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Directly observed treatment, short-course

April 14, 2024

"DOTS" redirects here. For the brand of gumdrops, see Dots (candy).

Directly observed treatment, short-course (DOTS, also known as TB-DOTS) is the name given to the tuberculosis (TB) control strategy recommended by the World Health Organization.[1] According to WHO, "The most cost-effective way to stop the spread of TB in communities with a high incidence is by curing it. The best curative method for TB is known as DOTS."[2] DOTS has five main components:

  • Government commitment (including political will at all levels, and establishment of a centralized and prioritized system of TB monitoring, recording and training)
  • Case detection by sputum smear microscopy
  • Standardized treatment regimen directly of six to nine months observed by a healthcare worker or community health worker for at least the first two months
  • Drug supply
  • A standardized recording and reporting system that allows assessment of treatment results

History edit

The technical strategy for DOTS was developed by Karel Styblo of the International Union Against TB & Lung Disease in the 1970s and 80s, primarily in Tanzania, but also in Malawi, Nicaragua and Mozambique. Styblo refined "a treatment system of checks and balances that provided high cure rates at a cost affordable for most developing countries." This increased the proportion of people cured of TB from 40% to nearly 80%, costing up to $10 per life saved and $3 per new infection avoided.[3]

In 2007, WHO and the World Bank began investigating the potential expansion of this strategy. In July 2008, the World Bank invited Styblo and WHO to design a TB control project for China. By the end of 2007 this pilot project was achieving phenomenal results, more than doubling cure rates among TB patients. China soon extended this project to cover half the country.[4]

During the early 1990s, WHO determined that of the nearly 700 different tasks involved in Styblo's meticulous system, only 100 of them were essential to run an effective TB control program. From this, WHO's relatively small TB unit at that time, led by Arata Kochi, developed an even more concise "Framework for TB Control" focusing on five main elements and nine key operations. The initial emphasis was on "DOT, or directly observed therapy, using a specific combination of TB medicines known as short-course chemotherapy as one of the five essential elements for controlling TB.[5] In 1993, the World Bank's Word Development Report claimed that the TB control strategies used in DOTS were one of the most cost-effective public health investments.[6]

In the Fall of 1994, Kraig Klaudt, WHO's TB Advocacy Officer, developed the name and concept for a marketing strategy to brand this complex public health intervention. To help market "DOTS" to global and national decision makers, turning the word "dots" upside down to spell "stop" proved a memorable shorthand that promoted "Stop TB. Use Dots!"[7][8]

According to POZ Magazine, "You know the worldwide epidemic of TB is entering a critical stage when the cash-strapped World Health Organization spends a fortune on glossy paper, morbid photos and an interactive, spinning (!) cover for its 1995 TB report."[9] India's Joint Effort to Eradicate TB NGO observed that, "DOTS became a clarion call for TB control programmes around the world. Because of its novelty, this health intervention quickly captured the attention of even those outside of the international health community."[7]

The DOTS report was released to the public on March 20, 1995, at New York City's Health Department. At the news conference, Tom Frieden, head of the city's Bureau of TB Control captured the essence of DOTS, "TB control is basically a management problem." Frieden had been credited for using the strategy to turn around New York City's TB outbreak a few years earlier.[10][11]

On March 19, 1997, at the Robert Koch Institute in Berlin, Germany, WHO announced that "DOTS was the biggest health breakthrough of the decade." According to WHO Director-General Hiroshi Nakajima, "We anticipate that at least 10 million deaths from TB will be prevented in the next ten years with the introduction and extensive use of the DOTS strategy."[12][13] Upon Nakajima's death in 2013, WHO recognized that the promotion of DOTS was one of WHO's most successful programs developed during his ten-year administration.[14]

