Ephrin A4

Ephrin A4 is a protein that in humans is encoded by the EFNA4 gene.^[5][6]

EFNA4
Identifiers
Aliases	EFNA4, EFL4, EPLG4, LERK4, ephrin A4, LERK-4
External IDs	OMIM: 601380 MGI: 106643 HomoloGene: 3830 GeneCards: EFNA4
Gene location (Human) Chr. Chromosome 1 (human)^[1] Band 1q21.3 Start 155,063,737 bp^[1] End 155,069,553 bp^[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)^[2] Band 3 F1|3 39.07 cM Start 89,240,697 bp^[2] End 89,245,335 bp^[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen rectum left adrenal gland minor salivary gland stromal cell of endometrium vagina right lobe of liver monocyte vulva canal of the cervix Top expressed in maxillary prominence lip superior surface of tongue hand saccule abdominal wall somite otic placode secondary oocyte ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane-ephrin receptor activity protein binding ephrin receptor binding Cellular component anchored component of membrane plasma membrane integral component of plasma membrane membrane extracellular region intrinsic component of plasma membrane Biological process cell-cell signaling ephrin receptor signaling pathway axon guidance osteoclast differentiation bone remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1945 13639 Ensembl ENSG00000243364 ENSMUSG00000028040 UniProt P52798 O08542 RefSeq (mRNA) NM_182690 NM_005227 NM_182689 NM_007910 RefSeq (protein) NP_005218 NP_872631 NP_872632 NP_031936 Location (UCSC) Chr 1: 155.06 – 155.07 Mb Chr 3: 89.24 – 89.25 Mb PubMed search ^[3] ^[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000243364 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028040 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cerretti DP, Lyman SD, Kozlosky CJ, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW (Jan 1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3". Genomics. 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976.
6. "Entrez Gene: EFNA4 ephrin-A4".

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". International Review of Cytology. Vol. 196. pp. 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
• Kozlosky CJ, Maraskovsky E, McGrew JT, et al. (1995). "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins". Oncogene. 10 (2): 299–306. PMID 7838529.
• Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
• Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum". J. Neurosci. 19 (12): 4962–71. doi:10.1523/JNEUROSCI.19-12-04962.1999. PMC 6782661. PMID 10366629.
• Choi S, Jeong J, Kim T, Park S (2000). "Characterization of ephrin-A1 and ephrin-A4 as ligands for the EphA8 receptor protein tyrosine kinase". Mol. Cells. 9 (4): 440–5. doi:10.1016/S1016-8478(23)13566-7. PMID 10515610.
• Aasheim HC, Munthe E, Funderud S, et al. (2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood. 95 (1): 221–30. doi:10.1182/blood.V95.1.221. PMID 10607706.
• Munthe E, Aasheim HC (2002). "Characterization of the human ephrin-A4 promoter". Biochem. J. 366 (Pt 2): 447–58. doi:10.1042/BJ20011693. PMC 1222801. PMID 12030849.