Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000119718 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000004788 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yang W, Hinnebusch AG (December 1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol Cell Biol. 16 (11): 6603–16. doi:10.1128/MCB.16.11.6603. PMC231662. PMID 8887689.
^Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.
^Kebache S, Zuo D, Chevet E, Larose L (April 2002). "Modulation of protein translation by Nck-1". Proc. Natl. Acad. Sci. U.S.A.99 (8): 5406–5411. Bibcode:2002PNAS...99.5406K. doi:10.1073/pnas.082483399. PMC122782. PMID 11959995.
Further readingedit
Labauge P, Fogli A, Niel F, Rodriguez D, Boespflug-Tanguy O (2007). "[CACH/VWM syndrome and leucodystrophies related to EIF2B mutations]". Rev. Neurol. (Paris). 163 (8–9): 793–9. doi:10.1016/s0035-3787(07)91461-7. PMID 17878805.
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–760. Bibcode:1995Natur.375..754S. doi:10.1038/375754a0. PMID 7596406. S2CID 4308372.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–11413. doi:10.1074/jbc.271.19.11410. PMID 8626696.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC139146. PMID 9110174.
Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". J. Biol. Chem. 273 (5): 3039–3044. doi:10.1074/jbc.273.5.3039. PMID 9446619.
Gomez E, Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation". Mol. Cell. Biol. 20 (11): 3965–3976. doi:10.1128/MCB.20.11.3965-3976.2000. PMC85753. PMID 10805739.
Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.
Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. 276 (27): 24697–24703. doi:10.1074/jbc.M011788200. PMID 11323413.
Leegwater PA, Vermeulen G, Könst AA, Naidu S, Mulders J, Visser A, Kersbergen P, Mobach D, Fonds D, van Berkel CG, Lemmers RJ, Frants RR, Oudejans CB, Schutgens RB, Pronk JC, van der Knaap MS (2001). "Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter". Nat. Genet. 29 (4): 383–388. doi:10.1038/ng764. PMID 11704758. S2CID 20313523.
Kebache S, Zuo D, Chevet E, Larose L (2002). "Modulation of protein translation by Nck-1". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5406–5411. Bibcode:2002PNAS...99.5406K. doi:10.1073/pnas.082483399. PMC122782. PMID 11959995.
Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. 59 (12): 1966–8. doi:10.1212/01.wnl.0000041666.76863.47. PMID 12499492. S2CID 13129517.
Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544–1550. doi:10.1086/375404. PMC1180314. PMID 12707859.
van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC (2004). "eIF2B-related disorders: antenatal onset and involvement of multiple organs". Am. J. Hum. Genet. 73 (5): 1199–1207. doi:10.1086/379524. PMC1180499. PMID 14566705.
Richardson JP, Mohammad SS, Pavitt GD (2004). "Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity". Mol. Cell. Biol. 24 (6): 2352–2363. doi:10.1128/MCB.24.6.2352-2363.2004. PMC355856. PMID 14993275.
Fogli A, Schiffmann R, Hugendubler L, Combes P, Bertini E, Rodriguez D, Kimball SR, Boespflug-Tanguy O (2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients". Eur. J. Hum. Genet. 12 (7): 561–566. doi:10.1038/sj.ejhg.5201189. PMID 15054402.
Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways". Mol. Cell. Biol. 24 (8): 3295–3306. doi:10.1128/MCB.24.8.3295-3306.2004. PMC381664. PMID 15060152.
