Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-mannose and NADP+, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase. Other names in common use include dTDP-4-keto-L-rhamnose reductase, reductase, thymidine diphospho-4-ketorhamnose, dTDP-4-ketorhamnose reductase, TDP-4-keto-rhamnose reductase, and thymidine diphospho-4-ketorhamnose reductase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.
Structural studiesedit
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KBZ, 1KC1, 1KC3, 1N2S, and 2GGS.
Referencesedit
Melo A, Glaser L (1968). "The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose". J. Biol. Chem. 243 (7): 1475–8. PMID 4384782.
dtdp, dehydrorhamnose, reductase, enzymology, enzyme, that, catalyzes, chemical, reactionidentifiersec, 133cas, 37250, 9databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwaypriamprofilepdb, structuresrcsb, p. In enzymology a dTDP 4 dehydrorhamnose reductase EC 1 1 1 133 is an enzyme that catalyzes the chemical reactiondTDP 4 dehydrorhamnose reductaseIdentifiersEC no 1 1 1 133CAS no 37250 64 9DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins dTDP 6 deoxy L mannose NADP displaystyle rightleftharpoons dTDP 4 dehydro 6 deoxy L mannose NADPH H Thus the two substrates of this enzyme are dTDP 6 deoxy L mannose and NADP whereas its 3 products are dTDP 4 dehydro 6 deoxy L mannose NADPH and H This enzyme belongs to the family of oxidoreductases specifically those acting on the CH OH group of donor with NAD or NADP as acceptor The systematic name of this enzyme class is dTDP 6 deoxy L mannose NADP 4 oxidoreductase Other names in common use include dTDP 4 keto L rhamnose reductase reductase thymidine diphospho 4 ketorhamnose dTDP 4 ketorhamnose reductase TDP 4 keto rhamnose reductase and thymidine diphospho 4 ketorhamnose reductase This enzyme participates in 3 metabolic pathways nucleotide sugars metabolism streptomycin biosynthesis and polyketide sugar unit biosynthesis Structural studies editAs of late 2007 5 structures have been solved for this class of enzymes with PDB accession codes 1KBZ 1KC1 1KC3 1N2S and 2GGS References editMelo A Glaser L 1968 The mechanism of 6 deoxyhexose synthesis II Conversion of deoxythymidine diphosphate 4 keto 6 deoxy D glucose to deoxythymidine diphosphate L rhamnose J Biol Chem 243 7 1475 8 PMID 4384782 Portal nbsp Biology This EC 1 1 1 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DTDP 4 dehydrorhamnose reductase amp oldid 1172345504, wikipedia, wiki, book, books, library,