Impact edit

There has been a steady uptake of DOTS TB control services over the subsequent decades. Whereas previously less than 2% of infectious TB patients were being detected and cured, with DOTS treatment services in 1990 approximately 60% have been benefitted from this care. Since 1995, 41 million people have been successfully treated and up to 6 million lives saved through DOTS and the Stop TB Strategy. 5.8 million TB cases were notified through DOTS programs in 2009.[15]

A systematic review of randomized clinical trials found no difference for cure rates as well as the treatment completion rates between directly observed therapy (DOT) and self-administered drug therapy.[16] A 2013 meta-analysis of both clinical trials and observational studies too did not find any difference between DOTS and self-administered therapy.[17] However, the WHO and all other TB programs continue to use DOTS as an important strategy for TB delivery for fear of drug resistance.[citation needed]

DOTS-Plus is for multi-drug-resistant tuberculosis (MDR-TB).

References edit

  1. ^ As of 1997, in its revised guidelines for national TB control programs, WHO increasingly stopped spelling out the DOTS acronym. This was due to the perceived overemphasis on the directly observed therapy component (DOT), which is only one of the five essential components of DOTS. See Treatment of TB: Guidelines for National Programmes. World Health Organization. WHO/TB/97.220. 1997
  2. ^ "Tuberculosis." WHO factsheet (revised). No. 104. March 1996.
  3. ^ "TB: Join the DOTS." The Economist. May 20, 1995. P. 89.
  4. ^ "Controlling Tuberculosis in China." In Millions Saved: Proven Successes in Global Health, edited by Ruth Levine, 31–37. Washington, D.C.: Center for Global Development, 2014.
  5. ^ "Framework for Effective Tuberculosis Control." World Health Organization. Document WHO/TB/94.179.
  6. ^ World Bank. 1993. World Development Report 1993: Investing in Health. Oxford University Press: New York.
  7. ^ a b "Creation of DOTS" JEET (Joint Effort to Eradicate Tuberculosis)
  8. ^ Ogden, J.; et al. (2003). "The politics of 'branding' in policy transfer: the case of DOTS for tuberculosis control". Social Science & Medicine. 57 (1): 179–188. doi:10.1016/S0277-9536(02)00373-8. PMID 12753826.
  9. ^ "Lives in Turnaround: WHO knows how to address TB." POZ Magazine. Aug./Sept. 1995. P. 16.
  10. ^ "WHO Calls for Action Against TB". Science. Vol. 267. March 24, 1995.
  11. ^ Klaudt, K. (2000). "The Political Causes and Solutions of the Current Tuberculosis Epidemic." In J. Whitman (Ed.), The Politics of Emerging and Resurgent Infectious Diseases (pp. 86–109). London: MacMillan Press.
  12. ^ "Breakthrough in TB Control Announced by WHO." WHO press release. WHO/23, March 19, 1997
  13. ^ "Is DOTS the Health Breakthrough of the 1990s?" World Health Form. Vol. 18, No. 3/4, 1997. World Health Organization. Geneva.
  14. ^ . www.WHO.int. 28 January 2013. Archived from the original on April 14, 2014. Retrieved 10 August 2017.
  15. ^ United Nations Millennium Development Goals Report 2011. 2011, p. 51.
  16. ^ Volmink, J; Garner P (2015). "Directly observed therapy for treating tuberculosis". Cochrane Database of Systematic Reviews. 2015 (5): CD003343. doi:10.1002/14651858.CD003343.pub4. PMC 4460720. PMID 26022367.
  17. ^ Pasipondya, JG; Gumbo T (2013). "A meta-analysis of self-administered vs directly observed therapy effect on microbiologic failure, relapse, and acquired drug resistance in tuberculosis patients". Clin Infect Dis. 57 (1): 21–31. doi:10.1093/cid/cit167. PMC 3669525. PMID 23487389.

