 52 33430 PMID 9407139 Haffner C Takei K Chen H Ringstad N Hudson A Butler MH Salcini AE Di Fiore PP De Camilli P 1998 Synaptojanin 1 localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15 FEBS Lett 419 2 3 175 80 doi 10 1016 S0014 5793 97 01451 8 PMID 9428629 S2CID 45186831 Benmerah A Lamaze C Begue B Schmid SL Dautry Varsat A Cerf Bensussan N 1998 AP 2 Eps15 interaction is required for receptor mediated endocytosis J Cell Biol 140 5 1055 62 doi 10 1083 jcb 140 5 1055 PMC 2132690 PMID 9490719 de Beer T Carter RE Lobel Rice KE Sorkin A Overduin M 1998 Structure and Asn Pro Phe binding pocket of the Eps15 homology domain Science 281 5381 1357 60 Bibcode 1998Sci 281 1357D doi 10 1126 science 281 5381 1357 PMID 9721102 Chen H Fre S Slepnev VI Capua MR Takei K Butler MH Di Fiore PP De Camilli P 1998 Epsin is an EH domain binding protein implicated in clathrin mediated endocytosis Nature 394 6695 793 7 Bibcode 1998Natur 394 793C doi 10 1038 29555 PMID 9723620 S2CID 4430975 Lewin DA Sheff D Ooi CE Whitney JA Yamamoto E Chicione LM Webster P Bonifacino JS Mellman I 1998 Cloning expression and localization of a novel gamma adaptin like molecule FEBS Lett 435 2 3 263 8 doi 10 1016 S0014 5793 98 01083 7 PMID 9762922 S2CID 83518205 Sengar AS Wang W Bishay J Cohen S Egan SE 1999 The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15 EMBO J 18 5 1159 71 doi 10 1093 emboj 18 5 1159 PMC 1171207 PMID 10064583 Poupon V Begue B Gagnon J Dautry Varsat A Cerf Bensussan N Benmerah A 1999 Molecular cloning and characterization of MT ACT48 a novel mitochondrial acyl CoA thioesterase J Biol Chem 274 27 19188 94 doi 10 1074 jbc 274 27 19188 PMID 10383425 Nakashima S Morinaka K Koyama S Ikeda M Kishida M Okawa K Iwamatsu A Kishida S Kikuchi A 1999 Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors EMBO J 18 13 3629 42 doi 10 1093 emboj 18 13 3629 PMC 1171441 PMID 10393179 Stephens DJ Banting G 1999 Direct interaction of the trans Golgi network membrane protein TGN38 with the F actin binding protein neurabin J Biol Chem 274 42 30080 6 doi 10 1074 jbc 274 42 30080 PMID 10514494 Retrieved from https en wikipedia org w index php title EPS15 amp oldid 1190648258, wikipedia, wiki, book, books, library,

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