Dennis Howard WrightFRCPath (11 August 1931 – 8 April 2020)[1][2] was a British medical doctor and professor of pathology with an international reputation in haematopathology.[3]
Wright grew up in the county of Norfolk and attended the City of Norwich School with a Norfolk county scholarship. He graduated from the University of Bristol in 1953 with a B.Sc. in physiology and in 1956 with an MB ChB (Hons). After receiving his degree, he fulfilled his national service requirement by serving as a pathologist in Kampala, Uganda. There he worked as a lecturer, senior lecturer, and then reader in pathology at Makerere University's medical school,[4] where he spent eight years.[5] During the late 1950s and early 1960s, he worked with Dr. Denis Burkitt in describing the pathology of Burkitt lymphoma. Wright became a leading expert on lymphomas. In 1964 he graduated from the University of Bristol with a higher doctorate MD. His M.D. thesis is entitled Malignant Lymphomas in Uganda. In 1965 he qualified as MRCPath. In 1968 he returned from Uganda to England to become a reader in pathology at Birmingham University. In 1972 he was appointed the Foundation Professor of Pathology at the University of Southampton and retired there in 1996 as professor emeritus.[4]
In the 1970s, Wright pioneered the use of immunofluorescence to investigate the cellular pathogenesis of Hodgkin lymphoma. He was the first to suggest that Reed–Sternberg cells are derived from B-cells — a controversial proposal that was not confirmed until several decades later. In the 1980s and 1990s, he and his coworkers were among the first to describe T-cell lymphomas associated with enteropathy and to describe lymphomas of mucosa-associated lymphoid tissue. His pioneering research transformed lymphoma diagnose by the use of immunoperoxidase staining of paraffin sections. Later, he and his coworkers published a number of papers involving molecular analysis of lymphomas.[4]
As a professor, Wright was committed not only to his research but also to general surgical and autopsy pathology. From 1983 to 1994 he was the editor-in-chief of The Journal of Pathology from 1983 to 1994. He was also served on the editorial board of Biomedicine. He served as the president of the European Haematopathology Society.[4]
Upon his death, Dennis H. Wright was survived by his widow, Elizabeth, and their two children, as well as six children from his first marriage, and ten grandchildren. Three of his eight children became medical doctors.[4][6]
Selected publicationsedit
Articlesedit
Wright, D. H. (1975). The Dead End of Medicine?: An Inaugural Lecture Delivered on 22 May, 1975. University of Southampton. ISBN0854321489; 13 pages{{cite book}}: CS1 maint: postscript (link)
Isaacson, Peter; Wright, Dennis H. (1978). "Malignant histiocytosis of the intestine". Human Pathology. 9 (6): 661–677. doi:10.1016/S0046-8177(78)80049-5. PMID 730148.
Isaacson, Peter; Wright, Dennis H.; Judd, Mary A.; Mepham, Brian L. (1979). "Primary gastrointestinal lymphomas:A classification of 66 cases". Cancer. 43 (5): 1805–1819. doi:10.1002/1097-0142(197905)43:5<1805::AID-CNCR2820430534>3.0.CO;2-6. PMID 376099. S2CID 42252144.
Isaacson, Peter; Wright, Dennis H. (1983). "Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma". Cancer. 52 (8): 1410–1416. doi:10.1002/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3. PMID 6193858. S2CID 10324919.
Herbert, Amanda; Wright, Dennis H.; Isaacson, Peter G.; Smith, John L. (1984). "Primary malignant lymphoma of the lung: Histopathologic and immunologic evaluation of nine cases". Human Pathology. 15 (5): 415–422. doi:10.1016/S0046-8177(84)80074-X. PMID 6373559.
Isaacson, Peter; Wright, Dennis H. (1984). "Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue". Cancer. 53 (11): 2515–2524. doi:10.1002/1097-0142(19840601)53:11<2515::AID-CNCR2820531125>3.0.CO;2-C. PMID 6424928. S2CID 23297912.
Flavell, D. J.; Jones, D. B.; Wright, D. H. (1987). "Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody". Journal of Histochemistry & Cytochemistry. 35 (11): 1217–1226. doi:10.1177/35.11.3309045. PMID 3309045. S2CID 32783494.
Niedobitek, Gerald; Agathanggelou, Angelo; Herbst, Hermann; Whitehead, Lucie; Wright, Dennis H.; Young, Lawrence S. (1997). "Epstein-Barr Virus (Ebv) Infection in Infectious Mononucleosis: Virus Latency, Replication and Phenotype of Ebv-Infected Cells". The Journal of Pathology. 182 (2): 151–159. doi:10.1002/(SICI)1096-9896(199706)182:2<151::AID-PATH824>3.0.CO;2-3. PMID 9274524. S2CID 21216533.
Gale, Joanna; Simmonds, Peter D.; Mead, Graham M.; Sweetenham, John W.; Wright, Dennis H. (2000). "Enteropathy-Type Intestinal T-Cell Lymphoma: Clinical Features and Treatment of 31 Patients in a Single Center". Journal of Clinical Oncology. 18 (4): 795–803. doi:10.1200/jco.2000.18.4.795. PMID 10673521.
