Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.[3]
Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):
The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.[22]
^Frishman, William H. (2007). "Calcium channel blockers: differences between subclasses". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 7 Suppl 1: 17–23. doi:10.2165/00129784-200707001-00003. ISSN 1175-3277. PMID 19845073. S2CID 21199295.
^Okumura, K.; Ichihara, K.; Nagasaka, M. (1997). "Effects of aranidipine, a novel calcium channel blocker, on mechanical responses of the isolated rat portal vein: comparison with typical calcium channel blockers and potassium channel openers". Journal of Cardiovascular Pharmacology. 29 (2): 209–215. doi:10.1097/00005344-199702000-00009. ISSN 0160-2446. PMID 9057070.
^Malhotra, H. S.; Plosker, G. L. (2001). "Barnidipine". Drugs. 61 (7): 989–996, discussion 997–998. doi:10.2165/00003495-200161070-00007. ISSN 0012-6667. PMID 11434453.
^Opie, LIONEL H. (2013-01-01), Opie, Lionel H.; Gersh, Bernard J. (eds.), "3 - Calcium channel blockers", Drugs for the Heart (Eighth Edition), Philadelphia: W.B. Saunders, pp. 64–92, ISBN978-1-4557-3322-4, retrieved 2023-01-05
^Shete, Mukesh Madhukar (2016). "Cilnidipine: Next Generation Calcium Channel Blocker". The Journal of the Association of Physicians of India. 64 (4): 95–99. ISSN 0004-5772. PMID 27734656.
^Deeks, Emma D.; Keating, Gillian M.; Keam, Susan J. (2009). "Clevidipine: a review of its use in the management of acute hypertension". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 9 (2): 117–134. doi:10.1007/BF03256583. ISSN 1175-3277. PMID 19331440.
^Matucci, R.; Ottaviani, M. F.; Barbieri, M.; Cerbai, E.; Mugelli, A. (2009-02-12). "Protective effect of darodipine, a calcium antagonist, on rat cardiomyocytes against oxygen radical-mediated injury". British Journal of Pharmacology. 122 (7): 1353–1360. doi:10.1038/sj.bjp.0701525. ISSN 0007-1188. PMC1565083. PMID 9421282.
^Hahn, K. A.; Legendre, A. M.; Schuller, H. M. (1997). "Amputation and dexniguldipine as treatment for canine appendicular osteosarcoma". Journal of Cancer Research and Clinical Oncology. 123 (1): 34–38. doi:10.1007/BF01212612. ISSN 0171-5216. PMID 8996538. S2CID 21129242.
^Tanaka, Hikaru; Shigenobu, Koki (2002). "Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels". Cardiovascular Drug Reviews. 20 (1): 81–92. doi:10.1111/j.1527-3466.2002.tb00084.x. ISSN 0897-5957. PMID 12070536.
^Tamargo, J.; López-Sendón, J.; Delpón, E.; González-Morales, M.; de Miguel, E. (1991). "Cardiovascular effects of the new dihydropyridine derivative elgodipine". Arzneimittel-Forschung. 41 (9): 895–900. ISSN 0004-4172. PMID 1796916.
^Mayhan, W. G.; Heistad, D. D. (1985). "Effect of flordipine on cerebral blood flow". The Journal of Pharmacology and Experimental Therapeutics. 235 (1): 92–97. ISSN 0022-3565. PMID 4045730.
^Krzemiński, Tadeusz F.; Hudziak, Damian; Sielańczyk, Andrzej W.; Porc, Maurycy; Kedzia, Agnieszka (2008). "Differential effects of furnidipine and its active metabolites in rat isolated working heart". Vascular Pharmacology. 49 (2–3): 91–96. doi:10.1016/j.vph.2008.06.005. ISSN 1537-1891. PMID 18656554.
^Ishii, Kiyoshi; Matsuo, Hiroshi; Fukaya, Yasuhiro; Tanaka, Sumiyoshi; Sakaki, Hideyuki; Waki, Mitsunori; Araie, Makoto (2003). "Iganidipine, a new water-soluble Ca2+ antagonist: ocular and periocular penetration after instillation". Investigative Ophthalmology & Visual Science. 44 (3): 1169–1177. doi:10.1167/iovs.02-0482. ISSN 0146-0404. PMID 12601046.
^Schachter, M. (1991). "Isradipine". Journal of Clinical Pharmacy and Therapeutics. 16 (2): 79–91. doi:10.1111/j.1365-2710.1991.tb00288.x. ISSN 0269-4727. PMID 1830320. S2CID 221850085.
