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Deborah Charlesworth

April 12, 2024

Deborah Charlesworth FRS FRSE (née Maltby; born 1943) is a population geneticist from the UK, notable for her important discoveries in population genetics and evolutionary biology.[6][7] Her most notable research is in understanding the evolution of recombination, sex chromosomes and mating system for plants.[6]

Deborah Charlesworth

BornMarch 1943 (age 81)
CitizenshipBritish
Alma materUniversity of Cambridge
Spouse
​
(m. 1967)​
Children1 daughter
Awards
Scientific career
FieldsEvolutionary biology
Institutions
ThesisBiometrical studies of some biochemical characters in the mouse (1969)
Doctoral studentsPhilip Awadalla
Other notable studentsGilean McVean (postdoc)

Early life and education edit

Charlesworth grew up in a London suburb, and from a young age was very interested in the natural world around her.[5]

Charlesworth initially studied biochemistry, however genetic variation played a significant role since the beginning her research.[8] Charlesworth obtained her doctorate at Cambridge University in 1968 with her thesis focusing on the quantitative genetics of mice, specifically the extent of genetic variation in the blood glucose levels across natural strains.[8] This also happened to be the topic of her first study.[8] Charlesworth continued her education at Cambridge and Chicago as a research fellow in human genetics examining amino acid variations in hemoglobins in human populations.[8] Charlesworth's interest in evolutionary biology continued through her collaboration with Brian Charlesworth, specifically their works on mimicry systems and recombination rates causing her to shift her focus to evolution.[8] She continued her post-doctoral research at, University of Chicago, Liverpool University, Sussex University as Brian Charlesworth took positions at each, causing Debrah to do research without Grant support.[8] She was mentored at Cambridge by Hermann Lehmann.[9]

At the age of 45, Charlesworth obtained her first faculty position teaching at University of Chicago from 1988–1997.[5] By this time, Charlesworth had already published ~50 articles.[8] Following this position, Charlesworth left to take up a Professorial Research Fellowship at the University of Edinburgh.[10] She is best known for her work on the evolution of genetic self-incompatibility in plants and is recognised as a leader in that field. According to the Web of Science she has published over 300 articles in peer-reviewed journals. These articles have been cited over 10,000 times and she has an h-index of 53.[11] She has been married since 1967 to the British evolutionary biologist Brian Charlesworth, who she ended up working in population genetics with.[5]

Awards and honors edit

Charlesworth was elected a Fellow of the Royal Society of Edinburgh in 2001[5] and a Fellow of the Royal Society (FRS) in 2005[4] In 2011, Charlesworth was awarded the Molecular Ecology Prize.[12] Charlesworth was awarded the Genetics Society Medal 2019.[3] She was awarded a Lifetime Achievement Award by the Society for the Study of Evolution in January 2020.[2] In 2022, she was elected to the National Academy of Sciences.[1]

Selected publications edit

 
Scholia has a profile for Deborah Charlesworth (Q4794846).
  • Charlesworth, D, Wright, SI. (2001) Breeding systems and genome evolution. Current Opinion in Genetics & Development 11, 685–690.
  • Jesper S. Bechsgaard, Vincent Castric, Deborah Charlesworth, Xavier Vekemans, Mikkel H. Schierup. 2006. The transition to self-compatibility in Arabidopsis thaliana and evolution within S-haplotypes over 10 million years. Molecular Biology and Evolution 23: 1741–1750.
  • Asher D. Cutter, Scott E. Baird and Deborah Charlesworth. 2006 Patterns of nucleotide polymorphism and the decay of linkage disequilibrium in wild populations of Caenorhabditis remanei. Genetics 174: 901–913.
  • Bergero, R., A. Forrest, E. Kamau, and D. Charlesworth. 2007. Evolutionary strata on the X chromosomes of the dioecious plant Silene latifolia: evidence from new sex-linked genes. Genetics 175:1945-1954.
  • D. Charlesworth 2006 Balancing selection and its effects on sequences in nearby genome regions. PLoS Genetics 2: e64 DOI: 10.1371/journal.pgen.0020064.
  • S. Qiu, R. Bergero, A. Forrest, V. Kaiser, D. Charlesworth 2010 Nucleotide diversity in Silene latifolia autosomal and sex-linked genes. Proceedings of the Royal Soc. 277: 3283-3290 (doi:10.1098/rspb.2010.0606).
  • Bergero, R., and D. Charlesworth, 2011 Preservation of the Y transcriptome in a 10MY old plant sex chromosome system. Current Biology 21: 1470–1474.
  • Jordan, C., and D. Charlesworth, 2012 The potential for sexually antagonistic polymorphism in different genome regions. Evolution 66: 505–516. DOI: 10.1111/j.1558-5646.2011.01448.x[13]

