Dynamin-3 is a protein that in humans is encoded by the DNM3gene.[5][6] The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.[7] DNM3 is upregulated in Sézary's syndrome.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000197959 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000040265 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
^Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008). "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3". Leukemia. 22 (2): 393–9. doi:10.1038/sj.leu.2405044. PMID 18033314.
Further readingedit
Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Sever S (2003). "Dynamin and endocytosis". Curr. Opin. Cell Biol. 14 (4): 463–7. doi:10.1016/S0955-0674(02)00347-2. PMID 12383797.
Wiejak J, Wyroba E (2003). "Dynamin: characteristics, mechanism of action and function". Cell. Mol. Biol. Lett. 7 (4): 1073–80. PMID 12511974.
Orth JD, McNiven MA (2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
Larsen MR, Graham ME, Robinson PJ, Roepstorff P (2004). "Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III". Mol. Cell. Proteomics. 3 (5): 456–65. doi:10.1074/mcp.M300105-MCP200. PMID 14762214.
Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
External linksedit
Overview of all the structural information available in the PDB for UniProt: Q9UQ16 (Dynamin-3) at the PDBe-KB.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
dnm3, dynamin, protein, that, humans, encoded, gene, protein, encoded, this, gene, member, dynamin, family, which, possess, mechanochemical, properties, involved, actin, membrane, processes, predominantly, membrane, budding, upregulated, sézary, syndrome, avai. Dynamin 3 is a protein that in humans is encoded by the DNM3 gene 5 6 The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin membrane processes predominantly in membrane budding 7 DNM3 is upregulated in Sezary s syndrome 8 DNM3Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes3L43 5A3FIdentifiersAliasesDNM3 Dyna III dynamin 3External IDsOMIM 611445 MGI 1341299 HomoloGene 22906 GeneCards DNM3Gene location Human Chr Chromosome 1 human 1 Band1q24 3Start171 817 887 bp 1 End172 418 466 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 1 H2 1Start161 810 022 bp 2 End162 305 603 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inponsBrodmann area 46corpus callosumpostcentral gyrussuperior vestibular nucleusorbitofrontal cortexinternal globus pallidussuperior frontal gyrusinferior ganglion of vagus nervesubthalamic nucleusTop expressed infacial motor nucleusanterior horn of spinal cordsuperior colliculusinferior colliculuspontine nucleimedial vestibular nucleussubstantia nigradorsal tegmental nucleusmedial dorsal nucleusventral tegmental areaMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding nitric oxide synthase binding type 1 metabotropic glutamate receptor binding GTP binding type 5 metabotropic glutamate receptor binding protein binding hydrolase activity GTPase activity microtubule binding identical protein binding structural constituent of postsynapseCellular componentcytoplasm Golgi apparatus postsynaptic density photoreceptor inner segment dendritic spine synapse axon dendritic spine head mitochondrion perinuclear region of cytoplasm synaptic cleft microtubule extracellular exosome cytoskeleton mitochondrial membranes postsynaptic endocytic zone membrane plasma membrane membrane cytoplasmic vesicle postsynaptic membrane apical tubulobulbar complex basal tubulobulbar complex presynapse glutamatergic synapseBiological processendocytosis positive regulation of filopodium assembly regulation of dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission synapse assembly filopodium assembly membrane fusion synaptic vesicle budding from presynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization receptor internalization synaptic vesicle endocytosis regulation of synapse structure or activity postsynapse organization positive regulation of synaptic