Wright, Dennis H.; Isaacson, Peter G. (17 December 2013). Biopsy Pathology of the Lymphoreticular System. ISBN9781489933966; 1st edition 1983{{cite book}}: CS1 maint: postscript (link)
Jones, D. B.; Wright, D. H., eds. (6 December 2012). Lymphoproliferative Diseases. ISBN9789400907393; 1st edition 1990{{cite book}}: CS1 maint: postscript (link)
Wilkins, Bridget S.; Wright, Dennis H. (24 February 2000). Illustrated Pathology of the Spleen. Cambridge University Press. ISBN9780521622271.
Wright, Dennis H.; Addis, Bruce J.; Leong, Anthony S.-Y. (2006). Diagnostic lymph node pathology. ISBN978-1-4441-1473-7.
Ashton-Key, Margaret; Wright, Penny; Wright, Dennis (8 October 2018). Diagnostic Lymph Node Pathology (3rd ed.). CRC Press. ISBN9781498732703.
Referencesedit
^biographical information from Who´s who of British Scientists, 1980
^Tribute to Professor Dennis Howard Wright, 1931 - 2020
^Ashton-Key, Margaret (2020). "Dennis H Wright". BMJ: m1723. doi:10.1136/bmj.m1723. S2CID 219015277.
^ abcdefAshton‐Key, Margaret; Bateman, Adrian (2020). "Professor Dennis H Wright: An appreciation". The Journal of Pathology. 252 (3): 217–218. doi:10.1002/path.5538. PMID 33064894. S2CID 222806785.
^Macon, William R. (2020). "COVID-19 and remembering Professor Dennis H. Wright". Journal of Hematopathology. 13 (2): 77–78. doi:10.1007/s12308-020-00397-6. PMC7247865. PMID 32837598.
^"Obituary: Professor Dennis H Wright BSc, MBChB, MD, FRCPath 11th August 1931 – 8th April 2020". Leukaemia Busters: Saving Young Lives Through Research; blog by Dr David J Flavell PhD FRCPath. 11 April 2020.
April 10, 2024
dennis, wright, dennis, howard, wright, frcpath, august, 1931, april, 2020, british, medical, doctor, professor, pathology, with, international, reputation, haematopathology, contents, biography, selected, publications, articles, books, referencesbiography, ed. Dennis Howard Wright FRCPath 11 August 1931 8 April 2020 1 2 was a British medical doctor and professor of pathology with an international reputation in haematopathology 3 Contents 1 Biography 2 Selected publications 2 1 Articles 2 2 Books 3 ReferencesBiography editWright grew up in the county of Norfolk and attended the City of Norwich School with a Norfolk county scholarship He graduated from the University of Bristol in 1953 with a B Sc in physiology and in 1956 with an MB ChB Hons After receiving his degree he fulfilled his national service requirement by serving as a pathologist in Kampala Uganda There he worked as a lecturer senior lecturer and then reader in pathology at Makerere University s medical school 4 where he spent eight years 5 During the late 1950s and early 1960s he worked with Dr Denis Burkitt in describing the pathology of Burkitt lymphoma Wright became a leading expert on lymphomas In 1964 he graduated from the University of Bristol with a higher doctorate MD His M D thesis is entitled Malignant Lymphomas in Uganda In 1965 he qualified as MRCPath In 1968 he returned from Uganda to England to become a reader in pathology at Birmingham University In 1972 he was appointed the Foundation Professor of Pathology at the University of Southampton and retired there in 1996 as professor emeritus 4 In the 1970s Wright pioneered the use of immunofluorescence to investigate the cellular pathogenesis of Hodgkin lymphoma He was the first to suggest that Reed Sternberg cells are derived from B cells a controversial proposal that was not confirmed until several decades later In the 1980s and 1990s he and his coworkers were among the first to describe T cell lymphomas associated with enteropathy and to describe lymphomas of mucosa associated lymphoid tissue His pioneering research transformed lymphoma diagnose by the use of immunoperoxidase staining of paraffin sections Later he and his coworkers published a number of papers involving molecular analysis of lymphomas 4 As a professor Wright was committed not only to his research but also to general surgical and autopsy pathology From 1983 to 1994 he was the editor in chief of The Journal of Pathology from 1983 to 1994 He was also served on the editorial board of Biomedicine He served as the president of the European Haematopathology Society 4 He received in 1973 the Paul Ehrlich and Ludwig Darmstaedter Prize for his research on the pathology of Burkitt lymphoma He was elected in 1977 a Fellow of the Royal College of Pathologists FRCPath His final publication which was the 3rd edition of Diagnostic Lymph Node Pathology 2016 received the accolade of Highly Commended in the British