This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[7]
EBI3 is a subunit in 2 distinct heterodimericcytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[8] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[7][9]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000105246 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000003206 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC189923. PMID 8551575.
^ abCollison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature. 450 (7169): 566–9. Bibcode:2007Natur.450..566C. doi:10.1038/nature06306. PMID 18033300. S2CID 4425281.
^Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID 16906167. S2CID 32503719.
^Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:10.1002/eji.200737810. PMID 17874423.
Further readingedit
Small RD (1976). "Letter: Statistical analysis of respiratory sensitivity to CO2". N. Engl. J. Med. 295 (7): 397. doi:10.1056/NEJM197608122950720. PMID 934235.
Devergne O, Hummel M, Koeppen H, et al. (1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC189923. PMID 8551575.
Devergne O, Birkenbach M, Kieff E (1997). "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 12041–6. Bibcode:1997PNAS...9412041D. doi:10.1073/pnas.94.22.12041. PMC23696. PMID 9342359.
Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Larousserie F, Pflanz S, Coulomb-L'Herminé A, et al. (2004). "Expression of IL-27 in human Th1-associated granulomatous diseases". J. Pathol. 202 (2): 164–71. doi:10.1002/path.1508. PMID 14743498. S2CID 25887054.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Gehlert T, Devergne O, Niedobitek G (2004). "Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease". J. Med. Virol. 73 (3): 432–8. doi:10.1002/jmv.20109. PMID 15170639. S2CID 40275209.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
ebi3, epstein, barr, virus, induced, gene, also, known, interleukin, subunit, beta, protein, which, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes7u7n, 7z0l, 7zg0, 7zxk, 8d85identifiersaliases, il27b, epstein, barr, viru. Epstein Barr virus induced gene 3 also known as interleukin 27 subunit beta or IL 27B is a protein which in humans is encoded by the EBI3 gene 5 6 EBI3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes7U7N 7Z0L 7ZG0 7ZXK 8D85IdentifiersAliasesEBI3 IL 27B IL27B Epstein Barr virus induced 3 IL35BExternal IDsOMIM 605816 MGI 1354171 HomoloGene 4207 GeneCards EBI3Gene location Human Chr Chromosome 19 human 1 Band19p13 3Start4 229 523 bp 1 End4 237 528 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 D 17 29 08 cMStart56 259 640 bp 2 End56 264 022 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inplacentaspleenappendixlymph nodegallbladderright adrenal glandright coronary arteryleft adrenal glandleft uterine tubeascending aortaTop expressed insplanchnocraniumribhyoid bonehumerussphenoid boneMeckel s cartilagelesser wing of sphenoid bonesacculebasisphenoidbloodMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncytokine receptor activity cytokine activity interleukin 27 receptor binding protein binding ciliary neurotrophic factor receptor activity cytokine bindingCellular componentextracellular region plasma membrane membrane extracellular space endoplasmic reticulum lumen external side of plasma membrane receptor complex ciliary neurotrophic factor receptor complex CNTFR CLCF1 complexBiological processT helper 1 type immune response T cell proliferation humoral immune response positive regulation of alpha beta T cell proliferation regulation of signaling receptor activity interleukin 27 mediated signaling pathway interleukin 35 mediated signaling pathway ciliary neurotrophic factor mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1014850498EnsemblENSG00000105246ENSMUSG00000003206UniProtQ14213O35228RefSeq mRNA NM 005755NM 015766RefSeq protein NP 005746NP 056581Location UCSC Chr 19 4 23 4 24 MbChr 17 56 26 56 26 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 References 