vesicle recyclingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez26052103967EnsemblENSG00000197959ENSMUSG00000040265UniProtQ9UQ16Q8BZ98RefSeq mRNA NM 001136127NM 001278252NM 015569NM 001350204NM 001350205NM 001350206NM 001038619NM 172646RefSeq protein NP 001129599NP 001265181NP 056384NP 001337133NP 001337134NP 001337135NP 001033708NP 766234Location UCSC Chr 1 171 82 172 42 MbChr 1 161 81 162 31 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000197959 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000040265 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nagase T Ishikawa K Suyama M Kikuno R Hirosawa M Miyajima N Tanaka A Kotani H Nomura N Ohara O May 1999 Prediction of the coding sequences of unidentified human genes XII The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 5 6 355 64 doi 10 1093 dnares 5 6 355 PMID 10048485 Entrez Gene DNM3 dynamin 3 Orth JD McNiven MA February 2003 Dynamin at the actin membrane interface Curr Opin Cell Biol 15 1 31 9 doi 10 1016 S0955 0674 02 00010 8 PMID 12517701 Booken N Gratchev A Utikal J Weiss C Yu X Qadoumi M Schmuth M Sepp N Nashan D Rass K Tuting T Assaf C Dippel E Stadler R Klemke CD Goerdt S February 2008 Sezary syndrome is a unique cutaneous T cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3 Leukemia 22 2 393 9 doi 10 1038 sj leu 2405044 PMID 18033314 Further reading editNakajima D Okazaki N Yamakawa H et al 2003 Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones DNA Res 9 3 99 106 doi 10 1093 dnares 9 3 99 PMID 12168954 Sever S 2003 Dynamin and endocytosis Curr Opin Cell Biol 14 4 463 7 doi 10 1016 S0955 0674 02 00347 2 PMID 12383797 Wiejak J Wyroba E 2003 Dynamin characteristics mechanism of action and function Cell Mol Biol Lett 7 4 1073 80 PMID 12511974 Orth JD McNiven MA 2003 Dynamin at the actin membrane interface Curr Opin Cell Biol 15 1 31 9 doi 10 1016 S0955 0674 02 00010 8 PMID 12517701 Tu JC Xiao B Yuan JP et al 1998 Homer binds a novel proline rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors Neuron 21 4 717 26 doi 10 1016 S0896 6273 00 80589 9 PMID 9808459 S2CID 2851554 Hartley JL Temple GF Brasch MA 2001 DNA cloning using in vitro site specific recombination Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 PMID 11076863 Wiemann S Weil B Wellenreuther R et al 2001 Toward a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs Genome Res 11 3 422 35 doi 10 1101 gr GR1547R PMC 311072 PMID 11230166 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Navarro Lerida I Martinez Moreno M Roncal F et al 2004 Proteomic identification of brain proteins that interact with dynein light chain LC8 Proteomics 4 2 339 46 doi 10 1002 pmic 200300528 PMID 14760703 S2CID 8868600 Larsen MR Graham ME Robinson PJ Roepstorff P 2004 Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry evidence for in vivo doubly phosphorylated dynamin I and dynamin III Mol Cell Proteomics 3 5 456 65 doi 10 1074 mcp M300105 MCP200 PMID 14762214 Kamioka Y Fukuhara S Sawa H et al 2004 A novel dynamin associating molecule formin binding protein 17 induces tubular membrane invaginations and participates in endocytosis J Biol Chem 279 38 40091 9 doi 10 1074 jbc M404899200 PMID 15252009 Wiemann S Arlt D Huber W et al 2004 From ORFeome to biology a functional genomics pipeline Genome Res 14 10B 2136 44 doi 10 1101 gr 2576704 PMC 528930 PMID 15489336 Mehrle A Rosenfelder H Schupp I et al 2006 The LIFEdb database in 2006 Nucleic Acids Res 34 Database issue D415 8 doi 10 1093 nar gkj139 PMC 1347501 PMID 16381901 Gregory SG Barlow KF McLay KE et al 2006 The DNA sequence and biological annotation of human chromosome 1 Nature 441 7091 315 21 Bibcode 2006Natur 441 315G doi 10 1038 nature04727 PMID 16710414 External links editOverview of all the structural information available in the PDB for UniProt Q9UQ16 Dynamin 3 at the PDBe KB nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DNM3 amp oldid 1115447922, wikipedia, wiki, book, books, library,