^Tushar, Chopra; Okusa, Mark Douglas (2019-01-01), Ronco, Claudio; Bellomo, Rinaldo; Kellum, John A.; Ricci, Zaccaria (eds.), "Chapter 63 - Aldosterone Antagonists, Amiloride, and Triamterene", Critical Care Nephrology (Third Edition), Philadelphia: Elsevier, pp. 368–373.e1, ISBN978-0-323-44942-7, retrieved 2023-01-05
November 15, 2023
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This article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Dihydropyridine calcium channel blockers news newspapers books scholar JSTOR January 2023 Learn how and when to remove this template message Dihydropyridine calcium channel blockers are derivatives of 1 4 dihydropyridine that are used as L type calcium channel blockers 1 They are used in the treatment of hypertension 2 Class members editCompared with certain other L type calcium channel blockers for example those of the phenylalkylamine class such as verapamil that have significant action at the heart they are relatively vascular selective in their mechanism of action in lowering blood pressure 3 Dihydropyridine class L type calcium channel blockers include in alphabetical order brand names vary in different countries Name Image Brand name CitationsAmlodipine nbsp Norvasc Istin Normodipine Tenox Cordi Cor 4 Aranidipine nbsp Sapresta サプレスタ 5 Azelnidipine nbsp CalBlock カルブロック 6 Barnidipine nbsp Vasexten Libradin Cyress HypoCa 7 Benidipine nbsp Coniel 8 Cilnidipine nbsp Atelec アテレック Cilacar Cinalong Siscard 9 Clevidipine nbsp Cleviprex 10 Cronidipine nbsp 11 Darodipine nbsp 12 Dexniguldipine nbsp 13 Efonidipine nbsp Landel ランデル 14 Elgodipine nbsp 15 Elnadipine nbsp 16 Felodipine nbsp Renedil Plendil 17 Flordipine nbsp 18 Furnidipine nbsp 19 Iganidipine nbsp 20 Isradipine nbsp DynaCirc CR 21 Lacidipine nbsp Lacipil Motens SakureLemildipine nbsp Lercanidipine nbsp Zanidip Zanidip RecordatiLevamlodipine nbsp EsCordi CorLevniguldipine nbsp Manidipine nbsp Manyper Caslot MadipineNicardipine nbsp Cardene Cardene SRNifedipine nbsp Adalat Nifedical Procardia Corinfar CordaflexNiguldipine nbsp Niludipine nbsp Nilvadipine nbsp NivadilNimodipine nbsp NimotopNisoldipine nbsp Sular Baymycard SyscorNitrendipine nbsp Baypress Cardif Nitrepin BaylotensinOlradipine nbsp Oxodipine nbsp Palonidipine nbsp Pranidipine nbsp AcalasRyodipine nbsp Sagandipine nbsp Sornidipine nbsp Teludipine nbsp Tiamdipine nbsp Trombodipine nbsp Vatanidipine nbsp The pharmaceutical drug finerenone is also a dihydrophyridine derivative but does not act as a calcium channel blocker but as an antimineralocorticoid 22 See also editCalcium channel blocker including section on non dihydropyridine calcium channel blockers Calcium channel Dihydropyridine receptorReferences edit Bladen Chris Gunduz Miyase Gozde Simsek Rahime Safak Cihat Zamponi Gerald W 2014 10 23 Synthesis and evaluation of 1 4 dihydropyridine derivatives with calcium channel blocking activity Pflugers Archiv European Journal of Physiology 466 7 1355 1363 doi 10 1007 s00424 013 1376 z ISSN 1432 2013 PMID 24149495 S2CID 253888496 Xu Lei Li Dan Tao Li Yang Yanling Li Youyong Hou Tingjun 2016 Binding mechanisms of 1 4 dihydropyridine derivatives to L type calcium channel Cav1 2 a molecular modeling study Molecular BioSystems 12 2 379 390 doi 10 1039 c5mb00781j ISSN 1742 2051 PMID 26673131 Frishman William H 2007 Calcium channel blockers differences between subclasses American Journal of Cardiovascular Drugs Drugs Devices and Other Interventions 7 Suppl 1 17 23 doi 10 2165 00129784 200707001 00003 ISSN 1175 3277 PMID 19845073 S2CID 21199295 Bulsara Kishen G Cassagnol Manouchkathe 2022 Amlodipine StatPearls Treasure Island FL StatPearls Publishing PMID 30137793 retrieved 2023 01 05 Okumura K Ichihara K Nagasaka M 1997 Effects of aranidipine a novel calcium channel blocker on