This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.
eif2b2, translation, initiation, factor, subunit, beta, protein, that, humans, encoded, gene, identifiersaliases, 2bbeta, eif2b, eukaryotic, translation, initiation, factor, subunit, beta, eif2bbetaexternal, idsomim, 606454, 2145118, homologene, 6507, genecard. Translation initiation factor eIF 2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene 5 6 EIF2B2IdentifiersAliasesEIF2B2 EIF 2Bbeta EIF2B eukaryotic translation initiation factor 2B subunit beta EIF2BbetaExternal IDsOMIM 606454 MGI 2145118 HomoloGene 6507 GeneCards EIF2B2Gene location Human Chr Chromosome 14 human 1 Band14q24 3Start75 002 921 bp 1 End75 012 366 bp 1 Gene location Mouse Chr Chromosome 12 mouse 2 Band12 12 D1Start85 266 255 bp 2 End85 273 402 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inleft lobe of thyroid glandright lobe of thyroid glandgastrocnemius muscleleft adrenal glandpopliteal arteryright coronary arteryleft coronary arteryanterior pituitaryascending aortaright lungTop expressed incondylefossarenal corpuscleinternal carotid arteryexternal carotid arteryendocardial cushionsacculeyolk sacsubstantia nigramedullary collecting ductMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiontranslation initiation factor activity guanyl nucleotide exchange factor activity GTP binding protein binding ATP bindingCellular componentcytoplasm cytosol eukaryotic translation initiation factor 2B complexBiological processresponse to peptide hormone response to heat response to glucose central nervous system development cell metabolism ovarian follicle development myelination oligodendrocyte development regulation of translational initiation protein biosynthesis translational initiation T cell receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8892217715EnsemblENSG00000119718ENSMUSG00000004788UniProtP49770Q99LD9RefSeq mRNA NM 014239NM 145445RefSeq protein NP 055054NP 663420Location UCSC Chr 14 75 75 01 MbChr 12 85 27 85 27 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editEukaryotic initiation factor 2B EIF2B is a GTP exchange protein essential for protein synthesis It consists of alpha EIF2B1 MIM 606686 beta EIF2B2 gamma EIF2B3 MIM 606273 delta EIF2B4 MIM 606687 and epsilon EIF2B5 MIM 603945 subunits EIF2B activates its EIF2 see MIM 603907 substrate by exchanging EIF2 bound GDP for GTP 6 Interactions editEIF2B2 has been shown to interact with EIF2B5 7 and NCK1 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000119718 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004788 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Yang W Hinnebusch AG December 1996 Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2 Mol Cell Biol 16 11 6603 16 doi 10 1128 MCB 16 11 6603 PMC 231662 PMID 8887689 a b Entrez Gene EIF2B2 eukaryotic translation initiation factor 2B subunit 2 beta 39kDa Anthony TG Fabian JR Kimball SR Jefferson LS June 2000 Identification of domains within the epsilon subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation Biochim Biophys Acta 1492 1 56 62 doi 10 1016 S0167 4781 00 00062 2 PMID 10858531 Kebache S Zuo D Chevet E Larose L April 2002 Modulation of protein translation by Nck 1 Proc Natl Acad Sci U S A 99 8 5406 5411 Bibcode 2002PNAS 99 5406K doi 10 1073 pnas 082483399 PMC 122782 PMID 11959995 Further reading editLabauge P Fogli A Niel F Rodriguez D Boespflug Tanguy O 2007 CACH VWM syndrome and leucodystrophies related to EIF2B mutations Rev Neurol Paris 163 8 9 793 9 doi 10 1016 s0035 3787 07 91461 7 PMID 17878805 Sherrington R Rogaev EI Liang Y Rogaeva EA Levesque G Ikeda M Chi H Lin C Li G Holman K Tsuda T Mar L Foncin JF Bruni AC Montesi MP Sorbi S Rainero I Pinessi L Nee L Chumakov I Pollen D Brookes A Sanseau P Polinsky RJ Wasco W Da