3 Further reading 4 External linksFunction editThis gene was identified by the induction of its expression in B lymphocytes by Epstein Barr virus infection The protein encoded by this gene is a secreted glycoprotein which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 IL 12 It plays a role in regulating cell mediated immune responses 7 EBI3 is a subunit in 2 distinct heterodimeric cytokines interleukin 27 IL27 and IL35 IL27 is composed of p28 IL27 and EBI3 IL27 can trigger signaling in T cells B cells and myeloid cells 8 IL35 an inhibitory cytokine involved in regulatory T cell function is composed of EBI3 and the p35 subunit of IL12 7 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000105246 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000003206 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene EBI3 Epstein Barr virus induced gene 3 Devergne O Hummel M Koeppen H Le Beau MM Nathanson EC Kieff E Birkenbach M February 1996 A novel interleukin 12 p40 related protein induced by latent Epstein Barr virus infection in B lymphocytes J Virol 70 2 1143 53 doi 10 1128 JVI 70 2 1143 1153 1996 PMC 189923 PMID 8551575 a b Collison LW Workman CJ Kuo TT Boyd K Wang Y Vignali KM Cross R Sehy D Blumberg RS Vignali DA November 2007 The inhibitory cytokine IL 35 contributes to regulatory T cell function Nature 450 7169 566 9 Bibcode 2007Natur 450 566C doi 10 1038 nature06306 PMID 18033300 S2CID 4425281 Batten M Li J Yi S Kljavin NM Danilenko DM Lucas S Lee J de Sauvage FJ Ghilardi N September 2006 Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17 producing T cells Nat Immunol 7 9 929 36 doi 10 1038 ni1375 PMID 16906167 S2CID 32503719 Niedbala W Wei XQ Cai B Hueber AJ Leung BP McInnes IB Liew FY November 2007 IL 35 is a novel cytokine with therapeutic effects against collagen induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells Eur J Immunol 37 11 3021 9 doi 10 1002 eji 200737810 PMID 17874423 Further reading editSmall RD 1976 Letter Statistical analysis of respiratory sensitivity to CO2 N Engl J Med 295 7 397 doi 10 1056 NEJM197608122950720 PMID 934235 Devergne O Hummel M Koeppen H et al 1996 A novel interleukin 12 p40 related protein induced by latent Epstein Barr virus infection in B lymphocytes J Virol 70 2 1143 53 doi 10 1128 JVI 70 2 1143 1153 1996 PMC 189923 PMID 8551575 Devergne O Birkenbach M Kieff E 1997 Epstein Barr virus induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin Proc Natl Acad Sci U S A 94 22 12041 6 Bibcode 1997PNAS 9412041D doi 10 1073 pnas 94 22 12041 PMC 23696 PMID 9342359 Pflanz S Timans JC Cheung J et al 2002 IL 27 a heterodimeric cytokine composed of EBI3 and p28 protein induces proliferation of naive CD4 T cells Immunity 16 6 779 90 doi 10 1016 S1074 7613 02 00324 2 PMID 12121660 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Larousserie F Pflanz S Coulomb L Hermine A et al 2004 Expression of IL 27 in human Th1 associated granulomatous diseases J Pathol 202 2 164 71 doi 10 1002 path 1508 PMID 14743498 S2CID 25887054 Grimwood J Gordon LA Olsen A et al 2004 The DNA sequence and biology of human chromosome 19 Nature 428 6982 529 35 Bibcode 2004Natur 428 529G doi 10 1038 nature02399 PMID 15057824 Gehlert T Devergne O Niedobitek G 2004 Epstein Barr virus EBV infection and expression of the interleukin 12 family member EBV induced gene 3 EBI3 in chronic inflammatory bowel disease J Med Virol 73 3 432 8 doi 10 1002 jmv 20109 PMID 15170639 S2CID 40275209 Colland F Jacq X Trouplin V et al 2004 Functional proteomics mapping of a human signaling pathway Genome Res 14 7 1324 32 doi 10 1101 gr 2334104 PMC 442148 PMID 15231748 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 External links editEBI3 human gene location in the UCSC Genome Browser EBI3 human gene details in the UCSC Genome Browser nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title EBI3 amp oldid 1115503793, wikipedia, 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