mechanical responses of the isolated rat portal vein comparison with typical calcium channel blockers and potassium channel openers Journal of Cardiovascular Pharmacology 29 2 209 215 doi 10 1097 00005344 199702000 00009 ISSN 0160 2446 PMID 9057070 Wellington Keri Scott Lesley J 2003 Azelnidipine Drugs 63 23 2613 2621 discussion 2623 2624 doi 10 2165 00003495 200363230 00004 ISSN 0012 6667 PMID 14636080 Malhotra H S Plosker G L 2001 Barnidipine Drugs 61 7 989 996 discussion 997 998 doi 10 2165 00003495 200161070 00007 ISSN 0012 6667 PMID 11434453 Opie LIONEL H 2013 01 01 Opie Lionel H Gersh Bernard J eds 3 Calcium channel blockers Drugs for the Heart Eighth Edition Philadelphia W B Saunders pp 64 92 ISBN 978 1 4557 3322 4 retrieved 2023 01 05 Shete Mukesh Madhukar 2016 Cilnidipine Next Generation Calcium Channel Blocker The Journal of the Association of Physicians of India 64 4 95 99 ISSN 0004 5772 PMID 27734656 Deeks Emma D Keating Gillian M Keam Susan J 2009 Clevidipine a review of its use in the management of acute hypertension American Journal of Cardiovascular Drugs Drugs Devices and Other Interventions 9 2 117 134 doi 10 1007 BF03256583 ISSN 1175 3277 PMID 19331440 PubChem Cronidipine pubchem ncbi nlm nih gov Retrieved 2023 01 05 Matucci R Ottaviani M F Barbieri M Cerbai E Mugelli A 2009 02 12 Protective effect of darodipine a calcium antagonist on rat cardiomyocytes against oxygen radical mediated injury British Journal of Pharmacology 122 7 1353 1360 doi 10 1038 sj bjp 0701525 ISSN 0007 1188 PMC 1565083 PMID 9421282 Hahn K A Legendre A M Schuller H M 1997 Amputation and dexniguldipine as treatment for canine appendicular osteosarcoma Journal of Cancer Research and Clinical Oncology 123 1 34 38 doi 10 1007 BF01212612 ISSN 0171 5216 PMID 8996538 S2CID 21129242 Tanaka Hikaru Shigenobu Koki 2002 Efonidipine hydrochloride a dual blocker of L and T type ca 2 channels Cardiovascular Drug Reviews 20 1 81 92 doi 10 1111 j 1527 3466 2002 tb00084 x ISSN 0897 5957 PMID 12070536 Tamargo J Lopez Sendon J Delpon E Gonzalez Morales M de Miguel E 1991 Cardiovascular effects of the new dihydropyridine derivative elgodipine Arzneimittel Forschung 41 9 895 900 ISSN 0004 4172 PMID 1796916 PubChem Elnadipine pubchem ncbi nlm nih gov Retrieved 2023 01 05 Bansal Agam B Khandelwal Gaurav 2022 Felodipine StatPearls Treasure Island FL StatPearls Publishing PMID 31194320 retrieved 2023 01 05 Mayhan W G Heistad D D 1985 Effect of flordipine on cerebral blood flow The Journal of Pharmacology and Experimental Therapeutics 235 1 92 97 ISSN 0022 3565 PMID 4045730 Krzeminski Tadeusz F Hudziak Damian Sielanczyk Andrzej W Porc Maurycy Kedzia Agnieszka 2008 Differential effects of furnidipine and its active metabolites in rat isolated working heart Vascular Pharmacology 49 2 3 91 96 doi 10 1016 j vph 2008 06 005 ISSN 1537 1891 PMID 18656554 Ishii Kiyoshi Matsuo Hiroshi Fukaya Yasuhiro Tanaka Sumiyoshi Sakaki Hideyuki Waki Mitsunori Araie Makoto 2003 Iganidipine a new water soluble Ca2 antagonist ocular and periocular penetration after instillation Investigative Ophthalmology amp Visual Science 44 3 1169 1177 doi 10 1167 iovs 02 0482 ISSN 0146 0404 PMID 12601046 Schachter M 1991 Isradipine Journal of Clinical Pharmacy and Therapeutics 16 2 79 91 doi 10 1111 j 1365 2710 1991 tb00288 x ISSN 0269 4727 PMID 1830320 S2CID 221850085 Tushar Chopra Okusa Mark Douglas 2019 01 01 Ronco Claudio Bellomo Rinaldo Kellum John A Ricci Zaccaria eds Chapter 63 Aldosterone Antagonists Amiloride and Triamterene Critical Care Nephrology Third Edition Philadelphia Elsevier pp 368 373 e1 ISBN 978 0 323 44942 7 retrieved 2023 01 05 Retrieved from https en wikipedia org w index php title Dihydropyridine calcium channel blockers amp oldid 1170436376, wikipedia, wiki, book, books, library,
