Solutions of this solid have been used in Europe as an antidote to cyanide poisoning, with the trade name Kelocyanor.[1] However, dicobalt edetate is itself toxic, particularly if there is not enough cyanide in the blood to react with it, so it is only suitable for serious cases of poisoning. In the past, workplaces in the UK that handle cyanide were recommended to keep a 'Kelocyanor kit', to be taken to the hospital along with the patient, but this practice has been discontinued since it may mislead doctors into using the antidote unnecessarily.[2]
Structure
The compound is polymeric in the crystalline form. Half of the Co2+ ions are bound to the EDTA2− and the other Co2+ ions are bound to four water ligands as well as carboxylateligands on the [Co(EDTA)]2− entity.[3] In aqueous solution, depolymerization occurs to give [Co(EDTA)]2− and [Co(H2O)6]2+ ions, each of which is kinetically labile and has a high affinity for cyanide.
Related compounds
Oxidation of [Co(II)(EDTA)]2− gives [Co(III)(EDTA)]−, which is so kinetically inert that it can be resolved optically.[4]
References
^Pickering WG (December 1985). "Cyanide toxicity and the hazards of dicobalt edetate". Br Med J (Clin Res Ed). 291 (6509): 1644. doi:10.1136/bmj.291.6509.1644-a. PMC1418389. PMID 2866807.
^"Cyanide poisoning – New recommendations on first aid treatment". Health and Safety Executive. from the original on 20 October 2009.
^E. F. K. Mccandlish, T. K. Michael; Rose, N. J.; Neal, J. A.; Lingafelter, E. C.; Rose, N. J. (1978). "Comparison of the Structures and Aqueous Solutions of [(O-Phenylenediaminetetraacetato(2-)]Cobalt(II) and [Ethylenediaminetetraacetato(2-)]Cobalt(II)". Inorg. Chem.17 (6): 1383–94. doi:10.1021/ic50184a001.
^Dwyer, F. P.; Garvan, F. L. (1960). Resolution of the Ethylenediaminetetracetatocobaltate(III) Ion. Inorg. Synth. Inorganic Syntheses. Vol. VI. pp. 192–4. doi:10.1002/9780470132371.ch61. ISBN978-0-470-13237-1.
January 30, 2023
dicobalt, edetate, coordination, compound, with, approximate, formula, edta, derivative, natural, amino, acid, ethylenediaminetetraacetate, namesother, names, kelocyanoridentifierscas, number, 36499, model, jsmol, interactive, imageinteractive, imagechemspider. Dicobalt edetate is the coordination compound with the approximate formula Co2 EDTA H2O 6 It is a derivative of the non natural amino acid ethylenediaminetetraacetate Dicobalt edetate NamesOther names KelocyanorIdentifiersCAS Number 36499 65 7 Y3D model JSmol Interactive imageInteractive imageChemSpider 64951 YECHA InfoCard 100 048 227PubChem CID 71942UNII UKC6GH80QR NCompTox Dashboard EPA DTXSID70189997InChI InChI 1S C10H16N2O8 2Co c13 7 14 3 11 4 8 15 16 1 2 12 5 9 17 18 6 10 19 20 h1 6H2 H 13 14 H 15 16 H 17 18 H 19 20 q 2 2 p 4 YKey TWAWHTJKASJPEK UHFFFAOYSA J YInChI 1 C10H16N2O8 2Co c13 7 14 3 11 4 8 15 16 1 2 12 5 9 17 18 6 10 19 20 h1 6H2 H 13 14 H 15 16 H 17 18 H 19 20 q 2 2 p 4Key TWAWHTJKASJPEK XBHQNQODAQSMILES C CN CC O O CC O O N CC O O CC O O Co 2 Co 2 Co 2 Co 2 O C O CN CC O O CCN CC O O CC O OPropertiesChemical formula C10H12Co2N2O8 6H2OMolar mass 406 08 g mol514 18 g mol hexahydrate Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox references Solutions of this solid have been used in Europe as an antidote to cyanide poisoning with the trade name Kelocyanor 1 However dicobalt edetate is itself toxic particularly if there is not enough cyanide in the blood to react with it so it is only suitable for serious cases of poisoning In the past workplaces in the UK that handle cyanide were recommended to keep a Kelocyanor kit to be taken to the hospital along with the patient but this practice has been discontinued since it may mislead doctors into using the antidote unnecessarily 2 Structure EditThe compound is polymeric in the crystalline form Half of the Co2 ions are bound to the EDTA2 and the other Co2 ions are bound to four water ligands as well as carboxylate ligands on the Co EDTA 2 entity 3 In aqueous solution depolymerization occurs to give Co EDTA 2 and Co H2O 6 2 ions each of which is kinetically labile and has a high affinity for cyanide Related compounds EditOxidation of Co II EDTA 2 gives Co III EDTA which is so kinetically inert that it can be resolved optically 4 References Edit Pickering WG December 1985 Cyanide toxicity and the hazards of dicobalt edetate Br Med J Clin Res Ed 291 6509 1644 doi 10 1136 bmj 291 6509 1644 a PMC 1418389 PMID 2866807 Cyanide poisoning New recommendations on first aid treatment Health and Safety Executive Archived from the original on 20 October 2009 E F K Mccandlish T K Michael Rose N J Neal J A Lingafelter E C Rose N J 1978 Comparison of the Structures and Aqueous Solutions of O Phenylenediaminetetraacetato 2 Cobalt II and Ethylenediaminetetraacetato 2 Cobalt II Inorg Chem 17 6 1383 94 doi 10 1021 ic50184a001 Dwyer F P Garvan F L 1960 Resolution of the Ethylenediaminetetracetatocobaltate III Ion Inorg Synth Inorganic Syntheses Vol VI pp 192 4 doi 10 1002 9780470132371 ch61 ISBN 978 0 470 13237 1 Retrieved from https en wikipedia org w index php title Dicobalt edetate amp oldid 1095843501, wikipedia, wiki, book, books, library,