External links edit

  • WHO - DOTS
  • ACTION Advocacy to Control TB Internationally
  • A guide to Understanding the WHO-recommended TB Control Strategy Known as DOTS by World Health Organization 1999
  • DOTS for treating TB Volmink J, Garner P. Directly observed therapy for treating tuberculosis. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD003343. DOI:10.1002/14651858.CD003343.pub3.
  • Every one need to apply DOT Medical Card DOT Medical Card

April 14, 2024
directly, observed, treatment, short, course, dots, redirects, here, brand, gumdrops, dots, candy, dots, also, known, dots, name, given, tuberculosis, control, strategy, recommended, world, health, organization, according, most, cost, effective, stop, spread, . DOTS redirects here For the brand of gumdrops see Dots candy Directly observed treatment short course DOTS also known as TB DOTS is the name given to the tuberculosis TB control strategy recommended by the World Health Organization 1 According to WHO The most cost effective way to stop the spread of TB in communities with a high incidence is by curing it The best curative method for TB is known as DOTS 2 DOTS has five main components Government commitment including political will at all levels and establishment of a centralized and prioritized system of TB monitoring recording and training Case detection by sputum smear microscopy Standardized treatment regimen directly of six to nine months observed by a healthcare worker or community health worker for at least the first two months Drug supply A standardized recording and reporting system that allows assessment of treatment resultsContents 1 History 2 Impact 3 References 4 External linksHistory editThis article appears to contradict the article Karel Styblo Please discuss at the talk page and do not remove this message until the contradictions are resolved The technical strategy for DOTS was developed by Karel Styblo of the International Union Against TB amp Lung Disease in the 1970s and 80s primarily in Tanzania but also in Malawi Nicaragua and Mozambique Styblo refined a treatment system of checks and balances that provided high cure rates at a cost affordable for most developing countries This increased the proportion of people cured of TB from 40 to nearly 80 costing up to 10 per life saved and 3 per new infection avoided 3 In 2007 WHO and the World Bank began investigating the potential expansion of this strategy In July 2008 the World Bank invited Styblo and WHO to design a TB control project for China By the end of 2007 this pilot project was achieving phenomenal results more than doubling cure rates among TB patients China soon extended this project to cover half the country 4 During the early 1990s WHO determined that of the nearly 700 different tasks involved in Styblo s meticulous system only 100 of them were essential to run an effective TB control program From this WHO s relatively small TB unit at that time led by Arata Kochi developed an even more concise Framework for TB Control focusing on five main elements and nine key operations The initial emphasis was on DOT or directly observed therapy using a specific combination of TB medicines known as short course chemotherapy as one of the five essential elements for controlling TB 5 In 1993 the World Bank s Word Development Report claimed that the TB control strategies used in DOTS were one of the most cost effective public health investments 6 In the Fall of 1994 Kraig Klaudt WHO s TB Advocacy Officer developed the name and concept for a marketing strategy to brand this complex public health intervention To help market DOTS to global and national decision makers turning the word dots upside down to spell stop proved a memorable shorthand that promoted Stop TB Use Dots 7 8 According to POZ Magazine You know the worldwide epidemic of TB is entering a critical stage when the cash strapped World Health Organization spends a fortune on glossy paper morbid photos and an interactive spinning cover for its 1995 TB report 9 India s Joint Effort to Eradicate TB NGO observed that DOTS became a clarion call for TB control programmes around the world Because of its novelty this health intervention quickly captured the attention of even those outside of the international health community 7 The DOTS report was released to the public on March 20 1995 at New York City s Health Department At the news conference Tom Frieden head of the city s Bureau of TB Control captured the essence of DOTS TB control is basically a management problem Frieden had been credited for using the strategy to turn around