EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1gene.[5][6][7][8][9] EMR1 is a member of the adhesion GPCR family.[10][11] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[12]
EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells.[13] The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations.[14] The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.[15]
Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.[16]
Clinical significanceedit
Legrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.[17]
^ abcGRCh38: Ensembl release 89: ENSG00000174837 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000004730 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
^McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–80. doi:10.1002/jlb.63.3.271. PMID 9500513. S2CID 6497890.
^Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. hdl:1765/71089. PMID 8083537.
^Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN978-1-4419-7912-4.
^Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC3321182. PMID 22333914.
^Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ (October 2007). "EMR1, the human homolog of F4/80, is an eosinophil-specific receptor". European Journal of Immunology. 37 (10): 2797–802. doi:10.1002/eji.200737553. PMID 17823986.
^Austyn JM, Gordon S (October 1981). "F4/80, a monoclonal antibody directed specifically against the mouse macrophage". European Journal of Immunology. 11 (10): 805–15. doi:10.1002/eji.1830111013. PMID 7308288. S2CID 8426640.
^Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–6. doi:10.1002/eji.201141715. PMID 21952799.
^Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J (May 2005). "The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance". The Journal of Experimental Medicine. 201 (10): 1615–25. doi:10.1084/jem.20042307. PMC2212925. PMID 15883173.
^Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology. 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMC4113341. PMID 24530099.
External linksedit
GPCR consortium
January 01, 1970
emr1, this, article, multiple, issues, please, help, improve, discuss, these, issues, talk, page, learn, when, remove, these, template, messages, this, article, lead, section, long, please, read, length, guidelines, help, move, details, into, article, body, ma. This article has multiple issues Please help improve it or discuss these issues on the talk page Learn how and when to remove these template messages This article s lead section may be too long Please read the length guidelines and help move details into the article s body March 2017 This article may be too technical for most readers to understand Please help improve it to make it understandable to non experts without removing the technical details March 2017 Learn how and when to remove this message Learn how and when to remove this message EGF like module containing mucin like hormone receptor like 1 also known as F4 80 is a protein encoded by the ADGRE1 gene 5 6 7 8 9 EMR1 is a member of the adhesion GPCR family 10 11 Adhesion GPCRs are characterized by an extended extracellular region often possessing N terminal protein modules that is linked to a TM7 region via a domain known as the GPCR Autoproteolysis INducing GAIN domain 12 ADGRE1IdentifiersAliasesADGRE1 TM7LN3 EMR1 adhesion G protein coupled receptor E1External IDsOMIM 600493 MGI 106912 HomoloGene 1493 GeneCards ADGRE1Gene location Human Chr Chromosome 19 human 1 Band19p13 3 p13 2Start6 887 566 bp 1 End6 940 459 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 D 17 29 8 cMStart57 665 691 bp 2 End57 790 527 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytebloodspleenbone marrowappendixright lungbone marrow cellspalpebral conjunctivaupper lobe of left lunggallbladderTop expressed incalvariaspleenright ventricleankle jointcarotid bodyinternal carotid arterysubmandibular glandexternal carotid arterycervixintercostal muscleMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncalcium ion binding G protein coupled receptor activity transmembrane signaling receptor activity signal transducer activityCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane cell periphery intracellular anatomical structureBiological processG protein coupled receptor signaling pathway cell surface receptor signaling pathway cell adhesion adaptive immune response signal transduction immune system process adenylate cyclase activating G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez201513733EnsemblENSG00000174837ENSMUSG00000004730UniProtQ14246Q61549RefSeq mRNA NM 001256252NM 