ENAH (gene)

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.^[5][6]

ENAH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HO2, 2IYB, 2XQN, 4MY6
Identifiers
Aliases	ENAH, ENA, MENA, NDPP1, enabled homolog (Drosophila), actin regulator
External IDs	OMIM: 609061 MGI: 108360 HomoloGene: 134005 GeneCards: ENAH
Gene location (Human) Chr. Chromosome 1 (human)^[1] Band 1q42.12 Start 225,486,835 bp^[1] End 225,653,142 bp^[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)^[2] Band 1 H5|1 84.93 cM Start 181,723,949 bp^[2] End 181,847,555 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein secondary oocyte vena cava urethra seminal vesicula cardia Achilles tendon sural nerve bronchial epithelial cell ganglionic eminence Top expressed in ascending aorta seminal vesicula stria vascularis medullary collecting duct aortic valve substantia nigra abdominal wall medial geniculate nucleus fossa ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding WW domain binding actin binding protein binding profilin binding Cellular component filopodium cell junction plasma membrane cell projection synapse cytoskeleton focal adhesion lamellipodium cytoplasm cytosol Biological process axon guidance actin polymerization or depolymerization actin polymerization-dependent cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55740 13800 Ensembl ENSG00000154380 ENSMUSG00000022995 UniProt Q8N8S7 Q03173 RefSeq (mRNA) NM_001008493 NM_018212 NM_001083120 NM_001083121 NM_008680 NM_010135 RefSeq (protein) NP_001008493 NP_060682 NP_001364410 NP_001364411 NP_001364412 NP_001076589 NP_001076590 NP_032706 NP_034265 Location (UCSC) Chr 1: 225.49 – 225.65 Mb Chr 1: 181.72 – 181.85 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ENAH has been shown to interact with ABI1,^[7] ZYX,^[7][8] and PCARE.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000154380 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022995 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (October 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1132 (3): 240–248. doi:10.1016/0167-4781(92)90156-t. hdl:2027.42/29785. PMID 1420303.
6. "Entrez Gene: ENAH enabled homolog (Drosophila)".
7. Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". The Journal of Biological Chemistry. 278 (24): 21685–21692. doi:10.1074/jbc.M301447200. PMID 12672821.
8. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". The Journal of Biological Chemistry. 275 (29): 22503–22511. doi:10.1074/jbc.M001698200. PMID 10801818.
9. Hwang T, Parker SS, Hill SM, Ilunga MW, Grant RA, Mouneimne G, Keating AE (December 2021). "A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers". eLife. 10: e70601. doi:10.7554/eLife.70601. PMC 8639148. PMID 34854809.

Further reading

• Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl UD, et al. (September 1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family". The EMBO Journal. 16 (17): 5433–5444. doi:10.1093/emboj/16.17.5433. PMC 1170174. PMID 9312002.
• Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (December 1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". The Journal of Biological Chemistry. 272 (52): 32869–32877. doi:10.1074/jbc.272.52.32869. PMID 9407065.
• Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, et al. (February 1998). "Interactions of drebrin and gephyrin with profilin". Biochemical and Biophysical Research Communications. 243 (1): 86–89. doi:10.1006/bbrc.1997.8068. PMID 9473484.
• Geese M, Schlüter K, Rothkegel M, Jockusch BM, Wehland J, Sechi AS (April 2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed". Journal of Cell Science. 113 ( Pt 8) (8): 1415–1426. doi:10.1242/jcs.113.8.1415. PMID 10725224.
• Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J (April 2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". The Journal of Cell Biology. 149 (1): 181–194. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
• Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (July 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". The Journal of Biological Chemistry. 275 (29): 22503–22511. doi:10.1074/jbc.M001698200. PMID 10801818.
• Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A (October 2001). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex". Current Biology. 11 (21): 1645–1655. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321. S2CID 11290377.
• Coutts AS, MacKenzie E, Griffith E, Black DM (March 2003). "TES is a novel focal adhesion protein with a role in cell spreading". Journal of Cell Science. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
• Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". The Journal of Biological Chemistry. 278 (24): 21685–21692. doi:10.1074/jbc.M301447200. PMID 12672821.
• Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Köcher T, et al. (April 2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". The Journal of Cell Biology. 161 (1): 33–39. doi:10.1083/jcb.200211015. PMC 2172870. PMID 12695497.
• Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, et al. (September 2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–267. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
• Giesemann T, Schwarz G, Nawrotzki R, Berhörster K, Rothkegel M, Schlüter K, et al. (September 2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system". The Journal of Neuroscience. 23 (23): 8330–8339. doi:10.1523/JNEUROSCI.23-23-08330.2003. PMC 6740687. PMID 12967995.
• Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, et al. (December 2003). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". The Journal of Biological Chemistry. 278 (49): 49031–49043. doi:10.1074/jbc.M308104200. PMID 14506234.
• Stüven T, Hartmann E, Görlich D (November 2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes". The EMBO Journal. 22 (21): 5928–5940. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989.
• Di Modugno F, Bronzi G, Scanlan MJ, Del Bello D, Cascioli S, Venturo I, et al. (May 2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response". International Journal of Cancer. 109 (6): 909–918. doi:10.1002/ijc.20094. PMID 15027125.
• Tanoue T, Takeichi M (May 2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact". The Journal of Cell Biology. 165 (4): 517–528. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305.
• Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, et al. (October 2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics". Developmental Cell. 7 (4): 571–583. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.