This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.
Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000105612 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Deoxyribonuclease II, lysosomal". Retrieved 2016-09-07.
Further readingedit
Chou SF, Chen HL, Lu SC (2002). "Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells". Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.
deoxyribonuclease, lysosomal, deoxyribonuclease, lysosomal, protein, that, humans, encoded, dnase2, gene, dnase2identifiersaliasesdnase2, dnase2a, dnl2, deoxyribonuclease, lysosomal, deoxyribonuclease, lysosomal, aipcsexternal, idsomim, 126350, 1329019, homolo. Deoxyribonuclease II lysosomal is a protein that in humans is encoded by the DNASE2 gene 4 DNASE2IdentifiersAliasesDNASE2 DNASE2A DNL DNL2 deoxyribonuclease II lysosomal deoxyribonuclease 2 lysosomal AIPCSExternal IDsOMIM 126350 MGI 1329019 HomoloGene 68179 GeneCards DNASE2Gene location Human Chr Chromosome 19 human 1 Band19p13 13Start12 875 209 bp 1 End12 881 466 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inpancreatic ductal cellstromal cell of endometriumexternal globus pallidusparotid glandcardiamonocytevena cavapylorussubthalamic nucleuslymph noden aMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding nuclease activity endonuclease activity endodeoxyribonuclease activity hydrolase activity deoxyribonuclease II activityCellular componentlysosome extracellular exosome intracellular anatomical structureBiological processerythrocyte differentiation multicellular organism development DNA metabolic process DNA catabolic process DNA catabolic process endonucleolytic apoptotic process apoptotic DNA fragmentation regulation of immune responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez177713423EnsemblENSG00000105612ENSMUSG00000003812UniProtO00115P56542RefSeq mRNA NM 001375NM 010062NM 001368295NM 001368296RefSeq protein NP 001366NP 001366 1NP 034192NP 001355224NP 001355225Location UCSC Chr 19 12 88 12 88 Mbn aPubMed search 2 3 WikidataView Edit HumanView Edit MouseFunction editThis gene encodes a member of the DNase family The protein located in the lysosome hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis Two codominant alleles have been characterized DNASE2 L low activity and DNASE2 H high activity that differ at one nucleotide in the promoter region The DNASE2 H allele is represented in this record References edit a b c GRCh38 Ensembl release 89 ENSG00000105612 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Deoxyribonuclease II lysosomal Retrieved 2016 09 07 Further reading editChou SF Chen HL Lu SC 2002 Up regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL 60 and THP 1 cells Biochem Biophys Res Commun 296 1 48 53 doi 10 1016 s0006 291x 02 00835 5 PMID 12147225 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 19 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Deoxyribonuclease ii lysosomal amp oldid 1079707753, wikipedia, wiki, book, books, library,