001256253NM 001256254NM 001256255NM 001974NM 010130NM 001355722NM 001355723RefSeq protein NP 001243181NP 001243182NP 001243183NP 001243184NP 001965NP 034260NP 001342651NP 001342652Location UCSC Chr 19 6 89 6 94 MbChr 17 57 67 57 79 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells 13 The murine homolog of EMR1 F4 80 is a well known and widely used marker of murine macrophage populations 14 The N terminal fragment NTF of EMR1 contains 4 6 Epidermal Growth Factor like EGF like domains in human and 4 7 EGF like domains in the mouse 15 Contents 1 Function 2 Clinical significance 3 See also 4 References 5 External linksFunction editUtilizing F4 80 knockout mice Lin et al showed that F4 80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8 regulatory T cells needed for peripheral tolerance 16 Clinical significance editLegrand et al demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies 17 See also editEGF module containing mucin like hormone receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000174837 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004730 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Baud V Chissoe SL Viegas Pequignot E Diriong S N Guyen VC Roe BA Lipinski M March 1995 EMR1 an unusual member in the family of hormone receptors with seven transmembrane segments Genomics 26 2 334 44 doi 10 1016 0888 7543 95 80218 B PMID 7601460 McKnight AJ Gordon S March 1998 The EGF TM7 family unusual structures at the leukocyte surface Journal of Leukocyte Biology 63 3 271 80 doi 10 1002 jlb 63 3 271 PMID 9500513 S2CID 6497890 Entrez Gene EMR1 egf like module containing mucin like hormone receptor like 1 Leenen PJ de Bruijn MF Voerman JS Campbell PA van Ewijk W September 1994 Markers of mouse macrophage development detected by monoclonal antibodies Journal of Immunological Methods 174 1 2 5 19 doi 10 1016 0022 1759 94 90005 1 hdl 1765 71089 PMID 8083537 Hamann J Aust G Arac D Engel FB Formstone C Fredriksson R Hall RA Harty BL Kirchhoff C Knapp B Krishnan A Liebscher I Lin HH Martinelli DC Monk KR Peeters MC Piao X Promel S Schoneberg T Schwartz TW Singer K Stacey M Ushkaryov YA Vallon M Wolfrum U Wright MW Xu L Langenhan T Schioth HB April 2015 International Union of Basic and Clinical Pharmacology XCIV Adhesion G protein coupled receptors Pharmacological Reviews 67 2 338 67 doi 10 1124 pr 114 009647 PMC 4394687 PMID 25713288 Stacey M Yona S 2011 Adhesion GPCRs Structure to Function Advances in Experimental Medicine and Biology Berlin Springer ISBN 978 1 4419 7912 4 Langenhan T Aust G Hamann J 21 May 2013 Sticky signaling adhesion class G protein coupled receptors take the stage Science Signaling 6 276 re3 doi 10 1126 scisignal 2003825 PMID 23695165 S2CID 6958640 Arac D Boucard AA Bolliger MF Nguyen J Soltis SM Sudhof TC Brunger AT March 2012 A novel evolutionarily conserved domain of cell adhesion GPCRs mediates autoproteolysis The EMBO Journal 31 6 1364 78 doi 10 1038 emboj 2012 26 PMC 3321182 PMID 22333914 Hamann J Koning N Pouwels W Ulfman LH van Eijk M Stacey M Lin HH Gordon S Kwakkenbos MJ October 2007 EMR1 the human homolog of F4 80 is an eosinophil specific receptor European Journal of Immunology 37 10 2797 802 doi 10 1002 eji 200737553 PMID 17823986 Austyn JM Gordon S October 1981 F4 80 a monoclonal antibody directed specifically against the mouse macrophage European Journal of Immunology 11 10 805 15 doi 10 1002 eji 1830111013 PMID 7308288 S2CID 8426640 Gordon S Hamann J Lin HH Stacey M September 2011 F4 80 and the related adhesion GPCRs European Journal of Immunology 41 9 2472 6 doi 10 1002 eji 201141715 PMID 21952799 Lin HH Faunce DE Stacey M Terajewicz A Nakamura T Zhang Hoover J Kerley M Mucenski ML Gordon S Stein Streilein J May 2005 The macrophage F4 80 receptor is required for the induction of antigen specific efferent regulatory T cells in peripheral tolerance The Journal of Experimental Medicine 201 10 1615 25 doi 10 1084 jem 20042307 PMC 2212925 PMID 15883173 Legrand F Tomasevic N Simakova O Lee CC Wang Z Raffeld M Makiya MA Palath V Leung J Baer M Yarranton G Maric I Bebbington C Klion AD May 2014 The eosinophil surface receptor epidermal growth factor like module containing mucin like hormone receptor 1 EMR1 a novel therapeutic target for eosinophilic disorders The Journal of Allergy and Clinical Immunology 133 5 1439 47 1447 e1 8 doi 10 1016 j jaci 2013 11 041 PMC 4113341 PMID 24530099 External links editGPCR consortium Retrieved from https en wikipedia org w index php title EMR1 amp oldid 1193136259, wikipedia, wiki, book, books, library,