Silva HA Haines JL Perkicak Vance MA Tanzi RE Roses AD Fraser PE Rommens JM St George Hyslop PH 1995 Cloning of a gene bearing missense mutations in early onset familial Alzheimer s disease Nature 375 6534 754 760 Bibcode 1995Natur 375 754S doi 10 1038 375754a0 PMID 7596406 S2CID 4308372 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 113 doi 10 1006 abio 1996 0138 PMID 8619474 Welsh GI Miyamoto S Price NT Safer B Proud CG 1996 T cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase 3 J Biol Chem 271 19 11410 11413 doi 10 1074 jbc 271 19 11410 PMID 8626696 Yu W Andersson B Worley KC Muzny DM Ding Y Liu W Ricafrente JY Wentland MA Lennon G Gibbs RA 1997 Large scale concatenation cDNA sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Kimball SR Heinzinger NK Horetsky RL Jefferson LS 1998 Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B J Biol Chem 273 5 3039 3044 doi 10 1074 jbc 273 5 3039 PMID 9446619 Gomez E Pavitt GD 2000 Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B eIF2Bepsilon required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation Mol Cell Biol 20 11 3965 3976 doi 10 1128 MCB 20 11 3965 3976 2000 PMC 85753 PMID 10805739 Anthony TG Fabian JR Kimball SR Jefferson LS 2000 Identification of domains within the epsilon subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation Biochim Biophys Acta 1492 1 56 62 doi 10 1016 S0167 4781 00 00062 2 PMID 10858531 Williams DD Price NT Loughlin AJ Proud CG 2001 Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein J Biol Chem 276 27 24697 24703 doi 10 1074 jbc M011788200 PMID 11323413 Leegwater PA Vermeulen G Konst AA Naidu S Mulders J Visser A Kersbergen P Mobach D Fonds D van Berkel CG Lemmers RJ Frants RR Oudejans CB Schutgens RB Pronk JC van der Knaap MS 2001 Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter Nat Genet 29 4 383 388 doi 10 1038 ng764 PMID 11704758 S2CID 20313523 Kebache S Zuo D Chevet E Larose L 2002 Modulation of protein translation by Nck 1 Proc Natl Acad Sci U S A 99 8 5406 5411 Bibcode 2002PNAS 99 5406K doi 10 1073 pnas 082483399 PMC 122782 PMID 11959995 Fogli A Dionisi Vici C Deodato F Bartuli A Boespflug Tanguy O Bertini E 2003 A severe variant of childhood ataxia with central hypomyelination vanishing white matter leukoencephalopathy related to EIF21B5 mutation Neurology 59 12 1966 8 doi 10 1212 01 wnl 0000041666 76863 47 PMID 12499492 S2CID 13129517 Fogli A Rodriguez D Eymard Pierre E Bouhour F Labauge P Meaney BF Zeesman S Kaneski CR Schiffmann R Boespflug Tanguy O 2003 Ovarian failure related to eukaryotic initiation factor 2B mutations Am J Hum Genet 72 6 1544 1550 doi 10 1086 375404 PMC 1180314 PMID 12707859 van der Knaap MS van Berkel CG Herms J van Coster R Baethmann M Naidu S Boltshauser E Willemsen MA Plecko B Hoffmann GF Proud CG Scheper GC Pronk JC 2004 eIF2B related disorders antenatal onset and involvement of multiple organs Am J Hum Genet 73 5 1199 1207 doi 10 1086 379524 PMC 1180499 PMID 14566705 Richardson JP Mohammad SS Pavitt GD 2004 Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity Mol Cell Biol 24 6 2352 2363 doi 10 1128 MCB 24 6 2352 2363 2004 PMC 355856 PMID 14993275 Fogli A Schiffmann R Hugendubler L Combes P Bertini E Rodriguez D Kimball SR Boespflug Tanguy O 2005 Decreased guanine nucleotide exchange factor activity in eIF2B mutated patients Eur J Hum Genet 12 7 561 566 doi 10 1038 sj ejhg 5201189 PMID 15054402 Li W Wang X Van Der Knaap MS Proud CG 2004 Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways Mol Cell Biol 24 8 3295 3306 doi 10 1128 MCB 24 8 3295 3306 2004 PMC 381664 PMID 15060152 nbsp This article on a gene on human chromosome 14 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title EIF2B2 amp oldid 1115949582, wikipedia, wiki, book, books, library,
