^Das S, Ghosh R, Maitra U (March 2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.
External linksEdit
Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)
Further readingEdit
Das S, Maiti T, Das K, Maitra U (1998). "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2". J. Biol. Chem. 272 (50): 31712–8. doi:10.1074/jbc.272.50.31712. PMID 9395514.
Bandyopadhyay A, Maitra U (1999). "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells". Nucleic Acids Res. 27 (5): 1331–7. doi:10.1093/nar/27.5.1331. PMC148320. PMID 9973622.
Das S, Maitra U (2000). "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo". Mol. Cell. Biol. 20 (11): 3942–50. doi:10.1128/MCB.20.11.3942-3950.2000. PMC85746. PMID 10805737.
Choi SK, Olsen DS, Roll-Mecak A, et al. (2000). "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2". Mol. Cell. Biol. 20 (19): 7183–91. doi:10.1128/MCB.20.19.7183-7191.2000. PMC86272. PMID 10982835.
Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
Asano K, Shalev A, Phan L, et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation". EMBO J. 20 (9): 2326–37. doi:10.1093/emboj/20.9.2326. PMC125443. PMID 11331597.
Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002). "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo". Nucleic Acids Res. 30 (5): 1154–62. doi:10.1093/nar/30.5.1154. PMC101238. PMID 11861906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. Bibcode:2003PNAS..100.1535M. doi:10.1073/pnas.0437845100. PMC149867. PMID 12569173.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Homma MK, Wada I, Suzuki T, et al. (2005). "CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15688–93. Bibcode:2005PNAS..10215688H. doi:10.1073/pnas.0506791102. PMC1266118. PMID 16227438.
Conte MR, Kelly G, Babon J, et al. (2006). "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors". Biochemistry. 45 (14): 4550–8. doi:10.1021/bi052387u. PMID 16584190.
Bieniossek C, Schütz P, Bumann M, et al. (2006). "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5". J. Mol. Biol. 360 (2): 457–65. doi:10.1016/j.jmb.2006.05.021. PMID 16781736.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.
eif5, eukaryotic, translation, initiation, factor, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2e9h, 2g2k, 2iu1identifiersaliases, eukaryotic, translation, initiation, factor, eukaryotic, initiation, fac. Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene 5 6 EIF5Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2E9H 2G2K 2IU1IdentifiersAliasesEIF5 EIF 5 EIF 5A eukaryotic translation initiation factor 5 Eukaryotic initiation factor 5External IDsOMIM 601710 MGI 95309 HomoloGene 49610 GeneCards EIF5Gene location Human Chr Chromosome 14 human 1 Band14q32 32Start103 333 544 bp 1 End103 345 025 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 F1 12 61 03 cMStart111 504 450 bp 2 End111 513 186 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inpostcentral gyrusponsspermexternal globus pallidussuperior frontal gyrusinferior olivary nucleussuperior vestibular nucleusoocytesuperficial temporal arterycardiaTop expressed inotic placodemedullary collecting ductrenal corpusclesacculebloodlacrimal glandspermatocyteparotid glandseminiferous tubuleepithelium of stomachMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontranslation initiation factor activity nucleotide binding translation factor activity RNA binding GTP binding GTPase activity protein binding eukaryotic initiation factor eIF2 binding RNA binding cadherin binding GDP dissociation inhibitor activityCellular componentnucleus plasma membrane cytoplasm cytosolBiological processregulation of translational initiation protein biosynthesis activation of GTPase activity formation of translation preinitiation complex translational initiation formation of cytoplasmic translation initiation complexSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1983217869EnsemblENSG00000100664ENSMUSG00000021282UniProtP55010P59325RefSeq mRNA NM 183004NM 001969NM 173363NM 178041RefSeq protein NP 001960NP 892116NP 775539NP 829887Location UCSC Chr 14 103 33 103 35 MbChr 12 111 5 111 51 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseEIF5 is a GTPase activating protein 7 References Edit a b c GRCh38 Ensembl release 89 ENSG00000100664 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000021282 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Si K Das K Maitra U Aug 1996 Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 eIF 5 J Biol Chem 271 28 16934 8 doi 10 1074 jbc 271 28 16934 PMID 8663286 Entrez Gene EIF5 eukaryotic translation initiation factor 5 Das S Ghosh R Maitra U March 2001 Eukaryotic translation initiation factor 5 functions as a GTPase activating protein J Biol Chem 276 9 6720 6 doi 10 1074 jbc M008863200 PMID 11092890 External links EditCap dependent translation initiation from Nature Reviews Microbiology A good image and overview of the function of initiation factors PDBe KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 EIF5 Further reading EditDas S Maiti T Das K Maitra U 1998 Specific interaction of eukaryotic translation initiation factor 5 eIF5 with the beta subunit of eIF2 J Biol Chem 272 50 31712 8 doi 10 1074 jbc 272 50 31712 PMID 9395514 Bandyopadhyay A Maitra U 1999 Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 eIF3 demonstration that eIF3 interacts with eIF5 in mammalian cells Nucleic Acids Res 27 5 1331 7 doi 10 1093 nar 27 5 1331 PMC 148320 PMID 9973622 Das S Maitra U 2000 Mutational analysis of mammalian translation initiation factor 5 eIF5 role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo Mol Cell Biol 20 11 3942 50 doi 10 1128 MCB 20 11 3942 3950 2000 PMC 85746 PMID 10805737 Choi SK Olsen DS Roll Mecak A et al 2000 Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2 Mol Cell Biol 20 19 7183 91 doi 10 1128 MCB 20 19 7183 7191 2000 PMC 86272 PMID 10982835 Das S Ghosh R Maitra U 2001 Eukaryotic translation initiation factor 5 functions as a GTPase activating protein J Biol Chem 276 9 6720 6 doi 10 1074 jbc M008863200 PMID 11092890 Wiemann S Weil B Wellenreuther R et al 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Asano K Shalev A Phan L et al 2001 Multiple roles for the C terminal domain of eIF5 in translation initiation complex assembly and GTPase activation EMBO J 20 9 2326 37 doi 10 1093 emboj 20 9 2326 PMC 125443 PMID 11331597 Majumdar R Bandyopadhyay A Deng H Maitra U 2002 Phosphorylation of mammalian translation initiation factor 5 eIF5 in vitro and in vivo Nucleic Acids Res 30 5 1154 62 doi 10 1093 nar 30 5 1154 PMC 101238 PMID 11861906 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Marintchev A Kolupaeva VG Pestova TV Wagner G 2003 Mapping the binding interface between human eukaryotic initiation factors 1A and 5B a new interaction between old partners Proc Natl Acad Sci U S A 100 4 1535 40 Bibcode 2003PNAS 100 1535M doi 10 1073 pnas 0437845100 PMC 149867 PMID 12569173 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Homma MK Wada I Suzuki T et al 2005 CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression Proc Natl Acad Sci U S A 102 43 15688 93 Bibcode 2005PNAS 10215688H doi 10 1073 pnas 0506791102 PMC 1266118 PMID 16227438 Conte MR Kelly G Babon J et al 2006 Structure of the eukaryotic initiation factor eIF 5 reveals a fold common to several translation factors Biochemistry 45 14 4550 8 doi 10 1021 bi052387u PMID 16584190 Bieniossek C Schutz P Bumann M et al 2006 The crystal structure of the carboxy terminal domain of human translation initiation factor eIF5 J Mol Biol 360 2 457 65 doi 10 1016 j jmb 2006 05 021 PMID 16781736 Olsen JV Blagoev B Gnad F et al 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 nbsp This article on a gene on human chromosome 14 is a 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