New York City s TB outbreak a few years earlier 10 11 On March 19 1997 at the Robert Koch Institute in Berlin Germany WHO announced that DOTS was the biggest health breakthrough of the decade According to WHO Director General Hiroshi Nakajima We anticipate that at least 10 million deaths from TB will be prevented in the next ten years with the introduction and extensive use of the DOTS strategy 12 13 Upon Nakajima s death in 2013 WHO recognized that the promotion of DOTS was one of WHO s most successful programs developed during his ten year administration 14 Impact editThere has been a steady uptake of DOTS TB control services over the subsequent decades Whereas previously less than 2 of infectious TB patients were being detected and cured with DOTS treatment services in 1990 approximately 60 have been benefitted from this care Since 1995 41 million people have been successfully treated and up to 6 million lives saved through DOTS and the Stop TB Strategy 5 8 million TB cases were notified through DOTS programs in 2009 15 A systematic review of randomized clinical trials found no difference for cure rates as well as the treatment completion rates between directly observed therapy DOT and self administered drug therapy 16 A 2013 meta analysis of both clinical trials and observational studies too did not find any difference between DOTS and self administered therapy 17 However the WHO and all other TB programs continue to use DOTS as an important strategy for TB delivery for fear of drug resistance citation needed DOTS Plus is for multi drug resistant tuberculosis MDR TB References edit As of 1997 in its revised guidelines for national TB control programs WHO increasingly stopped spelling out the DOTS acronym This was due to the perceived overemphasis on the directly observed therapy component DOT which is only one of the five essential components of DOTS See Treatment of TB Guidelines for National Programmes World Health Organization WHO TB 97 220 1997 Tuberculosis WHO factsheet revised No 104 March 1996 TB Join the DOTS The Economist May 20 1995 P 89 Controlling Tuberculosis in China In Millions Saved Proven Successes in Global Health edited by Ruth Levine 31 37 Washington D C Center for Global Development 2014 Framework for Effective Tuberculosis Control World Health Organization Document WHO TB 94 179 World Bank 1993 World Development Report 1993 Investing in Health Oxford University Press New York a b Creation of DOTS JEET Joint Effort to Eradicate Tuberculosis Ogden J et al 2003 The politics of branding in policy transfer the case of DOTS for tuberculosis control Social Science amp Medicine 57 1 179 188 doi 10 1016 S0277 9536 02 00373 8 PMID 12753826 Lives in Turnaround WHO knows how to address TB POZ Magazine Aug Sept 1995 P 16 WHO Calls for Action Against TB Science Vol 267 March 24 1995 Klaudt K 2000 The Political Causes and Solutions of the Current Tuberculosis Epidemic In J Whitman Ed The Politics of Emerging and Resurgent Infectious Diseases pp 86 109 London MacMillan Press Breakthrough in TB Control Announced by WHO WHO press release WHO 23 March 19 1997 Is DOTS the Health Breakthrough of the 1990s World Health Form Vol 18 No 3 4 1997 World Health Organization Geneva WHO Former Director General of WHO dies health contributions remembered www WHO int 28 January 2013 Archived from the original on April 14 2014 Retrieved 10 August 2017 United Nations Millennium Development Goals Report 2011 2011 p 51 Volmink J Garner P 2015 Directly observed therapy for treating tuberculosis Cochrane Database of Systematic Reviews 2015 5 CD003343 doi 10 1002 14651858 CD003343 pub4 PMC 4460720 PMID 26022367 Pasipondya JG Gumbo T 2013 A meta analysis of self administered vs directly observed therapy effect on microbiologic failure relapse and acquired drug resistance in tuberculosis patients Clin Infect Dis 57 1 21 31 doi 10 1093 cid cit167 PMC 3669525 PMID 23487389 External links editDOTS program WHO DOTS ACTION Advocacy to Control TB Internationally What is DOTS A guide to Understanding the WHO recommended TB Control Strategy Known as DOTS by World Health Organization 1999 DOTS for treating TB Volmink J Garner P Directly observed therapy for treating tuberculosis Cochrane Database of Systematic Reviews 2007 Issue 4 Art No CD003343 DOI 10 1002 14651858 CD003343 pub3 Every one need to apply DOT Medical Card DOT Medical Card Retrieved from https en wikipedia org w index php title Directly observed treatment short course amp oldid 1185034812, wikipedia, wiki, book, books, library,

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