References edit

  1. ^ a b "2022 NAS Election". Retrieved 18 June 2022.
  2. ^ a b "Awards & Grants: 2020 Lifetime Achievement Award Recipient". Society for the Study of Evolution. Retrieved 29 January 2020.
  3. ^ a b "Genetics Society".
  4. ^ a b "EC/1991/08: Charlesworth, Deborah". The Royal Society.
  5. ^ a b c d e Mable, Barbara; Hill Bill (February 2008). "Deborah Charlesworth". Genet. Res. 90 (1): 1. doi:10.1017/S0016672307009093. PMID 18509956.
  6. ^ a b Mable, Barbara; Hill, Bill (February 2008). "editorial". Genetics Research. 90 (1): 1. doi:10.1017/S0016672307009093. ISSN 1469-5073.
  7. ^ "Deborah Charlesworth | Royal Society". royalsociety.org. Retrieved 19 November 2020.
  8. ^ a b c d e f g Wright, S. (2012). "Recipient of the 2011 Molecular Ecology Prize: Deborah Charlesworth". Molecular Ecology. 21 (1): 23–25. doi:10.1111/j.1365-294X.2011.05385.x. ISSN 1365-294X. PMID 22181850. S2CID 28511114.
  9. ^ "Evolution Tree - Deborah Charlesworth". academictree.org. Retrieved 23 November 2020.
  10. ^ "Biological Sciences". The University of Edinburgh.
  11. ^ "Web of Science". 2008. Retrieved 24 August 2008.
  12. ^ Wright, S. (2012). "Recipient of the 2011 Molecular Ecology Prize: Deborah Charlesworth". Molecular Ecology. 21 (1): 23–25. doi:10.1111/j.1365-294X.2011.05385.x. ISSN 1365-294X. PMID 22181850. S2CID 28511114.
  13. ^ . ed.ac.uk. Archived from the original on 26 March 2018. Retrieved 12 January 2017.

Bibliography edit

  • Introduction to Plant Population Biology (with Jonathan W Silvertown) ISBN 0-632-04991-X
  • Evolution: A Very Short Introduction (with Brian Charlesworth) OUP ISBN 0-19-280251-8

External links edit

  • Homepage


 