Medical Association s 2017 book awards 4 Upon his death Dennis H Wright was survived by his widow Elizabeth and their two children as well as six children from his first marriage and ten grandchildren Three of his eight children became medical doctors 4 6 Selected publications editArticles edit Wright D H 1975 The Dead End of Medicine An Inaugural Lecture Delivered on 22 May 1975 University of Southampton ISBN 0854321489 13 pages a href Template Cite book html title Template Cite book cite book a CS1 maint postscript link Isaacson Peter Wright Dennis H 1978 Malignant histiocytosis of the intestine Human Pathology 9 6 661 677 doi 10 1016 S0046 8177 78 80049 5 PMID 730148 Isaacson Peter Wright Dennis H Judd Mary A Mepham Brian L 1979 Primary gastrointestinal lymphomas A classification of 66 cases Cancer 43 5 1805 1819 doi 10 1002 1097 0142 197905 43 5 lt 1805 AID CNCR2820430534 gt 3 0 CO 2 6 PMID 376099 S2CID 42252144 Isaacson Peter Wright Dennis H 1983 Malignant lymphoma of mucosa associated lymphoid tissue A distinctive type of B cell lymphoma Cancer 52 8 1410 1416 doi 10 1002 1097 0142 19831015 52 8 lt 1410 AID CNCR2820520813 gt 3 0 CO 2 3 PMID 6193858 S2CID 10324919 Herbert Amanda Wright Dennis H Isaacson Peter G Smith John L 1984 Primary malignant lymphoma of the lung Histopathologic and immunologic evaluation of nine cases Human Pathology 15 5 415 422 doi 10 1016 S0046 8177 84 80074 X PMID 6373559 Isaacson Peter Wright Dennis H 1984 Extranodal malignant lymphoma arising from mucosa associated lymphoid tissue Cancer 53 11 2515 2524 doi 10 1002 1097 0142 19840601 53 11 lt 2515 AID CNCR2820531125 gt 3 0 CO 2 C PMID 6424928 S2CID 23297912 Flavell D J Jones D B Wright D H 1987 Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody Journal of Histochemistry amp Cytochemistry 35 11 1217 1226 doi 10 1177 35 11 3309045 PMID 3309045 S2CID 32783494 Niedobitek Gerald Agathanggelou Angelo Herbst Hermann Whitehead Lucie Wright Dennis H Young Lawrence S 1997 Epstein Barr Virus Ebv Infection in Infectious Mononucleosis Virus Latency Replication and Phenotype of Ebv Infected Cells The Journal of Pathology 182 2 151 159 doi 10 1002 SICI 1096 9896 199706 182 2 lt 151 AID PATH824 gt 3 0 CO 2 3 PMID 9274524 S2CID 21216533 Gale Joanna Simmonds Peter D Mead Graham M Sweetenham John W Wright Dennis H 2000 Enteropathy Type Intestinal T Cell Lymphoma Clinical Features and Treatment of 31 Patients in a Single Center Journal of Clinical Oncology 18 4 795 803 doi 10 1200 jco 2000 18 4 795 PMID 10673521 Books edit Burkitt Denis P Wright Dennis H 1970 Burkitt s Lymphoma Edinburgh Livingstone ISBN 0443007004 LCCN 72021505 xi 251 pages foreword by Sir Harold Himsworth a href Template Cite book html title Template Cite book cite book a CS1 maint postscript link Wright Dennis H Isaacson Peter G 17 December 2013 Biopsy Pathology of the Lymphoreticular System ISBN 9781489933966 1st edition 1983 a href Template Cite book html title Template Cite book cite book a CS1 maint postscript link Jones D B Wright D H eds 6 December 2012 Lymphoproliferative Diseases ISBN 9789400907393 1st edition 1990 a href Template Cite book html title Template Cite book cite book a CS1 maint postscript link Wilkins Bridget S Wright Dennis H 24 February 2000 Illustrated Pathology of the Spleen Cambridge University Press ISBN 9780521622271 Wright Dennis H Addis Bruce J Leong Anthony S Y 2006 Diagnostic lymph node pathology ISBN 978 1 4441 1473 7 2nd edition London Hodder Arnold 2011 ISBN 9781444146776 Ashton Key Margaret Wright Penny Wright Dennis 8 October 2018 Diagnostic Lymph Node Pathology 3rd ed CRC Press ISBN 9781498732703 References edit biographical information from Who s who of British Scientists 1980 Tribute to Professor Dennis Howard Wright 1931 2020 Ashton Key Margaret 2020 Dennis H Wright BMJ m1723 doi 10 1136 bmj m1723 S2CID 219015277 a b c d e f Ashton Key Margaret Bateman Adrian 2020 Professor Dennis H Wright An appreciation The Journal of Pathology 252 3 217 218 doi 10 1002 path 5538 PMID 33064894 S2CID 222806785 Macon William R 2020 COVID 19 and remembering Professor Dennis H Wright Journal of Hematopathology 13 2 77 78 doi 10 1007 s12308 020 00397 6 PMC 7247865 PMID 32837598 Obituary Professor Dennis H Wright BSc MBChB MD FRCPath 11th August 1931 8th April 2020 Leukaemia Busters Saving Young Lives Through Research blog by Dr David J Flavell PhD FRCPath 11 April 2020 Retrieved from https en wikipedia org w index php title Dennis H Wright amp oldid 1212033778, wikipedia, wiki, book, books, library,