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April 12, 2024
deborah, charlesworth, frse, née, maltby, born, 1943, population, geneticist, from, notable, important, discoveries, population, genetics, evolutionary, biology, most, notable, research, understanding, evolution, recombination, chromosomes, mating, system, pla. Deborah Charlesworth FRS FRSE nee Maltby born 1943 is a population geneticist from the UK notable for her important discoveries in population genetics and evolutionary biology 6 7 Her most notable research is in understanding the evolution of recombination sex chromosomes and mating system for plants 6 Deborah CharlesworthFRSFRSEBornMarch 1943 age 81 CitizenshipBritishAlma materUniversity of CambridgeSpouseBrian Charlesworth m 1967 wbr Children1 daughterAwardsElected member of NAS 2022 1 Lifetime Achievement Award by the Society for the Study of Evolution 2020 2 Genetics Society Medal 2019 3 FRS 2011 4 FRSE 2001 5 Scientific careerFieldsEvolutionary biologyInstitutionsUniversity of Liverpool University of Sussex University of Chicago University of EdinburghThesisBiometrical studies of some biochemical characters in the mouse 1969 Doctoral studentsPhilip AwadallaOther notable studentsGilean McVean postdoc Contents 1 Early life and education 2 Awards and honors 3 Selected publications 4 References 5 Bibliography 6 External linksEarly life and education editCharlesworth grew up in a London suburb and from a young age was very interested in the natural world around her 5 Charlesworth initially studied biochemistry however genetic variation played a significant role since the beginning her research 8 Charlesworth obtained her doctorate at Cambridge University in 1968 with her thesis focusing on the quantitative genetics of mice specifically the extent of genetic variation in the blood glucose levels across natural strains 8 This also happened to be the topic of her first study 8 Charlesworth continued her education at Cambridge and Chicago as a research fellow in human genetics examining amino acid variations in hemoglobins in human populations 8 Charlesworth s interest in evolutionary biology continued through her collaboration with Brian Charlesworth specifically their works on mimicry systems and recombination rates causing her to shift her focus to evolution 8 She continued her post doctoral research at University of Chicago Liverpool University Sussex University as Brian Charlesworth took positions at each causing Debrah to do research without Grant support 8 She was mentored at Cambridge by Hermann Lehmann 9 At the age of 45 Charlesworth obtained her first faculty position teaching at University of Chicago from 1988 1997 5 By this time Charlesworth had already published 50 articles 8 Following this position Charlesworth left to take up a Professorial Research Fellowship at the University of Edinburgh 10 She is best known for her work on the evolution of genetic self incompatibility in plants and is recognised as a leader in that field According to the Web of Science she has published over 300 articles in peer reviewed journals These articles have been cited over 10 000 times and she has an h index of 53 11 She has been married since 1967 to the British evolutionary biologist Brian Charlesworth who she ended up working in population genetics with 5 Awards and honors editCharlesworth was elected a Fellow of the Royal Society of Edinburgh in 2001 5 and a Fellow of the Royal Society FRS in 2005 4 In 2011 Charlesworth was awarded the Molecular Ecology Prize 12 Charlesworth was awarded the Genetics Society Medal 2019 3 She was awarded a Lifetime Achievement Award by the Society for the Study of Evolution in January 2020 2 In 2022 she was elected to the National Academy of Sciences 1 Selected publications edit nbsp Scholia has a profile for Deborah Charlesworth Q4794846 Charlesworth D Wright SI 2001 Breeding systems and genome evolution Current Opinion in Genetics amp Development 11 685 690 Jesper S Bechsgaard Vincent Castric Deborah Charlesworth Xavier Vekemans Mikkel H Schierup 2006 The transition to self compatibility in Arabidopsis thaliana and evolution within S haplotypes over 10 million years Molecular Biology and Evolution 23 1741 1750 Asher D Cutter Scott E Baird and Deborah Charlesworth 2006 Patterns of nucleotide polymorphism and the decay of linkage disequilibrium in wild populations of Caenorhabditis remanei Genetics 174 901 913 Bergero R A Forrest E Kamau and D Charlesworth 2007 Evolutionary strata on the X chromosomes of the dioecious plant Silene latifolia evidence from new sex linked genes Genetics 175 1945 1954 D Charlesworth 2006 Balancing selection and its effects on sequences in nearby genome regions PLoS Genetics 2 e64 DOI 10 1371 journal pgen 0020064 S Qiu R Bergero A Forrest V Kaiser D Charlesworth 2010 Nucleotide diversity in Silene latifolia autosomal and sex linked genes Proceedings of the Royal Soc 277 3283 3290 doi 10 1098 rspb 2010 0606 Bergero R and D Charlesworth 2011 Preservation of the Y transcriptome in a 10MY old plant sex chromosome system Current Biology 21 1470 1474 Jordan C and D Charlesworth 2012 The potential for sexually antagonistic polymorphism in different genome regions Evolution 66 505 516 DOI 10 1111 j 1558 5646 2011 01448 x 13 References edit a b 2022 NAS Election Retrieved 18 June 2022 a b Awards amp Grants 2020 Lifetime Achievement Award Recipient Society for the Study of Evolution Retrieved 29 January 2020 a b Genetics Society a b EC 1991 08 Charlesworth Deborah The Royal Society a b c d e Mable Barbara Hill Bill February 2008 Deborah Charlesworth Genet Res 90 1 1 doi 10 1017 S0016672307009093 PMID 18509956 a b Mable Barbara Hill Bill February 2008 editorial Genetics Research 90 1 1 doi 10 1017 S0016672307009093 ISSN 1469 5073 Deborah Charlesworth Royal Society royalsociety org Retrieved 19 November 2020 a b c d e f g Wright S 2012 Recipient of the 2011 Molecular Ecology Prize Deborah Charlesworth Molecular Ecology 21 1 23 25 doi 10 1111 j 1365 294X 2011 05385 x ISSN 1365 294X PMID 22181850 S2CID 28511114 Evolution Tree Deborah Charlesworth academictree org Retrieved 23 November 2020 Biological Sciences The University of Edinburgh Web of Science 2008 Retrieved 24 August 2008 Wright S 2012 Recipient of the 2011 Molecular Ecology Prize Deborah Charlesworth Molecular Ecology 21 1 23 25 doi 10 1111 j 1365 294X 2011 05385 x ISSN 1365 294X PMID 22181850 S2CID 28511114 People ed ac uk Archived from the original on 26 March 2018 Retrieved 12 January 2017 Bibliography editIntroduction to Plant Population Biology with Jonathan W Silvertown ISBN 0 632 04991 X Evolution A Very Short Introduction with Brian Charlesworth OUP ISBN 0 19 280251 8External links editHomepage nbsp This article about a geneticist or evolutionary biologist is a stub You can help Wikipedia by expanding it vte nbsp This article about a British scientist is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Deborah Charlesworth amp oldid 1202983942, wikipedia, wiki, book, books, library,

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